• 한국터널공학회:학술대회논문집
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• 2005.04a
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• pp.348-358
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• 2005

Although the evaluation of the mechanical properties and behavior of discontinuous rock masses is very important for the design of underground openings, it has always been considered the most difficult problem. One of the difficulties in describing the rock mass behavior is assigning the appropriate constitutive model. This limitation may be overcome with the progress in discrete element software such as PFC, which does not need the user to prescribe a constitutive model for rock mass. Instead, the micro-scale properties of the intact rock and joints are defined and the macro-scale response results from those properties and the geometry of the problem. In this paper, a $30m{\times}30m{\times}30m$ jointed rock mass of road tunnel site was analyzed. A discrete fracture network was developed from the joint geometry obtained from core logging and surface survey. Using the discontinuities geometry from the DFN model, PFC simulations were carried out, starting with the intact rock and systematically adding the joints and the stress-strain response was recorded for each case. With the stress-strain response curves, the mechanical properties of discontinuous rock masses were determined and compared to the results of empirical methods such as RMR, Q and GSI. The values of Young's modulus, Poisson's ratio and peak strength are almost similar from PFC model and Empirical methods. As expected, the presence of joints had a pronounced effect on mechanical properties of the rock mass. More importantly, the mechanical response of the PFC model was not determined by a user specified constitutive model.

• Korean Journal of Adult Nursing
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• v.29 no.1
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• pp.41-50
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• 2017

Purpose: The purpose of this study was to identify and compare the factors influencing attitude toward one's own aging among Korean middle-aged adults and the elderly. Methods: A cross sectional study was performed with a total sample of 70 middle-aged adults and 64 elderly reside in two metropolitan areas. Data were collected from August 2015 to November 2015 using the Perceived Health Status Scale, the Health Locus of Control Scale and the Attitude Toward own Aging (ATOA) Scale. The statistics used include percentage, t-test, Pearson's correlation coefficient, and multiple regression. Results: Mean age for each age group were about 52 and 76 years old for middle-aged adults and the elderly respectively. A considerable proportion of all participants reported a negative attitude toward aging. Perceived health status was the common factor influencing attitude toward one's own aging in both age groups. Middle-aged adults identified presence of chronic illness and internal health locus of control as important factors. In contrast, the elderly reported that education and others-dependent health locus of control such as powerful others had a significant impact on ATOA. Each regression model explained 31% and 55% of the total variance of ATOA among middle-aged adults and among the elderly. Conclusion: Both middle-aged adults and the elderly with low perceived health status are at risk of negative ATOA's. The type health locus of control need to be identified and utilized based on individuals' tendency to improve positive ATOA. That is, middle-aged adults might need reinforcement of their self-will whereas the elderly might need enhancement of social support and network of family and healthcare providers.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.19 no.4
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• pp.116-125
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• 2020

Incalculable damage will be incurred if the national infrastructure that provides services using GNSS signals is affected by jamming signals. To prevent this, a nationwide GNSS jamming monitoring network is necessary to detect the occurrence of a jamming signal, determine the type, and properly localize the jammer position. In this paper, 2-D images for live GNSS signals were generated to verify the environment of the jamming signals through the presence and type of GNSS jamming signals at K-City, which are the test beds for self-driving vehicles, and Incheon International Airport. The analysis was also conducted to detect the occurrence of the jamming signals, determine the type, and measure the jamming signal strength. As a result, a CWI type of jamming signal was detected in L2 band at K-City and in L5 band at Incheon International Airport.

