• Title/Summary/Keyword: Non-integrity

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Gelatinase, a Possible Etiologic Factor of Photoaging, is Present in Healthy Human Facial Skin and is Inhibited by Turmeric Extract

  • Takada, Keiko;Amano, Satoshi;Matsunaga, Yukiko;Kohno, Yoshiyuki;Inomata, Shinji
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.387-412
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    • 2003
  • Influence of gelatinase on basement membrane (BM) structure was investigated by using a skin equivalent (SE) model. The results showed that (1) gelatinase produced by cells degraded the BM and (2) the addition of matrix metalloproteinase-specific inhibitor to the SE medium accelerated the formation of BM structure, indicating that gelatinase is involved in BM impairment. The activity of gelatinase was also studied in healthy human facial skin tissues. The result of in situ zymography revealed gelatinase activity around the basal layer of the epidermis, where BM integrity was severely compromised. Therefore, this enzyme was suggested to be associated with BM decomposition in human facial skin. To assess the behavior of gelatinase in stratum corneum (SC) non-invasively, an immunological study was performed. Since positive immunostaining of pro-gelatinase B was observed in SC stripped from sun-exposed skin, whereas no positive staining detected in SC of non-irradiated skin, gelatinase in the epidermis could be non-invasively detected by measuring gelatinase in SC. Gelatinase in SC of healthy female volunteers was monitored using a special film that sensitively and conveniently detects gelatinase. Ninetr percent of SC from facial skin (l00 women, 40's-50's) was gelatinase-positive. On the other hand, SC from non-irradiated skin was negative. These results strongly suggest that (1) gelatinase is constantly produced in the facial epidermis of most middle-aged woman during their daily life, and (2) the enzyme might be involved in the aging-related degeneration of both BM and the matrix fibers of the upper layer of the dermis, acting as a very important aging factor. Strong inhibitory activity against gelatinase was found in turmeric extract and identified curcumin as the major ingredient. Topical application of cream containing turmeric extract significantly decreased the number of gelatinase-positive SC clusters in human facial skins. These results indicated that turmeric is an effective ingredient to prevent skin from photo aging by suppressing chlonically upregulated gelatinase activity by UV and to improve skin condition.

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The Effect of Degradation on the Fretting fatigue for 1Cr-0.5Mo Steel (1Cr-0.5Mo 강의 재질열화가 프레팅 피로거동에 미치는 영향)

  • Kwon, Jae-Do;Choi, Sung-Jong;Kim, Kyung-Soo;Bae, Yong-Tak
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.27 no.11
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    • pp.1979-1985
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    • 2003
  • Fretting is a kind of surface degradation mechanism observed in mechanical components and structures. The fretting damage decreases in 50-70% of the plain fatigue strength. This may be observed in the fossil power plant and the nuclear power plant used in special environments and various loading conditions. The thermal degradation of material is observed when the heat resisting steel is exposed for long period time at the high temperature. In the present study, the degraded 1Cr-0.5Mo steel used for long period time at high temperature (about 515$^{\circ}C$) and artificially reheat-treated materials are prepared. These materials are used for evaluating an effect of thermal aging on the fretting fatigue behavior. Through the experiment, it is found that the fretting fatigue endurance limit of the reheat-treated 1Cr-0.5Mo steel decreased about 46% from the non-fretting fatigue endurance limit, while the fretting fatigue endurance limit of the degraded 1Cr-0.5Mo steel decreased about 53% from the non-fretting fatigue endurance limit. The maximum value of fatigue endurance limit difference is observed as 57%(244 MPa) between the fretting fatigue of degraded material and non-fretting fatigue of reheat-treated material. These results can be a basic data to a structural integrity evaluation of heat resisting steel considered to thermal degradation effect.

Analysis of Incarceration Attacks with RRCReject and RRCRelease in 5G Standalone Non-Public Network

  • Kim, Keewon;Park, Jong-Geun;Park, Tae-Keun
    • Journal of the Korea Society of Computer and Information
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    • v.26 no.10
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    • pp.93-100
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    • 2021
  • In this paper, the possibility of a UE (User Equipment) incarceration attack using RRCRejecet and RRCRelease in 5G SNPN (Standalone Non-Public Network) is analyzed based on the 3GPP standard document. First, the cell selection and reselection procedures of the UE are analyzed, and then the processing process of the false base station and the UE before and after transmission of RRCReject and RRCRelease is analyzed. As a result of the analysis, it is possible that the false base station that transmits a strong signal causes the victim UE to establish an RRC connection to the false base station itself. In addition, if the false base station transmits an RRCReject message without integrity protection in response to the victim UE's attempt to establish an RRC connection, it is determined that the victim UE can continue to stay in the RRC connection attempt process. On the other hand, it is determined that it is impossible to incarcerate the victim UE by inducing an attempt to establish an RRC connection to another false base station using RRCRelease.

