• 제목/요약/키워드: Neuroendocrine tumor

검색결과 116건 처리시간 0.024초

쿠싱 증후군을 동반한 흉선의 신경내분비 종양종 - 2례 보고 - (Thymic Neuroendocrine Tumor Associated with Cushing's Syndrome - 2 case report -)

  • 최진호;김진국;심영목;김관민;한정호
    • Journal of Chest Surgery
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    • 제34권11호
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    • pp.887-890
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    • 2001
  • 흉선에 발생하는 신경내분비 종양은 매우 드문 질환으로 재발이나 전이가 많아 예후가 좋지 못하다. 절반에서 내분비 증상을 보이며, 이 중 33%에서 쿠싱 증후군을 동반한다. 치료로는 수술적 절제가 우선이며, 방사선 치료나 항암치료는 아직 논란의 여지가 많다. 저자들은 쿠싱 증후군을 동반한 흉선의 신경내분비 종양 2례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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데스모이드 섬유종증과 점액성 낭성 종양으로 이루어진 췌장의 충돌 종양: 증례 보고 (Pancreatic Collision Tumor of Desmoid-Type Fibromatosis and Mucinous Cystic Neoplasm: A Case Report)

  • 류민중;김재운;이승은;최준혁
    • 대한영상의학회지
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    • 제82권5호
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    • pp.1297-1303
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    • 2021
  • 췌장의 충돌 종양은 매우 드문 종양으로서 췌장선암종과 신경내분비 종양, 췌관내유두상 점액 종양과 신경내분비 종양, 그리고 췌장 고형성 가유두상 종양으로 이루어진 증례들이 보고된 바 있다. 우리는 30세 임신한 여성에서 빠르게 자란, 데스모이드 섬유종증과 점액성 낭성종양으로 이루어진 췌장의 충돌 종양의 증례를 보고하고자 한다. 저자들이 아는 한, 섬유종증과 점액성 낭성 종양으로 이루어진 췌장의 충돌 종양을 최초로 보고하는 증례이다.

Multiregion Comprehensive Genomic Profiling of a Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Trilineage Differentiation

  • Farooq, Faheem;Zarrabi, Kevin;Sweeney, Keith;Kim, Joseph;Bandovic, Jela;Patel, Chiraag;Choi, Minsig
    • Journal of Gastric Cancer
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    • 제18권2호
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    • pp.200-207
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    • 2018
  • Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) are a group of rare tumors previously known as mixed adenoneuroendocrine carcinomas (MANECs). The neuroendocrine component is high-grade and may consist of small-cell carcinoma or large-cell neuroendocrine carcinoma. The nonneuroendocrine component may consist of adenocarcinoma or squamous cell carcinoma. We report a unique case of a MiNEN with trilineage differentiation: large-cell neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma. The reported patient presented with symptoms of an upper gastrointestinal bleed and was ultimately diagnosed with a MiNEN with trilineage differentiation. This is the first report of this exceedingly rare tumor type to include next-generation sequencing of the 3 separate tumor entities. In addition, we review the current literature and discuss the role of next-generation sequencing in classifying and treating MiNEN tumors.

폐의 신경내분비 종양의 세침흡인 세포검사 소견 (Fine Needle Aspiration Cytologic Findings of Pulmonary Neuroendocrine Tumors)

  • 고재수
    • 대한세포병리학회지
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    • 제19권1호
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    • pp.9-15
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    • 2008
  • The major categories of neuroendocrine tumors of lung are typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma. The histologic classification criteria of neuroendocrine tumors are well documented in the "WHO Classification of Tumors" based on mitotic figures and necrosis. Cytologic characteristics of neuroendocrine tumors are trabecular, acinar, and solid arrangement of tumor cells and occasional rosette formation. Nuclear chromatin patterns are characteristically described as "salt and pepper chromatin pattern". Many of cytologic classifications documented in the literature are before the "WHO Classification". In this review, the cytologic features of pulmonary neuroendocrine tumors are documented according to the WHO classification, and recent concepts of neuroendocrine tumors of lung are discussed.

