• Proceedings of the KSME Conference
• /
• 2004.11a
• /
• pp.916-921
• /
• 2004

The penalty method has been widely applied to analyses of incompressible fluid flow. However, we have not yet found any prior studies that employed penalty method to analyze compressible fluid flow. In this study, with an eye on the apparent similarity between the slight compressible formulation and the penalty formulation, we have proposed a new approximate approach that can analyze compressible packing process using the penalty parameter l. Based on the assumption of the isothermal flow, a set of reference solutions was obtained to verify the validity of the proposed scheme. Furthermore, we have applied the proposed scheme to the analysis of the packing process of different cases.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.21 no.12
• /
• pp.2156-2164
• /
• 1997

A new formulation for the dynamic analysis of constrained multibody systems is presented in this paper. The formulation employs Kane's method along with the null space method. Kane's method reduces the dimension of equations of motion by using partial velocity matrix introduced in this study : it can improve the efficiency of the formulation. Three numerical examples are given to demonstrate the accuracy and efficiency of the formulation.

• Nuclear Engineering and Technology
• /
• v.43 no.6
• /
• pp.477-488
• /
• 2011

A formulation is proposed for modelling the process of intra-granular diffusion of fission gas during irradiation of $UO_2$ under both normal operating conditions and power transients. The concept represents a simple extension of the formulation of Speight, including an estimation of the contribution of bubble motion to fission gas diffusion. The resulting equation is formally identical to the diffusion equation adopted in most models that are based on the formulation of Speight, therefore retaining the advantages in terms of simplicity of the mathematical-numerical treatment and allowing application in integral fuel performance codes. The development of the new model proposed here relies on results obtained by means of molecular dynamics simulations as well as finite element computations. The formulation is proposed for incorporation in the TRANSURANUS fuel performance code.

• Structural Engineering and Mechanics
• /
• v.83 no.2
• /
• pp.273-282
• /
• 2022

In this paper, we propose a new concept for error estimation in finite element solutions, which we call mode-based error estimation. The proposed error estimation predicts a posteriori error calculated by the difference between the direct finite element (FE) approximation and the recovered FE approximation. The mode-based FE formulation for the recently developed self-updated finite element is employed to calculate the recovered solution. The formulation is constructed by searching for optimal bending directions for each element, and deep learning is adopted to help find the optimal bending directions. Through various numerical examples using four-node quadrilateral finite elements, we demonstrate the improved predictive capability of the proposed error estimator compared with other competitive methods.

• Archives of Pharmacal Research
• /
• v.28 no.7
• /
• pp.848-853
• /
• 2005

Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part of S. deltoides extract, 0.9 part of Angelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1 % inhibition of AA-induced ear edema at an oral dose of 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7 -day model of multiple treatment of TPA (38.1 % inhibition at 200 mg/kg/day). Furthermore, SAG (50-800 mg/kg/day) as well as S. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin $E_2$ production from the skin lesion of the animals of 7-day model. These results were well correlated with in vitro finding that SAG as well as S. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. Therefore, these results suggest that SAG possesses anti-inflammatory activity in vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed by S. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.

• Korean Journal of Weed Science
• /
• v.17 no.2
• /
• pp.135-138
• /
• 1997

Sulfonylureas are highly active herbicides which can be applied at very low rate(10-50g/ha) to control broadleaf weeds. The nature of this category of compound is, however, very unstable toward hydrolysis. Therefore, the preparation of these compounds as liquid formulation was not possible. Most of the current formulations of sulfonylurea are in dry forms such as water dispersible granule or wettable powder. Even in these dry forms, the active ingredients also encounter significant chemical decomposition. This study involves the preparation of the sulfonylurea salts by reacting the parent compound with base such as sodium hydroxide. The salt becomes stable toward hydrolysis and it turns soluble when diluted with water. This discovery makes the preparation for liquid formulation or soluble granule of sulfonylurea possible. The stoichiometry of base added to the neutral sulfonylurea is controlled quite precisely. The base has to be added enough to quench the acidic impurities in the technical material and to convert the active ingredient into salt. However, the base should not be overused to cause further saponification of the sulfonylurea salts. The chemical nature of these compounds is presented and the chemical reaction is described. New soluble liquid formulation and solid granule formulation of sulfonylurea are suggested.

• Korean Journal of Biological Psychiatry
• /
• v.16 no.4
• /
• pp.266-270
• /
• 2009

Adverse drug reactions are very common in clinical practice, and skin is one of the most frequent organs for adverse drug reactions. We report a case of a 71-year-old male patient who developed skin eruptions after switching formulation of quetiapine immediate release(IR) to quetiapine extended release(XR). He had been taking quetiapine IR(400mg/day) for treatment of manic episode which was developed one year ago. The patient showed great improvement of symptoms after taking quetiapine IR for about one year, thus dosage of medication was reduced to 50mg/day on the average. Unfortunately dose reduction has tended to worsen symptoms, so dose of quetiapine was increased again to 200mg/day with formulation changes to XR. Two days after he took new formulation, erythematous papules were occurred over his anterior neck and ventral side of left wrist. As he stopped quetiapine XR, the skin lesions gradually subsided. And he was successfully treated with readministration of quetiapine IR without any skin lesions.

• Structural Engineering and Mechanics
• /
• v.38 no.3
• /
• pp.261-281
• /
• 2011

A new method of formulation of a class of elements that are immune to mesh distortion effects is proposed here. The simple three-noded bar element with an offset of the internal node from the element center is employed here to demonstrate the method and the principles on which it is founded upon. Using the function space approach, the modified formulation is shown here to be superior to the conventional isoparametric version of the element since it satisfies the completeness requirement as the metric formulation, and yet it is in agreement with the best-fit paradigm in both the metric and the parametric domains. Furthermore, the element error is limited to only those that are permissible by the classical projection theorem of strains and stresses. Unlike its conventional counterpart, the modified element is thus not prone to any errors from mesh distortion. The element formulation is symmetric and thus satisfies the requirement of the conservative nature of problems associated with all self-adjoint differential operators. The present paper indicates that a proper mapping set for distortion immune elements constitutes geometric and displacement interpolations through parametric and metric shape functions respectively, with the metric components in the displacement/strain replaced by the equivalent geometric interpolation in parametric co-ordinates.

• 한국임상약학회:학술대회논문집
• /
• 1994.11a
• /
• pp.97-130
• /
• 1994

'The formulation of a research problem is far more often essential than its solution, which may be merely a matter of mathematical or experimental skill. To raise new questions, new possibilities, to regard old problems from a new angle requires creative imagination and marks real edvance in science.'

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 2000.11a
• /
• pp.134-154
• /
• 2000

New engine design changes and ever increasing requirements make the design of gear oils challenging. Proper understanding of fundamental lubrication theory and formulation knowledge is necessary to develop new gear oils. This paper provides an overview on fundamentals of lubrication theory and functions of each additive. Also, key technical issues facing gear oils are discussed.