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Fe3O4 magnetic nanoparticles provide a novel alternative strategy for Staphylococcus aureus bone infection

  • Youliang, Ren;Jin, Yang;Jinghui, Zhang;Xiao, Yang;Lei, Shi;Dajing, Guo;Yuanyi, Zheng;Haitao, Ran;Zhongliang, Deng;Lei, Chu
    • Advances in nano research
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    • v.13 no.6
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    • pp.575-585
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    • 2022
  • Due to its biofilm formation and colonization of the osteocyte-lacuno canalicular network (OLCN), Staphylococcus aureus (S.aureus) implant-associated bone infection (SIABI) is difficult to cure thoroughly, and may occur recurrently subsequently after a long period dormant. It is essential to explore an alternative therapeutic strategy that can eradicate the pathogens in the infected foci. To address this, the polymethylmethacrylate (PMMA) bone cement and Fe3O4 nanoparticles compound cylinder were developed as implants based on their size and mechanical properties for the alternative magnetic field (AMF) induced thermal ablation, The PMMA mixed with optimized 2% Fe3O4 nanoparticles showed an excellent antibacterial efficacy in vitro. It was evaluated by the CFU, CT scan and histopathological staining on a rabbit 1-stage transtibial screw model. The results showed that on week 7, the CFU of infected soft tissue and implants, and the white blood cells (WBCs) of the PMMA+2% Fe3O4+AMF group decreased significantly from their controls (p<0.05). PMMA+2% Fe3O4+AMF group did not observe bone resorption, periosteal reaction, and infectious reactive bone formation by CT images. Further histopathological H&E and Gram Staining confirmed there was no obvious inflammatory cell infiltration, neither pathogens residue nor noticeably burn damage around the infected screw channel in the PMMA+2% Fe3O4+AMF group. Further investigation of nanoparticle distributions in bone marrow medullary and vital organs of heart, liver, spleen, lung, and kidney. There were no significantly extra Fe3O4 nanoparticles were observed in the medullary cavity and all vital organs either. In the current study, PMMA+2% Fe3O4+AMF shows promising therapeutic potential for SIABI by providing excellent mechanical support, and promising efficacy of eradicating the residual pathogenic bacteria in bone infected lesions.

A Comparative study on smoothing techniques for performance improvement of LSTM learning model

  • Tae-Jin, Park;Gab-Sig, Sim
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.1
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    • pp.17-26
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    • 2023
  • In this paper, we propose a several smoothing techniques are compared and applied to increase the application of the LSTM-based learning model and its effectiveness. The applied smoothing technique is Savitky-Golay, exponential smoothing, and weighted moving average. Through this study, the LSTM algorithm with the Savitky-Golay filter applied in the preprocessing process showed significant best results in prediction performance than the result value shown when applying the LSTM model to Bitcoin data. To confirm the predictive performance results, the learning loss rate and verification loss rate according to the Savitzky-Golay LSTM model were compared with the case of LSTM used to remove complex factors from Bitcoin price prediction, and experimented with an average value of 20 times to increase its reliability. As a result, values of (3.0556, 0.00005) and (1.4659, 0.00002) could be obtained. As a result, since crypto-currencies such as Bitcoin have more volatility than stocks, noise was removed by applying the Savitzky-Golay in the data preprocessing process, and the data after preprocessing were obtained the most-significant to increase the Bitcoin prediction rate through LSTM neural network learning.

The Empathy and Justice Contemplated From the Neuroscientific Perspective in the Age of Social Divisions and Conflicts (분열과 반목의 시대에 신경과학적 관점에서 고찰해보는 공감과 정의)

  • Ji-Woong, Kim
    • Korean Journal of Psychosomatic Medicine
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    • v.30 no.2
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    • pp.55-65
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    • 2022
  • Although humans exist as Homo Empathicus, human society is actually constantly divided and conflicted between groups. The human empathy response is very sensitive to the justice of others, and depending on the level of others' justice, they may feel empathy or schadenfreude to the suffering of them. However, our empathy to others' suffering are not always fair, and have inherent limitations of ingroup-biased empathy. Depending on whether the suffering other persons belongs to an ingroup or an outgroup, we may feel biased empathy or biased schadenfreude to them without even realizing it. Recent advances in information and communication technology facilitate biased access to ingroup-related SNS or ingroup media, thereby deepening the establishment of a more biased semantic information network related groups. These processes, through interacting with the inherent limitation of empathy, can form a vicious cycle of more biased ingroup empathy and ingroup-related activities, and accelerate divisions and conflicts. This research investigated the properties and limitations of empathy by reviewing studies on the neural mechanism of empathy. By examining the relationship between empathy and justice from a neuroscientific point of view, this research tried to illuminate the modern society of division and conflict in a different dimension from the classical perspective of social science.

