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검색결과 345건 처리시간 0.031초

Contribution of Macrophage Migration Inhibitory Factor -173G/C Gene Polymorphism to the Risk of Cancer in Chinese Population

  • Wang, Cheng-Di;Li, Tai-Ming;Ren, Zheng-Ju;Ji, Yu-Lin;Zhi, Liu-Shou
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권11호
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    • pp.4597-4601
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    • 2015
  • Background: Macrophage migration inhibitory factor (MIF) -173G/C (rs755622) gene polymorphism has been associated with cancer risk. Previous studies have revealed that MIF -173G/C gene polymorphism may increase cancer in the Chinese population, while results of individual published studies remain inconsistent and inconclusive.We performed this meta-analysis to derive a more precise estimation of the relationship. Materials and Methods: We conducted a search on PubMed, Embase, MEDLINE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang, Weipu on Dec 31, 2014.Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. A total of eight studies including 2,186 cases and 2,285 controls were involved in this meta-analysis. Results: The pooled results indicated the significant association between MIF -173G/C polymorphism and the risk of cancer for Chinese population (CC + CG vs GG: OR=1.14, 95%CI=1.02-127, pheterogeneity<0.01; P=0.023; CC vs CG+GG: OR=1.12, 95%CI=1.02-1.23, pheterogeneity<001; P=0.017;CC vs GG: OR=1.18, 95%CI=1.04-1.33, pheterogeneity<001; P=0.008; CG vs GG:OR=1.03, 95%CI=0.91-1.15, pheterogeneity<001; P=0.656; C vs G:OR=1.24, 95%CI=1.14-1.25, pheterogeneity<001; P<001). Subgroup analysis showed that in patients with "solid tumors", heterogeneity was very large (OR=0.94,95%CI=0.83-1.06,pheterogeneity=0.044; p=0.297). Within "non-solid tumors", the association became even stronger (OR=6.62, 95 % CI=4.32-10.14, pheterogeneity<0.001; p<0.001). Conclusions: This study suggested that MIF -173G/C gene polymorphism may increase increase cancer in the Chinese population.Furthermore, more larger sample and representative population-based casees and well-matched controls are needed to validate our results.

NPC 행동 제어를 위한 유한상태기계와 추론 엔진의 하이브리드 구조 (NPC Control by Hybrid Architecture of Finite State Machine and Inference Engine ?)

  • 조동현;오성진;성미영;전경구
    • 한국HCI학회:학술대회논문집
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    • 한국HCI학회 2007년도 학술대회 1부
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    • pp.168-173
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    • 2007
  • 게임이나 가상환경에서 오락성과 실감성을 증진시키는 여러 가지 방법들 가운데 지능적인 Non-Player Character (NPC)들의 존재는 중요하다. 컴퓨터 그래픽과 관련 하드웨어 플랫폼 기술의 발전으로 인해 사용자들은 이제 시각적인 만족을 넘어서서, NPC들이 보다 지능적으로 행동하면서 오락적인 만족감과 동시에 보다 향상된 실감성을 제공하기를 원한다. 하지만, 유한상태기계 (Finite State Machine, FSM)를 기반으로 하는 NPC 구현의 한계와 어려움으로 인해 이러한 사용자들의 요구사항을 만족시키는 것은 어렵다. 본 논문에서는 FSM과 추론 엔진(Inference Engine)을 결합한 새로운 NPC 행동제어 구조를 제안한다. 또한 제안된 구조의 가능성을 시연하기 위해 실제로 동작하는 데모를 소개한다. 이러한 FSM과 추론 엔진의 하이브리드 구조는 FSM이 제공하는 NPC 반응의 실시간성을 보장하는 동시에 추론 엔진이 제공할 수 있는 보다 지능적이고 계획적인 NPC들의 행동을 만들어 낼 수 있다는 장점이 있다.