간으로 전이된 자궁경부의 신경내분비 소세포암의 세포학적 소견 (Metastatic Small Cell Neuroendocrine Carcinoma of the Liver from the Uterine Cervix)

  • 김의정;이광길
    • 대한세포병리학회지
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    • 제2권2호
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    • pp.98-104
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    • 1991
  • We present the cytologic features of small ceil neuroendocrine carcinoma of the liver metastasized from the uterine cervix. Cytologically, tumor cells were arranged in a pattern of solid sheet in necrotic background. The tumor cells were characterized by uniform, small cells, round hyperchromatic nuclei, and high nuclear cytoplasmic ratio. The smears showed frequent mitotic figures and rosette formation. These findings were identified with the previous histologic sections of uterine cervix. To make a diagnosis of metastatic small ceil neuroendocrine carcinoma on the Papanicolaou smear, a high index of suspicion and careful review of clinical history are needed.

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간전이가 있는 직장구불결장의 신경내분비 종양 환자의 카르시노이드 증후에 의해 발생한 설사에 대한 한약 치료 시도 : 증례 보고 (Herbal Medicine Therapeutic Attempt for Diarrhea Induced by Carcinoid Symptoms of Rectosigmoid Neuroendocrine Tumor with Liver Metastasis Patient : a Case Report)

  • 전형준;김종민;조종관;이연월;유화승
    • 동의생리병리학회지
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    • 제29권1호
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    • pp.72-78
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    • 2015
  • This study aims to report a case of rectosigmoid neuroendocrine tumor patient with liver metastasis whose outstanding carcinoid symptom was mucosal diarrhea for more than 10 times a day. Three different herbal decoctions were administered orally for the treatment of diarrhea which was among carcinoid symptoms from diffuse metastatic liver lesion. The herbal decoctions given were modified Lijung-tang, modified Sambaek-tang and modified Jeokseokjiuyeoryang-tang. The administration period was 5, 14 and 9 days respectively. Frequency of patient's mucosal diarrhea had increased consistently during hospitalization. It had almost doubled compared to pre-hospitalization up to 27 times/24 hrs. But during the period of modified Sambaek-tang administration, frequency of diarrhea was maintained between 9 to 15 times/24hrs. There was no difference of liver tumors between Nov 16th 2013 and Dec 9th 2013 in computed tomography images. Three conventional established herbal prescriptions administered in this case didn't show any favorable effect on improving mucosal diarrhea induced by carcinoid symptoms of a rectosigmoid neuroendocrine tumor with liver metastasis. Even if modified Sambaek-tang showed partial effect on frequency of diarrhea, we concluded that it was not sufficient to be a therapeutic method of the diarrhea as carcinoid symptom. Furthermore, it is necessary to conduct additional studies about the diarrhea of neuroendocrine tumor with liver metastasis.

Current Status of the Diagnosis and Management of Pancreatic Neuroendocrine Tumors in Japan

  • Tetsuhide Ito;Masami Miki;Keijiro Ueda;Lingaku Lee;Ken Kawabe;Hisato Igarashi;Nao Fujimori;Kazuhiko Nakamura;Kohei Yasunaga;Robert T. Jensen;Takao Ohtsuka;Yoshihiro Ogawa
    • Journal of Digestive Cancer Research
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    • 제4권2호
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    • pp.51-57
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    • 2016
  • The epidemiology of pancreatic neuroendocrine neoplasms (PNENs) in Asia has been clarified through epidemiological studies, including one conducted in Japan, and subsequently another in South Korea. As endoscopic ultrasonography (EUS) has become more widely accessible, endoscopic ultrasound-fine needle aspiration (EUS-FNA) has been performed in pancreatic tumors for which the clinical course was only monitored previously. This has enabled accurate diagnosis of pancreatic tumors based on the 2010 WHO classification; as a result, the number of patients with an accurate diagnosis has increased. Although surgery has been the standard therapy for PNENs, new treatment options have become available in Japan for the treatment of advanced or inoperable PNENs; of particular note is the recent introduction of molecular target drugs (such as everolimus and sunitinib) and streptozocin. Treatment for progressive PNENs needs to be selected for each patient with consideration of the performance status, degree of tumor differentiation, tumor mass, and proliferation rate. Somatostatin receptor (SSTR)-2 is expressed in many patients with neuroendocrine tumor. Somatostatin receptor scintigraphy (SRS), which can visualize SSTR-2 expression, has been approved in Japan. The SRS will be a useful diagnostic tool for locating neuroendocrine neoplasms, detecting distant metastasis, and evaluating therapy outcomes. In this manuscript, we review the latest diagnostic methods and treatments for PNENs.