• Journal of Contemporary Eastern Asia
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• v.17 no.1
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• pp.130-151
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• 2018

China's cultural diplomacy is mostly understood as an endeavour to build and project soft power, which draws on three sources of 'culture, political values and foreign policy' according to Nye. This paper focuses on the debates about the vehicle and agents of China's cultural diplomacy. It starts with a theoretical discussion of the competing views in the Chinese context, and develops an argument that the vehicle of China's cultural diplomacy tries to project soft power on two wheels of culture and political values, to serve the purpose of reshaping China's image away from being the 'cultural other' and 'ideological other' respectively. However, the state-led approach to driving this vehicle is generating some side effects with its sponsorship, censorship and presence in the driver's seat. Then the paper analyses the inherent tensions existing in practice both between the two sources of building soft power and between the two means of doing so, attraction and persuasion, with empirical evidence through a comparative case study of the Confucius Institutes in the US and South Korea. The finding shows that China's attempt at reshaping its image as an Eastern cultural contestant is often disrupted by its authoritarian political values, and the state-led persuasion is often reducing China's cultural attraction. Following this, the paper finishes with some recommendations regarding evolving the cultural diplomacy approach from a vertical one that is government-centred to a horizontal one that is network-based with multiple agents, and localising its practice by engaging the target audiences as stakeholders.

• IMMUNE NETWORK
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• v.6 no.3
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• pp.145-153
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• 2006

Background: Tumor cell lysate has been considered as a preferential antigen source for the therapeutic dendritic cell pulsing. Our experiences with in vivo study with animal tumor model indicate the tumor cell lysate dependent differential effect of DC therapy. Our previous data show that MC38 lysate pulsed-DC induced stronger ag-specific immunity than CT26 lysate pulsed-DC in vitro. In this study we tried to reveal the mechanism for differential induction of ag-specific immunity of different colon cancer cell lysate pulsed-DCs. Methods: MC38 and CT26 cell lines were prepared as lysate by freezing-thawing procedure. Tumor cell antigenicity was confirmed by detecting the surface expression of MHC I/II & B7.1/2 molecules. IL-10, IL-12 and TGF-beta in the tumor cell lysate were detected by ELISA and the presence of heat shock proteins were analysed by western blotting. Results: The secretion of IL-10, a immune-inhibitory cytokine was about 470% higher in CT26 lysate than in MC38. Hsp 70 was detected only in the MC38 lysate but not in the CT26. On the other hand, Hsp 60 and 90 expression were not different in two colon cancer cell lysates. Conclusion: In two different colon cancer cell lysate, immune inhibitory IL-10 (higher in CT26) and Hsp70 (MC38 superiority) were differentially expressed. These data indicate that higher agspecific immunity induction by MC38 lysate pulsed-DC may due to the expression of hsp70 and lower secretion of IL-10, a immune-inhibitory cytokine than CT26 lysate. The significance of other cytokine and the surface marker expression will be discussed.

• IMMUNE NETWORK
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• v.15 no.3
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• pp.135-141
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• 2015

Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a novel immune-modulatory peptide that was originally isolated from infected insects. It shows anti-inflammatory effects by the regulation of cytokine production by immune cells and their activities. Therefore, we investigated the effect of alloferon in a mouse model of colitis using dextran sulfate sodium (DSS). Colitis was induced by administration of DSS in drinking water for 7 consecutive days. It was confirmed by the presence of weight loss, diarrhea, hematochezia, and colon contraction. Alloferon was injected 4 days after DSS administration. We found that alloferon improved the pathogenesis of IBD based on the reduced disease activity index (DAI) and colon contraction. Edema, epithelial erosion, and immune cell infiltration were found in mice administered DSS, but the phenomena were reduced following alloferon treatment. The plasma level of IL-6, a classical pro-inflammatory cytokine in colitis, was also decreased by alloferon. Moreover, alloferon inhibited the TNF-${\alpha}$-induced degradation and phosphorylation of $I{\kappa}B$ in Colo205 colon cancer cells. Taken together, these results show that alloferon has anti-inflammatory effects and attenuates DSS-induced colitis.

