• 한국지진공학회논문집
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• 제2권1호
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• pp.79-93
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• 1998

철근콘크리트부재가 갖는 균열의 발생, 항복 및 파괴 등의 단계별 역학적 거동의 특성을 정확히 예측하고 모사할 수 있는 해석기법의 개발을 목적으로 하였다. 이를 위해서 균열발생후의 철근과 콘크리트의 부착거동, 균열면에서의 골재의 맞물림 거동 및 철근항복후의 모델링 등에 의해서 반복하중을 받는 철근콘크리트 구조부재의 항복후 파괴거동을 예측할 수 있는 해석모델을 개발하였다. 두께가 서로 다릉 부재간의 접합부에서는 단면강성이 급변하기 때문에 기초의 바닥으로부터 철근의 인발, 접합면의 미끄러짐 및 접합면의 관입 등의 국소적인 불연속 변형이 집중하게 된다. 이와 같은 국소적인 불연속 교각구조의 변형능력에 미치는 기여도는 일반적으로 무시할 수 없는 정도이므로, 불연속 변형을 고려하기 위한 접합요소(joint element)를 도입하였다. 또한 축방향철근 및 횡방향 구속철근의 유무 및 그 양 등에 따른 구속효과를 적절히 표현할 수 있는 해석모델을 개발하였다. 각각의 해석모델들을 조합한 유한요소 해석프로그램에 의한 결과를 다른 연구자들의 결과와 비교하여 타당성을 검증하였다.

• Smart Structures and Systems
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• 제9권6호
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• pp.505-534
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• 2012

The present work deals with second order statistics of post buckling response of piezoelectric laminated composite cylindrical shell panel subjected to hygro-thermo-electro-mechanical loading with random system properties. System parameters such as the material properties, thermal expansion coefficients and lamina plate thickness are assumed to be independent of the temperature and electric field and modeled as random variables. The piezoelectric material is used in the forms of layers surface bonded on the layers of laminated composite shell panel. The mathematical formulation is based on higher order shear deformation shell theory (HSDT) with von-Karman nonlinear kinematics. A efficient $C^0$ nonlinear finite element method based on direct iterative procedure in conjunction with a first order perturbation approach (FOPT) is developed for the implementation of the proposed problems in random environment and is employed to evaluate the second order statistics (mean and variance) of the post buckling load of piezoelectric laminated cylindrical shell panel. Typical numerical results are presented to examine the effect of various environmental conditions, amplitude ratios, electrical voltages, panel side to thickness ratios, aspect ratios, boundary conditions, curvature to side ratios, lamination schemes and types of loadings with random system properties. It is observed that the piezoelectric effect has a significant influence on the stochastic post buckling response of composite shell panel under various loading conditions and some new results are presented to demonstrate the applications of present work. The results obtained using the present solution approach is validated with those results available in the literature and also with independent Monte Carlo Simulation (MCS).

• 약학회지
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• 제57권1호
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• pp.1-7
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• 2013

Induction of effective and increased levels of antibody production may be major points in vaccine development. This is especially the case when the antigenic sources are carbohydrates. Thus, in our Lab various types of formulations such as liposomal and conjugate vaccines have been researched. However, the fastidious formulation process and high costs are a problem. For this reason, there is currently a focus on utilizing immunoadjuvants. In this present study, we tested whether ginsenosides Re (a panaxdiol) and Rg1 (a panaxtriol) from Panax ginseng have immunoadjuvant activity against the cell wall of Candida albicans (CACW). The resulting data showed that Rd and Rg1 caused LPS-treated B lymphocytes to be proliferative. Rd had greater proliferation activity than that of Rg1. In the murine model of antibody production, CACW combined with Rd [CACW/Rd/IFA] or Rg1 [CACW/Rg1/IFA] increased the production of antibodies specific to C. albicans when compared to the antibody production by [CACW/IFA]-induction, which was used as a negative control (P<0.05). In the case of [CFA/Rd/IFA], the antibody production was almost twice as that of the CFA. In addition, formulations containing either had a prolonged antibody inducing activity as compared to the CFA formula. In conclusion, Rd and Rg1 have an immunologic activity, and yet Rd can be a better candidate than Rg1 for a new immunoadjuvant.

• Parasites, Hosts and Diseases
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• 제57권1호
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• pp.1-8
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• 2019

There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. In this study, the niosomal formulations of selenium and in combination with glucantime were prepared. The size and morphology of the niosomal formulations were characterized and the effectivity of the new formulation was also evaluated using in vitro MTT assay, intra-macrophage model, and gene expression profile. From the results obtained, no cytotoxicity effect was observed for niosomal and simple forms of drugs, as alone or in combination. Niosomal formulations of the drugs significantly showed more inhibitory effects ($P{\leq}0.001$) than the simple drugs when the selectivity index was considered. The gene expression levels of Interleukin (IL-10) significantly decreased, while the level of IL-12 and metacaspase significantly increased ($P{\leq}0.001$). The results of the present study showed that selenium plus glucantime niosome possess a potent anti-leishmanial effect and enhanced their lethal activity as evidenced by the in vitro experiments.

