• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제2권8호
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• pp.327-334
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• 2013

네트워크의 고속화와 다양한 응용 서비스의 등장으로 오늘날의 네트워크 트래픽은 복잡해지고 다양해졌다. 지금 이 순간에도 수 많은 응용들이 나타나고 사라지기를 반복하고 있는데, 이러한 다양한 트래픽의 변화에 현재의 트래픽 분류 시스템은 빠르게 대처 하지 못하고 있다. 본 논문에서는 이러한 문제점을 해결하기 위해 새롭게 출현하는 응용에 빠르게 대처할 수 있는 응용 인식 시스템을 제안한다. 응용 인식 시스템은 빠르게 변화하는 네트워크 환경에서 응용프로그램들의 이름을 인식하여 새로운 응용의 출현과 기존 응용의 변화 추이 등의 정보를 제공한다. 본 논문에서 빠르고 정확한 응용 인식을 위해 HTTP 프로토콜의 Host 필드를 이용한다. Host 필드의 domain정보를 추출하여 응용의 이름을 임시로 정하고 추후 관리자의 개입을 통해 응용의 이름을 확정 짓는 구조이다. 단순히 응용의 이름만을 알아내는데 그치지 않고 응용마다 고유의 Client IP를 카운팅하여 분석 대상 망에서 많이 사용된 응용들을 알아 낼 수 있다. 또한 응용 인식을 통해 나온 응용들을 트래픽 분류 시스템에 등록하여 기존에 분석 되지 않았던 새로운 응용들에 대한 분석도 가능하게 된다. 제안한 방법은 학내 망에서의 실험을 통해 결과를 도출하고 시나리오 별로 결과를 나눠서 분석함으로써 타당성을 증명하였다.

• 한국동물위생학회지
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• 제42권2호
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• pp.73-83
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• 2019

Foot-and-Mouth Disease (FMD) is a highly contagious trans-boundary viral disease caused by FMD virus, which causes huge economic losses. FMDV infects cloven hoofed (two-toed) mammals such as cattle, sheep, goats, pigs and various wildlife species. To control the FMDV, it is necessary to understand the life cycle and the pathogenesis of FMDV in host. Especially, the protein-protein interaction between FMDV and host will help to understand the survival cycle of viruses in host cell and establish new therapeutic strategies. However, the computational approach for protein-protein interaction between FMDV and pig hosts have not been applied to studies of the onset mechanism of FMDV. In the present work, we have performed the prediction of the pig's proteins which interact with FMDV based on RNA-Seq data, protein sequence, and structure information. After identifying the virus-host interaction, we looked for meaningful pathways and anticipated changes in the host caused by infection with FMDV. A total of 78 proteins of pig were predicted as interacting with FMDV. The 156 interactions include 94 interactions predicted by sequence-based method and the 62 interactions predicted by structure-based method using domain information. The protein interaction network contained integrin as well as STYK1, VTCN1, IDO1, CDH3, SLA-DQB1, FER, and FGFR2 which were related to the up-regulation of inflammation and the down-regulation of cell adhesion and host defense systems such as macrophage and leukocytes. These results provide clues to the knowledge and mechanism of how FMDV affects the host cell.

• Biomolecules & Therapeutics
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• 제25권1호
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• pp.69-79
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• 2017

Viruses continue to evolve a new strategy to take advantage of every aspect of host cells in order to maximize their survival. Due to their central roles in transducing a variety of transmembrane signals, GPCRs seem to be a prime target for viruses to pirate for their own use. Incorporation of GPCR functionality into the genome of herpesviruses has been demonstrated to be essential for pathogenesis of many herpesviruses-induced diseases. Here, we introduce US28 of human cytomegalovirus (HCMV) as the best-studied example of virally-encoded GPCRs to manipulate host GPCR signaling. In this review, we wish to summarize a number of US28-related topics including its regulation of host signaling pathways, its constitutive internalization, its structural and functional analysis, its roles in HCMV biology and pathogenesis, its proliferative activities and role in oncogenesis, and pharmacological modulation of its biological activities. This review will aid in our understanding of how pathogenic viruses usurp the host GPCR signaling for successful viral infection. This kind of knowledge will enable us to build a better strategy to control viral infection by normalizing the virally-dysregulated host GPCR signaling.

