• Title/Summary/Keyword: Next-generation Technologies

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Accelerating next generation sequencing data analysis: an evaluation of optimized best practices for Genome Analysis Toolkit algorithms

  • Franke, Karl R.;Crowgey, Erin L.
    • Genomics & Informatics
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    • v.18 no.1
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    • pp.10.1-10.9
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    • 2020
  • Advancements in next generation sequencing (NGS) technologies have significantly increased the translational use of genomics data in the medical field as well as the demand for computational infrastructure capable processing that data. To enhance the current understanding of software and hardware used to compute large scale human genomic datasets (NGS), the performance and accuracy of optimized versions of GATK algorithms, including Parabricks and Sentieon, were compared to the results of the original application (GATK V4.1.0, Intel x86 CPUs). Parabricks was able to process a 50× whole-genome sequencing library in under 3 h and Sentieon finished in under 8 h, whereas GATK v4.1.0 needed nearly 24 h. These results were achieved while maintaining greater than 99% accuracy and precision compared to stock GATK. Sentieon's somatic pipeline achieved similar results greater than 99%. Additionally, the IBM POWER9 CPU performed well on bioinformatic workloads when tested with 10 different tools for alignment/mapping.

Core Technologies of Next-generation Machine Tools

  • Lee, Jae-yoon
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2000.06a
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    • pp.61-70
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    • 2000
  • This paper described the current status of machine tool technology and its future trends with a particular emphasis on high-speed machining. People in machine tool industry have continuously sought to serve fast-changing manufacturing industry with economical machining solutins. At presents, it appears that more productivity gain is demanded to shorten time-to-market and machining requirements become more stringent. In this regard, this paper firstly addressed a high-speed spindle as a key element for the next-generation machine tools. The sequel to it apparently went to high-speed feed axes and final discussion included the problem of how to optimize overall system including servo function. Lastly a brief look to NC technology including machine intelligence was taken.

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CPNT Based Next Generation Smart TV Service Technology (CPNT 기반 차세대 스마트TV 서비스 기술)

  • Hong, Jin-Woo
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.16 no.6
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    • pp.1209-1216
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    • 2012
  • Smart TV is approaching as a new media service to integrate the broadcasting and the internet according to the technology evaluation of convergence to broadcasting, telecommunication, and computing. Therefore, This paper proposes the next generation smart TV(Smart TV 2.0) technology based on CPNT which supports those services such as the broadcasting, telecommunication, a convergence of broadcasting & communication, and computer service through multi-screen. Also, this paper describes the concept and details of the related technologies.

Status of Advanced Tecnhologies and Domestic Researches for Development of Korean Next Generation Maglev (한국형 차세대 자기부상열차 개발을 위한 선진기술분석 및 국내연구현황)

  • Cho, Han-Wook;Bang, Je-Sung;Han, Hyung-Seok;Sung, Ho-Kyung;Kim, Dong-Sung;Kim, Byung-Hyun
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.57 no.10
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    • pp.1767-1776
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    • 2008
  • This paper presents the status of advanced technologies and domestic researches for development of Korean next generation maglev. Generally, two specific configurations such as the EMS (Electromagnetic Suspension) with LSM (Linear Synchronous Motor) and EDS (Electrodynamic Suspension) with LSM can be employed as a propulsion and levitation device of high-speed maglev. Worldwide high-speed maglev developments refer to projects such as the German Transrapid with EMS, the Japanese MLX with EDS, and the U.S. Inductrack with PM (Permanent Magnet) EDS maglev system. In this paper, the propulsion and levitation systems of these world wide high-speed maglev have been reviewed and analysed.

Next-Generation Converged Networking in Korea: The Concept and Its R&D Activities

  • Kang, Kug-Chang;Park, No-Ik;Lee, Soon-Seok;Kim, Young-Sun;Jun, Kyung-Pyo
    • Journal of Communications and Networks
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    • v.8 no.4
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    • pp.475-479
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    • 2006
  • In Korea, we witness vivid evidences of changing trend in communication that insist the emergence of new networking architecture. To accommodate the changing trend and to hold current strong position in global IT industry, Korea have launched broadband convergence network (BcN) initiative. BcN vision for Korea is to be the first in the world to realize converged network infrastructure and ubiquitous service environment. In this paper, we have introduced the concept and the vision of BcN with a viewpoint of a new paradigm to prepare future-proof communication environment. And then, we have disclosed BcN research and development (R&D) activities including R&D philosophy, R&D phases, and key technologies required. Also, we have discussed current development issues in three technology branches including service and control technology, unified transport technology, and next-generation access technology.

Strategies for Mutation Discovery in Retinitis Pigmentosa: Transition to the Next Generation

  • Yoon, Chang Ki;Yu, Hyeong Gon
    • Journal of Genetic Medicine
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    • v.10 no.1
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    • pp.13-19
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    • 2013
  • Retinitis pigmentosa (RP) is the most common hereditary retinal disorder and is characterized by progressive retinal degeneration and decline in vision. RP comprises a heterogeneous group of disorders caused by various genetic variants. Since the first discovery of the causal mutation in the RHO gene using positional cloning, numerous mutations have been detected in more than 60 loci and 50 genes. However, causal genes have not been discovered in about 50% of cases. We attempt here to review the strategies to identify causal alleles of retinitis pigmentosa. These include conventional methods as well as state-of-the-art technologies based on next-generation sequencing.

