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http://dx.doi.org/10.5230/jgc.2011.11.2.122

Mixed Exocrine and Endocrine Carcinoma in the Stomach: A Case Report  

Lee, Han-Hong (Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, School of Medicine)
Jung, Chan-Kwon (Division of Gastrointestinal Surgery, Department of Pathology, The Catholic University of Korea, School of Medicine)
Jung, Eun-Sun (Division of Gastrointestinal Surgery, Department of Pathology, The Catholic University of Korea, School of Medicine)
Song, Kyo-Young (Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, School of Medicine)
Jeon, Hae-Myung (Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, School of Medicine)
Park, Cho-Hyun (Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, School of Medicine)
Publication Information
Journal of Gastric Cancer / v.11, no.2, 2011 , pp. 122-125 More about this Journal
Abstract
We report a rare case of the coexistence of a gastric small cell neuroendocrine carcinoma with a gastric adenocarcinoma. A 62-year-old man presented with epigastric soreness for 1 month. Esophagogastroduodenoscopy revealed a Borrmann type I tumor at the lesser curvature of the lower body of the stomach. The patient underwent a distal gastrectomy with D2 lymph node dissection and the resected specimen exhibited a $3.5{\times}3.5$ cm sized, fungating lesion. Two separated, not intermingling, lesions with non-adenocarcinoma components encircled by well differentiated adenocarcinoma components were identified microscopically. The non-adenocarcinoma component showed neuroendocrine features, such as a solid and trabecular pattern, and the tumor cells showed a high nuclear grade with minimal cytoplasm, indistinct nucleoli, and positive response for synaptophysin, CD56. The final pathological diagnosis was a gastric mixed exocrine-endocrine carcinoma (MEEC) composed of an adenocarcinoma and small cell neuroendocrine carcinoma of the collision type.
Keywords
Stomach neoplasms; Neuroendocrine tumor; Adenocarcinoma;
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