• Title/Summary/Keyword: New host

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Exploration of the Binding Mode of Indole Derivatives as Potent HIV-1 Inhibitors Using Molecular Docking Simulations

  • Balupuri, Anand;Cho, Seung Joo
    • Journal of Integrative Natural Science
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    • v.6 no.3
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    • pp.138-142
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    • 2013
  • The HIV-1 envelope glycoprotein gp120 plays a vital role in the entry of the virus into the host cells. The crucial role of the glycoprotein suggests gp120 as potential drug target for the future antiviral therapies. Identification of the binding mode of small drug like compounds has been an important goal in drug design. In the current study we attempt to propose binding mode of indole derivatives in the binding pocket of gp120. These derivatives are reported to inhibit HIV-1 by acting as attachment inhibitors that bind to gp120 and prevent the gp120-CD4 interaction and thus inhibit the infectivity of HIV-1. To elucidate the molecular basis of the small molecules interactions to inhibit the glycoprotein function we employed the molecular docking simulation approach. This study provides insights to elucidate the binding pattern of indole-based gp120 inhibitors and may help in the rational design of novel HIV-1 inhibitors with improved potency.

A New Anthracnose of Neoregelia carolinae Smith var. tricolor Hort. Caused by Colletotrichum gloeosporioides Penz. (Colletotrichum gloeosporioides Penz에 의한 Neoregelia carolinae Smith var. tricolor Hort. 炭疽病)

  • Kim, Wan-Gyu
    • The Korean Journal of Mycology
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    • v.15 no.2
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    • pp.116-117
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    • 1987
  • 1985년 9월, 경기지방의 꽃 재배온실에서 네오레게리아(Neoregelia carolinae Smith var, tricolor Hort.)에 탄저병징이 심하게 발생하여, 병반에서 병원균을 분리, 동정한 결과 Colletotrichum gloeosporioides Penz.에 의한 것으로 밝혀졌다. 이 균은 PDA배양에서 완전세대 Glomerella cingulata (Stonem.) Spauld. & v. Sch.의 자낭과 자낭포자를 형상하였다. 병징은 2-5mm 크기로 원형 내지 타원형의 적갈색 반점이며, 반점 주위는 황색을 띄었다. 병이 심하게 진전되면 잎의 대부분이 황갈색으로 변하여 말라 죽었다. 이 균의 분생포자현탁액을 네오레게리아에 분무접종한 결과 병원성이 확인되었다. C. gloeosporioides에 의한 네오레게리아 탄저병은 아직까지 보고된 바 없으므로 새로운 탄저병으로 보고한다.

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Synthesis of Host Polymers and Guests for Electrophosphorescence

  • Holmes Andrew B.;Chan, Khai-Leok;Cho, Sung-Yong;Evans Nicholas R.;Grimsdale Andrew C.;Mak Chris S.K.;Sandee Albertus J.;Watkins Scott E.;Williams Charlotte K.
    • Proceedings of the Polymer Society of Korea Conference
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    • 2006.10a
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    • pp.21-22
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    • 2006
  • Significant progress has been realized in the design and synthesis of light emitting polymers with emission over the whole range of the visible spectrum. However up to seventy-five percent of charge recombination events can lead to triplet states that decay non-radiatively. Following the pioneering work in the field of small molecule organic light emitting devices it has been found that solution processible iridium polymer complexes can be used to harness the wasted triplet energy. In this paper new results concerning electrophosphorescence of solution processible tethered iridium polymer derivatives will be presented. Furthermore our approaches to the design of new high triplet energy conjugated polymer hosts will be reported.

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Improvement of Accuracy for Determination of Hydrogen Storage of Sieverts Apparatus (부피법을 이용한 수소 저장 성능 평가 장치의 수소 저장량 측정법 개선)

  • Cho, Won-Chul;Han, Sang-Sub;Park, Chu-Sik
    • Journal of Hydrogen and New Energy
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    • v.19 no.1
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    • pp.64-70
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    • 2008
  • This paper briefly discusses the main sources of errors and their solutions for measuring hydrogen uptake from gas phase by the Sieverts technique. Correction of volumetric errors of apparatus, density of hydrogen storage material, estimation of temperature gradient are investigated. Systematic errors and the change of density of the host material according to the pressure have been the subject of much controversy in recent years. We considered the standard ball calibration, temperature gradient distribution, pretreatment of hydrogen storage materials to minimize errors. We could lessen the miscalculations after applying those methods to Equilibrium pressure-composition isotherm data.

Molecular Design of New Organic Electroluminescence Materials: DCM Derivatives

  • Seong, See-Yearl;Park, Sung-Soo;Seo, Jeong-In;No, Kyoung-Tai;Hong, Jong-In;Park, Su-Jin;Choi, Seung-Hoon;Lee, Han-Yong
    • 한국정보디스플레이학회:학술대회논문집
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    • 2003.07a
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    • pp.178-180
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    • 2003
  • We performed semiempirical (AMl and ZINDO) and ab initio (HF and DFT) calculations, to investigate molecular structures and optical properties of DCM and its derivatives. DCM and its derivatives are used as a red fluorescent dopant of the organic electroluminescent host materials, $Alq_3$. We have studied the relationship between the molecular structure and the optical properties of these molecules for the improvement of EL efficiencies. Wavelength at the absorption maximum was found to be red-shifted when the molecule is substituted with both strong electron donating and withdrawing functional groups. A new red fluorescent dye was predicted by QSPR study based on calculations and experimental data.