• Journal of Communications and Networks
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• 제7권4호
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• pp.525-536
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• 2005

In an IP-based network, automated dynamic assignment of IP addresses is preferable. In most wired networks, a node relies on a centralized server by using dynamic host configuration protocol (DHCP) to obtain a dynamic IP address. However, the DHCP­based approach cannot be employed in a mobile ad hoc network (MANET) due to the uncertainty of any centralized DHCP server. That is, a MANET may become partitioned due to host mobility. Therefore, there is no guarantee to access a DHCP server. A general approach to address this issue is to allow a mobile host to pick a tentative address randomly, and then use duplicate address resolution (DAR) protocol to resolve any duplicate addresses. In this paper, an innovative distributed dynamic host configuration protocol designed to configure nodes in MANET is presented. The proposed protocol not only can detect the duplicate address, but also can resolve the problem caused by duplicate address. It shows that the proposed protocol works correctly and is more universal than earlier approaches. An enhanced version of DAR scheme is also proposed in this paper to solve the situation of duplicate MAC address. The new and innovative approach proposed in this paper can make the nodes in MANET provide services to other networks and avoid packets from being delivered to incorrect destinations.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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• pp.767-770
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• 2009

We synthesized a spirobenzofluorene type phosphine oxide (SPPO2) as a new triplet host and an universal electron transport material for phosphorescent organic light-emitting diodes(PHOLEDs). Red PHOLEDs with the SPPO2 host material showed a high quantum efficiency of 14.3 % with a current efficiency of 20.4 cd/A. In addition, the SPPO2 could be applied as an electron transport material which can be matched with any host material due to the lowest unoccupied molecular orbital of 2.4 eV. Electron injection from a cathode to the SPPO2 electron transport layer was better than common electron transport materials. In particular, the SPPO2 was effective as the electron transport material in blue PHOLEDs and the quantum efficiency was more than doubled and driving voltage was lowered by more than 3 V using the SPPO2 instead of common electron transport material.

• 한국안전학회지
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• 제19권1호
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• pp.23-30
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• 2004

Modern production systems are very complex by request of automation, and failure modes that occur in thisautomatic system are very various and complex. The efficient fault diagnosis for these complex systems is essential for productivity loss prevention and cost saving. Traditional fault diagnostic system which perforns sequential fault diagnosis can cause catastrophic failure during diagnosis when fault propagation is very fast. This paper describes the Real-time Intelligent Multiple Fault Diagnosis System (RIMFDS). RIMFDS assesses current machine condition by using sensor signals. This system deals with multiple fault diagnosis, comprising of two main parts. One is a personal computer for remote signal generation and transmission and the other is a host system for multiple fault diagnosis. The signal generator generates various faulty signals and image information and sends them to the host. The host has various modules and agents for efficient multiple fault diagnosis. A SUN workstation is used as a host for multiple fault modules and agents for efficient multiple fault diagnosis. A SUN workstation is used as a host for multiple fault diagnosis and graphic representation of the results. RIMFDS diagnoses multiple faults with fast fault propagation and complex physical phenomenon. The new system based on multiprocessing diagnoses by using Hierarchical Artificial Neural Network (HANN).

