• Biomolecules & Therapeutics
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• v.15 no.4
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• pp.240-244
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• 2007

Cigarette smoking causes serious health problems in humans, especially if smoking habits are established during their adolescence. Nicotine is known to mutate DNA and interfere with apoptosis. Apoptosis is considered as a potent defense mechanism against cellular damaging agents. This study aims to investigate the effect of nicotine on the progression of apoptosis induced under ER stress conditions using four different established cell lines: HEK293, 3T3-L1, C2C12, and HepG2. When treated with nicotine, the progression of apoptosis was notably inhibited in the four cell lines according to the assays of caspase-3 activation and DNA fragmentation. In ER-stressed cells, nicotine appears to inhibit the progression of apoptosis in a concentration-dependent manner. When cells were treated with nicotine prior to ER stress, GRP94 level significantly increased compared to other ER stress markers of PDI and GRP78. This observation suggests that the inhibitory effect of nicotine may results from up-regulation of GRP94, an anti-apoptotic chaperone, under nicotine treatment. Taken together, the present study strongly implies that nicotine may inhibit apoptosis, caused by prolonged ER stress, based on promotion of GRP94 expression.

• Journal of Korean Academy of Nursing
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• v.37 no.7
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• pp.1139-1148
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• 2007

Purpose: The purpose of this study was to investigate the effects of a community-based group smoking cessation program among adult smokers in a rural community. Method: The study design was quasi-experimental with a pre and posttest. A total of 55 adult smokers participated in the study. They were evaluated 1, 3, and 6 months after the program to identify the long-term effectiveness of the program. The program consisted of a total of 5 sessions provided twice a week. To test the effectiveness of the program, urine creatinine, expired air carbon monoxide, nicotine dependence, and smoking-related knowledge were used as dependent variables. Data was analyzed with the SPSS 10.0 program with a t-test, paired t-test, and Scheffe test. Result: Urine creatinine, expired air carbon monoxide, and nicotine dependence were significantly decreased after the program. Also, the rates of continuous abstinence were 81.8% at posttest, 65.5% at 1 month, 54.5% at 3 months, and 54.5% at 6 months follow-up. Conclusion: This community-based group smoking cessation program implemented by a nurse and smoking cessation counselors was effective for quitting smoking and decreasing urine creatinine and nicotine dependence. Therefore, this smoking cessation program could be recommended to induce smoking cessation as health promotion management in the rural community.

• The Journal of Korean Academic Society of Nursing Education
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• v.10 no.2
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• pp.229-238
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• 2004

This study was conducted to identify the factors affecting smoking cessation behavior of the university student smokers for developing the effective smoking cessation program. For this purpose, data were collected from 64 students registrated at the university health center for anti-smoking acupuncture through May, 2003. Data were analyzed with percentile, mean, t-test, ANOVA, pearson correlation by SPSS/PC program. The results were as follows ; There was significant relationship in the scores on perceived benefits(t=-2.05, p=.045), chance-health locus of control(t=-2.28, p=.026) and nicotine dependence (t=-1.96, p=.056) according to the grade. And also there was significant increase in the nicotine dependence in the higher grades. There were significant positive relationship between external locus of control and perceived benefits(r=.389, p=.001), perceived barriers and benefits(r=.457, p=.000), and significant negative relationship between the daily life activities and perceived barriers(r=-.350, p=.005). From these results, it can be concluded that the effective smoking cessation program could be considered of perceived benefits & barriers, and nicotine dependence to promote anti-smoking behavior for university student smokers.

