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Pulmonary Mucormycosis with an Appearance of Consolidation (경화 양상으로 나타난 폐의 Mucormycosis)

  • Kim, Shin-Chae;Lee, Heung-Bum;Lee, Yong-Chul;Rhee, Yang-Keun
    • Tuberculosis and Respiratory Diseases
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    • v.49 no.1
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    • pp.117-121
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    • 2000
  • The mucormycosis is a group of serious opportunistic infections caused by fungi of the class Zygomycetes and order Mucorales. Pulmonary mucormycosis is a relatively rare disease but typically manifested by a rapidly progressive, often fatal pneumonia in patients with diabetes mellitus, hematologic malignant neoplasms, or organ transplants. The radiologic manifestations of pulmonary mucormycosis are nonspecific and include progressive lobar or multilobar consolidations, pulmonary masses and pulmonary nodules. Recently, we experienced a pulmonary mucormycosis in 32-year-old man with uncontrolled diabetes. He complained of cough, left pleuritic chest pain and generalized weakness. Initial chest X-ray finding was the consolidation on the lower lobe of the left lung. On the sixth hospital day, bronchoscopic examination with lung biopsy revealed broad, non-septate hyphae with right-angle branching, diagnostic of mucormycosis, and consequently amphotericin B therapy was started. We performed a lobectomy of the left lower lobe of the lung on 29th hospital day.

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Effects of Boron Application on the Outbreak of Granville wilt in Flue-cured Tobacco (붕소시용에 잎담배입고병발생에 미치는 영향)

  • Lee J.D.;Ban Y.S.;Yu I.S.
    • Korean journal of applied entomology
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    • v.21 no.2 s.51
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    • pp.73-77
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    • 1982
  • This experiment was carried out to study the effect of boron application on the physiological response and the outbreak of Granville wilt flue-cured tobacco. NC2326 and Coker 86(flue-cured tobacco) were transplante dand investigated in all field culture plots for this experiment. Elongation of shoots were retarded, and stem heights were shortened in all boron applied plots and the more boron applied, the greater these tendency was. The ratio of root branching and root discoloration, and contraction by Granville wilt were docreased markedly in boron plots. Amount of harvested loaves (yield) was increased greatly in 2 and 4kg plots of borax and boric acid per 10a, and the increasing tendency was greater in NC2326 variety than Coker 86. Phenol compounds content in harvested leaves were higher in boron applied plots than non-applied, and was higher in Coker 86, Granville wilt resistant variety, than NC2326. The more boron applied, the higher nicotine content in the harvested leaves was.

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Effect of Grafting Cultivation on the Growth of Hot Pepper (고추 접목재배가 생육에 미치는 영향)

  • Kim Eun-Hyun;Kim Hak-Jin;Kwon Byung-Sun;Lim June-Taeg;Hyun Kyu-Hwan;Kim Do-Young;Shin Dong-Young
    • Korean Journal of Plant Resources
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    • v.18 no.1
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    • pp.78-84
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    • 2005
  • Charactertistics of growth from graft induced three stock of red pepper cultivar were analysed. R-safe rootstock was more higher and vigorous than that of the Yeok kang, Konesian hot cultivar at seedling stage and had good characteristics for grafting in the space of cut surface and the amount of sap released. Numbers of branches were more numerous in the grafted plants than those of non-grafted as grafting affected their growths in the process of branching. There was no distinct difference in plant height among the different rootstock. However the R-safe rootstock showed considerably high growth in the 41st days after grafting. Grafting was effective in the early flowering and the R-safe was the earliest in flowering because of it's good growth under the low temperature.

C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons

  • Park, Jeong Hyang;Chung, Chang Geon;Seo, Jinsoo;Lee, Byung-Hoon;Lee, Young-Sam;Kweon, Jung Hyun;Lee, Sung Bae
    • Molecules and Cells
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    • v.43 no.9
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    • pp.821-830
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    • 2020
  • Altered dendritic morphology is frequently observed in various neurological disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the cellular and molecular basis underlying these pathogenic dendritic abnormalities remains largely unclear. In this study, we investigated dendritic morphological defects caused by dipeptide repeat protein (DPR) toxicity associated with G4C2 expansion mutation of C9orf72 (the leading genetic cause of ALS and FTD) in Drosophila neurons and characterized the underlying pathogenic mechanisms. Among the five DPRs produced by repeat-associated non-ATG translation of G4C2 repeats, we found that arginine-rich DPRs (PR and GR) led to the most significant reduction in dendritic branches and plasma membrane (PM) supply in Class IV dendritic arborization (C4 da) neurons. Furthermore, expression of PR and GR reduced the number of Golgi outposts (GOPs) in dendrites. In Drosophila brains, expression of PR, but not GR, led to a significant reduction in the mRNA level of CrebA, a transcription factor regulating the formation of GOPs. Overexpressing CrebA in PR-expressing C4 da neurons mitigated PM supply defects and restored the number of GOPs, but the number of dendritic branches remained unchanged, suggesting that other molecules besides CrebA may be involved in dendritic branching. Taken together, our results provide valuable insight into the understanding of dendritic pathology associated with C9-ALS/FTD.