Recent Advances in the Clinical Application of Next-Generation Sequencing

  • Ki, Chang-Seok
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.24 no.1
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    • pp.1-6
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    • 2021
  • Next-generation sequencing (NGS) technologies have changed the process of genetic diagnosis from a gene-by-gene approach to syndrome-based diagnostic gene panel sequencing (DPS), diagnostic exome sequencing (DES), and diagnostic genome sequencing (DGS). A priori information on the causative genes that might underlie a genetic condition is a prerequisite for genetic diagnosis before conducting clinical NGS tests. Theoretically, DPS, DES, and DGS do not require any information on specific candidate genes. Therefore, clinical NGS tests sometimes detect disease-related pathogenic variants in genes underlying different conditions from the initial diagnosis. These clinical NGS tests are expensive, but they can be a cost-effective approach for the rapid diagnosis of rare disorders with genetic heterogeneity, such as the glycogen storage disease, familial intrahepatic cholestasis, lysosomal storage disease, and primary immunodeficiency. In addition, DES or DGS may find novel genes that that were previously not linked to human diseases.

Trends and Activation Plans for Next-generation Wireless Broadband Industry (차세대 무선 브로드밴드 산업 동향과 활성화 방안)

  • Shim, Beom-Soo;Yoo, Dong-Hee
    • Journal of Digital Convergence
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    • v.13 no.12
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    • pp.13-21
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    • 2015
  • Ongoing advances in wireless broadband technologies can affect all of industrial society. As new wireless broadband technologies emerge, they will improve competition between established industries and their current services and produce new industries and new converged services. This paper analyzes the trend of next-generation wireless broadband and suggests ways of activating the industry further. To this end, we analyze the trend for previous wireless broadband industries and find out three influential factors (content, wireless network technology, and service) that will produce the continued growth of wireless broadband. Using these three factors, we propose a network technology-driven growth model. Based on that model, we offer activation plans for next-generation wireless broadband industries. This study thus provides an insightful perspective for next-generation wireless broadband industries by establishing additional useful guidelines for developing wireless broadband industries in the future.

Solar Photovoltaics Technology: No longer an Outlier

  • Kazmerski, Lawrence L.
    • Proceedings of the Korean Vacuum Society Conference
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    • 2011.08a
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    • pp.70-70
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    • 2011
  • The prospects of current and coming solar-photovoltaic (PV) technologies are envisioned, arguing this solar-electricity source is beyond a tipping point in the complex worldwide energy outlook. Truly, a revolution in both the technological advancements of solar PV and the deployment of this energy technology is underway; PV is no longer an outlier. The birth of modern photovoltaics (PV) traces only to the mid-1950s, with the Bell Telephone Laboratories' development of an efficient, single-crystal Si solar cell. Since then, Si has dominated the technology and the markets, from space through terrestrial applications. Recently, some significant shift toward technology diversity have taken place. Some focus of this presentation will be directed toward PV R&D and technology advances, with indications of the limitations and relative strengths of crystalline (Si and GaAs) and thin-film (a-Si:H, Si, Cu(In,Ga)(Se,S)2, CdTe). Recent advances, contributions, industry growth, and technological pathways for transformational now and near-term technologies (Si and primarily thin films) and status and forecasts for next-generation PV (nanotechnologies and non-conventional and "new-physics" approaches) are evaluated. The need for R&D accelerating the now and imminent (evolutionary) technologies balanced with work in mid-term (disruptive) approaches is highlighted. Moreover, technology progress and ownership for next generation solar PV mandates a balanced investment in research on longer-term (the revolution needs revolutionary approaches to sustain itself) technologies (quantum dots, multi-multijunctions, intermediate-band concepts, nanotubes, bio-inspired, thermophotonics, ${\ldots}$ and solar hydrogen) having high-risk, but extremely high performance and cost returns for our next generations of energy consumers. This presentation provides insights to the reasons for PV technology emergence, how these technologies have to be developed (an appreciation of the history of solar PV)-and where we can expect to be by this mid-21st century.

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The Strategies of Technology Development for Geospatial Web Platform (Geospatial Web 플랫폼 기술 분석 및 기술개발전략)

  • Kim, Eun-Hyung
    • Spatial Information Research
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    • v.17 no.2
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    • pp.171-181
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    • 2009
  • In Web2.0 environment, with advanced platform technologies, global vendors such as Google, Microsoft and Yahoo provide competitive geospatial services based on global map and satellite image. But the relatively low level of platform technologies has not rapidly increased the land information and geospatial service markets in Korea. For the ubiquitous next generation Internet, as a one of the R&D projects by Korean Land Spatialization Group, the project for platform technologies has being made to provide customized land information and geospatial service. The platform technologies can be categorized for streamming, mashup and geosearch. More specifically, the 2D/3D Hybird streamming engine, mashup engine for u-GIS service and next generation search engine for land information have being developed. In this context, the strategies for efficient development and use of geoweb platform technologies are required. This study surveys the present geospatial products and services using of platform technologies to propose the strategies for efficient development and use of platform technologies. The strategies for efficient development and use of platform technologies can be proposed focusing on target market and each of platform technologies.

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