• Clinical and Experimental Pediatrics
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• 제45권11호
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• pp.1426-1429
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• 2002

저자들은 재태연령 35주 2일, 출생 체중 2.19 kg으로 출생시 낮은 Apgar score(1/2)와 흉부 촬영상 우측 횡격막 거상을 보였던 환아에서 복부 초음파 검사와 컴퓨터 단층촬영을 시행하여 간 우엽에 생긴 단발성 농양을 발견하였으며 초음파를 이용한 경피적 천자 흡인물 배양 검사에서 포도상 구균이 검출된 선천성 간농양 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제46권10호
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• pp.1047-1050
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• 2003

저자들은 분만 10일 전 herpes zoster 진단받은 산모에서 출생한 환아에서 피부 병변 없이 신경학적 이상 증세만을 보이는 perinatal varicella infection 1례를 경험하였기에 보고하는 바이다.

• Reproductive and Developmental Biology
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• 제35권4호
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• pp.457-461
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• 2011

JAZF1 (Juxtaposed with Another Zinc Finger gene 1) transcription factor are Zn-finger proteins that bind to the nuclear orphan receptor TAK/TR4 (Nakajima et al., 2004). The nuclear orphan receptor TAK1/TR4 functions as a positive as well as a negative regulator of transcription. It was recently reported that congenital cardiovascular malformations are significantly more frequent in Neurofibromatosis 1 (NF1) patients with microdeletion syndrome than in those with classical NF1. JAZF1 was expressed in adult heart of patients with microdeletion syndrome. JAZF1 is highly conserved among various species include zebrafish. We hypothesized that the expression of zebrafish Jazf1 may lead to severe forms of congenital heart disease that allow the survival of newborns and adults. In this study, we created Jazf1 transgenic zebrafish which over-express zebrafish Jazf1 cDNA under control of the CMV promoter. Our results suggested that Jazf1 expression may play an important role in zebrafish cardiac development.

• Childhood Kidney Diseases
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• 제7권1호
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• pp.103-105
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• 2003

저자들은 고환초막강내의 농양(감염성 음낭수종)에 의한 발열과 보챔, 음낭부종으로 내원한 신생아에서 조기진단 및 적절한 치료로 성공적으로 회복된 1례를 경험하였으며 감염성 음낭수종은 신생아에서 드물지만 조기에 정확하게 진단되어 질 때, 그리고 고환, 부고환에 영향을 끼치지 않았을 경우 단지 배액술과 항생제 치료만으로도 성공적으로 치료할 수 있음을 보고하는 바이다.

• Neonatal Medicine
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• 제17권1호
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• pp.123-126
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• 2010

성인에서 A형 간염은 현증 감염이 대부분이지만, 소아에서는 무증상 또는 경한 증상을 보이는 경우가 많았다. 그동안 외국에서는 임신 및 분만 기간 동안에 발생한 A형 간염의 산모와 이로 인한 신생아 A형 간염에 대한 증례 보고가 드물지 않게 있었다. 국내에서는 20대와 30대의 젊은 성인에서 A형 간염에 대한 항체 양성률이 낮아지고 있는 가운데, 이들 산모들의 A형 간염에 대한 위험성이 증가하고 있는 상황이며, 아직까지 국내에서는 A형 간염에 이환된 신생아에 대한 증례 보고가 없었다. 이에 저자들은 A형 간염 산모로부터 이환된 것으로 보이는 급성 A형 간염 신생아를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한유전성대사질환학회지
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• 제13권1호
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• pp.1-19
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• 2013

Inherited metabolic disorders are individually rare but as a whole, they are nor rare. Since Archibald Garrod introduced a concept of "inborn error of metabolism" or "chemical individuality", more than 600 diseases are currently known, affecting approximately one in 500 newborns cumulatively. They frequently manifest with acute, life-threatening crisis that requires immediate specific intervention or they present with insidious diverse symptoms and signs involving multiple visceral organs or tissues as well as central nervous system, hampering a correct diagnosis. In addition, many pediatricians are not familiar with all diagnostic and therapeutic strategies for diverse inherited metabolic disorders. However, the prognosis of affected children are heavily dependent on rapid and effective treatment. In this lecture, practical guidelines for the specific diagnosis based on diverse clinical features of inherited metabolic disorders will be described. Many sophisticated laboratory tests are available for the confirmatory diagnosis of each disease, which is challenging to general pediatricians with respect to knowledge about biochemical metabolite assay test, enzymatic test and DNA diagnostic tests. Sample collections, indications, methods and interpretation of results in varying laboratory tests will be listed as well.

