• Genomics & Informatics
• /
• 제18권1호
• /
• pp.10.1-10.9
• /
• 2020

Advancements in next generation sequencing (NGS) technologies have significantly increased the translational use of genomics data in the medical field as well as the demand for computational infrastructure capable processing that data. To enhance the current understanding of software and hardware used to compute large scale human genomic datasets (NGS), the performance and accuracy of optimized versions of GATK algorithms, including Parabricks and Sentieon, were compared to the results of the original application (GATK V4.1.0, Intel x86 CPUs). Parabricks was able to process a 50× whole-genome sequencing library in under 3 h and Sentieon finished in under 8 h, whereas GATK v4.1.0 needed nearly 24 h. These results were achieved while maintaining greater than 99% accuracy and precision compared to stock GATK. Sentieon's somatic pipeline achieved similar results greater than 99%. Additionally, the IBM POWER9 CPU performed well on bioinformatic workloads when tested with 10 different tools for alignment/mapping.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2000년도 Handout for 2000 Inter. Machine Tool Technical Seminar
• /
• pp.61-70
• /
• 2000

This paper described the current status of machine tool technology and its future trends with a particular emphasis on high-speed machining. People in machine tool industry have continuously sought to serve fast-changing manufacturing industry with economical machining solutins. At presents, it appears that more productivity gain is demanded to shorten time-to-market and machining requirements become more stringent. In this regard, this paper firstly addressed a high-speed spindle as a key element for the next-generation machine tools. The sequel to it apparently went to high-speed feed axes and final discussion included the problem of how to optimize overall system including servo function. Lastly a brief look to NC technology including machine intelligence was taken.

• 한국정보통신학회논문지
• /
• 제16권6호
• /
• pp.1209-1216
• /
• 2012

방송과 통신의 융합에 이어 컴퓨팅이 융합되는 기술적 진화에 따라 방송과 인터넷이 연계된 스마트TV가 새로운 미디어 서비스로 부각되고 있다. 따라서, 본 논문에서는 TV와 인터넷의 결합을 기반으로 이용자 친화적인 멀티모달 휴먼 인터페이스에 의한 화면제어가 가능하고, N-스크린 기반으로 방송형, 통신형, 방송통신 융합형, 컴퓨터형 서비스를 제공하는 CPNT기반의 차세대 스마트TV(스마트TV 2.0)의 서비스 기술에 대해 제안하고, 관련 기술의 개념 및 세부 내용에 대해 기술한다.

• 전기학회논문지
• /
• 제57권10호
• /
• pp.1767-1776
• /
• 2008

This paper presents the status of advanced technologies and domestic researches for development of Korean next generation maglev. Generally, two specific configurations such as the EMS (Electromagnetic Suspension) with LSM (Linear Synchronous Motor) and EDS (Electrodynamic Suspension) with LSM can be employed as a propulsion and levitation device of high-speed maglev. Worldwide high-speed maglev developments refer to projects such as the German Transrapid with EMS, the Japanese MLX with EDS, and the U.S. Inductrack with PM (Permanent Magnet) EDS maglev system. In this paper, the propulsion and levitation systems of these world wide high-speed maglev have been reviewed and analysed.

• Journal of Communications and Networks
• /
• 제8권4호
• /
• pp.475-479
• /
• 2006

In Korea, we witness vivid evidences of changing trend in communication that insist the emergence of new networking architecture. To accommodate the changing trend and to hold current strong position in global IT industry, Korea have launched broadband convergence network (BcN) initiative. BcN vision for Korea is to be the first in the world to realize converged network infrastructure and ubiquitous service environment. In this paper, we have introduced the concept and the vision of BcN with a viewpoint of a new paradigm to prepare future-proof communication environment. And then, we have disclosed BcN research and development (R&D) activities including R&D philosophy, R&D phases, and key technologies required. Also, we have discussed current development issues in three technology branches including service and control technology, unified transport technology, and next-generation access technology.

• Journal of Genetic Medicine
• /
• 제10권1호
• /
• pp.13-19
• /
• 2013

Retinitis pigmentosa (RP) is the most common hereditary retinal disorder and is characterized by progressive retinal degeneration and decline in vision. RP comprises a heterogeneous group of disorders caused by various genetic variants. Since the first discovery of the causal mutation in the RHO gene using positional cloning, numerous mutations have been detected in more than 60 loci and 50 genes. However, causal genes have not been discovered in about 50% of cases. We attempt here to review the strategies to identify causal alleles of retinitis pigmentosa. These include conventional methods as well as state-of-the-art technologies based on next-generation sequencing.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제24권1호
• /
• pp.1-6
• /
• 2021

Next-generation sequencing (NGS) technologies have changed the process of genetic diagnosis from a gene-by-gene approach to syndrome-based diagnostic gene panel sequencing (DPS), diagnostic exome sequencing (DES), and diagnostic genome sequencing (DGS). A priori information on the causative genes that might underlie a genetic condition is a prerequisite for genetic diagnosis before conducting clinical NGS tests. Theoretically, DPS, DES, and DGS do not require any information on specific candidate genes. Therefore, clinical NGS tests sometimes detect disease-related pathogenic variants in genes underlying different conditions from the initial diagnosis. These clinical NGS tests are expensive, but they can be a cost-effective approach for the rapid diagnosis of rare disorders with genetic heterogeneity, such as the glycogen storage disease, familial intrahepatic cholestasis, lysosomal storage disease, and primary immunodeficiency. In addition, DES or DGS may find novel genes that that were previously not linked to human diseases.

