• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.205-210
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• 2008

Recent studies suggest that activated microglial cells play an essential role in the inflammatory responses and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. This study was conducted to evaluate the protective mechanisms of Asiasarum sieboldi (AS) on LPS-induced activation of BV-2 microglial cells. The effects of AS on gene expression profiles in activated BV-2 microglial cells were evaluated using microarray analysis. BV-2 microglial cells were cultured in a 100 mm dish ($1{\times}10^7$/mL) for 24 h and then pretreated with 1 ${\mu}g$/mL AS or left untreated for 30 min. Next, 1 ${\mu}g$/mL LPS was added to the samples and the cells were reincubated at $37^{\circ}C$ for 30 min and 1 hr. The gene expression profiles of the BV-2 microglial cells varied depending on the AS. The microarray analysis revealed that MAPK signaling pathway-related genes were downregulated in AS-treated BV-2 microglial cells. AS can affect the neuroinflammatory-related pathway such as MAPK signaling pathway in activated BV-2 microglial cells.

• Molecular & Cellular Toxicology
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• v.5 no.1
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• pp.1-6
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• 2009

Microglial cells constitute the first line of defense against infection and injury in the brain. This study was conducted to evaluate the protective mechanisms of Agrimonia pilosa (AP) on LPS-induced activation of BV-2 microglial cells. The effects of AP on gene expression profiles in activated BV-2 microglial cells were evaluated using microarray analysis. BV-2 microglial cells were cultured in a 100 mm dish ($1{\times}10^7/mL$) for 24 hr and then pretreated with 1 g/mL AP or left untreated for 30 min. Next, 1 g/mL LPS was added to the samples and the cells were reincubated at $37^{\circ}C$ for 30 min, 3 hr and 6 hr. The gene expression profiles of the BV-2 microglial cells varied depending on the AP. The microarray analysis revealed that MAPK signaling pathway-related genes were down-regulated and IL10 gene was up-regulated in AP-treated BV-2 microglial cells. AP can affect the inflammatory response and MAPK pathway in BV-2 microglial cells.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2002.11a
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• pp.189-194
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• 2002

This study aimed at the design trends and characteristics of flexible housing unit plan. In this paper, flexible unit plans of 256 examples that are constructed or will be constructed from 1991 to 2005 on the basis of the initial year of dwelling are analyzed. Divided into 60$m^2$, 85$m^2$, 102$m^2$, 135$m^2$, 165$m^2$ and above 180$m^2$ areas, kinds, characteristics and trend of planning of flexible housing unit plan are analyzed with the frequency and percentage method. The results of this study are as follows; 16 types of flexible kinds; room and living roon/room and room/room, room and living room. Since 2000, various types of flexible planning have came into existence (12 types of 16 types). 3bay is next to 4bay in number of flexible housing planning. There are R/L type in 3bay, R/L type and R/R types in 4bay. Flexible space organization is differentiated various types in R/L and public-private space has expanded in many ways.

• Science of Emotion and Sensibility
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• v.24 no.4
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• pp.79-90
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• 2021

Consumers have an increasingly active role in the marketing cycle, using social media channels to create, distribute, and consume digital content. In this context, this paper investigates the impact of user- and marketer-generated content on consumer purchase intentions and the approach to designing an effective social media marketing platform. Referencing a literature review of social media marketing and consumer purchase intentions, a case study of the social media-marketing platform, 0.8L, was undertaken using both qualitative and quantitative results through content analysis and a participatory survey. First, about 450 consumer reviews for ten sunscreen products posted on the 0.8L platform were compared with products' marketer-generated content. Next, 55 subjects participated in a survey regarding purchase intentions toward moisturizing creams on the 0.8L platform. The results indicated that user-generated content (i.e., texts and photos) provided more personal experiences of the product usage process, whereas marketers focused on distinctive product photos and features. Moreover, customer reviews (particularly high volume and narrative format) had more impact on purchase decisions than marketer information in the online cosmetics market. Real users' honest reviews (both positive and negative) were found to aid companies' prompt and straightforward assessment of newly released products. In addition to the importance of customer-driven marketing practices, distinctive user experience design features of a competitive social media-marketing platform are identified to facilitate the creation and sharing of sincere customer reviews that resonate with potential buyers.

• Journal of the Society of Disaster Information
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• v.19 no.4
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• pp.924-935
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• 2023

Purpose: The central aim of this study is to leverage machine learning techniques for the classification of Intrusion Detection System (IDS) data, with a specific focus on identifying the variables responsible for enhancing overall performance. Method: First, we classified 'R2L(Remote to Local)' and 'U2R (User to Root)' attacks in the NSL-KDD dataset, which are difficult to detect due to class imbalance, using seven machine learning models, including Logistic Regression (LR) and K-Nearest Neighbor (KNN). Next, we use the SHapley Additive exPlanation (SHAP) for two classification models that showed high performance, Random Forest (RF) and Light Gradient-Boosting Machine (LGBM), to check the importance of variables that affect classification for each model. Result: In the case of RF, the 'service' variable and in the case of LGBM, the 'dst_host_srv_count' variable were confirmed to be the most important variables. These pivotal variables serve as key factors capable of enhancing performance in the context of classification for each respective model. Conclusion: In conclusion, this paper successfully identifies the optimal models, RF and LGBM, for classifying 'R2L' and 'U2R' attacks, while elucidating the crucial variables associated with each selected model.

