• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2005.03a
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• pp.185-192
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• 2005

Using existing static methods, it is possible to estimate accurately the reponses of structures governed by the fundamental mode. However, these methods do not provide reliable estimates for the structure where higher mode effects are significant. Parametric study was performed to analyze the dynamic characteristics of the structure with long vibration period. Based on the investigations, a new modal combination method using modal combination coefficients, Factored Modal Combination, was developed, and static earthquake load patterns addressing higher mode effects reasonably were proposed. Existing modal combination methods, such as SRSS and CQC, lack a theoretical basis to be applied to inelastic structures. In contrast, the proposed method can be applied conveniently in inelastic range as well as in elastic range.

• Korean Journal of Clinical Pharmacy
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• v.28 no.3
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• pp.243-249
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• 2018

Background: The new type of diabetes treatment, SGLT2 inhibitors, has been approved for monotherapy and combination therapy, but medical insurance is only allowed in combination therapy with metformin, which is the first choice for type 2 diabetes treatment. Methods: The SGLT2 inhibitors prescribed in Korea are dapagliflozin, empagliflozin and ipragliflozin. A review was conducted using Pubmed to evaluate efficacy and safety for these medications with metformin combination therapy. 10 studies were selected by searching for keywords and related references and were reviewed in full. The mechanism of action, pharmacokinetics, and the economics of treatment with SGLT2 inhibitors were examined. Results: SGLT2 inhibitors had moderate glycemic control when added to the treatment of patients with type 2 diabetes who were not being regulated by metformin monotherapy. They also showed positive effects such as weight loss, as well as the lowering of blood pressure. Hypotension and serious side effects were relatively low. However, the risk of genital infection was increased. Conclusion: The SGLT2 inhibitors are a new class of drugs that promote glucose excretion in the urine. They are a good choice for combination therapy with metformin for the treatment of type 2 diabetes, with weight loss and very low risk of serious side effects.

• Journal of the Korea Fashion and Costume Design Association
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• v.15 no.1
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• pp.59-74
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• 2013

Post-modern society leads us to accept diversity and variability instead of pursuit of the absolute truth, beauty or classical value systems, thus leading to hybrid phenomena. The purpose of this study is to analyze characteristics and expressive effects of hybrid expressions through which to provide conceptual bases for interpreting expanded meanings of fashion illustrations that express aesthetic concepts of hybrid culture. Hybrid refers to a condition on which diverse elements are mixed with each other, so any one element can not dominate others. It is often used to create something unique and new by a combination of unprecedented things. Hybrid can be classified into four categories: temporal hybrid, spatial hybrid, morphological hybrid and hybrid of different genres. Temporal hybrid from a combination of past and present in fashion illustration includes temporal blending by repetition and juxtaposition. Spatial hybrid shows itself in the form of inter-penetration and interrelationship by means of projection, overlapping, juxtaposition and multiple space. Morphological hybrid expresses itself through combination of heterogenous forms and restructuring of deformed forms. Hybrid of different genres in fashion illustration applies various graphic elements or photos within the space, and represents blending of arts and daily living. Such hybrid expressions in fashion illustrations reflect the phenomena of diversity and variability of post-modern society. Hybrid expressions in fashion illustrations predict endless possibility of expressing new images through combining various forms or casual elements and can develop toward a new creative technique.

• Journal of Pharmacopuncture
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• v.21 no.3
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• pp.203-206
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• 2018

Objectives: There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional "single compound, single target" approach as demonstrated in our current modern drug development. TCM might be the new cornerstone of treatment alternative when the current treatment option is no longer as effective or that we have exhausted it as an option. Orthogonal stimulus-response compatibility group study is one of the most frequently employed formulas to produce optimal herbal combination for treatment of multi-syndromic diseases. This approach could solve the relatively low efficacy single drug therapy usage and chronic adverse effects caused by long terms administration of drugs that has been reported in the field of pharmacology and medicine Methods: The present review was based on the Science Direct database search for those related to the TCM and the development of antihypertensive TCM herbal combination using orthogonal stimulus-response compatibility group studies approach. Results: Recent studies have demonstrated that the orthogonal stimulus-response compatibility group study approach was most frequently used to formulate TCM herbal combination based on the TCM principles upon the selection of herbs, and the resulting formulated TCM formula exhibited desired outcomes in treating one of global concerned complex multi-syndromic diseases, the hypertension. These promising therapeutic effects were claimed to have been attributed by the holistic signaling mechanism pathways employed by the crude combination of herbs. Conclusion: The present review could serve as a guide and prove the feasibility of TCM principles to be used for future pharmacological drug research development.

