• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.1
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• pp.57-66
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• 2008

An experimental study was performed to evaluate seismic reduction performance and applicability of 3-dimensional floor isolation system to the main control room of nuclear power plant. A friction pendulum system(FPS) and air spring were designed and fabricated for 3-dimensional floor isolation system. Two kind of the partial experimental model of a main control room attached to the FPS and air spring were tested on the shaking table. The experimental model consisted of a control panel, a $2.5m{\times}2.5m$ access floor, four FPS and air springs. The artificial time histories based on the vertical and horizontal floor response spectrums(OBE, SSE) of the main control room were used as the earthquake input signals in the test. Compared to non-isolated system, the seismic response of experimental models using 3-dimensional floor isolation system were shown considerable seismic reduction performance.

• The Journal of the Korea Contents Association
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• v.22 no.10
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• pp.349-358
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• 2022

This study was aim to understand the relationship between uncertainty, social isolation, social support and resilience of coronavirus infectious diseases-19 (COVID-19) patients and to identify factors related to resilience. Data were carried out from March 7 to May 5, 2021, and a total of 200 questionnaires were used for data analysis. Data were analyzed with descriptive statistics, t-test, ANOVA, Pearson correlation coefficient and multiple regression using SPSS WIN 24.0 program. As a result of the analysis, the lower the sense of social isolation, the higher the social support, the satisfaction with the explanation of isolation and the economic status of 'medium' were identified as related factors for resilience. Based on the above results, a systematic program should be developed and applied to improve the resilience of COVID-19 patients including strengthening social support through families and health care providers, reducing social isolation through non-face-to-face counseling, providing sufficient information about diseases, and providing economic support.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.1
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• pp.9-15
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• 2022

Anti-cancer and therapeutic effects using therapeutic radioisotopes have been demonstrated by various studies, and it is well-known that therapeutic radioisotopes are useful in cancer treatment. Recently, one of the therapeutic radioisotopes, scandium is emerging as a radioisotope applicable to PET imaging (⁴³Sc, ⁴⁴Sc) and therapy (⁴⁷Sc) in cancer theranostic approach. However, ⁴⁷Sc has little known radiobiological and therapeutic efficacy compared to other therapeutic radioisotopes. Here, we investigated the quality and therapeutic efficacy of ⁴⁷Sc radioisotope produced by our production/isolation technology at the research reactor 'HANARO' in KAERI (Korea Atomic Energy Research Institute). We showed that the therapeutic efficacy of ⁴⁷Sc, produced by our production/isolation technology, effectively suppressed epidermal growth factor receptor (EGFR)-targeted non-small cell lung cancer (NSCLC) cells. Consequently, these results suggest that the high quality of the produced ⁴⁷Sc by our production/isolation technology enables the development of therapeutic strategies for cancer treatment and radiopharmaceuticals using ⁴⁷Sc.

• Microbiology and Biotechnology Letters
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• v.48 no.2
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• pp.167-178
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• 2020

Lipase-producing fungi have been isolated from environments containing lipids. The non-dairy creamer industrial waste has a high amount of lipids so it is a potential source for the isolation of lipase-producing fungi. However, the study of fungi that secrete lipase from this industrial waste has not been reported. The purpose of this study was to obtain lipase-producing filamentous fungi from non-dairy creamer industrial waste. Mineral salt and potato dextrose agar were used as media for the isolation process. The qualitative screening was conducted using phenol red agar medium and the quantitative screening using broth medium containing glucose and olive oil. Isolates producing the highest amounts of lipase were identified with molecular methods. We found that 5 out of 19 isolated filamentous fungi are lipase producers. Further analysis showed that isolate Ms.11 produced the highest amount of lipase compared to others. Based on ITS sequence Ms.11 was identified as Aspergillus aculeatus. The lipase activity in medium containing 1% glucose + 1% olive oil at pH 7.0 and 30℃ after 96 and 120 h of incubation was 5.13 ± 0.30 U/ml and 5.22 ± 0.59 U/ml, respectively. The optimum lipase activity was found at pH 7.0, 30℃ and using methanol or ethanol in the reaction tube. Lipase was more stable at 20-30℃ and maintained 85% of its activity. It was concluded that isolate Ms.11 is a potential source of lipase that catalyzes transesterification reactions. Further studies are required to optimize lipase production to make the strain suitable for industry purposes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.5
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• pp.1026-1033
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• 2007

This paper compared simulation characteristics on the design of center strip by structure simulator with manufacture of 2.6GHz non-reciprocal element. Secures condition that affect in PIMD and confirmed change value of PIMD by change of condition. Implemented non-reciprocal element shows more than 20dB isolation characteristic at center frequency(2,650MHz) and has 0.2dB insertion loss in overall 100MHz operating bandwidth. Return losses of input and output port are measured below -20dB. IMD of non-reciprocal element exhibited superior value when there were no gaps between internal components and when materials having identical substances were used, and it showed an improving tendency when the pressure was increased higher, however, in case of applying pressure higher than a certain level, it results in damages, etc. of the magnet inside and ferrite as well, so then the characteristics of IMD was rapidly increased along with decrease of frequency characteristics.

