• Herbal Formula Science
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• v.25 no.4
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• pp.483-497
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• 2017

Background : Behavioral stress has been suggested as one of the significant factors that is able to disrupt physiological systems and cause depression as well as changes in various body systems. The stressful events can alter cognition, learning, memory and emotional responses, resulting in mental disorders such as depression and anxiety. Results : We used a restraint stress model to evaluate the alteration of behavior and stress-related blood parameter. The animals were randomly divided into two groups of five animals each group. Furthermore, we assessed the change of body weight to evaluate the locomotor activity as well as status of emotional and anxiety in mice. After 7 days of restraint stress, the body weight had significantly decreased in the restraint stress group compared with the control group. We also observed stress-associated behavioral alterations, as there was a significant decrease in open field and forced swim test, whereas the immobilization time was significantly increased in the stress group compared to the control group. We observed the morphological changes of neuronal death and microglia by immunohistochemistry and western blot. In our study restraint stress did not cause change in neuronal cell density in the frontal cortex and CA1 hippocampus region, but there was a trend for an increased COX-2 and iNOS protein expression and microglia (CD11b) in brain, which is restraint stress. Conclusion : Our study, there were significant alterations observed in the behavioral studies. We found that mice undergoing restraint stress changed behavior, confirming the increased expression of inflammatory factors in the brain.

• IMMUNE NETWORK
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• v.6 no.1
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• pp.27-32
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• 2006

Background: Chronic inflammation in the brain has known to be associated with the development of a various neurological diseases including dementia. In general, the characteristic of neuro-inflammation is the activated microglia over the brain where the pathogenesis occurs. Pro-inflammatory repertoires, interleukin-1${\beta}$ (IL-1${\beta}$) and nitric oxide (NO), are the main causes of neuro-degenerative disease, particularly in Alzheimer's disease (AD) which is caused by neuronal destruction. Those pro-inflammatory repertoires may lead the brain to chronic inflammatory status, and thus we hypothesized that chronic inflammation would be inhibited when pro-inflammatory repertoires are to be well controlled by inactivating the signal transduction associated with inflammation. Methods: In the present study, we examined whether biphenyl dimethyl dicarboxylate (DDB), an active compound from Schizandra chinensis Baillon, inhibits the NO production by a direct method using Griess reagent and by RT-PCR in the gene expression of inducible nitric oxide synthase (iNOS) and IL-1${\beta}$. Western blots were also used for the analysis of NF-${\kappa}B$ and I${\kappa}B$. Results: In the study, we found that DDB effectively inhibited IL-1${\beta}$ as well as NO production in BV-2 microglial cell, and the translocation of NF-${\kappa}B$ was comparably inhibited in the presence of DDB comparing those to the positive control, lipopolysaccharide. Conclusion: The data suggested that the DDB from Schizandra chinensis Baillon may play an effective role in inhibiting the pro-inflammatory repertoires which may cause neurodegeneration and the results imply that the compound suppresses a cue signal of the microglial activation which can induce the brain pathogenesis such as Alzheimer's disease.

• Journal of Photoscience
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• v.9 no.2
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• pp.475-478
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• 2002

In zoological research, penetration of light has been reported of the frontal bones of fish, birds, and reptiles, suggesting the existence of physiologically direct photic routes to frontal lobes and/or deep parts of the brain. We studied the influences of frontal exposure to photodiode light on frontal alpha wave and peripheral NK cells. Repetitive exposure of the subject's forehead to a red light diode (660nm) significantly increased the effective amplitude of the frontal alpha waves (using a mean frequency with a range of +1.0 Hz), peripheral NK activity, and the level of CD57-CD16+. Frontal alpha wave activity and the level of CD57-CD16+ increased, suggesting the possibility of a non-invasive procedure for the activation of the frontal lobe and the increase of NK cells. This light is considered to penetrate the frontal bones of humans directly, and to act on the frontal lobe and/or other immunological regulatory centers in the brain, resulting in some neuro-immunological changes.