FATIGUE DESIGN OF BUTT-WELDED TUBULAR JOINTS

  • Kim, D. S.;S. Nho;F. Kopp
    • Proceedings of the KWS Conference
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    • 2002.10a
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    • pp.127-132
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    • 2002
  • Recent deepwater offshore structures in Gulf of Mexico utilize butt welded tubular joints. Application of welded tubular joint includes tendons, production risers, and steel catenary risers. Fatigue life assessment of these joints becomes more critical because the structures to which they are attached are allowed to undergo cyclic and sometimes large displacements around an anchored position. Estimating the fatigue behavior of these tubular members in the design stage is generally conducted by using S-N curves specified in the codes and standards. Applying the stress concentration factor of the welded structure to S-N approach often results in very conservative assessment because the stress field acting on the tubular has a non-uniform distribution through the thickness. Fracture mechanics and fitness for service (FFS) technology have been applied in the design of the catenary risers. This technology enables the engineer to establish proper requirements on weld quality and inspection acceptance criteria to assure satisfactory structural integrity during its design life. It also provides guidance on proper design curves to be used and a methodology for accounting for the effects of non-uniform stress distribution through the wall thickness. An attempt was made to develop set of S-N curves based on fracture mechanics approach by considering non-uniform stress distribution and a threshold stress intensity factor. Series of S-N curves generated from this approach were compared to the existing S-N curves. For flat plate butt joint, the S-N curve generated from fracture mechanics matches with the IIW class 100 curve when initial crack depth was 0.5 mm (0.02"). Similar comparison with API X′ was made for tubular joint.. These initial crack depths are larger than the limits of inspection by current Non-destructive examination (NDE) means, such as Automatic Ultrasonic Inspection (AUT). Thus a safe approach can be taken by specifying acceptance criteria that are close to limits of sizing capability of the selected NDE method. The comparison illustrates conservatism built into the S-N design curve.

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Tamper Detection of Digital Images using Hash Functions (해쉬 함수를 이용한 디지털 영상의 위변조 검출)

  • Woo, Chan-Il;Lee, Seung-Dae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.7
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    • pp.4516-4521
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    • 2014
  • Digital watermarking for digital image authentication and integrity schemes are based on fragile watermarking and can detect any modifications in a watermark embedded image by comparing the embedded watermark with the regenerated watermark. Therefore, the digital watermark for image authentication and integrity should be erased easily when the image is changed by digital image processing, such as scaling or filtering etc. This paper proposes an effective tamper detection scheme for digital images. In the proposed scheme, the original image was divided into many non-overlapping $2{\times}2$ blocks. The digital watermark was divided into two LSB of each block and the image distortion was imperceptible to the human eye. The watermark extraction process can be used to determine if the watermarked image has been tampered. The experimental results successfully revealed the effectiveness of the proposed scheme.

Evaluation of Software Diagnostics for Secure Operational Environment in Nuclear I&C systems (원전 계측제어 시스템 보안성환경을 위한 진단기능 평가)

  • Yoo, Sung Goo;Seul, Namo
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.8
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    • pp.107-112
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    • 2016
  • Safety Critical Instrumentation and Control Systems perform those functions to maintain nuclear power plants' parameters within acceptable limits established for a design basis events and anticipated operating occurrence to ensure safety function. Those digitalized systems shall protect inadvertent and non-malicious behavior to ensure the reliable operation of systems, known as a Secure Development and Operational Environment(SDOE). SDOE would be established through managerial and technical controls. The objective of this paper is to evaluate the effectiveness of Cyclic Redundancy Checksum diagnostic, which is one of technical controls for SDOE, that can confirm the integrity of software of I&C systems to establish the secure environment. The results of this assessment would be the practical implementation of design and safety review of nuclear I&C systems.

