• Bulletin of the Korean Chemical Society
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• 제32권1호
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• pp.109-112
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• 2011

A new derivative of tacrolimus was evaluated for its molecular weight, using LC-MS of the tacrolimus bulk active pharmaceutical ingredient (API) recovered through the purification of crude tacrolimus produced by Streptomyces clavuligerus CKD-1119. In addition, the molecular weight of the new derivative of tacrolimus was found to be at m/z 818 and was identified by $^{13}C$-NMR with peak assignments based on the differences in methyl group location resulting from the chemical structure. The structure of the new derivative, an unknown impurity of tacrolimus, was found to be 18-methyltacrolimus through comparison of the spectral data of the structural differences between ascomycin, tacrolimus, and the new derivative 18-methyltacrolimus.

• Korean Journal of Mathematics
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• 제23권4호
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• pp.503-519
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• 2015

In this work, certain classes of admissible functions are considered. Some strong dierential subordination and superordination properties of analytic functions associated with new generalized derivative operator $B^{{\mu},q,s}_{{\lambda}_1,{\lambda}_2,{\ell},d}$ are investigated. New strong dierential sandwich-type results associated with the generalized derivative operator are also given.

• 호남수학학술지
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• 제41권1호
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• pp.153-161
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• 2019

In practical applications play an new important role timelike biharmonic particle by Fermi-Walker derivative. In this article, we get a innovative interpretation about timelike biharmonic particle by means of Fermi-Walker derivative and parallelism in Heisenberg spacetime. With this new representation, we derive necessary and sufficient condition of the given particle to be the inextensible flow. Moreover, we provide several characterizations designed for this particles in Heisenberg spacetime.

• International Journal of Aeronautical and Space Sciences
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• 제18권2호
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• pp.175-185
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• 2017

This paper presents new differential methods for computing the combined and single dynamic stability derivatives of flight vehicle. Based on rigid dynamic mesh technique, the combined dynamic stability derivative can be achieved by imposing the aircraft pitching to the same angle of attack with two different pitching angular velocities and also translating it to the same additional angle of attack with two different rates of angle of attack. As a result, the acceleration derivative is identified. Moreover, the rotating reference frame is adopted to calculate the rotary derivatives when simulating the steady pull-up with different pitching angular velocities. Two configurations, the Hyper Ballistic Shape (HBS) and Finner missile model, are considered as evaluations and results of all the cases agree well with reference or experiment data. Compared to traditional ones, the new differential methods are of high efficiency and accuracy, and potential to be extended to the simulation of combined and single stability derivatives of directional and lateral.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권1호
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• pp.272-287
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• 2017

This paper proposes new methods, named Derivative Code (DerivativeCode) and Derivative Code Pattern (DCP), for object recognition. The discriminative derivative code is used to capture the local relationship in the input image by concatenating binary results of the mathematical derivative value. Gabor based DerivativeCode is directly used to solve the palmprint recognition problem, which achieves a much better performance than the state-of-art results on the PolyU palmprint database. A new local pattern method, named Derivative Code Pattern (DCP), is further introduced to calculate the local pattern feature based on Dervativecode for object recognition. Similar to local binary pattern (LBP), DCP can be further combined with Gabor features and modeled by spatial histogram. To evaluate the performance of DCP and Gabor-DCP, we test them on the FERET and PolyU infrared face databases, and experimental results show that the proposed method achieves a better result than LBP and some state-of-the-arts.

• 대한수학회논문집
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• 제37권2호
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• pp.503-520
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• 2022

We introduce a new type of fractional derivative, which we call as the right local general truncated M-fractional derivative for α-differentiable functions that generalizes the fractional derivative type introduced by Anastassiou. This newly defined operator generalizes the standard properties and results of the integer order calculus viz. the Rolle's theorem, the mean value theorem and its extension, inverse property, the fundamental theorem of calculus and the theorem of integration by parts. Then we represent a relation of the newly defined fractional derivative with known fractional derivative and in context with this derivative a physical problem, Kirchoff's voltage law, is generalized. Also, the importance of this newly defined operator with respect to the flexibility in the parametric values is described via the comparison of the solutions in the graphs using MATLAB software.

• Journal of Mechanical Science and Technology
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• 제20권5호
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• pp.658-667
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• 2006

Fractional derivative models, which are used to describe the viscoelastic behavior of material, have received considerable attention. Thus it is necessary to put forward the analysis solutions of dynamic systems containing a fractional derivative. Although previously reported such kind of fractional calculus-based constitutive models, it only handles the particularity of rational number in part, has great limitation by reason of only handling with particular rational number field. Simultaneously, the former study has great unreliability by reason of using the complementary error function which can't ensure uniform real number. In this paper, a new approach is proposed for an analytical scheme for dynamic system of a spring-mass-damper system of single-degree of freedom under general forcing conditions, whose damping is described by a fractional derivative of the order $0<{\alpha}<1$ which can be both irrational number and rational number. The new approach combines the fractional Green's function and Laplace transform of fractional derivative. Analytical examples of dynamic system under general forcing conditions obtained by means of this approach verify the feasibility very well with much higher reliability and universality.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.819-822
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• 2002

It is necessary for the numerical simulation of 3-dimensional incompressible isotropic decaying turbulence to construct 3-dimensional initial velocity field which resembles the fully developed turbulence. Although the previous velocity field generation method proposed by Rogallo(1981) satisfies continuity equation and 3-dimensional energy spectrum, it has limitation, as indicated in his paper, that it does not produce the higher velocity moments(e. g. velocity derivative skewness) characteristic of real turbulence. In this study, a new velocity field generation method which is able to control velocity derivative skewness of initial velocity field is proposed. Brief descriptions of the new method and a few parameters which is used to control velocity derivative skewness are given. A large eddy simulation(LES) of isotropic decaying turbulence using dynamic subgrid-scale model is carried out to evaluate the performance of the initial velocity field generated by the new method. It was shown that the resolved turbulent kinetic energy decay curve and the resolved enstrophy decay curve from the initial field of new method were more realistic than those from the initial field of Rogallo's method. It was found that the dynamic model coefficient from the former was initially half the stationary value and experienced relatively short transition period, though that from the latter was initially zero and experienced relatively longer transition period.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제23권3호
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• pp.179-202
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• 2019

This paper presents second derivative generalized extended backward differentiation formulas (SDGEBDFs) based on the second derivative linear multi-step formulas of Cash [1]. This class of second derivative linear multistep formulas is implemented as boundary value methods on stiff problems. The order, error constant and the linear stability properties of the new methods are discussed.

• Steel and Composite Structures
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• 제21권6호
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• pp.1389-1410
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• 2016

This paper proposes a hybrid of topological derivative-based level set method (LSM) and isogeometric analysis (IGA) for structural topology optimization. In topology optimization a significant drawback of the conventional LSM is that it cannot create new holes in the design domain. In this study, the topological derivative approach is used to create new holes in appropriate places of the design domain, and alleviate the strong dependency of the optimal topology on the initial design. Furthermore, the values of the gradient vector in Hamilton-Jacobi equation in the conventional LSM are replaced with a Delta function. In the topology optimization procedure IGA based on Non-Uniform Rational B-Spline (NURBS) functions is utilized to overcome the drawbacks in the conventional finite element method (FEM) based topology optimization approaches. Several numerical examples are provided to confirm the computational efficiency and robustness of the proposed method in comparison with derivative-based LSM and FEM.