• Journal of Korean Neurosurgical Society
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• 제47권2호
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• pp.89-94
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• 2010

Objective : To evaluate the role of cranial sonography and computed tomography in the diagnosis of neonatal intracranial hemorrhage and hypoxic-ischemic injury in an Indian set-up. Methods : The study included 100 neonates who underwent cranial sonography and computed tomography (CT) in the first month of life for suspected intracranial ischemia and hemorrhage. Two observers rated the images for possible intracranial lesions and a kappa statistic for interobserver agreement was calculated. Results : There was no significant difference in the kappa values of CT and ultrasonography (USG) for the diagnosis of germinal matrix hemorrhage/intraventricular hemorrhage (GMH/IVH) and periventricular leucomalacia (PVL) and both showed good interobserver agreement. USG, however detected more cases of GMH/IVH (24 cases) and PVL (19) cases than CT (22 cases and 16 cases of IVH and PVL, respectively). CT had significantly better interobserver agreement for the diagnosis of hypoxic ischemic injury (HII) in term infants and also detected more cases (33) as compared to USG (18). CT also detected 6 cases of extraaxial hemorrhages as compared to 1 detected by USG. Conclusion : USG is better modality for imaging preterm neonates with suspected IVH or PVL. However, USG is unreliable in the imaging of term newborns with suspected HII where CT or magnetic resonance image scan is a better modality.

• 대한기관식도과학회지
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• 제5권1호
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• pp.42-48
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• 1999

Background： This study was undertaken to detect the patterns of ciliogenesis in newborn rats trachea. Materials and Methods： The experimental animals(Sprague-Dawley strain) were divided five groups, one day, two day, three day, five day and seven day newborns as experimental groups. To obtain differential distribution of $\alpha$-tubulins in the ciliated cells and patterns of ciliogenesis, we used immunohistochemical stain method with mouse anti $\alpha$-tubulin monoclonal antibody as the primary antibody and gold particles conjugated goat anti mouse IgG as the secondary antibody. And we observed the specimens by electron microscope (Hitach-600 Model). Results : 1) The distribution of the $\alpha$ -tubulin reactions in apical zone was slightly decreased from three day after birth. 2) From 5th day after birth, the decreasing number of gold particles in intermediate zone was remarkable. 3) On the comparison with the other zones, the number of gold particles in the Golgi zone for seven days showed no statistical difference. Conclusion : The ciliogenesis of the tracheal ciliated cells in early newborn rat were made via centriolar and acentriolar pathways, in late groups, from five day after birth, the major ciliogenesis pattern might be centriolar pathway.

• Clinical and Experimental Pediatrics
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• 제50권8호
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• pp.711-717
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• 2007

Sleep is a vital, highly organized process regulated by complex systems of neuronal networks and neurotransmitters. Normal sleep comprises non-rapid eye movement (NREM) and REM periods that alternate through the night. Sleep usually begins in NREM and progresses through deeper NREM stages (2, 3, and 4 stages), but newborns enter REM sleep (active sleep) first before NREM (quiet sleep). A period of NREM and REM sleep cycle is approximately 90 minutes, but newborn have a shorter sleep cycle (50 minutes). As children mature, sleep changes as an adult pattern: shorter sleep duration, longer sleep cycles and less daytime sleep. REM sleep is approximately 50% of total sleep in newborn and dramatically decreases over the first 2 years into adulthood (20% to 25%). An initial predominant of slow wave sleep (stage 3 and 4) that peaks in early childhood, drops off abruptly after adolescence by 40% from preteen years, and then declines over the life span. The hypothalamus is recognized as a key area of brain involved in regulation of sleep and wakefulness. The basic function of sleep largely remains elusive, but it is clear that sleep plays an important role in the regulation of CNS and body physiologic processes. Understanding of the architecture of sleep and basic mechanisms that regulate sleep and wake cycle are essential to evaluate normal or abnormal development of sleep pattern changes with age. Reduction or disruption of sleep can have a significant impact on daytime functioning and development, including learning, growth, behavior, and emotional regulation.

• Child Health Nursing Research
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• 제10권3호
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• pp.311-320
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• 2004

Purpose: To investigate the relationships among mother's perception of her own newborn, her caring-confidence level, and her child-rearing attitude; and to provide data for developing effective nursing education programs on maternal newborn care. Method: Explorative survey questionnaires were completed by 159 married mothers of newborns from November 2003 to March 2004. Data were analyzed using SPSS/Win 10.0 by t-test and Pearson's Correlation coefficient. Result: The mean scores of the mother's perception of her own newborn, her caring- confidence level, and her child-rearing attitude were .26, 3.13, and 3.43 respectively. There was a positive correlation between mother's perception of her own newborn and her child-rearing attitude. There was a significant correlation between mothers caring-confidence level and her child-rearing attitude. Score of caring-confidence was significantly different depending on the availability of helper and history of delivery. Conclusion: Availability of helper and history of delivery significantly affected mothers caring-confidence. This in turn, along with mothers perception of her own newborn, enhanced mothers child-rearing attitude. Thus, an effective education for mothers should include these factors.