• Tuberculosis and Respiratory Diseases
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• v.62 no.5
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• pp.365-373
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• 2007

Background: Smoking is one of the most important leading causes of morbidity and mortality. Smoking habit is recognized as nicotine dependence, which consists of physical and psychosocial dependence. To evaluate social nicotine dependence, the Kano Test for Social Nicotine Dependence (KTSND) working group developed a new questionnaire, which consists of 10 questions with a total score of 30 in Japan. We examined the social nicotine dependence among healthy adults using the new KTSND questionnaire and evaluated validity of the KTSND questionnaire in Korea. Method: We applied Korean KTSND questionnaire version 2 to employees of hospital, university students and people for medical examination and promotion test. Complete data obtained from the 741 responders were analyzed. Result: The mean age of responders was 31.8 years. Among them, males were 57.8%. Current smokers, ex-smokers, and non-smokers were 13.8%, 12.8%, and 73.4% respectively. According to smoking status, the total KTSND scores of current smokers were significantly higher than those of ex-smokers, and of non-smokers ($17.1{\pm}5.4$ versus $14.3{\pm}5.5$, and $12.3{\pm}5.5$, $p{\leq}0.001$). The total KTSND scores of males were higher than those of females, suggesting that males have a propensity for depending nicotine socially much more than females ($14.3{\pm}5.7$ and $11.7{\pm}5.4$ respectively, p<0.001). Eight of ten questions produced significantly different scores among three different smoking groups. When current smokers were sub-classified by heavy smoking index (HSI) that represented physical nicotine dependence, we did not find a significant difference of KTSND score between low HSI group (<4) and high HSI group (${\geq}4$), This finding suggested that the psychosocial dependence might play a different role from physical nicotine dependence in smoking. Most of the non-smokers (62.5%) had an experience of harmful passive smoking especially in public place. Conclusion: Our study suggested that the KTSND questionnaire could be a useful method to evaluate psychosocial aspects of smoking.

• Journal of the Korean Society of Tobacco Science
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• v.23 no.2
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• pp.179-184
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• 2001

This study was conducted to determine the smoke component distribution and the relationship between chemical components and physical characteristics of cigarettes. 16 different cigarette brands which were sold in the market were selected for this study. Five kinds of smoke components which have been tar, nicotine, water, carbon monoxide(CO) puff No., and six kinds of physical characteristics which were filter type, leaf weight, filter weight, UPD, EPD, dilution rate were analyzed. The average values in tar, nicotine, water, CO concentration were 6.5 mg/cig. 0.66 mg/cig, 1.12 mg/cig. and 6.32 mg/cig., respectively. The average ratios of nicotine/tar and CO/tar were 0.10, and 1.02 respectively. The distribution of smoke components collected in the cambridge filter and cigarette filter was different. The averages of tar and nicotine removal efficiency by a cigarette filter were 53%, and 48%, respectively. All smoking components were positively correlated with other smoking components. filter types, EPD, and dilution rate were showed high correlation to the changes of smoke components. Especially, dilution rate of cigarette strongly affected on the changes of all smoke components.

• Sleep Medicine and Psychophysiology
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• v.25 no.2
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• pp.45-50
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• 2018

Smoking is one of the most harmful causes of disease. Many previous researches have shown that cigarette smoking leads to cardiovascular, respiratory, oncologic, and cerebrovascular diseases. In addition to such adverse effects, the literature indicates that cigarette smoking can worsen sleep quality and induce sleep disorders. This review focuses on the relationship between smoking/nicotine and sleep and sleep disorders of insomnia, obstructive sleep apnea, and restless legs syndrome. Because smoking is a behavioral pattern that can be changed, it is important to quit smoking to improve overall health and sleep.