• Journal of Microbiology and Biotechnology
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• 제20권10호
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• pp.1463-1470
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• 2010

E. coli has long been widely used as a host system for the manufacture of recombinant proteins intended for human therapeutic use. When considering the impurities to be eliminated during the downstream process, residual host cell DNA is a major safety concern. The presence of residual E. coli host cell DNA in the final products is typically determined using a conventional slot blot hybridization assay or total DNA Threshold assay. However, both the former and latter methods are time consuming, expensive, and relatively insensitive. This study thus attempted to develop a more sensitive real-time PCR assay for the specific detection of residual E. coli DNA. This novel method was then compared with the slot blot hybridization assay and total DNA Threshold assay in order to determine its effectiveness and overall capabilities. The novel approach involved the selection of a specific primer pair for amplification of the E. coli 16S rRNA gene in an effort to improve sensitivity, whereas the E. coli host cell DNA quantification took place through the use of SYBR Green I. The detection limit of the real-time PCR assay, under these optimized conditions, was calculated to be 0.042 pg genomic DNA, which was much higher than those of both the slot blot hybridization assay and total DNA Threshold assay, where the detection limits were 2.42 and 3.73 pg genomic DNA, respectively. Hence, the real-time PCR assay can be said to be more reproducible, more accurate, and more precise than either the slot blot hybridization assay or total DNA Threshold assay. The real-time PCR assay may thus be a promising new tool for the quantitative detection and clearance validation of residual E. coli host cell DNA during the manufacturingprocess for recombinant therapeutics.

• 한국컴퓨터정보학회논문지
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• 제8권4호
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• pp.126-131
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• 2003

다중 유니캐스트 전송기법보다 멀티캐스트 전송기법이 장점이 많은 것이 사실이지만 IP 멀티캐스트 프로토콜은 간편한 관리제어 목적으로 몇몇 네트워크 영역으로 국한된다. 영역간 멀티캐스트 배치는 기술적인 면과 관리적인 면으로 인하여 진척이 느려지고 있다. 이에 대안으로 최근에 오버레이 멀티캐스팅 기술이 제시되었고, 본 논문에서 우리는 종단 호스트 멀티캐스트 트리 프로토콜 (EMTP)를 제안한다. EMTP는 리프 노드에 도달할 때까지 한번에 트리의 두 레벨을 검색하면서 또 한편으로는 가입하고자 하는 노드와 트리상의 가장 가까운 노드를 찾아낸다. 비록 해당 위치의 노드가 허용 가능한 차수가 없을지라도 그 노드를 잠재적인 부모노드로 선택 가능하게 함으로써 차후에 스위칭 횟수를 줄여 트리의 안정성을 높이고 데이터 전송 시간의 감소를 가져온다.

• 한국응용곤충학회지
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• 제59권4호
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• pp.357-360
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• 2020

본 연구에서는 국내 광릉숲에서 우리나라 천연기념물이자 멸종위기 종인 장수하늘소(Callipogon relictus Semenov)의 새로운 기주식물로 졸참나무(Quercus serrata Thunb. ex Murray)를 처음 보고한다. 졸참나무 안에서 발견하였던 장수하늘소 유충의 형태학적 측정값과 재검토한 장수하늘소의 기주식물 목록을 제공한다.

• Mycobiology
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• 제50권3호
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• pp.166-171
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• 2022

Virginia creeper (or five-leaved ivy; Parthenocissus quinquefolia) is one of the most popular and widely grown climbers worldwide. In September 2021, Virginia creeper leaves with typical rust symptom were found in an arboretum in Korea, with severe damage. Globally, there is no record of a rust disease on Virginia creeper. Using morphological investigation and molecular phylogenetic inferences, the rust agent was identified as Neophysopella vitis, which is a rust pathogen of other Parthenocissus spp. including Boston ivy (P. tricuspidata). Given that the two ivy plants, Virginia creeper and Boston ivy, have common habitats, especially on buildings and walls, throughout Korea, and that N. vitis is a ubiquitous rust species affecting Boston ivy in Korea, it is speculated that the host range of N. vitis may recently have expanded from Boston ivy to Virginia creeper. The present study reports a globally new rust disease on Virginia creeper, which could be a major threat to the ornamental creeper.