Regeneration of Bovine Mammary Gland in Immunodeficient Mice by Transplantation of Bovine Mammary Epithelial Cells Mixed with Matrigel

  • Park, Hyun Jung;Lee, Won Young;Jeong, Ha Yeon;Song, Hyuk
    • International Journal of Stem Cells
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    • v.9 no.2
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    • pp.186-191
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    • 2016
  • Background and Objectives: With the global demand for dairy protein for consumption growing annually, there has been increasing activity in the research field of dairy protein synthesis and production. From a manipulation perspective, it is more difficult to use live cattle for laboratory studies on the production of milk as well as of dairy protein such as casein, as compared with using laboratory animals like rodents. Therefore, we aimed to develop a mouse model of bovine mammary alveolar ducts for laboratory-scale studies. We studied the formation of the bovine mammary gland ductal structure by transplanting the MAC-T bovine alveolar cell line into mice. Methods and Results: MAC-T cells ($1{\times}10^7$) were suspended in Matrigel and injected into the dorsal tissue of 8-week-old male BALB/C nude mice. Histological analysis of tissue dissected from the MAC-T cell-transplanted mice after 6 weeks showed the typical morphology of the tubuloalveolar female gland, as well as glands made up of branching ducts that were surrounded by smooth muscle with small alveoli budding off the ducts. In addition, the epithelial markers CK14 and CK18 were expressed within the duct-like structure. Prolactin was detected in the duct interior in these CK14+ and CK18+ cells but not in the non-transplanted MAC-T cells. Conclusions: These results showed that duct-like tissue had been successfully formed after 6 weeks of transplantation of the CK14+ and CK18+ MAC-T cells into mice dorsal tissue. This mouse model will be a useful tool for further research on the bovine mammary gland.

Effect of Controlled Release Fertilizer on the Growth and Flowering of Oncidium 'Sweet Sugar' (완효성비료 시비가 온시디움 생육과 개화에 미치는 영향)

  • Kim, Si Dong;Lee, Hee Doo;Kim, Ju Hyoung;Kim, Tae Jung
    • FLOWER RESEARCH JOURNAL
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    • v.17 no.4
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    • pp.246-250
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    • 2009
  • This study was conducted to determine the effect of controlled-release fertilizer on growth of Oncidium. Leaf and pseudobulb length increased with controlled-release fertilizer from 2 g to 3 g treatment compared to hyponex and controlled-release fertilizer I g treatment, while leaf width and number of leaf was not significant among treatments. Plant weight increased with controlled-release fertilizer from 2 g to 3 g treatment compared to hyponex and controlled-release fertilizer I g treatment. Flowering date(bloomed October early) did not show significant difference among treatments. The number of flowers showed the most in controlled-release fertilizer 3 g treatment as 62.4 ea/plant, but was not different significantly among treatments. Flower stem length and width were also non-significant among treatments. Branching numbers increased in the controlled-release fertilizer 2 g and 3 g treatments. Mineral elements of shoot increased from 2 g to 3 g treatment rather than the controlled-release fertilizer 1g treatment. Especially, K content was higher compared to N and P content. Therefore, appropriate controlled-release fertilizer amount for Oncidium was recommended as 2 g.

International cyber security strategy as a tool for comprehensive security assurance of civil aviation security: methodological considerations

  • Grygorov, Oleksandr;Basysta, Albina;Yedeliev, Roman;Paziuk, Andrii;Tropin, Zakhar
    • International Journal of Computer Science & Network Security
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    • v.21 no.9
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    • pp.332-338
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    • 2021
  • Civil aviation cybersecurity challenges are global in nature and must be addressed using global best practices and the combined efforts of all stakeholders. This requires the development of comprehensive international strategies and detailed plans for their implementation, with appropriate resources. It is important to build such strategies on a common methodology that can be applied to civil aviation and other interrelated critical infrastructure sectors. The goal of the study was to determine the methodological basis for developing an international civil aviation cybersecurity strategy, taking into account existing experience in strategic planning at the level of international specialized organizations. The research was conducted using general scientific and theoretical research methods: observation, description, formalization, analysis, synthesis, generalization, explanation As a result of the study, it was established the specifics of the approach to formulating strategic goals in civil aviation cybersecurity programs in the documents of intergovernmental and international non-governmental organizations in the aviation sphere, generally based on a comprehensive vision of cybersecurity management. A comparative analysis of strategic priorities, objectives, and planned activities for their implementation revealed common characteristics based on a single methodological sense of cybersecurity as a symbiosis of five components: human capacity, processes, technologies, communications, and its regulatory support. It was found that additional branching and detailing of priority areas in the strategic documents of international civil aviation organizations (by the example of Cybersecurity Strategy and Cybersecurity Action Plan) does not always contribute to compliance with a unified methodological framework. It is argued that to develop an international civil aviation cybersecurity strategy, it is advisable to use the methodological basis of the Cyber Security Index.

