• 한국환경과학회지
• /
• 제6권1호
• /
• pp.45-52
• /
• 1997

Methyl methanesulfonate (MMS) was fed to Drosophila melnogaster in order to investigate its toxic capability at developmental and adult stages, and the hereditary effect of toxicity and the potency for induction of sex-linked lethal mutation during the slyer-matogenesis by the means of an attached-X method. In the control group, the egg to adult viability of D. melnogaster was 95.2%, while 3. 5mM and 5.0mM treated groups were 90.0% and 84.1%, respectively. In the case of their progenies (Fl), the viability was 96.9% in the control group, while 3.5mM and 5.0mM treated groups were 54.5% and 1.6%, respectively. Therefore, these differences between two generations show significant physiological toxic effects in the next generation. In the parental generation, the developmental time was calculated 11.05 days in the control group, 12.43 days In 3.5%mM treated group, and 13.23 days in 5.0mM. In the case of Fl it was estimated 10.35 days in the control group, and 11.43 days In 3.5mM treated group. Compared with the control groups In two generations, the developmental time generally delayed as the dose of MMS increased. As to the sex-ratio, there was no differences between the control and MMS treated groups. The toxic values of adult stage showed which increased the frequency of mortality with MMS concentrations. The mortality at 120hr In the control group was 1.67% and it in 0.5mM MMS treated group 3.33%. In 2.5mM MMS treated group, it was 33.3% at 72hr, and it 95% at 120hr The increase of the morality was shown from 72hr in 4.0mM treated group which was 100% at 96hr. There was the concentration-dependent induction of sex-linked lethal mutation during the spermatogenesis by means of an attached-X method, MMS had more pronounced effect in sperm and spermaid stages in D. melnogaster.

• 산업경영시스템학회지
• /
• 제39권1호
• /
• pp.1-8
• /
• 2016

Patent management activities are considered to play a key role for technology-based firms under the recent knowledge-based economies. This is because intellectual property, including patents, can act as a system for continuous profit generation by protecting firms' products, processes and services. In Korea, healthcare industry is now regarded as one of the promising next generation industries. Despite the promise of healthcare industry, Korean healthcare product manufacturers are faced with turbulent business changes, such as market opening. Even though there are various industrial studies on the effect of patent management activities on firm outcome, previous studies have hardly paid attention to Korean healthcare product manufacturing firms. For this reason, this study identifies the effect of patent management activities, such as patenting activeness, technical excellence and cooperation degree, on firm outcomes, including financial profitability and firm growth, with respect to the Korean healthcare product manufacturers. In this study, we located 86 Korean healthcare manufacturing firms from KORCHAMBIZ and DART, and then collected the data of their patenting activities and outcomes between 2001 and 2013. By applying factor analysis and regression analysis, our empirical study found that firms' patenting activeness has the significant positive relationship on firms' financial profitability, and firms' patenting activeness and technical excellence have the significant positive relationship on firms' financial growth. Our study is an initial attempt to identify the effect of patent management activities on firm outcome within Korean healthcare product manufacturing industry, and thus its results can be used as the basis to formulate national policies for Korean healthcare product industry.

• 대한기계학회논문집B
• /
• 제30권6호
• /
• pp.553-559
• /
• 2006

Most diesel injector, which is currently used in high-pressure common rail fuel injection system of diesel engine, is driven by the solenoid coil energy for its needle movement. The main disadvantage of this solenoid-driven injector is a high power consumption, high power loss through solenoid coil and relatively fixed needle response's problem. In this study, a prototype piezo-driven injector, as a new injector mechanism driven by piezoelectric energy based on the concept of inverse piezo-electric effect, has been designed and fabricated to know the effect of piezo-driven injection processes on the diesel spray structure and internal nozzle flow. Firstly we investigated the spray characteristics in a constant volume chamber pressurized by nitrogen gas using the back diffusion light illumination method for high-speed temporal photography and also analyzed the inside nozzle flow by a fully transient simulation with cavitation model using VOF(volume of fraction) method. The numerical calculation has been performed to simulate the cavitating flow of 3-dimensional real size single hole nozzle along the injection duration. Results were compared between a conventional solenoid-driven injector and piezo-driven injector, both equipped with the same micro-sac multi-hole injection nozzle. The experimental results show that the piezo-driven injector has short injection delay and a faster spray development and produces higher injection velocity than the solenoid-driven injector. And the predicted simulation results with the degree of cavitation's generation inside nozzle for faster needle response In a piezo-driven injector were reflected to spray development in agreement with the experimental spray images.

