• Maxillofacial Plastic and Reconstructive Surgery
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• v.35 no.1
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• pp.1-12
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• 2013

Purpose: Vascular endothelial growth factor (VEGF)-C and its tyrosine kinase receptor, VEGF receptor (VEGFR)-3 are recently known to have lymphangiogenic activities in various tumor types. In this study, we determined whether the expression of lymphangiogenic factors correlate with nodal metastasis or survival in a nude mouse model of oral squamous cell carcinoma (OSCC). Methods: Three OSCC cells (KB, SCC4, SCC9) were xenografted into the right mandibular gland of athymic nude mice. The mice were followed for tumor development and growth, and the mice were sacrificed when they had lost more than 20% of their initial body weight, or the diameter of the induced tumor exceeds 20 mm. After necropsy, the murine tumors were examined histologically and radiologically (micro-positron emission tomography computed tomography) for regional or distant metastasis. We performed immunohistochemical assays with anti-VEGF-C, VEGFR-3, CD105, and D2-40 antibodies. Immunofluorescence double staining for LYVE-1/CD31 was also performed. To quantify the VEGF-C and VEGFR-3 level in the cancer tissue, Western blotting was performed. Finally, we determined the correlation between the degree of expression of VEGF-C/VEGFR-3 and the mean survival time. Results: OSCC tumor cells into the mandibular gland of the nude mice successfully resulted in the formation of recapitulating orthotopic tumor. Tumor cells of the induced tumor did not express VEGF-C. VEGF-C/VEGFR-3 expression was mainly distributed in the endothelial cells of the stromal area. There were no correlation between the degree of expression of VEGF-C/VEGFR-3 and the mean survival time of mice injected with different OSCC cell lines. Conclusion: An recapitulating orthotopic model of OSCC in nude mice was established, which copies the cervical nodal metastasis of human OSCC. Overexpression of lymphangiogenic factors seems to have no effect on survival of hosts in this in vivo experiment.

• Nuclear Engineering and Technology
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• v.25 no.2
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• pp.193-203
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• 1993

A new heuristic method for loading pattern search has been developed to overcome short-comings of the algorithmic approach. To reduce the size of vast solution space, general shuffling rules, a regionwise shuffling method, and a pattern grouping method were introduced. The entropy theory was applied to classify possible loading patterns into groups with similarity between them. The pattern search program was implemented with use of the PROLOG language. A two-group nodal code MEDIUM-2D was used for analysis of power distribution in the core. The above mentioned methodology has been tested to show effectiveness in reducing of solution space down to a few hundred pattern groups. Burnable poison rods were then arranged in each pattern group in accordance with burnable poison distribution rules, which led to further reduction of the solution space to several scores of acceptable pattern groups. The method of maximizing cycle length(MCL) and minimizing power-peaking factor(MPF) were applied to search for specific useful loading patterns from the acceptable pattern groups. Thus, several specific loading patterns that have low power-peaking factor and large cycle length were successfully searched from the selected pattern groups.

• Journal of Gastric Cancer
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• v.4 no.1
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• pp.32-35
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• 2004

Purpose: The most important prognostic factors in gastric cancer is the depth of invasion of the primary tumor and lymph node metastasis. The nodal staging of the 5th edition of the Union Internationale Contrala Cancrums (UICC) TNM classification in 1997 was changed based on the number of metastatic lymph node. We attempted to evaluate the prognostic significance of N2 group metastasis in pT3pN1 gastric cancer patients by comparing two different nodal staging systems. Materials and Methods: A retrospective analysis was made for 352 gastric cancer patients who underwent curative resection, including D2 dissection, from 1991 to 1997 at Asan Medical Center. A clinicopathologic comparison between two groups by using a nodal staging systems was summarized into a table. Cumulative survival rates were calculated by using the Kaplan-Meier method. The difference between the two groups was evaluated by using the log rank test with SPSS 11.5 for Windows Results: There were no statistical differences in clinicopathologic factors. However, there was a significant difference in survival rate between the two groups (P=0.0009). This suggests that N2 group metastasis in pT3pN1 gastric cancer patients has a clinical significance for predicting prognosis. Conclusion: Our results suggest a possibility of prognostic significance of N2 group metastasis. Therefore, anatomical location of the lymph node should be described.

• Journal of Korean Association for Spatial Structures
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• v.5 no.1 s.15
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• pp.81-89
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• 2005

Walking loads are influenced by various parameters so that they need to be measured considering such parameters. Walking frequency(rate) is experimentally investigated as the most important parameter in determining the walking load expressed with dynamic load factor. This study focuses on the derivation of continuous walking load-time functions at any walking frequency ranging from 1.30Hz to 2.70Hz. Experiments were conducted to obtain time-histories of walking loads at the increment of 0.1Hz, which are decomposed into harmonic loads by the Fourier transformation. The polynomial load-time functions are proposed representing the relationship between harmonic coefficients and walking frequencies, thereby easily formulating walking load-time histories for dynamic load factor with various walking frequencies.