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벽체형 매스콘크리트구조물의 온도 및 온도응력측정에 관한 실험적 연구 (An Experimental Study on the Measurement of Temperature and Thermal Stress of Wall Type Mass Concrete Structure)

  • 강석화;이용호;정한중;박칠림
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 1995년도 가을 학술발표회 논문집
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    • pp.173-177
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    • 1995
  • Thermal cracks ard occured when thermal stress due to the hydration of cement exceeds the tensile strength of concrete. Since cracking causes poor durability of concrete, the effect of thermal cracking should be included for the desing and construction of massive concrete structures. In this study, an experiments are performed for the investigation of time dependent temperature and thermal stress of massive concrete structure at early ages. In order to measure temperatures and thermal stresses, concrete stress meter, embedded strain meter, non-stress meter, and thermocouples are used. Based on the analyses of measured thermal stress data, measured values by concrete stress meter are more reliable than those by embedded strain meter and non-stress meter, And measured values by concrete stress meter are compared with the calculated values by FEM program developed by DICT (DWTS2D). Calculated values by DWTS2D show good agreement with measured values.

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A Case of Primary Pulmonary Lymphoepithelioma-like Carcinoma Misdiagnosed as Adenocarcinoma

  • Jeong, Jae Seok;Kim, So Ri;Park, Seung Yong;Chung, Myoung Ja;Lee, Yong Chul
    • Tuberculosis and Respiratory Diseases
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    • 제75권4호
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    • pp.170-173
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    • 2013
  • Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is rare, with a more favorable prognosis compared with that of other types of non-small cell lung cancers. Herein, we describe an interesting case of primary pulmonary LELC confirmed postoperatively, which had been initially diagnosed as poorly differentiated adenocarcinoma. We suggest that despite the rarity of pulmonary LELC, it should be included as one of the differential diagnoses for lung malignancies. Physicians should consider taking a larger biopsy, especially when histologic examination shows undifferentiated nature.

양모/카티온화 면 혼방품의 산성염료/직접염료에 의한 1욕2단 염색에 관한 연구 (A Study on the One Bath Two Step Dyeing of Wool/Cationized Cotton Blends With Acid Dye/Direct Dye)

  • 성우경;이춘길
    • 한국의류산업학회지
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    • 제3권2호
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    • pp.168-173
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    • 2001
  • In order to overcome the disadvantage of the conventional two bath dyeing method of wool/cotton blends, it had prompted significant effort to the development of the one bath dyeing method which can accomplish savings in energy, water usage and time. To improve the dyeability of cotton toward direct dyes in a non-electrolytic and acidic dyebath, cotton component was pretreated with cationizing agent containing chlorohydrine group in aqueous solution of sodium hydroxide. This study was carried out to investigate almost equal color strength between wool component and cationized cotton component when wool/cationized cotton blends was dyed with acid dye/direct dye by the one bath two step method in a non-electrolytic and acidic dyebath.

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단일클론항체를 이용한 Milk Progesterone Test(EIA) 측정법의 개발과 이에 의한 소의 발정 및 임신조기진단의 정확도 향상에 관한 연구 (Development of Milk Progesterone Test(EIA) using Monoclonal Antibody and It's Application to Estrus-and Early Pregnancy Detection in Dairy Cattle)

  • 김정우;홍승욱
    • 한국가축번식학회지
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    • 제14권3호
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    • pp.165-173
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    • 1990
  • A simple and sensitive microplate enzyme immunoassay(ELISA) was developed for progesterone, based on progesterone monoclonal antibody as anti-progesterone, horseradish peroxise(HRP) as enzyme-label and tetramethylbenzidine(TMB) as substrate. The assay has a sensitivity of 5pg-120pg/well and intra- and inter assay coefficients of variation for progesterone standard curve(0.1ng-3.2ng/ml) were ranged 4.4-10.6% and 5.-12.6%, respectively. They assay is performed in less than two hours and provide reliable values to differentiate among samples from day 0(A.I.), day 14 and day 19. The discriminatory levels for early pregnancy diagnosis are [>10ng(day 19) & decreasing rate <1.5 : pregnancy] and [ 7ng & decreasing rate 1.5 : non-pregnancy]. The accuracy of the pregnancy diagnosis for cows classified as positive(pregnancy) and negative(non-pregnancy) were 96% and 100%, respectively.