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Mixed Exocrine and Endocrine Carcinoma in the Stomach: A Case Report

  • Lee, Han-Hong;Jung, Chan-Kwon;Jung, Eun-Sun;Song, Kyo-Young;Jeon, Hae-Myung;Park, Cho-Hyun
    • Journal of Gastric Cancer
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    • 제11권2호
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    • pp.122-125
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    • 2011
  • We report a rare case of the coexistence of a gastric small cell neuroendocrine carcinoma with a gastric adenocarcinoma. A 62-year-old man presented with epigastric soreness for 1 month. Esophagogastroduodenoscopy revealed a Borrmann type I tumor at the lesser curvature of the lower body of the stomach. The patient underwent a distal gastrectomy with D2 lymph node dissection and the resected specimen exhibited a $3.5{\times}3.5$ cm sized, fungating lesion. Two separated, not intermingling, lesions with non-adenocarcinoma components encircled by well differentiated adenocarcinoma components were identified microscopically. The non-adenocarcinoma component showed neuroendocrine features, such as a solid and trabecular pattern, and the tumor cells showed a high nuclear grade with minimal cytoplasm, indistinct nucleoli, and positive response for synaptophysin, CD56. The final pathological diagnosis was a gastric mixed exocrine-endocrine carcinoma (MEEC) composed of an adenocarcinoma and small cell neuroendocrine carcinoma of the collision type.

Poor Prognosis of Grade 2 Spread Through Air Spaces in Neuroendocrine Tumors

  • Chae, Mincheol;Cho, Sukki;Chung, Jin-Haeng;Yum, Sungwon;Kim, Kwhanmien;Jheon, Sanghoon
    • Journal of Chest Surgery
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    • 제55권2호
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    • pp.101-107
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    • 2022
  • Background: Spread through air spaces (STAS) has recently emerged as a prognostic factor in lung adenocarcinoma, but little is known about the association of STAS and its grade with recurrence in neuroendocrine tumors (NETs). This study investigated the prognostic effect of STAS grade in NETs after curative resection. Methods: Seventy-seven patients were retrospectively reviewed, including 9 with typical carcinoid (TC), 6 with atypical carcinoid (AC), 26 with large cell neuroendocrine carcinoma (LCNEC), and 36 with small cell carcinoma (SCC). STAS was defined as the presence of floating tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. STAS was classified as grade 1 or 2 depending on whether it was found within or beyond one ×10 objective lens field away from the main tumor margin, respectively. Results: Fifty-four patients (70%) had STAS, including 22% with TC, 50% with AC, 69% with LCNEC, and 86% with SCC. Patients with STAS had more nodal metastasis, lymphatic and vascular invasion, tumor necrosis, and tumor subtypes other than TC. Among STAS cases, grade 2 STAS was present in 33% of AC, 78% of LCNEC, and 87% of SCC. The 5-year recurrence-free survival (RFS) rate was 81%, 63%, and 35% in patients with no STAS, grade 1, and grade 2 STAS, respectively. Multivariate analysis found that grade 2 STAS was an independent negative prognostic factor for RFS. Conclusion: Although STAS itself was not associated with a poor prognosis, grade 2 STAS was an independent negative prognostic factor for RFS.

A Rare Case of Concomitant Intramedullary Gangliocytoma at the Cervicomedullary Junction in Patient with Neuroendocrine Tumor of Lung

  • Aydemir, Fatih;Cekinmez, Melih;Kardes, Ozgur;Kayaselcuk, Fazilet
    • Journal of Korean Neurosurgical Society
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    • 제59권2호
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    • pp.158-160
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    • 2016
  • Ganglion cell tumors (GCT) are divided into two subtypes : gangliocytoma and ganglioglioma. Intramedullary gangliocytomas are extremely rare. A 20-year-old male patient with pain of neck, who also had a previously known neuroendocrine tumor of lung, was operated for mass found in the cervicomedullary junction with a presumptive diagnosis of metastases. Only partial resection could be performed. Pathological diagnosis had been reported as gangliocytoma. Only ten cases of intramedullary gangliocytoma have been reported in the literature. Although association with scoliosis and Von Recklinghausen;s disease were previously reported in the literature, no gangliocytoma case concomitant with endocrine tumor of lung have been published. Pathological study is the most important diagnostic method for gangliocytomas. Surgical excision is the primary treatment, but difficulty in total surgical tumor resection is the most important problem.