• Transactions of the Korean Society of Mechanical Engineers
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• v.7 no.3
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• pp.270-277
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• 1983

Plastic plane stress solutions are given for a center cracked strip, characterized by the Ramberg-Osgood plastic index, under bi-axial tension. Using a power law hardening stress-strain relation, an incremental plasticity finite element formulation is developed, and simple formulation is given for computing J-integral with nodal displacements. The near tip angular distribution of von Mises effective stress doesn't differ significantly in magnitude according to the change of loading stress and bi-axial load combination factor. But, for smaller plastic index, the location of its maximum value moves vertically at a head of crack. J-integral value, in the plastic zone near crack tip, decreases with load combination factor for large and small plastic index.

• Journal of Korean Society of Water and Wastewater
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• v.11 no.3
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• pp.51-58
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• 1997

Determining sizes and the locations of reservoirs in the water distribution system(WDS) with multi-reservoirs is much difficult than that with single reservoir. The extended period simulation(EPS) models provide more comprehensive analysis of water distribution systems than the steady-state models can do. Therefore, EPS models should be applied to the WDS with multi-reservoirs. This study is to investigate the variations of required reservoir sizes and residual nodal pressures according to reservoir locations. In this study, EPS was applied to analyze an artificial and a real WDS under several water demand patterns. As a result, it was found that water demand patterns make no significant differences in the determining of the reservoir size, if they have similar peaking factors. And the variations of the peaking factor should be carefully checked in the design and the analysis of the WDS with multi-reservoirs, because the peaking factor itself will affect the minimum allowable sizes of reservoirs in those systems.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.52 no.7
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• pp.429-436
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• 2003

This paper presents a new approach for evaluating the transmission marginal loss factors (MLFs) considering the reactive power. Generally, MLFs are represented as the sensitivity of transmission losses, which is computed from the change of the generation at reference bus by the change of the load at the arbitrary bus-i. The conventional evaluation method for MLFs uses the only H matrix, which is a part of jacobian matrix. Therefore, the MLFs computed by the existing method, don't consider the effect of the reactive power, although the transmission losses are a function of the reactive power as well as the active power. To compensate the limits of the existing method for evaluating MLFs, the power factor at the bus-i is introduced for reflecting the effect of the reactive power in the evaluation method of the MLFs. Also, MLFs calculated by the developed method are applied to energy spot markets to reflect the impacts of reactive power. This method is tested with the sample system with 5-bus, and analyzed how much MLFs have an effect on the bidding/offer price, market clearing price(MCP), and settlement in the competitive energy spot market. This paper compared the results of MLFs calculated by the existing and proposed method for the IEEE 14-bus system, and the KEPCO system.

• Structural Engineering and Mechanics
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• v.4 no.2
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• pp.139-148
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• 1996

Vector algorithms and the relative importance of the four basic modules (computation of element stiffness matrices, assembly of the global stiffness matrix, solution of the system of linear simultaneous equations, and calculation of stresses and strains) of a finite element computer program for inelastic analysis of reinforced concrete shells are presented. Performance of the vector program is compared with a scalar program. For a cooling tower problem, the speedup factor from the scalar to the vector program is 34 for the element stiffness matrices calculation, 25.3 for the assembly of global stiffness matrix, 27.5 for the equation solver, and 37.8 for stresses, strains and nodal forces computations on a Gray Y-MP. The overall speedup factor is 30.9. When the equation solver alone is vectorized, which is computationally the most intensive part of a finite element program, a speedup factor of only 1.9 is achieved. When the rest of the program is also vectorized, a large additional speedup factor of 15.9 is attained. Therefore, it is very important that all the modules in a nonlinear program are vectorized to gain the full potential of the supercomputers. The vector finite element computer program for inelastic analysis of RC shells with layered elements developed in the present study enabled us to perform mesh convergence studies. The vector program can be used for studying the ultimate behavior of RC shells and used as a design tool.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7559-7562
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• 2014

Currently the most important prognostic factor in lung cancer is the stage. In the current lung TNM classification system, N category is defined exclusively by anatomic nodal location though, in other type of tumours, number of lymph nodes is confirmed to be a fundamental prognostic factor. Therefore we evaluated the number of mediastinal lymph nodes as a prognostic factor in locally advanced NSCLC after multimodality treatment, observing a significant effect of the number of lymph nodes in terms of OS (p<0.01) and DFS (p<0.001): patients with a low number of positive mediastinal nodes have a better prognosis.

• Wind and Structures
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• v.5 no.6
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• pp.543-562
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• 2002

The main purpose of this study is to discuss the design wind loads for the structural frames of single-layer latticed domes with long spans. First, wind pressures are measured simultaneously at many points on dome models in a wind tunnel. Then, the dynamic response of several models is analyzed in the time domain, using the pressure data obtained from the wind tunnel experiment. The nodal displacements and the resultant member stresses are computed at each time step. The results indicate that the dome's dynamic response is generally dominated by such vibration modes that contribute to the static response significantly. Furthermore, the dynamic response is found to be almost quasi-static. Then, a series of quasi-static analyses, in which the inertia and damping terms are neglected, is made for a wide range of the dome's geometry. Based on the results, a discussion is made of the design wind load. It is found that a gust effect factor approach can be used for the load estimation. Finally, an empirical formula for the gust effect factor and a simple model of the pressure coefficient distribution are provided.