• Journal of the Korean Mathematical Society
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• v.59 no.1
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• pp.151-170
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• 2022

In this paper we introduce a new notion of expansive flows, which is the combination of expansivity in the sense of Katok and Hasselblatt and kinematic expansivity, named KH-kinematic expansivity. We present new properties of several variations of expansivity. A new hierarchy of expansive flows is given.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2012.06a
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• pp.110-112
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• 2012

Education and training of technical staff for the new generation technological equipment has a vital importance for developing countries in order to maintain sustainable development and keep up with new generation technologies. Mechatronics the synergistic combination of mechanical, electronic and software engineering from an engineering perspective to serve the purposes of controlling advanced hybrid systems is a product of new generation technology which can be given as a sample to this phenomenon. Recent marine engines are combination of heavy industry with high technology. Nowadays, ships are built in full automation and equipped with computer controlled mechatronics systems. However, finding qualified officer and engineers who can operate, maintain, control and repair when it is required such full automatic systems with knowledge of a new generation system became a serious issue. Due to importance of this fact STCW Manila amendment has new training and certification requirements for electro-technical officers. In this paper, Mechatronics applications on ship are introduced, importance of it highlighted and a new syllabus is proposed for the training of marine engineers to be nurtured with mechatronics knowledge as it is required.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2006.04a
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• pp.99-104
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• 2006

The new gravity field combination models are expected to improve the knowledge of the Earth's global gravity field. This study evaluates eleven global gravity field models derived from gravimetry and altimetry surface data in a comparison with ground truth in South Korea. Geoid heights obtained from GPS and levelling in South Korea are compared with geoid heights from the models. The results show that the gravity satellites CHAMP, GRACE and LAGEOS plus gravimetry and altimetry surface data have led to an improvement in gravity field models. As expected, the new combination gravity field model which are EIGEN-CG03C and EIGEN-GL04C give better results than the predecessors widely used models(EGM96, OSU91A etc.).

• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.267-274
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• 2014

Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive and efficient tools are required to discover high quality targets and increase the probability of success in the process of new drug development. One such solution to the challenges faced in the development of new drugs and combination therapies is the use of low-cost and experimentally manageable in vivo animal models. Since the 1980's, scientists have been able to genetically modify the mouse genome by removing or replacing a specific gene, which has improved the identification and validation of target genes of interest. Now genetically engineered mouse models (GEMMs) are widely used and have proved to be a powerful tool in drug discovery processes. This review particularly covers recent fascinating technologies for drug discovery and preclinical trials, targeted transgenesis and RNAi mouse, including application and combination of inducible system. Improvements in technologies and the development of new GEMMs are expected to guide future applications of these models to drug discovery and preclinical trials.

• Mycobiology
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• v.49 no.4
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• pp.297-307
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• 2021

A cordycipitoid fungus infecting Hepialidae sp. in Nepal was supposed to be identical to Cordyceps liangshanensis, originally described from southwestern China, and thus, transferred to the genus Metacordyceps or Papiliomyces in previous studies. However, our multi-gene (nrSSU-nrLSU-tef-1α-rpb1-rpb2) phylogenetic and morphological studies based on the type specimen and additional collections of C. liangshanensis revealed that the fungus belongs to the genus Ophiocordyceps (Ophiocordycipitaceae). Therefore, a new combination O. liangshanensis was made, and a detailed description of this species was provided.

• Journal of the Korean housing association
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• v.23 no.3
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• pp.71-78
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• 2012

This study analyzed metaphorical characteristics of composite materials in terms of a visual aspect on a new material that is applicable for housing space. The results are as follows. First, the recent trend of housing space tends to stimulate emotions of residents through visual finishing materials, and for this reason, visual expression of a new material that is applicable to finishing materials plays an important role. Second, convertibleness, association and duplicity were selected as items of metaphorical expressions through the precedent studies. Third, most of combinations of materials were shown different from the existing materials in an expressive characteristic of composite materials through analysis, and application of a technology showed a different visual effect of patterns and textures from the existing materials. This implies that visual expression and directing are being attempted using such technology on finishing materials of housing space with development of digital technologies. Fourth, for metaphorical characteristics of composite material for housing space, combination of various materials and a digital technology were applied on convertibleness. For association, a combination of materials that have each different characteristic associated with the third material, and combination with subsidiary material of optical fiber and a digital technology were appled for duplicity. Data obtained from the results of this study has high efficiency in planning finishing materials for emotional housing space in future, and it will be basic data for a study on development of new finishing materials.