• Journal of Environmental Health Sciences
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• v.4 no.1
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• pp.13-22
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• 1977

In an attempt to evaluate working conditions and hazardous environmental factors, a survey on health problems was conducted for 721 employees from 18 industrial plants in Young Dung Po and Sung Dong districts of Seoul in the period from May 1975 to Feb, 1976. The questionnaire and survey was inclusive of all illnesses known as most common to industrial workers (according to the report by Korea Industrial Health Association) of this country and envi ronmental factors pointed out by the workers. The results were as following. 1. The over whelming majority of complaints were psychiatric, ear,eye, and digestive disorders. 2. Those whose work time is the longest have a propotionately higer incidence of complaints especially in eye,ear, neuromusculoskeletal, and neurosensory systems. 3. In females whose occupational history is relatively short, a higher incidence of digestive and skin section disorders was noted and this is especially true among those working in night shift. 4. Among machinery industry workers, most complaints were of eye, ear, and neuro musculoskeletal disturbances, and this fact seems to be closely related to physical over works. 5. Dust and noise were pointed out by the largest number of workers as undisirable conditions in work environment. 6. Distribution of complaints are closely related to the type of industry, and in comparison with the result reported by Korea Industrial Health Association in 1972, the prevalence rates of occupational disorder were similar in our study,

• Proceedings of the KIEE Conference
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• 1999.07c
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• pp.1314-1317
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• 1999

In this paper, we design an Adaptive Neuro-Fuzzy Inference System(ANFIS) Precompensator for the performance improvement of conventional proportional integral derivative (PID) controller that the governor system of power plant constantly maintains the load frequency of two-area power system. The ANFIS Precompensator is expressed as the membership functions of premise parameters and the linear combination of consequent parameters by Sugeno's fuzzy if-then rules using nonlinear input-output relation for the set point automatic modification maintaining conventional PID controller. The proposed compensation design technique is hoped to be satisfactory method overcome difficulty of exact modelling and arising problems by the complex nonlinearities of power system, and our design shows merit that is easily implemented by adding an ANFIS precompenastor to an existing PID controller without replacement.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2008.02a
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• pp.173-178
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• 2008

본 연구에서는 영상음향의 사운드디자인 구조의 차이가 수용자에게 어떠한 감응도 변화가 있는가를 알아 보았다. 실험은 60초의 TV광고음향을 음악으로만 디자인한 음향트랙과(A), 음향효과와 음악으로 디자인한 음향트랙(B)을 청취하게 하여, 어떠한 사운드 구조가 감응도(주의력, 활성도, 감성도)에 더 유의한 영향을 미치는가를 알아 보았다. 실험은5명씩의 남.여 대학생을 대상으로 이루어 졌고 안정상태와 Fp1, Fp2를 중심으로 한 전두엽측정방식으로 한 뉴로피드백(Neuro feedback)뇌파측정방법으로 측정하였다. 그 결과, 음악으로만 디자인한 A음향트랙에서의 감응도는 주의((ATQ)와 활성도(ACQ), 감성도(EQ)모두가 증가했으나 B트랙보다는 낮았다. 음악+효과음으로 디자인한 B트랙에서는 주의력(ATQ), 활성도(ACQ),는 A트랙보다 증가하였으나 EQ(감성도)는 반대로 A트랙보다 낮았다. 결과적으로 영상에서 음향은 주의력과 활성도 에는 기본적으로 뇌의 변화에 작용하나 정서적인 면은 역시 음악이 유효한 것으로 나타났다. 그러나 강한 효과음들은 음악보다 주의력과 집중도를 높이기는 하나 스트레스적(SQ)지수는 오히려 높은 것으로 나타났다. 본 연구를 통하여 방송과 영화 등의 사운드구조는 영상과의 호흡을 기본으로 하지만 실제로 시각정보와 청각정보가 동시에 합쳐져서, 심리적으로 어떠한 영향을 미치는가를 뇌신경측정으로 고찰한 것에 의의가 있다.