Inspection of Heat Exchanger Tubing Defects with Ultrasonic Guided Waves (유도초음파를 이용한 열 교환기 튜브 결함 탐상)

  • Shin, Hyeon-Jae;Rose, Joseph L.;Song, Sung-Jin
    • Journal of the Korean Society for Nondestructive Testing
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    • v.20 no.1
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    • pp.1-9
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    • 2000
  • This study shows the defect detection and sizing capability of ultrasonic guided waves in the nondestructive inspection of heat exchanger and steam generator tubing. Phase and group velocity dispersion curves for the longitudinal and flexural modes of a sample Inconel tube were presented for the theoretical analysis. EDM(Electric Discharge Machining) wears in tubing under a tube support plate and circumferential laser notches in tubing were detected by an axisymmetric and a non-axisymmetric transducer set up, respectively. EDM wears were detected with L(0, 2), L(0, 3) and L(0, 4) modes and among them L(0, 4) mode was found to be the most sensitive. It was also found that the flexural modes around L(0, 1) mode could be used for the detection and sizing of laser notches in the tubing.

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Integrity Evaluation of Railway Bogie Using Infrared Thermography Technique (적외선 열화상 기술을 이용한 철도차량 대차 건전성 평가)

  • Kim, Jeong-Guk
    • Journal of the Korean Society for Nondestructive Testing
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    • v.31 no.2
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    • pp.144-149
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    • 2011
  • The lock-in thermography was employed to evaluate the integrity of railway bogies. Prior to the actual application on railway bogies, in order to assess the detectability of known flaws, the calibration reference panel was prepared with various dimensions of artificial flaws. The panel was composed of structural steel, which was the same material with actual bogies. Through lock-in thermography evaluation, the optimal frequency of heat source was determined for the best flaw detection. Based on the defects information, the actual defect assessments on railway bogie were conducted with different types of railway bogies, which were used for the current operation. In summary, the defect assessment results with thermography method showed a good agreement as compared with the conventional inspection techniques. Moreover, it was found that the novel infrared thermography technique could be an effective way for the inspection and the detection of surface defects on bogies since the infrared thermography method provided rapid and non-contact mode for the investigation of railway bogies.

The Test for Verifying a Tip-Over Analysis of a Dry Storage Cask (건식저장용기에 대한 전복해석의 검증시험)

  • Kim Dong-Hak;Seo Ki-Seog;Lee Ju-Chan;Cho Chun-Hyung;Jang Hyun-Kee;Choi Byung-Il
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.4 no.3
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    • pp.245-253
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    • 2006
  • A test of the 1/3 scale model was conducted to verify the tip-over analysis of a dry. concrete storage cask under a hypothetical accident condition. The tip-over analysis was executed using the velocity at each point as the initial conditions of the model just before the impact. The initial velocity was determined from the initial angular velocity, which would make the equivalent kinetic energy to the potential energy. To confirm the structural integrity of the canister, the visual testing and the non-detective testings such as Liquid Penetrant testing and Ultrasonic Testing were conducted. The lid of a storage cask was plastically deformed near the impact point. The structural integrity of storage cask was maintained. To verify the tip-over analysis the strains and the accelerations acquired by the tip-over test were compared with those by the analyses. The results of the analysis were larger than the test results about two times.

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Spinous Process-Splitting Hemilaminoplasty for Intradural and Extradural Lesions

  • Lee, Young-Seok;Kim, Young-Baeg;Park, Seung-Won
    • Journal of Korean Neurosurgical Society
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    • v.58 no.5
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    • pp.494-498
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    • 2015
  • Objective : To describe a novel spinous process-splitting hemilaminoplasty technique for the surgical treatment of intradural and posterior epidural lesions that promotes physiological restoration. Methods : The spinous process was split, the area of the facet lamina junction was drilled, and en bloc hemilaminectomy was then performed. After removing intradural and posterior epidural lesions, we fitted the previously en bloc-removed bone to the pre-surgery same shape, and held it in place with non-absorbable sutures. Surgery was performed on 16 laminas from a total of nine patients between 2011 and 2014. Bony union of the reconstructed lamina was assessed using computed tomography (CT) at 6 months after surgery. Results : Spinous process-slitting hemilaminoplasty was performed for intradural extramedullary tumors in eight patients and for ossification of the ligament flavum in one patient. Because we were able to visualize the margin of the ipsilateral and contralateral dura, we were able to secure space for removal of the lesion and closure of the dura. None of the cases showed spinal deformity or other complications. Bone fusion and maintenance of the spinal canal were found to be perfect on CT scans. Conclusion : The spinous process-splitting hemilaminoplasty technique presented here was successful in creating sufficient space to remove intradural and posterior epidural lesions and to close the dura. Furthermore, we were able to maintain the physiological barrier and integrity after surgery because the posterior musculature and bone structures were restored.