Radionuclide identification method for NaI low-count gamma-ray spectra using artificial neural network

  • Qi, Sheng;Wang, Shanqiang;Chen, Ye;Zhang, Kun;Ai, Xianyun;Li, Jinglun;Fan, Haijun;Zhao, Hui
    • Nuclear Engineering and Technology
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    • v.54 no.1
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    • pp.269-274
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    • 2022
  • An artificial neural network (ANN) that identifies radionuclides from low-count gamma spectra of a NaI scintillator is proposed. The ANN was trained and tested using simulated spectra. 14 target nuclides were considered corresponding to the requisite radionuclide library of a radionuclide identification device mentioned in IEC 62327-2017. The network shows an average identification accuracy of 98.63% on the validation dataset, with the gross counts in each spectrum Nc = 100~10000 and the signal to noise ratio SNR = 0.05-1. Most of the false predictions come from nuclides with low branching ratio and/or similar decay energies. If the Nc>1000 and SNR>0.3, which is defined as the minimum identifiable condition, the averaged identification accuracy is 99.87%. Even when the source and the detector are covered with lead bricks and the response function of the detector thus varies, the ANN which was trained using non-shielding spectra still shows high accuracy as long as the minimum identifiable condition is satisfied. Among all the considered nuclides, only the identification accuracy of 235U is seriously affected by the shielding. Identification of other nuclides shows high accuracy even the shielding condition is changed, which indicates that the ANN has good generalization performance.

Effects of the Agar and Auxins Concentrations on Vitrification in Tissue Culture of Gypsophila paniculata L. cv. 'Bristol Fairy' (숙근(宿根)안개초의 조직배양(組織培養)에 있어서 Agar 농도(濃度) 및 Auxins의 농도(濃度)가 Vitrification에 미치는 영향(影響))

  • Chun, Chae Ki;Choi, Sang Tai;Park, In Hwan;Shin, Hak Ki
    • Current Research on Agriculture and Life Sciences
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    • v.6
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    • pp.37-41
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    • 1988
  • The present work deals with the effect of agar and auxins concentrations on vitrification in tissue culture of Gypsophila paniculata L. cv. 'Bristol Fairy' in vitro. The results were summarized as follows. 1. Plant growth, that is, plant height, fresh weight and branching were decreased as increasing agar concentration. On the other hand, addition effect of IAA 1.0mg/l+NAA 0.5mg/l and IAA 2.0mg/l+NAA 1.0mg/l on the plant height were increased strikingly. 2. Addition effect of auxins on the days to rooting were little. And the root development showed same tendency as plant growth. 3. The rate of non-vitrified plants were gradually increased as rising agar concentration. But the addition of agar 1.5g/l in the medium resulted in poor growth. 4. From these results, it was found that following media were the most effective for increasing of non-vitrified and good plant growth in Gypsophila paniculata L. tissue culture.

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Effects of Shading treatments and Harvesting methods on the Growth of Eleutherococcus senticosus Maxim (차광처리(遮光處理) 및 수확방법(收穫方法)이 가시오갈피 생육(生育)에 미치는 영향(影響))

  • Han, Jong-Su;Kim, Seung-Kyeong;Kim, Sae-Won;Kim, Young-Jin
    • Korean Journal of Medicinal Crop Science
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    • v.9 no.1
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    • pp.1-7
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    • 2001
  • This experiment was carried out to investigate the effects of shading treatments and harvesting methods on the growth of Eleutherococcus senticosus, which was known as the medicine of anticancer, anti-stress, hepatic detoxification activity, immunoactivity, and tonic. Light transmission ratio and air temperature were decreased as $40{\sim}64%$,$1.9{\sim}2^{\circ}C$, respectively, in 30% to 70% shading net treatment compared to non-shading. Fifty percentage shading net treatment was effective for the growth and yield of Eleutherococcus senticosus. During summer Eleutherococcus senticosus was growing under shading net treatment compared to non-shading. Tunnel type was more effective for growth than vertical type in shading method. 30cm length included 2 to 3 nodes cutting from soil surface was the most effective for branching stem length, plant height and yield as harvesting methods.

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