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식이섬유의 주요기능 (Nutritional Role of Dietary Fiber-Recent Knowledge on Dietary fiber)

  • Tsuji, Keisuke
    • 한국식품위생안전성학회지
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    • 제7권4호
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    • pp.173-176
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    • 1992
  • Non-absorbable substances in foods, for instance dietary fiber had been previously known as a non-nutritive part of foods. Recently , such a category has been gradually changed to as one of nutrients, As a main reason, dietary fibers includes many poly-or oligo-saccharides, which as resistant to alimentary hydrolyzing enzyme, However, parts of them are fermented by intestinal micro-organism to produce short chain fatty acids and so on. They are absorbed and utilized by human being. Now, it may be naturally accepted that dietary fiber is a kind of nutrients. Dietary fiber exerts many useful functions on body. They are classified into three large function , physicochemical function, physiological function and biological function. The last function of dietary fiber will be presented in the symphosium. Dietary fiber has several kinds of nutritional properties. One is energy source. Short chain fatty acids(SCFA) are oxidized and produced energy in body. Dietary fiber has not high energy, but not zero kilocalories. Another one is to be a constitutional component of higher animals' tissue. Last but most important one is physiological functions of dietary fiber.

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비선형 부하를 고려한 새로운 부하합성 기법 (A New Load Aggregation Method in Consideration of Non-linear Load)

  • 이종필;김성수
    • 전기학회논문지P
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    • 제61권4호
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    • pp.168-173
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    • 2012
  • The aggregation of group loads, which consists of the linear and the non-linear systems, yields the error involved in the reactive power aggregation, which is greater than the active power aggregation in the component based load modeling. Each individual reactive power in a group load affects the aggregated load different from composition rate. This paper proposes a new method that determines the degree of impacts by adjusting the coefficient of weight factors of each load using the least squares error method. The effectiveness of proposed algorithm is demonstrated by simulating three aggregation cases.

건축 사유체계 변화에 의한 색채사용 특성에 관한 연구 (A study on the characteristics of color by change in architectural thinking system)

  • 이선민
    • 한국실내디자인학회논문집
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    • 제15권2호
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    • pp.166-173
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    • 2006
  • Architectural color has been preserved the multiple characteristics reflected the change of social value criteria and technical development. Especially, the change of technical paradigm has led to variation from simple and fixed color system, as through the considerable change of architect's subject thinking, favored and symbolic system. Now, architectural color has also been revealed as the timely, moving, behavioral and existent color by anthropolatric thinking system. Therefore, it could be transformed expressive system reflected from abstract-pictorial characteristics, from the fixed to non-determining system, constructive to non-constructive system, context to expressive system, reasonal to emotional system, respectively. So, the range of architectural color has been extended as a element in reinforced the planned concept of the architect beyond the past decorated and symbolic color scope. As thereinafter, future's architectural color could be expected to concrete to the public-friendly relation system, developed widely to the system for reinforcing the concept not introduction of meaningless, fragmental and instinct color through the relational adaptation with design concept.

인공위성용 전기 전자 부품의 평가 방법

  • 이창호;한동인
    • 항공우주기술
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    • 제1권2호
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    • pp.173-178
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    • 2002
  • 전자부품 높은 신뢰성이 요구되며 극한의 운용 환경을 견디어야 하는 우주 프로그램에는 High-Reliability Part로 분류되는 Class S 이상의 Microcircuit, JANS 급 이상의 Discrete Semiconductor, 그리고 ER(Established Reliability) 등급 R 수준 이상의 Passive 소자들이 주로 사용된다. 그러나 일부 부품에 대해서는 High-Reliability Part로서 검증되지 않은 이른바 비표준 부품을 사용해할 경우가 빈번하게 생기고 있다. 이 경우 위성의 제작자는 자체적으로 부품을 검증하여 잠재적인 결함이 있는 부품들을 Screening할 수 있어야 한다. 본 기술 논문에서는 아리랑위성 1호기 및 2호기 개발을 통해서 이루어진 부품 검증과정을 간략히 소개하고자한다.

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