• Progress in Superconductivity
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• v.5 no.1
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• pp.17-20
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• 2003

We have designed and measured a SFQ(Single Flux Quantum) DFFC and an Inverter(NOT) for superconducting ALU(Arithmetic Logic Unit) development. To optimize the circuit, we used Julia, XIC, and L meter for circuit simulations and circuit layouts. The Inverter was consisted of a D Flip-Flop, a data input, a clock input and a data output. If a data pulse arrives at the inverter, then the output reads ‘0’ (no output pulse is produced) at the next clock period. If there is no input data pulse, it reads out ‘1’(output pulse is produced). The DFFC was consisted of a D flip-Flop, an Inverter, a Data in, a Clock in and two outputs. If a data pulse arrives at the DFFC circuit, then the output2 reads ‘1’ at the next clock period, otherwise it reads out ‘1’ to output1. Operation of the fabricated chip was performed at the liquid helium temperature and at the frequencies of 1KHz.

• Korean Institute of Interior Design Journal
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• no.10
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• pp.77-81
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• 1997

The study is for interior design and planning of new c conceptual modern shop(called "Value Conscious Store") t through the history of retail store, and its process is based on m most great cites in USA. The Value Conscious Store has c come into existence for consumer and retailer who have had v various lifestyles and characters. From analysis of new l lifestyle consumer to retailer's strategy. we could find i interesting design solutions and, forecast next concerns for d designing store. Store has been designed up-scaled and opened to give pleasure and comfort and made by a theme to m make unique and strong impact for customers. Also it uses M Multi-Media for excitment, and is designed as exhibition of m museum to lead constomers to new culture and trend. From t these interior trends will go on to next generation with new c concepts : environment and nature, senses and sensibility. T These words will be the new solution for creative and s successful store design by the designer who has environm mentally conscious and social responsibility in his mind. his mind.

• The Journal of Korean Physical Therapy
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• v.21 no.3
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• pp.9-16
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• 2009

Purpose: The purpose of this study was to investigate the effects of intermittent lumbar traction and manual traction on a $L_{4-5}$ herniated disc. Method: The subjects were randomly divided into the intermittent lumbar traction group (n=10) and the manual traction group (n=10). The intermittent traction group had traction-treatment applied for 12 times in the first two weeks, and then 6 times in the next two weeks. The time the traction was applied was for 30 minutes. The manual traction group had flexion-distraction therapy applied for 12 times in first two weeks, and for 6 times in next two weeks. The time the traction was applied was 3 to 6 minutes per treatment. Results: The change of the muscle test (MT), the disc herniation index (DHI) and the sagittal $T_2$ weighted MRI was measured at pretreatment and 4weeks and 12weeks after treatment. Conclusion: We found that intermittent lumbar traction and manual traction could improved the MT and DHI and this could improve the rehabilitation of patients with lumbar herniated disc.

• Journal of the Korea Organic Resources Recycling Association
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• v.19 no.1
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• pp.115-122
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• 2011

Ecotoxicological effects of synthetic detergents such as laundry detergent and $Shampoo^{(R)}$ on cocoon productivity, hatchability, number of hatched individuals per cocoon and growth of next generation of Eisenia fetida population were evaluated. Synthetic detergents mixed with earthworm feed increased the cocoon productivity, number of hatched individuals per cocoon and growth of next generation of Eisenia fetida population, but there was no effect on hatchability. From those results, it could be concluded that synthetic detergents that might be present in the sewage sludge would not cause ecotoxicological effect on Eisenia fetida population.

• Journal of The Korean Society of Grassland and Forage Science
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• v.15 no.4
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• pp.238-244
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• 1995

The objective of this study is to obtain the basic data for investigating the effects of organic reserves on winter survial or regrowth yield. Forage rape(Brassica napus L.) was sown on Sep. 1, 1994. Experimental plots were divided into three replicates under 6 different cutting dates(l0 days interval from Oct. 15 to Dec. 4). Field-grown palnts were sampled on the each cutting date and on the wintering period (Jan. 16) to analyze the nitrogen and non-structural cahohydrate reserves. The rate of winter survival and regrowth yield were also measured in the spring of next year. On the before wintering, dry matter yields were 152, 274, 500, 718, 776 and 981 kg/lOa, respectively, from the cutting date on Oct. 15, Oct. 25, Nov. 4, Nov. 14, Nov. 24, and Dec. 4. Cmde protein yield significantly increased as cutting date was later until Nov. 14, thereafter a significant increase did not occured. Nitrogen and starch contents per plant significnatly increased as the cutting date was later. The increasing rate of starch was greatly higher than that of nitrogen. On the wintering period, nitrogen reserves in mts were 85.3, 68.8, 47.6, 28.3, 44.3, and 55.3 mglplant, and starch reserve were 11 1.3, 75.3, 39.3, 19.6, 26.4 and 34.6 mglplant, respectively, in the plots cut on Oct. 15, Oct. 25, Nov. 4, Nov. 14, Nov. 24, and Dec. 4. It showed that carbohydrate reserves were much highly utilized than nitrogen reserves during wintering period. The rates of winter survival were 91, 83, 46, 22, 35 and 43% and regrowth yields were 692, 545, 316, 84, 127 and 140 kgD.M/lOa, respectively, in each plots. The highly significant correlation (p<0.01) between the level of organic reserves and the rate of winter survival or regrowth yield were obtained.