• IMMUNE NETWORK
• /
• 제14권3호
• /
• pp.138-148
• /
• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• Journal of Electrical Engineering and Technology
• /
• 제9권2호
• /
• pp.514-522
• /
• 2014

A new type of high precision electromagnetic suspension (EMS) which can support heavy tray along long stroke rail is proposed in this paper. Compared with the conventional EMS, the suggested moving-core typed EMS has the levitation electromagnets (EMs) on the fixed rail. This scheme has high load capability caused by iron-core and enables simple tray structure. Also it does not have precision degradation caused by heat generation from EMs, which is a drawback of conventional EMS. With these merits, the proposed EMS can be an optimal contactless linear bearing in next generation flat panel display (FPD) manufacturing process if the ability of long stroke movement is proved. So a special Section Switching Algorithm (SSA) is derived from the resultant force and moment equations of the levitated tray which enables long stroke movement of the tray. In order to verify the feasibility of the suggested SSA, a simple test-setup of the EMS with 2 Section-changes is made up and servo-controlled in the simulation and experiment. The simulation shows the perfect changeover the EMs, and the experiment shows overall control performance of under ${\pm}40{\mu}m$ gap deviations. These results reveal that the newly suggested contactless linear bearing can simultaneously achieve high load capability and precision gap control as well as long stroke.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
• /
• 제11권2호
• /
• pp.180-191
• /
• 2005

무선 통신 기술의 급속한 발전으로 세계적으로 무선 인터넷 서비스가 점차 확대되고 있고 그중 모바일 전자상거래가 큰 비중을 차지하고 있다. 현재의 모바일 전자 상거래 서비스는 제한적인 컨텐츠와 고가의 과금 시스템, 무선 디바이스 기기의 하드웨어적 제약 등 그것의 활성화를 저해하는 여러 가지문제점을 지니고 있음에도 불구하고 차세대 인터넷 사업으로 기대되고 있다. 본 논문에서는 이러한 기존의 모바일 전자상거래 서비스의 문제점을 정리하고, 이를 개선하기 위한 방안으로 유선 인터넷상의 상품정보를 자동으로 수집하여 모바일 전자상거래용으로 자동 변환하는 기능, 무선 디바이스상에서 오프라인으로 상품 검색 및 주문 등을 가능하게 하는 미들릿 애플리케이션, 개인적응형 상품 추천 기능을 가진 종합적인 해결책을 제안한다. 제안 시스템은 실제로 설계, 구현되어 그 기능과 유효성을 확인하였다

• 한국전자거래학회지
• /
• 제24권2호
• /
• pp.91-112
• /
• 2019

5세대 통신기술(5G)의 등장에 따라 4차 산업혁명 관련 첨단기술과 융합한 다양한 통신 서비스가 나타나고 있다. 그 중, 5G 기술의 효과적 실용적 활용을 위해 본 논문에서는 IT 전문가들을 대상으로 설문을 실시하였고, 그 결과 5G 기술과 융합하여 가장 많은 서비스 활성화를 이끌 수 있는 4차 산업혁명 분야로서 자율주행차가 선정되었다. 이를 기반으로, 5G 기반 자율주행차 활용 산업 및 서비스 분류체계를 개발함으로써 자율주행차를 활용한 신사업 개발 및 새로운 비즈니스 모델개발을 지원하는 기틀을 제공하였다. 이와 더불어, 개발된 새로운 자율주행자동차 산업-서비스 분류체계를 통해 연계 Matrix를 작성하여 향후 차세대 자율 주행차가 활용될 수 있는 분야에 대한 실용적인 산업-서비스 개발을 위한 가이드라인을 제공하고자 한다.

