Changes in NK Activity and CD57-CD16+ Level by Frontal Exposure to Red Photodiode Light

In zoological research, penetration of light has been reported of the frontal bones of fish, birds, and reptiles, suggesting the existence of physiologically direct photic routes to frontal lobes and/or deep parts of the brain. We studied the influences of frontal exposure to photodiode light on frontal alpha wave and peripheral NK cells. Repetitive exposure of the subject's forehead to a red light diode (660nm) significantly increased the effective amplitude of the frontal alpha waves (using a mean frequency with a range of +1.0 Hz), peripheral NK activity, and the level of CD57-CD16+. Frontal alpha wave activity and the level of CD57-CD16+ increased, suggesting the possibility of a non-invasive procedure for the activation of the frontal lobe and the increase of NK cells. This light is considered to penetrate the frontal bones of humans directly, and to act on the frontal lobe and/or other immunological regulatory centers in the brain, resulting in some neuro-immunological changes.