• 대한인간공학회지
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• 제32권5호
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• pp.421-427
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• 2013

Objective: This paper is to analyze the impact of musical training to the fast ${\alpha}$ wave activation of the EEG. Background: EEG is neurological research method that can observe the brain function in real time. EEG can be used to determine the nervousness and relaxedness of a person who receives stimuli in a structured environment. Therefore, it is possible to interpret the functional state of human brain by the analysis of EEG. Method: The brain activities of two groups of university students in the point of RFA(Relative Fast Alpha) caused by different music are analyzed in this paper. One is the group of music majors and the other is the group of non-majors. Results: Music major and non-major groups show meaningful differences in RFA during exposed to classic and metal music. Conclusion: Learning experience on music affects RFA increment of music majors. Application: The result of this study will be used as basic data to evaluate the learning effects of students who want to study music.

• Childhood Kidney Diseases
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• 제7권2호
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• pp.197-203
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• 2003

다양한 신경학적 이상을 동반한 소두증과 조기발현 신증군을 보이는 Galloway-Mowat 증후군은 치료반응이 불량하며 신기능의 저하가 진행되 조기에 사망하는 드문 유전성 질환이다. 임상적, 조직학적 다양성을 보이는 소두증과 신증후군을 동반한 일련의 질환군에 대해 아직 그 견해가 정립되지 않았고 향후 지속적인 연구가 이어질 것으로 생각되며 유전성 및 예후 등을 고려할 때 주목해야 할 필요가 있다고 생각되어 저자들이 경험한 소두증과 신경학적 이상을 동반한 조기발현 신증후군 1례를 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제61권6호
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• pp.661-668
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• 2018

Among the spinal disorders, the treatment approach for spinal deformities has been discussed least among department of neurosurgery. But nowadays, more and more neurosurgeons are interested in spinal deformities as well as complex spinal disorders and are doing not a few surgeries for these kinds of disease. Nevertheless, it is mandatory to understand the course of spinal deformity, principles of treatment, and surgical outcomes and complications. Understanding of the biology, biomechanics and metallurgy of the spine and instrumentation are also required for successful spinal deformity surgery. We need senior mentors and good surgical and neurophysiologic monitoring team. Knowledge of spinal deformity may be augmented with spine fellowships and surgical experience. Step by step training such as basic knowledge, orthopedic as well as neurosurgical disciplines and surgical skills would be mandatory. Neurosurgeons can have several advantages for spinal deformity surgeries. By high-level technical ability of the spinal cord handling to preserve neurological function and familiarity with microscopic surgery, better synergistic effect could be expected. A fundamental understanding of pediatric spinal deformity and growing spine should be needed for spinal deformity surgery.

• Journal of Ginseng Research
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• 제45권5호
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• pp.599-609
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• 2021

Ginseng has long been considered as an herbal medicine. Recent data suggest that ginseng has antiinflammatory properties and can improve learning- and memory-related function in the central nervous system (CNS) following the development of CNS neuroinflammatory diseases such as Alzheimer's disease, cerebral ischemia, and other neurological disorders. In this review, we discuss the role of ginseng in the neurovascular unit, which is composed of endothelial cells surrounded by astrocytes, pericytes, microglia, neural stem cells, oligodendrocytes, and neurons, especially their blood-brain barrier maintenance, anti-inflammatory effects and regenerative functions. In addition, cell-cell communication enhanced by ginseng may be attributed to regeneration via induction of neurogenesis and angiogenesis in CNS diseases. Thus, ginseng may have therapeutic potential to exert cognitive improvement in neuroinflammatory diseases such as stroke, traumatic brain injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease.

• 한방재활의학과학회지
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• 제31권3호
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• pp.105-114
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• 2021

A 38-year-old Korean man without any other history was diagnosed with myelopathy due to a spinal dural arteriovenous fistula. Following embolization and high-dose steroid therapy, the patient was treated with complex Korean medical therapies including acupuncture, pharmacopuncture, electro-acupuncture, Chuna manual therapy, herbal medicine, and cupping therapy in addition to conventional treatment. To assess the patient's improvement, international standard for neurological classification of spinal cord injury, Korean version of modified Barthel index, functional independence measure, spinal cord independence measure III, walking index for spinal cord injury II, modified Ashworth scale were used. After treatment, the muscle strength and sensory function of the lower extremities were improved, and the spasticity was reduced, resulting in a rapid improvement in performance of daily activities. These results suggest that complex Korean medical therapies may be effective for myelopathy, and further clinical studies are needed to clarify their effects.

• Journal of Acupuncture Research
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• 제38권2호
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• pp.165-169
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• 2021

A burst fracture refers to the fracture of the anterior and middle vertebral columns which are moving into the spinal canal causing neurological impairments, generally requiring surgical treatment. We herein report a rare case of burst fracture with kissing spine in a 90-year-old man who had severe lower back pain that worsened during back extension. Considering the surgical treatment risk, he was hospitalized at a Korean medicine hospital for 85 days and underwent combined Korean medicine treatments including pharmacopuncture, herbal medicine, chuna, deep-fascia meridian therapy, walking practice, and abdominal breathing. Based on patient-reported scales, his pain was alleviated, and his physical function improved. Furthermore, his range of motion and walking time increased. This case report suggests that combined Korean medicine treatments could be an effective alternative for patients with burst fracture who have surgery risks.