• Journal of the Korean Society of Tobacco Science
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• v.6 no.1
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• pp.84-93
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• 1984

Six kinds of sugars (Maltose, Sucrose, Glucose, Fructose, Mannose and Lactose) and four kinds of organic acids (Malic, Tartaric, Lactic and Citric) were added by 2-10% for the former and 0.2-1.8% for the later in quantitatively to the inferior quality of Flue-cured leaf tobaccos, and treated at 135$^{\circ}C$ for 10 minutes to examine the effect on deliveries of tar and nicotine in smoke, variation of smoke pH and smoking taste. The results obtained are as follows. Tar and nicotine deliveries in smoke of tobacco show a great reduction with 5-6% addition of sugars. Reduction of nicotine delivery was to be 19% with addition of Glucose. Tar in smoke was, however, increased by 5-8% with 4% addition of Sucrose or Lactose. On the other hand, 4% addition of Glucose and Fructose gave 1 % reduction of tar delivery, but the reduction rate became to be small with increase of adding quantity. The smoking taste by the addition of Glucose and Fructose tobacco was found to be milder than by the other sugars. Tar and nicotine deliveries show a decreasing trend with the addition of organic acid, and Tartaric acid, among the organic acids described above, had greater effect than the other acids. 1% addition of Tartaric acid gaves 10-11% reduction in tar and nicotine delivery, and a fall of smoke pH, from 6.40 to 6.05, was found. Smoking taste by the addition of Lactic and Tartaric acid had milder than the others. And heat treatment for 10 minutes at $135^{\circ}C$ gave also better on smoking taste. The addition of mixture of sugars and organic acids, (Glucose 4%+Lactic acid 0.8% + Tartaric acid 0.2%) and then the successive heat treatment for 10 minutes at $135^{\circ}C$ improved greatly the quality of Fluecured leaf tobacco, and nicotine were reduced to 16-29%, and pH was changed from 6.46 to 6.14.

• Journal of the Korean Society of Tobacco Science
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• v.3 no.2
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• pp.83-88
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• 1981

Transfer of nicotine into the mails stream of smote in Korean commercial cigarettes was investigated. The mass transfer of nicotine into tile main stream of smote and accumulation of nicotine in cigarette filler got higher as the puffing number increased. Only about 14oyo of nicotine ill a cigarette was puffed into mouth end. and the rest of the nicotine went to side stream of smote or converted to other volatile bases.

• Journal of Korean Public Health Nursing
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• v.21 no.1
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• pp.37-45
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• 2007

Purpose: A diverse range of measurement methods to evaluate the effect of smoking is more powerful than using a single measure. The objectives of this study were to examine the relationships among smoking pack year, self-reported smoking dependence, and urinary cotinine levels, and to investigate the psychological variables in working men. Method: In this cross-sectional study, we surveyed men working in an electronic company who participated in a smoking cessation program. Among 57 men who completed questionnaires, 25 participate in a test for cotinine levels. Results: Smoking pack year was significantly and positively correlated with the FTND-K (Korean version of Fagerstrom test for nicotine dependence) sum scores (r=0.631, p=0.000) and with the levels of urine cotinine (r=0.463, p=0.023). The relationship between FTND-K sum scores and urinary cotinine levels was also significantly positive (r=0.639, p=0.001). Those with higher social support, especially family support, tended to perceive a higher self-efficacy to smoking cessation. Conclusion: These findings suggest that self-reported smoking pack year and nicotine dependence in working men may be a valid way to evaluate the effect of smoking. A supportive family may influence smoking cessation in working men as it increases self-efficacy to avoid smoking.

• Korean Journal of Clinical Pharmacy
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• v.32 no.2
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• pp.133-143
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• 2022

E-cigarettes were considered safe at the early stage of market entry because they were thought not to contain harmful ingredients such as nicotine and because the smoke emitted was vapor. For this reason, the use of e-cigarettes as a safer alternative to tobacco cigarettes or as a smoking cessation aid has emerged. However, the study results on the effectiveness of e-cigarettes for smoking cessation are mixed. In response to the increased use of e-cigarettes, foreign countries have implemented various regulations, such as utilizing e-cigarettes for smoking cessation with a prescription in Australia; however, South Korea is still standing firm on recommending not to use e-cigarettes at all. Therefore, the effectiveness of e-cigarettes for smoking cessation and the regulatory trends of e-cigarette use overseas will be reviewed to discuss the future direction in South Korea needs to take.