• The Journal of Korean Medicine
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• v.36 no.2
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• pp.50-55
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• 2015

Infants with tuberous sclerosis complex (TSC) have a higher chance of experiencing seizures before the age of 1 year; in particular, they commonly accompany infantile spasms. In cases where infantile spasms resulting from TSC are drug-resistant, more severe neuro-developmental and cognitive impairments occur. This particular case dealt with an infant with TSC who continued to experience partial seizures and infantile spasms despite using two different kinds of antiepileptic drugs (AEDs). His spasms ceased on the seventh day of taking modified Yukmijihwang-tang (YMJ), at which point he stopped the use of all AEDs. He became seizure-free after a month of the treatment and modified hypsarrythmia was found to have been resolved in the electroencephalogram test. Until now, the infant has been taking YMJ for 16 months and is maintaining the seizure-free state without side effects. Moreover, his developmental status is continually improving, with a significant progress in language and cognitive-adaptive abilities. Such results suggest that YMJ can serve as an alternative treatment option for refractory epilepsy.

• International Journal of Industrial Entomology and Biomaterials
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• v.7 no.2
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• pp.235-239
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• 2003

The silkworm Bombyx mori L. was studied as the potential “host” of popular in Uzbekistan biocontrol ectoparasite, entomophagous Bracon hebetor Say. Being one of representatives of economic-beneficial insects, the silkworm (larvae, pupae and imago) can be used as highly sensitive test organism for revealing of neuro toxic effects of insects venom as well as of their purified components in screening assays. In comparative aspect, except a mulberry silkworm, representatives of Uzbekistan pests cotton-boll worm Helycoverpa armigera Hbn., lesser mulberry pyralid Glyphodes pyloalis Wlk., codling moth Corpocapsa pomonella L., malaria mosquito Anopheles claviger and Colorado potato beetle Leptinotarsa decemlineata Say have been subjected to insect toxic test of bracon venom gland extract (VGE) and its fractions which were obtained by gel-chromatography on Sephadex G-100. The paralyzing effect of the VGE and its fractions was shown in a various degree on the pests.

• CELLMED
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• v.1 no.1
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• pp.2.1-2.16
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• 2011

Diverse medicinal uses of different types of products obtainable from Brassica juncea have been known for centuries. Most such traditionally known uses of the plant have been centered on its seeds and oils obtainable from them. During more recent decades diverse bio-active molecules and their therapeutically interesting pharmacological properties of its green edible leaves have also been described, and they are now often considered to be effective substitutes for other so called "healthy" Brassica vegetables. However, little concentrated effort has yet been made to obtain a pharmacologically better defined phytopharmaceutical from this easily cultivable plant of commercial interest in many underdeveloped and developing countries. The main aim of this overview is to point out some possibilities for designing and developing such products from the plant for combating the rapidly spreading obesity epidemic in the developed countries and some other countries. Efforts to achieve such goals could as well be an economically more feasible, and culturally more acceptable, starting point for better understanding the potential health benefits of other vegetarian foods.

• Journal of Electrical Engineering and Technology
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• v.5 no.2
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• pp.209-219
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• 2010

In this paper, a novel dynamic available transfer capability (DATC) has been computed for real time applications using three different intelligent techniques viz. i) back propagation algorithm (BPA), ii) radial basis function (RBF), and iii) adaptive neuro fuzzy inference system (ANFIS) for the first time. The conventional method of DATC is tedious and time consuming. DATC is concerned with calculating the maximum increase in point to point transfer such that the transient response remains stable and viable. The ATC information is to be continuously updated in real time and made available to market participants through an internet based Open Access Same time Information System (OASIS). The independent system operator (ISO) evaluates the transaction in real time on the basis of DATC information. The dynamic contingency screening method [1] has been utilized and critical contingencies are selected for the computation of DATC using the energy function based potential energy boundary surface (PEBS) method. The PEBS based DATC has been utilized to generate patterns for the intelligent techniques. The three different intelligent methods are tested on New England 68-bus 16 machine and 39-bus 10 machine systems and results are compared with the conventional PEBS method.