• Journal of Korean Biological Nursing Science
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• 제24권2호
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• pp.77-85
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• 2022

Purpose: Aging process comes with cognitive impairment due to decreased neuronal cell number, activity, and neuronal circuit. Alteration of inhibitory neurons contributes to cognitive impairment in normal aging and is responsible for disrupting the excitation/inhibition balance by reducing the synthesis of gamma-aminobutyric acid (GABA). Morus nigra (Mulberry) is a natural physiologically active substance that has been proven to have anti-oxidant, anti-diabetic, and anti-inflammatory effects through many studies. This study aimed to evaluate the effects of the mulberry extract (ME) on cognitive function through anti-oxidant enzyme and GABAergic neuronal activity in aged rat brain. Methods: Sprague Dawley rats were randomly assigned as the young group (8 weeks, n= 8), aging group (67 weeks, n= 8), and aging+ mulberry extract group (67 weeks, n= 8). The aging+ mulberry extract group was orally administered 500 mg/kg/d mulberry extract for 6 weeks. Results: The aging+ mulberry extract group improved spatial and short-term memory. The antioxidant potential of ME increased the expression of superoxide dismutase-1 (SOD-1) and decreased inducible nitric oxide synthase (iNOS). Also, the aging+ mulberry extract group significantly increased the expression of GABAergic interneuron in hippocampus cornu ammonis1 (CA1) compared to the aging group. Conclusion: The number of GABAergic inhibitory interneurons was deceased and memory functions in the aging process, but those symptoms were improved and restored by mulberry extract administration.

• Journal of Ginseng Research
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• 제47권2호
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• pp.193-198
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• 2023

Several chemicals have been developed owing to the progression of industrialization, among which endocrine-disrupting chemicals (EDCs; essential for plastic production) are used as plasticizers and flame retardants. Plastics have become an essential element in modern life because they provide convenience, thus increasing EDCs exposure to humans. EDCs cause adverse effects such as deterioration of reproductive function, cancer, and neurological abnormalities by disrupting the endocrine system and hence are classified as "dangerous substances." Additionally, they are toxic to various organs but continue to be used. Therefore, it is necessary to review the contamination status of EDCs, select potentially hazardous substances for management, and monitor the safety standards. In addition, it is necessary to discover substances that can protect against EDC toxicity and conduct active research on the protective effects of these substances. According to recent research, Korean Red Ginseng (KRG) exhibits protective effects against several toxicities caused by EDCs to humans. In this review, the effects of EDCs on the human body and the role of KRG in protection against EDC toxicity are discussed.

• Molecules and Cells
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• 제46권11호
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• pp.655-663
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• 2023

Autophagy dysfunction is associated with human diseases and conditions including neurodegenerative diseases, metabolic issues, and chronic infections. Additionally, the decline in autophagic activity contributes to tissue and organ dysfunction and aging-related diseases. Several factors, such as down-regulation of autophagy components and activators, oxidative damage, microinflammation, and impaired autophagy flux, are linked to autophagy decline. An autophagy flux impairment (AFI) has been implicated in neurological disorders and in certain other pathological conditions. Here, to enhance our understanding of AFI, we conducted a comprehensive literature review of findings derived from two well-studied cellular stress models: glucose deprivation and replicative senescence. Glucose deprivation is a condition in which cells heavily rely on oxidative phosphorylation for ATP generation. Autophagy is activated, but its flux is hindered at the autolysis step, primarily due to an impairment of lysosomal acidity. Cells undergoing replicative senescence also experience AFI, which is also known to be caused by lysosomal acidity failure. Both glucose deprivation and replicative senescence elevate levels of reactive oxygen species (ROS), affecting lysosomal acidification. Mitochondrial alterations play a crucial role in elevating ROS generation and reducing lysosomal acidity, highlighting their association with autophagy dysfunction and disease conditions. This paper delves into the underlying molecular and cellular pathways of AFI in glucose-deprived cells, providing insights into potential strategies for managing AFI that is driven by lysosomal acidity failure. Furthermore, the investigation on the roles of mitochondrial dysfunction sheds light on the potential effectiveness of modulating mitochondrial function to overcome AFI, offering new possibilities for therapeutic interventions.

• 재활치료과학
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• 제7권2호
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• pp.17-27
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• 2018

목적 : 본 연구는 만성 뇌졸중 환자를 대상으로 완전 몰입형 가상현실 기기를 이용한 작업치료 중재가 환자의 상지기능 향상에 미치는 효과를 알아보고자 하였다. 연구방법 : 본 연구의 연구 대상은 좌측 편마비를 가지고 있는 만성 뇌졸중 환자 1명이며, 개별사례 실험연구 중 ABA 설계를 사용하였다. 기초선 기간 4회, 중재 기간 12회, 기초선 회귀기간 4회로 총 20회의 실험을 휴지기간을 포함하여 총 10주간 진행하였다. 독립변수인 완전 몰입형 가상현실 기기를 이용한 작업치료 중재는 매 회기 30분씩 시행되었으며 종속변수 중 Fugl-Meyer Assessment(FMA) 평가는 각 기간 마다 1회씩 측정하였다. Box and Block Test(BBT) 평가와 Wolf Motor Function Test(WMFT) 평가는 매 회기 마다 시행하여 그 측정 결과를 꺾은선 그래프를 통해 제시하였다. 결과 : 완전 몰입형 가상현실 기기를 이용한 작업치료 중재 후 대상자의 환측 상지기능이 향상되었다. 기초선 회귀 기간에는 중재를 제거한 뒤 치료유지 효과를 확인하였지만 큰 변화는 나타나지 않았다. 결론 : 본 연구의 결과, 완전 몰입형 가상현실 기기를 이용한 작업치료 중재가 만성 뇌졸중 환자의 상지기능에 효과적인 중재라는 것을 알 수 있었다. 다만 치료유지 효과는 크지 않았기 때문에 보다 사용이 간편한 가정용 중재 프로그램 등의 개발이 필요하다.