• 정보보호학회논문지
• /
• 제21권4호
• /
• pp.149-160
• /
• 2011

스마트그리드는 기존의 전력망과 정보통신 기술을 융합하여 에너지 효율을 최적화할 수 있는 차세대 지능형 전력망이다. 이는 소비자에게는 전력 요금의 실시간 확인을 통해 능동적인 전력소비를 유도하고, 공급자에게는 예상 발전량 측정을 통해 보다 안정적인 전력 시스템을 운용하도록 할 수 있다는 장점이 있다. 그러나 스마트그리드는 지능형 장치를 통한 양방향 통신 사이에서 데이터 노출, 데이터 도용, 프라이버시 침해와 같은 다양한 보안 위협들이 존재할 가능성이 있다. 따라서 이러한 스마트그리드의 보안 위협에 대응할 수 있는 안전한 환경을 구축하기 위해서는 보안 메커니즘 개발에 핵심이 되는 키 관리 기법이 필수적으로 요구된다. 본 논문에서는 해쉬 체인을 이용하여 계층적 구조를 갖는 스마트그리드 환경에 효율적으로 적용 가능한 그룹키 관리 메커니즘을 제안하고, 제안하는 그룹키 관리 메커니즘의 안전성 및 효율성을 분석한다.

• Ocean Systems Engineering
• /
• 제13권4호
• /
• pp.349-365
• /
• 2023

Targeting a floating wave and offshore wind hybrid power generation system (FWWHybrid) designed in the Republic of Korea, this study examines the impact of the interaction, with multiple wave energy converters (WECs) placed on the platform, on platform motion. To investigate how the motion of WECs affects the behavior of the FWWHybrid platform, it was numerically compared with a scenario involving a 'single-body' system, where multiple WECs are constrained to the platform. In the case of FWWHybrid, because the platform and multiple WECs move in response to waves simultaneously as a 'multi-body' system, hydrodynamic interactions between these entities come into play. Additionally, the power take-off (PTO) mechanism between the platform and individual WECs is introduced for power production. First, the hydrostatic/dynamic coefficients required for numerical analysis were calculated in the frequency domain and then used in the time domain analysis. These simulations are performed using the extended HARP/CHARM3D code developed from previous studies. By conducting regular wave simulations, the response amplitude operator (RAO) for the platform of both single-body and multi-body scenarios was derived and subsequently compared. Next, to ascertain the difference in response in the real sea environment, this study also includes an analysis of irregular waves. As the floating body maintains its position through connection to a catenary mooring line, the impact of the slowly varying wave drift load cannot be disregarded. To assess the influence of the 2^nd-order wave exciting load, irregular wave simulations were conducted, dividing them into cases where it was not considered and cases where it was included. The analysis of multi-degree-of-freedom behavior confirmed that the action of multiple WECs had a substantial impact on the platform's response.

• 항공우주기술
• /
• 제13권2호
• /
• pp.115-121
• /
• 2014

천리안위성(2010년 발사)의 성공적인 개발을 바탕으로 두 기의 위성을 동시에 개발하는 정지궤도 복합위성(GEO-KOMPSAT-2) 프로그램이 진행 중이다. 정지궤도 복합위성 중 GEO-KOMPSAT-2A(GK2A)위성에는 차세대 고성능 기상 탑재체와 우주기상 탑재체가 개발 탑재될 예정이다. 국내 주도로 개발되는 우주기상 탑재체는 대한민국 최초의 정지궤도용 우주기상 센서가 될 예정이다. 세 가지 종류의 우주기상 탑재체(고에너지 입자 검출기, 자력계, 위성 대전 감시기)는 정지궤도에서 우주공간에 대한 물리적 현상(고에너지 입자 분포, 지구 주위의 자기장, 위성 대전 전류)을 관측하여 우주기상 예 경보에 활용될 목적을 가지고 있다. 본 논문에서는 GK2A위성의 부탑재체인 우주기상탑재체 개발 요구사항, 시스템 설계 및 접속 설계에 대해 요약 기술하였다.