• 디지털융복합연구
• /
• 제13권12호
• /
• pp.13-21
• /
• 2015

무선 브로드밴드 기술의 발전은 산업계 전반에 다양한 변화를 안겨주고 있다. 새로운 무선 브로드밴드 기술의 등장으로 인해 기존 산업의 경쟁력은 강화되었고 새로운 융합형 서비스와 신생산업들이 등장하게 되었다. 본 연구에서는 차세대 무선 브로드밴드 산업의 동향을 분석하고 이를 활성화시킬 수 있는 방안을 제시하는 것을 목적으로 한다. 이를 위해, 먼저 최근 무선 브로드밴드 산업의 동향을 분석하였고, 무선 브로드밴드 산업 성장에 영향을 주는 요소로 무선 네트워크 기술, 콘텐츠, 서비스를 파악하였다. 파악된 요소별로 차세대 무선 브로드밴드 산업의 동향을 조사하였고, 네트워크 기술 발전을 성장 동력으로 하는 무선 브로드밴드 산업의 선순환 성장 모형을 제시하였다. 끝으로 무선 네트워크 기술 개발 관점에서 무선 브로드밴드 산업을 활성화시킬 수 있는 방안들을 기술하였다. 본 연구의 결과는 차세대 무선 브로드밴드 산업에 대한 통찰력 있는 시각을 제공하며 향후 무선 브로드밴드 산업을 발전시키는 제도방안 수립에 도움을 줄 것으로 기대된다.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2011년도 제41회 하계 정기 학술대회 초록집
• /
• pp.70-70
• /
• 2011

The prospects of current and coming solar-photovoltaic (PV) technologies are envisioned, arguing this solar-electricity source is beyond a tipping point in the complex worldwide energy outlook. Truly, a revolution in both the technological advancements of solar PV and the deployment of this energy technology is underway; PV is no longer an outlier. The birth of modern photovoltaics (PV) traces only to the mid-1950s, with the Bell Telephone Laboratories' development of an efficient, single-crystal Si solar cell. Since then, Si has dominated the technology and the markets, from space through terrestrial applications. Recently, some significant shift toward technology diversity have taken place. Some focus of this presentation will be directed toward PV R&D and technology advances, with indications of the limitations and relative strengths of crystalline (Si and GaAs) and thin-film (a-Si:H, Si, Cu(In,Ga)(Se,S)2, CdTe). Recent advances, contributions, industry growth, and technological pathways for transformational now and near-term technologies (Si and primarily thin films) and status and forecasts for next-generation PV (nanotechnologies and non-conventional and "new-physics" approaches) are evaluated. The need for R&D accelerating the now and imminent (evolutionary) technologies balanced with work in mid-term (disruptive) approaches is highlighted. Moreover, technology progress and ownership for next generation solar PV mandates a balanced investment in research on longer-term (the revolution needs revolutionary approaches to sustain itself) technologies (quantum dots, multi-multijunctions, intermediate-band concepts, nanotubes, bio-inspired, thermophotonics, ${\ldots}$ and solar hydrogen) having high-risk, but extremely high performance and cost returns for our next generations of energy consumers. This presentation provides insights to the reasons for PV technology emergence, how these technologies have to be developed (an appreciation of the history of solar PV)-and where we can expect to be by this mid-21st century.

• Spatial Information Research
• /
• 제17권2호
• /
• pp.171-181
• /
• 2009

구글, 마이크로소프트, 야후 등의 대형업체들이 플랫폼을 기반으로 전 세계 위성사진과 지도 서비스를 선보이고 있는데 반해, 국내의 경우 뛰어난 지도 서비스들을 보유하고 있음에도 플랫폼으로 발전시키지는 못하여 경쟁에서 밀리고 있다. 웹을 통해 국토정보를 효과적으로 활용하기 위해서는 다양한 원천자료와 소프트웨어를 통합해 줄 플랫폼이 필요한 현실에서, 차세대 유비쿼터스 웹 환경에서 공공 및 민간의 공간정보를 통합하여 맞춤형 국토정보의 활용을 극대화할 수 있는 기술로서 맞춤형 국토정보 플랫폼기술이 개발되고 있다. 스트리밍, 매쉬업, 검색의 크게 세 가지로 나뉘어 2D/3D Hybrid 스트리밍엔진, u-GIS 서비스 매쉬업엔진, 차세대 국토정보 검색엔진 등이 그것이다. 이에 맞춤형 국토정보 플랫폼기술의 효과적인 개발을 위해 관련 Geospatial Web 플랫폼기술이 구현되고 있는 기존의 제품 및 시장동향을 분석하고, 이를 토대로 목표시장중심 및 플랫폼의 기술 특성에 따라 맞춤형 국토정보 플랫폼기술개발전략을 모색하였다.