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Taxonomic Studies of Trichodoridae (Nematoda:Trichodoroidea) from Korea, with Descriptions of a New Species (한국산 궁침선충과의 분류학적 연구 및 1 신종 기재)

  • Hyun Sil Baek;Young Eoun Choi
    • Korean journal of applied entomology
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    • v.34 no.3
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    • pp.206-217
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    • 1995
  • A new species, Trichodorus jeonjuensis n. sp., resembles T. cedarus Yokoo, 1964, T. tricaulatus Shishida, 1979, and T. californicus Allen, 1957, from which it differs by male with three ventromedian cervical pores anterior to excretory pore. The spicules are straited all over and first supplement is located on half of spicules and the female has kidney shape vagina. T. tricaulatus Shishida, 1979 is newly reported from Korea. T. cedarus Yokoo, 1964 and paratrichodorus porosus (Alen, 1957) Siddigi, 1974 were found at several localities and some morphological data were compared by localities.

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Three Species of the Genus Meganola Dyar, 1898 (Lepidoptera, Noctuidae, Nolinae) New to China (중국산 Meganola 속의 미기록 3종 관한 보고)

  • Deng, Gang;Qi, Mu-Jie;Han, Hui-Lin
    • Korean journal of applied entomology
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    • v.51 no.3
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    • pp.231-234
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    • 2012
  • Three species of the genus Meganola Dyar, 1898 (M. bryophilalis (Staudinger, 1887), M. costalis (Staudinger, 1887) and M. strigulosa (Staudinger, 1887)), are reported for the first time from China. The adults and genitalia of the species are briefly redescribed and illustrated with their distributions and host plants.

Spectroscopic Analysis on Hydroquinone Clathrates for an Application to Storage/Recovery of Olefin Compounds (올레핀 저장/회수 기술 응용을 위한 하이드로퀴논 크러스레이트의 분광학적 분석 연구)

  • Lee, Jong-Won;Pratik, Dotel;Kang, Seong-Pil
    • Journal of Hydrogen and New Energy
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    • v.24 no.5
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    • pp.437-443
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    • 2013
  • Clathrate samples, using hydroquinone as a host and ethylene or propylene as a possible guest, were prepared and analyzed by means of spectroscopic measurements. Obtained results showed that ethylene can form clathrate compounds with hydroquinone at 4.0MPa and room temperature, while propylene cannot form clathrate compounds. Different formation behaviors of these two olefin compounds can be applied to a clathrate-based storage/recovery of ethylene in a selective way, and can provide useful information on the cavity size of the formed clathrate compounds.

Hematopoietic stem cell transplantation : overview for general pediatrician (조혈모세포이식)

  • Hwang, Tai Ju
    • Clinical and Experimental Pediatrics
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    • v.50 no.7
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    • pp.613-621
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    • 2007
  • Hematopoietic stem cell transplantation (HSCT) has expanded and evolved substantially in the last decades to treat various malignant and nonmalignant diseases. However, the conditioning regimen can lead to transplantation related death by major organ dysfunction, severe infection and bleeding. In the allogeneic setting, graft versus host disease may also develop, making post-transplant management complex. To overcome these problems, new stem cell sources, stem cell mobilizing agents and new skills, nonmyeloablative stem cell transplantation including reduced intensity stem cell transplantation has been introduced in clinical practice, but problems remained so far. Recipients of stem cell transplant may be severely immunocompromised for many months after transplantation. Furthermore, long-term complications (endocrine, metabolic, relapse, second malignancies, etc) can develop. Pediatrician is open called on to participate in the evaluation and consideration of patients for possible transplant and long-term follow-up of HSCT patients. This review is intended as a basic overview of HSCT relevant to general pediatrician.

Regulation of Pathogenesis by Light in Cercospora zeae-maydis: An Updated Perspective

  • Kim, Hun;Ridenour, John B.;Dunkle, Larry D.;Bluhm, Burton H.
    • The Plant Pathology Journal
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    • v.27 no.2
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    • pp.103-109
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    • 2011
  • The fungal genus Cercospora is one of the most ubiquitous groups of plant pathogenic fungi, and gray leaf spot caused by C. zeae-maydis is one of the most widespread and damaging foliar diseases of maize in the world. While light has been implicated as a critical environmental regulator of pathogenesis in C. zeae-maydis, the relationship between light and the development of disease is not fully understood. Recent discoveries have provided new insights into how light influences pathogenesis and morphogenesis in C. zeae-maydis, particularly at the molecular level. This review is focused on integrating old and new information to provide an updated perspective of how light influences pathogenesis, and provides a working model to explain some of the underlying molecular mechanisms. Ultimately, a thorough molecular-level understanding of how light regulates pathogenesis will augment efforts to manage gray leaf spot by improving host resistance and disease management strategies.