• Journal of Microbiology and Biotechnology
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• v.17 no.6
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• pp.993-1001
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• 2007

The technique of serological analysis of antigens by recombinant cDNA expression library (SEREX) uses autologous patient sera as a screening probe to isolate tumor-associated antigens for various tumor types. Isolation of tumor-associated antigens that are specifically reactive with patient sera, but not with normal sera, is important to avoid false-positive and autoimmunogenic antigens for the cancer immunotherapy. Here, we describe a selection methodology to isolate patient sera-specific antigens from a yeast surface-expressed cDNA library constructed from 15 patient lung tissues with non-small cell lung cancer (NSCLC). Several rounds of positive selection using patient sera alone as a screening probe isolated clones exhibiting comparable reactivity with both patient and normal sera. However, the combination of negative selection with allogeneic normal sera to remove antigens reactive with normal sera and subsequent positive selection with patient sera efficiently enriched patient sera-specific antigens. Using the selection methodology described here, we isolated 3 known and 5 unknown proteins, which have not been isolated previously, but and potentially associated with NSCLC.

• Journal of the Korea institute for structural maintenance and inspection
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• v.28 no.1
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• pp.70-81
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• 2024

In this study, Tridimensional Hybrid Isolation System(THIS) was proposed as a vibration isolator for traffic loads, combining vertical and horizontal isolation systems. Its efficacy in improving serviceability for vertical vibration was analytically evaluated. Firstly, for the analysis, the major vibration modes of the existing apartment were identified through eigenvalue analysis for the system and pulse response analysis for the bedroom slab using commercial structural analysis software. Subsequently, a 16-story model with horizontal, vertical and rotational degrees of freedom for each slab was numerically organized to represent the achieved modes. The dynamic analysis for the measured acceleration from an adjacent ground to high-speed railway was performed by state-space equations with the stiffness and damping ratio of THIS as variables. The result indicated that as the vertical period ratio increased, the threshold period ratio where the slab response started to be suppressed varied. Specifically, when the period ratio is greater than or equal to 5, the acceleration levels of all slabs decreased to approximately 70% or less compared to the non-isolated condition. On the other hand, it was ascertained that the influence of damping ratios on the response control of THIS is inconsequential in the analysis. Finally, the improvement in vertical vibration performance of THIS was evaluated according to design guidelines for floor vibration of AIJ, SCI and AISC. It was confirmed that, after the application of THIS, the residential performance criteria were met, whereas the non-isolated structure failed to satisfy them.

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.11a
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• pp.64-64
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• 2003

고집적화된 시스템 LSI 반도체 소자 제조 공정에서 소자의 고속화 및 고성능화에 따른 배선층수의 증가와 배선 패턴 미세화에 대한 요구가 갈수록 높아져, 광역평탄화가 가능한 STI CMP(Shallow Trench Isolation Chemical-Mechanical-Polishing)공정의 중요성이 더해가고 있다. 이러한 STI CMP 공정에서 세리아 슬러리에 첨가되는 계면활성제의 농도에 따라 산화막과 질화막 사이의 연마 선택비를 제어하는 것이 필수적 과제로 등장하고 있다. 일반적인 CMP 공정에서 압력 증가에 따른 연마 제거량이 Prestonian 거동을 나타내는 반면, 연마 입자의 크기를 변화시켜 계면활성제의 농도를 달리 하였을 경우, 압력 변화에 따라 Non-Prestonian 거동이 나타나는 것을 고찰할 수 있었다. 따라서 본 연구에서는 세리아 슬러리 내에 첨가되는 계면활성 제의 농도와 연마입자의 크기를 달리한 후, 압력을 변화시킴으로 나타나는 non-Prestonian 거동에 미치는 영향에 대하여 연구하였다.

• Journal of Animal Science and Technology
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• v.58 no.7
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• pp.26.1-26.11
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• 2016

The use of probiotics for human and animal health is continuously increasing. The probiotics used in humans commonly come from dairy foods, whereas the sources of probiotics used in animals are often the animals' own digestive tracts. Increasingly, probiotics from sources other than milk products are being selected for use in people who are lactose intolerant. These sources are non-dairy fermented foods and beverages, non-dairy and non-fermented foods such as fresh fruits and vegetables, feces of breast-fed infants and human breast milk. The probiotics that are used in both humans and animals are selected in stages; after the initial isolation of the appropriate culture medium, the probiotics must meet important qualifications, including being non-pathogenic acid and bile-tolerant strains that possess the ability to act against pathogens in the gastrointestinal tract and the safety-enhancing property of not being able to transfer any antibiotic resistance genes to other bacteria. The final stages of selection involve the accurate identification of the probiotic species.

• Structural Engineering and Mechanics
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• v.43 no.4
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• pp.475-502
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• 2012

In this paper, the seismic analysis modeling technologies for sodium-cooled fast reactor (SFR) are presented with detailed descriptions for each structure, system and component (SSC) model. The complicated reactor system of pool type SFR, which is composed of the reactor vessel, internal structures, intermediate heat exchangers, primary pumps, core assemblies, and core support structures, is mathematically described with simple stick models which can represent fundamental frequencies of SSC. To do this, detailed finite element analyses were carried out to identify fundamental beam frequencies with consideration of fluid added mass effects caused by primary sodium coolant contained in the reactor vessel. The calculation of fluid added masses is performed by detailed finite element analyses using FAMD computer program and the results are discussed in terms of the ways to be considered in a seismic modeling. Based on the results of seismic time history analyses for both seismic isolation and non-isolation design, the functional requirements for relative deflections are discussed, and the design floor response spectra are proposed that can be used for subsystem seismic design.