• Advances in nano research
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• 제7권4호
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• pp.241-248
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• 2019

Recent researches demonstrated well promising anticancer activities for antibiotics. Such effects would be significantly increased while nanoparticle based delivery systems were applied. In this study, the goal was aim to improve anticancer and antitoxic effects of Streptomycin by loading on special kind of dendrimer (anionic-linear-globular second generation). In the current study, Size and zeta potential as well as AFM techniques have been used to prove the fact that the loading was performed correctly. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the drug loaded on dendrimer nanoparticle were determined and compared with both of dendrimer alone and free drug with respect to staphylococcus aureus as the test microorganism. The anticancer activity among three groups including Streptomycin, Streptomycin -G2 dendrimer, and control was measured in vitro. In vitro studies showed that G2 anionic linear-globular polyethylene-glycol-based dendrimer, which loaded on Streptomycin was able to significantly improve the treatment efficacy over clinical Streptomycin alone with respect to proliferation assay. Maximal inhibitory concentration (IC50) was calculated to be $257{\mu}g/mL$ for streptomycin alone and $55{\mu}g/mL$ for Streptomycin -G2 dendrimer. In addition, Streptomycin -G2 dendrimer conjugate prevented the growth of MCF-7 cancerous cells in addition to enhance the number of apoptotic and necrotic cells as demonstrated by an annexin V-fluorescein isothiocyanate assay. Streptomycin -G2 dendrimer conjugate was able to increase Bcl-2/Bax ratio in a large scale compared with the control group and Streptomycin alone. Based on results a new drug formulation based nano-particulate was improved against S. aureus with sustained release and enhanced antibacterial activity as well as anticancer activity shown for functional cancer treatment with low side effects.

• Computers and Concrete
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• 제27권4호
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• pp.333-341
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• 2021

Steel slag, an industrial reject from the steel rolling process, has been identified as one of the suitable, environmentally friendly materials for concrete production. Given that the coarse aggregate portion represents about 70% of concrete constituents, other economic approaches have been found in the use of alternative materials such as steel slag in concrete. Unfortunately, a standard framework for its application is still lacking. Therefore, this study proposed functional model equations for the determination of strength properties (compression and splitting tensile) of steel slag aggregate concrete (SSAC), using gene expression programming (GEP). The study, in the experimental phase, utilized steel slag as a partial replacement of crushed rock, in steps 20%, 40%, 60%, 80%, and 100%, respectively. The predictor variables included in the analysis were cement, sand, granite, steel slag, water/cement ratio, and curing regime (age). For the model development, 60-75% of the dataset was used as the training set, while the remaining data was used for testing the model. Empirical results illustrate that steel aggregate could be used up to 100% replacement of conventional aggregate, while also yielding comparable results as the latter. The GEP-based functional relations were tested statistically. The minimum absolute percentage error (MAPE), and root mean square error (RMSE) for compressive strength are 6.9 and 1.4, and 12.52 and 0.91 for the train and test datasets, respectively. With the consistency of both the training and testing datasets, the model has shown a strong capacity to predict the strength properties of SSAC. The results showed that the proposed model equations are reliably suitable for estimating SSAC strength properties. The GEP-based formula is relatively simple and useful for pre-design applications.

• 한국구조물진단유지관리공학회 논문집
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• 제24권5호
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• pp.1-8
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• 2020

이 연구에서는 철근콘크리트 부재의 전단파괴가 휨-전단 메커니즘에 지배된다는 가정을 바탕으로 인장측과 압축측에 대한 2개의 전단요구곡선들과 이에 대응되는 잠재전단강도곡선들을 각각 도출하였으며, 이를 기반으로 전단강도 산정모델을 제안하였다. 제안모델에서는 철근과 콘크리트의 부착거동을 고려하여 휨균열폭과 철근의 국부응력증가분을 산정하였다. 또한, 휨균열로부터 발전되는 지배전단균열의 생성과 균열진전거동을 이론적으로 모사하기 위하여 균열집중계수를 도입하였으며, 이를 통해 단면높이가 큰 철근콘크리트 부재에서 관측되는 크기효과를 반영하였다. 또한, 기존의 해석모델과는 다르게 전단철근과 콘크리트의 전단기여분 사이의 상호작용을 고려할 수 있는 새로운 형태의 수식을 개발하였다. 제안모델의 검증을 위하여 방대한 전단실험체들을 기존문헌으로부터 수집하였으며, 이를 통해 해석모델을 검증한 결과는 제안모델이 실험체들의 재료, 크기 및 철근의 부착특성에 관계없이 실험결과를 정확하게 평가할 수 있음을 보여주었다.

