• 동의신경정신과학회지
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• 제20권2호
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• pp.1-17
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• 2009

Objectives : Alzheimer's disease(AD) is the most common form of dementia, which is characterized by progressive deterioration of memory and higher cortical functions that ultimately results in total degradation of intellectual and mental activities. Nokyongdaebo-tang(Lurongdabutang) has been usually used for the treatment for the deficiency syndrome dementia and amnesia. This experiment was designed to investigate the effect of the Nokyongdaebo-tang(Lurongdabutang) hot water extract on pathological AD model. Methods : The effects of the Nokyongdaebo-tang(Lurongdabutang) hot water extract on cultured spinal cord cells induced by ${\beta}$-amyloid were investigated. The effects of the Nokyongdaebo-tan(Lurongdabutang) hot water extract on the memory deficit mice induced by scopolamine were investigated. Results : 1. ${\beta}$-amyloid treatment on cultured spinal cord cells increased both GFAP-staining intensity of astrocytes and caspase 3 immunoreactivity on cultured cells. Then, Nokyongdaebo-tang(Lurongdabutang) treatment reduced the labeling intensity for both GFAP and caspase 3 proteins in culture cells. 2. Scopolamine treatment into mice increased levels of GFAP-positive astrocytes and caspase 3-labeled cells of the hippocampal subfields dentate hilar region, CA3 and CA1 area. In vivo administration of Nokyongdaebo-tang(Lurongdabutang) attenuated labeling intensity for those two proteins in the same hippocampal areas. Similar effects were observed by the treatment of galanthamine, an inhibitor of acetylcholinesterase. Conclusions : This experiment shows that the Nokyongdaebo-tang(Lurongdabutang) may play a protective role in damaged neural tissues. Since neuronal damage seen in degenerative brains such as AD are largely unknown, the current data may provide possible insight into therapeutic strategies for AD treatments. Nokyongdaebo-tang(Lurongdabutang) might be effective for the prevention and treatment of AD.

• 생약학회지
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• 제24권3호
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• pp.235-243
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• 1993

We have concerned the action of traditional herbal medicine (THM) to relate with longevity, aging and immune, etc. Espically, we have studied on the role of intestinal bacteria on THM such as Nokyongdaebo-Tang, Bojungikgi-Tang, Ikgibohyul-Tang, Bobyulansin-Tang and Bojanggunbi-Tang. Samples of the p.o. administration of 2 g/kg for 2 weeks did not find the change transaminase activities in mice. But, Nokyongdaebo-Tang and Bojanggunbi-Tang elevated the serum glucose levels and Bojungikgi-Tang elevated the total cholesterol levels in mice. ${\beta}-Glucuronidase$ activities in mice faeces are decreased by the treatment of Nokyongdaebo-Tang, Bojungikgi-Tang, Ikgibohyul-Tang and Bojanggunbi-Tang, but increased by the treatment of Bohyulansin-Tang. Number of lactic acid bacteria in mice faeces are increased by the treatment of Nokyongdaebo-Tang, Bojungikgi-Tang, lkgibohyul-Tang, Bohyulansin-Tang and Bojanggunbi-Tang. We recognized that ${\beta}-glucuronidase$ activities and the number of lactic acid bacteria were remarkably decreased by the pretreatment of antibiotics in mice. Nokyongdaebo-Tang and Ikgibohyul-Tang at the p.o. administration of 2 g/kg significantly increased the ${\beta}-glucuronidase$ activities and Bojungikgi-Tang and Bohyulansin-Tang remarkably increased the number of lactic acid bacteria in antibiotics pretreated mice.

• 대한한의학회지
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• 제41권4호
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• pp.112-119
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• 2020

Objectives: The present study reports a case of chronic anemia patient who was significantly improved after taking Nokyongdaebo-tang (NYDBT) Methods: A 48-year-old male patient diagnosed with iron deficiency anemia (IDA) visited the Daejeon Korean medicine Hospital of Daejeon University on June 2018. The patient was treated with Korean medicine for 23 months including acupuncture, herbal medicine and Sasang constitutional medicine prescription. Improvement of anemia was assessed by changes of Hemoglobin value. Laboratory analysis was used to evaluate the safety of treatment. Results: Chronic anemia has significantly improved since taking NYDBT on 9 days (2019.12.09-2019.12.17). The Hb value has been maintained in the normal range since it first entered the normal range on January 18, 2020. The patient had become transfusion-free and this condition persisted for 6 months after stopping the transfusion. Conclusion: This case demonstrates the therapeutic potential of Sasang constitutional medicine for chronic anemia as a personalized medicine.

• 대한한방내과학회지
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• 제42권5호
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• pp.1074-1081
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• 2021

Objectives: This study demonstrated the positive effect of herbal medication on a suspected idiopathic thrombocytopenic purpura (ITP) patient-a 57-year-old male with suspected ITP and a decreased platelet count. Methods: The patient was treated with an herbal medicine named Nokyongdaebo-tang, and its effect was measured with periodic platelet blood tests. Results: Before taking the herbal medicine, the patient's blood platelet count was 98 K/μl, but following treatment, the blood platelet count increased to 201 K/μl and maintained a continuously elevated level. Conclusion: The results indicated that herbal medication may improve the blood platelet count of suspected ITP patients.

• 대한한방부인과학회지
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• 제30권3호
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• pp.1-19
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• 2017

목 적: 본 연구는 녹용대보탕이 안와정맥총 방혈로 유발시킨 랫트의 아급성 출혈성 빈혈 모델에 대해 항빈혈 및 조혈촉진 효과를 확인하였다. 방 법: 본 실험에서는 안와 정맥총에서 혈액을 채혈하여 아급성 출혈성 빈혈을 유발시켰으며, 녹용대보탕 추출물을 경구투여하고, 체중 및 조혈 관련 장기(대퇴골 골수, 비장 및 간) 중량, 적혈구 관련 혈액학적 지표의 변화, 혈액 도말 표본의 세포학적 변화, 조혈관련 장기의 조직병리학적 변화와 함께 조혈장기 내 혈구형성 줄기세포의 수적 변화를 면역조직화학적으로 관찰하였다. 또한 철분 보충제의 대표적 부작용인 소화 장애, 특히 변비 유발 여부를 확인하기 위해 탄분을 이용해 위장관 운동성을 평가하였으며, 결장내 분변 표면의 점막 두께와 결장점막 내 점액생산세포 및 결장 점막 두께 변화를 조직병리학적으로 평가하였다. 결 과: 본 실험에서 유발된 아급성 출혈성 빈혈 소견이 모든 세 용량의 녹용대보탕 추출물의 용량 의존적으로 현저히 억제되었다. 또한 세 용량의 녹용대보탕 투여군에서는 정상 대조군 및 아급성 출혈성 빈혈 대조군에 비해 위장관 운동성 변화 및 결장 및 결장내 분변의 점액성분의 유의미한 변화는 없었다. 결 론: 이상의 결과에서, 녹용대보탕의 경구투여는 아급성 출혈성 빈혈 유발 랫트에서 단순 철분 보충제의 부작용인 소화관 장애 없이, 조혈관련 장기들에서 혈구형성줄기세포의 증식 촉진을 통해 투여 용량 의존적으로 철 결핍성 빈혈의 증상을 현저히 완화시키는 것으로 관찰되었다. 따라서 녹용대보탕은 새로운 개념의 조혈촉진 빈혈치료제로서의 개발 가치가 충분할 것으로 판단된다.