Browse > Article

Symptomatic Hepatitis A Virus Infection in a Newborn  

Jin, Jang-Yong (Department of Pediatrics, Soonchunhyang University Hospital)
Hong, Ye-Seul (Department of Pediatrics, Soonchunhyang University Hospital)
Lee, Woo-Ryoung (Department of Pediatrics, Soonchunhyang University Hospital)
Publication Information
Neonatal Medicine / v.17, no.1, 2010 , pp. 123-126 More about this Journal
Abstract
Hepatitis A virus (HAV) infection is a common cause of acute hepatitis, but is rarely responsible for neonatal hepatitis. HAV infection is usually transmitted by the fecal-oral route, but during the neonatal period can be transmitted by the intrauterine vertical route or postnatal horizontal route. HAV infection is usually self-limited, but it can be potentially life-threatening in adults. The clinical course and symptoms are mild and the infection can be asymptomatic in newborns. Recently, we experienced a case of symptomatic neonatal hepatitis A. To our knowledge, this is the first case of neonatal hepatitis with HAV infection in Korea.
Keywords
Hepatitis A virus; Newborn; Korea;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Hong WS, Kim CY. Seroepidemiology of type A and type B hepatitis in Seoul area. Korean J Med. 1982;25:19-26.
2 Watson JC, Fleming DW, Borella AJ, Olcott ES, Conrad RE, Baron RC. Vertical transmission of hepatitis A resulting in an outbreak in a neonatal intensive care unit. J Infect Dis 1993;167:567-71.   DOI   ScienceOn
3 Tong MJ, Thursby M, Rakela J, McPeak C, Edwards VM, Mosley JW. Studies on the maternal-infant transmission of the viruses which cause acute hepatitis. Gastroenterology 1981;80:999-1004.
4 Kang HM, Jeong SH, Kim JW, Lee D, Choi CK, Park YS, et al. Recent etiology and clinical features of acute viral hepatitis in a single center of Korea. Korean J Hepatol 2007;13:495-502.   DOI   ScienceOn
5 Choi W, Eom HS, Kim IH, Lee DH, Kim PS, Kim HG, et al. Patterns of acute hepatitis A and anti-HAV seroprevalence of Kyungin province. Korean J Gastroenterol 1999;34:69-75.
6 Motte A, Blanc J, Minodier P, Colson P. Acute hepatitis A in a pregnant woman at delivery. Int J Infect Dis 2009;13:e49-51.   DOI   ScienceOn
7 Urganci N, Arapoglu M, Akyildiz B, Nuhoglu A. Neonatal cholestasis resulting from vertical transmission of hepatitis A infection. Pediatr Infect Dis J 2003;22:381-2.
8 Fagan EA, Hadzic N, Saxena R, Mieli-Vergani G. Symptomatic neonatal hepatitis A disease from a virus variant acquired in utero. Pediatr Infect Dis J 1999;18:389-91.   DOI   ScienceOn
9 Renge RL, Dani VS, Chitambar SD, Arankalle VA. Vertical transmission of hepatitis A. Indian J Pediatr 2002;69:535-6.   DOI   ScienceOn
10 Noble RC, Kane MA, Reeves SA, Roeckel I. Posttransfusion hepatitis A in a neonatal intensive care unit. JAMA 1984;252:2711-5.   DOI   ScienceOn
11 Lee D, Cho YA, Park Y, Hwang JH, Kim JW, Kim NY, et al. Hepatitis A in Korea: epidemiological shift and call for vaccine strategy. Intervirology 2008;51:70-4.
12 Lee EJ, Kwon SY, Seo TH, Yun HS, Cho HS, Kim BK, et al. Clinical features of acute hepatitis A in recent two years. Korean J Gastroenterol 2008;52:298-303.
13 Selander B, Blackberg J, Widell A, Johansson PJ. No evidence of intrauterine transmission of hepatitis A virus from a mother to a premature infant. Acta Paediatr 2009;98:1603-6.   DOI   ScienceOn
14 Cuthbert JA. Hepatitis A: old and new. Clin Microbiol Rev 2001;14:38-58.   DOI   ScienceOn
15 Elinav E, Ben-Dov IZ, Shapira Y, Daudi N, Adler R, Shouval D, et al. Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. Gastroenterology 2006;130:1129-34.   DOI   ScienceOn
16 Leikin E, Lysikiewicz A, Garry D, Tejani N. Intrauterine transmission of hepatitis A virus. Obstet Gynecol 1996;88:690-1.   DOI   ScienceOn
17 McDuffie RS Jr, Bader T. Fetal meconium peritonitis after maternal hepatitis A. Am J Obstet Gynecol 1999;180:1031-2.   DOI   ScienceOn
18 Red Book: 2006 Report of the Committee on Infectious Disease. 27th ed. American Academy of Pediatrics: Elk Grove, 2006:326-35.
19 Cho HJ, Lee MH, Kim JH, Hur JK, Lee JH, Kim JT, et al. Prevalence and persistence of transferred maternal hepatitis A antibody during the second year of life in Korean infants. Korean J Infect Dis 2001;33:331-7.
20 De Silvestri A, Avanzini MA, Terulla V, Zucca S, Polatti F, Belloni C. Decline of maternal hepatitis A virus antibody levels in infants. Acta Paediatr 2002;91:882-4.   DOI   ScienceOn