• IMMUNE NETWORK
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• v.15 no.3
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• pp.125-134
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• 2015

Acute graft-versus-host-disease (GVHD) is characterized by selective damage to the liver, the skin, and the gastrointestinal tract. Following allogeneic hematopoietic stem cell transplantation, donor bone marrow (BM) cells repopulate the immune system of the recipient. We previously demonstrated that the acute intestinal GVHD (iGVHD) mortality rate was higher in MyD88-deficient BM recipients than that in the control BM recipients. In the present study, the role of MyD88 (expressed by donor BM) in the pathophysiology of hepatic GVHD (hGVHD) was examined. Unlike iGVHD, transplantation with MyD88-deficient T-cell depleted (TCD) BM attenuated hGVHD severity and was associated with low infiltration of T cells into the liver of the recipients. Moreover, GVHD hosts, transplanted with MyD88-deficient TCD BM, exhibited markedly reduced expansion of $CD11b^+Gr-1^+$ myeloidderived suppressor cells (MDSC) in the liver. Adoptive injection of the MDSC from wild type mice, but not MyD88-deficient mice, enhanced hepatic T cell infiltration in the MyD88-deficient TCD BM recipients. Pre-treatment of BM donors with LPS increased MDSC levels in the liver of allogeneic wild type BM recipients. In conclusion, hGVHD and iGVHD may occur through various mechanisms based on the presence of MyD88 in the non-T cell compartment of the allograft.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.8A
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• pp.702-711
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• 2011

This paper proposes a HAG(Hidden-Node-Aware Grouping) algorithm for IEEE 802.15.4 networks to enhance the performance by eliminating collisions resulted from the hidden node problem without adopting the RTS/CTS packet exchanges. To solve the hidden node problem, the HAG algorithm organizes nodes into disjoint transmission groups by dynamically allocating hidden nodes into separate groups which take turns in a round robin way for their transmission. For dynamic group adjustment, it periodically evaluates the presence of hidden nodes based on subordinate nodes' receipt reports. To accurately measure its behavior, this paper also builds an analytical model to estimate its throughput fluctuation over various network topologies. The mathematical model along with simulation results confirmed that the HAG technique gracefully degraded the throughput of IEEE 802.15.4 networks whereas the standard IEEE 802.15.4 networks suffer severe throughput fallout as hidden nodes become populated.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.8
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• pp.1890-1910
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• 2013

Routing overlay offers an ideal methodology to improve the end-to-end communication performance by deriving a backup path for any node pair. This paper focuses on a challenging issue of selecting a proper backup path to bypass the failures on the default path with high probability for any node pair. For existing backup path selection approaches, our trace-driven evaluation results demonstrate that the backup and default paths for any node pair overlap with high probability and hence usually fail simultaneously. Consequently, such approaches fail to derive a robust backup path that can take over in the presence of failure on the default path. In this paper, we propose a three-phase RBPS approach to identify a proper and robust backup path. It utilizes the traceroute probing approach to obtain the fine-grained topology information, and systematically employs the grid quorum system and the Bloom filter to reduce the resulting communication overhead. Two criteria, delay and fault-tolerant ability on average, of the backup path are proposed to evaluate the performance of our RBPS approach. Extensive trace-driven evaluations show that the fault-tolerant ability of the backup path can be improved by about 60%, while the delay gain ratio concentrated at 14% after replacing existing approaches with ours. Consequently, our approach can derive a more robust and available backup path for any node pair than existing approaches. This is more important than finding a backup path with the lowest delay compared to the default path for any node pair.

• Journal of the Korean Society for Railway
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• v.15 no.5
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• pp.454-458
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• 2012

The CBTC(Communication based Train Control) and WPAN(Wireless Personal Area Network) systems employed on 2.4GHz ISM band wireless networks provide complementary service within the same environment. Coexistence between the networks will be impaired if the mutual packets are uncertainty associated the timing or gaussian distance. This paper analyzes the impact of the mutual interference and proposed method to minimize the effect of the WPAN system signals on CBTC system. The performance analysis is illustrated by examining the symbol error rate versus signal to noise interference ratio in terms of carrier frequency offset. The method contributes to reduce the symbol error rate drastically. However it can't be a fundamental solution for the impact on the interference problem. It may be needed for railway only frequency after checking the problems of the current railway frequency.