• 디지털융복합연구
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• 제19권2호
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• pp.415-423
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• 2021

본 연구는 20세기 이후 다원화된 사회의 모습을 담아냈던 1980년대 멤피스 디자인의 작품들을 분석하고 이를 바탕으로 한 실내 조명등의 조형화 작업으로 대중과 함께 소통할 수 있는 실용 가능한 디자인을 제시하는 것에 그 목적이 있다. 연구 방법으로는 멤피스 그룹의 발생 배경, 멤피스 디자인의 이론적 배경과 조형적 특징을 문헌 및 선행연구를 중심으로 고찰하였다. 이를 기반으로 본 연구에서는 멤피스의 조형적 특성과 색채, 패턴을 응용하여 새롭게 조형화된 디자인을 조명등에 접목시켰다. 기본 도형에 작은 변화를 준 형태들의 조명등은 그것의 기능성과 장식성에 그치지 않고, 인간 내면에 간직된 감성을 들려주는 조형언어로의 확장성을 보여준다. 또한 작품제작에 있어 조형적 변화에 따른 재료의 선택은 새로운 조형예술의 창작 가능성을 제시해 줄 것이다.

• Structural Engineering and Mechanics
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• 제77권4호
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• pp.441-461
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• 2021

Reinforced concrete (RC) columns are crucial in building structures and they are of higher vulnerability to terrorist threat than any other structural elements. Thus it is of great interest and necessity to achieve a comprehensive understanding of the possible responses of RC columns when exposed to high intensive blast loads. The primary objective of this study is to derive analytical formulas to assess vulnerability of RC columns using an advanced numerical modelling approach. This investigation is necessary as the effect of blast loads would be minimal to the RC structure if the explosive charge is located at the safe standoff distance from the main columns in the building and therefore minimizes the chance of disastrous collapse of the RC columns. In the current research, finite element model is developed for RC columns using LS-DYNA program that includes a comprehensive discussion of the material models, element formulation, boundary condition and loading methods. Numerical model is validated to aid in the study of RC column testing against the explosion field test results. Residual capacity of RC column is selected as damage criteria. Intensive investigations using Arbitrary Lagrangian Eulerian (ALE) methodology are then implemented to evaluate the influence of scaled distance, column dimension, concrete and steel reinforcement properties and axial load index on the vulnerability of RC columns. The generated empirical formulae can be used by the designers to predict a damage degree of new column design when consider explosive loads. With an extensive knowledge on the vulnerability assessment of RC structures under blast explosion, advancement to the convention design of structural elements can be achieved to improve the column survivability, while reducing the lethality of explosive attack and in turn providing a safer environment for the public.

• The Plant Pathology Journal
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• 제38권3호
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• pp.182-193
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• 2022

Turfgrass, the most widely grown ornamental crop, is severely affected by fungal pathogens including Sclerotinia homoeocarpa, Rhizoctonia solani, and Magnaporthe poae. At present, turfgrass fungal disease management predominantly relies on synthetic fungicide treatments. However, the extensive application of fungicides to the soil increases residual detection frequency, raising concerns for the environment and human health. The bacterial volatile compound, 2,3-butanediol (BDO), was found to induce plant resistance. In this study, we evaluated the disease control efficacy of a combination of stereoisomers of 2,3-BDO and commercial fungicides against turfgrass fungal diseases in both growth room and fields. In the growth room experiment, the combination of 0.9% 2R,3R-BDO (levo) soluble liquid (SL) formulation and 9% 2R,3S-BDO (meso) SL with half concentration of fungicides significantly increased the disease control efficacy against dollar spot and summer patch disease when compared to the half concentration of fungicide alone. In field experiments, the disease control efficiency of levo 0.9% and meso 9% SL, in combination with a fungicide, was confirmed against dollar spot and large patch disease. Additionally, the induction of defense-related genes involved in the salicylic acid and jasmonic acid/ethylene signaling pathways and reactive oxygen species detoxification-related genes under Clarireedia sp. infection was confirmed with levo 0.9% and meso 9% SL treatment in creeping bentgrass. Our findings suggest that 2,3-BDO isomer formulations can be combined with chemical fungicides as a new integrated tool to control Clarireedia sp. infection in turfgrass, thereby reducing the use of chemical fungicides.