National Agenda Service Model Development Research of Policy Information Portal of National Sejong Library (국립세종도서관 정책정보포털 국정과제 서비스 모형개발 연구)

  • Younghee, Noh;Inho, Chang;Hyojung, Sim
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.33 no.4
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    • pp.73-92
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    • 2022
  • This study intends to design a model that can effectively service policy data necessary for the implementation of new national agenda in order to provide high-quality policy information services that go beyond those of the existing Policy Information Portal (POINT) of National Sejong Library. To this end, it was determined that providing an integrated search environment, in lieu of data search through individual access, was necessary. Subsequently, four possible models for a national agenda service model were presented. First, designing a computerized system for both interface and electronic information source aspects was proposed for the national agenda service system operation. Second, designing the Linked Open Data system and the time-series service system for national policy information, providing the translation service of overseas original data, and securing the researcher's desired data were presented for the national agenda service information source operation. Third, strengthening public relations for policy users, building and promoting the site brand, operating SNS channels, and reinforcing the activation of auxiliary materials and the accessibility of external services were proposed for public relations of national agenda service. Fourth, expanding the information network with Open API, cloud service, and overseas libraries was proposed for collaborating and cooperating with the agenda service.

A Ship-Wake Joint Detection Using Sentinel-2 Imagery

  • Woojin, Jeon;Donghyun, Jin;Noh-hun, Seong;Daeseong, Jung;Suyoung, Sim;Jongho, Woo;Yugyeong, Byeon;Nayeon, Kim;Kyung-Soo, Han
    • Korean Journal of Remote Sensing
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    • v.39 no.1
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    • pp.77-86
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    • 2023
  • Ship detection is widely used in areas such as maritime security, maritime traffic, fisheries management, illegal fishing, and border control, and ship detection is important for rapid response and damage minimization as ship accident rates increase due to recent increases in international maritime traffic. Currently, according to a number of global and national regulations, ships must be equipped with automatic identification system (AIS), which provide information such as the location and speed of the ship periodically at regular intervals. However, most small vessels (less than 300 tons) are not obligated to install the transponder and may not be transmitted intentionally or accidentally. There is even a case of misuse of the ship'slocation information. Therefore, in this study, ship detection was performed using high-resolution optical satellite images that can periodically remotely detect a wide range and detectsmallships. However, optical images can cause false-alarm due to noise on the surface of the sea, such as waves, or factors indicating ship-like brightness, such as clouds and wakes. So, it is important to remove these factors to improve the accuracy of ship detection. In this study, false alarm wasreduced, and the accuracy ofship detection wasimproved by removing wake.As a ship detection method, ship detection was performed using machine learning-based random forest (RF), and convolutional neural network (CNN) techniquesthat have been widely used in object detection fieldsrecently, and ship detection results by the model were compared and analyzed. In addition, in this study, the results of RF and CNN were combined to improve the phenomenon of ship disconnection and the phenomenon of small detection. The ship detection results of thisstudy are significant in that they improved the limitations of each model while maintaining accuracy. In addition, if satellite images with improved spatial resolution are utilized in the future, it is expected that ship and wake simultaneous detection with higher accuracy will be performed.

A Study on the Secondary Science Teachers' YouTuber Experience and Identity: Focusing on Foucault's Concept of Heterotopia (중등과학교사의 유튜버 경험과 정체성에 대한 연구 -푸코의 헤테로토피아 개념을 중심으로-)

  • Sein, Shin;Jun-Ki, Lee
    • Journal of The Korean Association For Science Education
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    • v.42 no.6
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    • pp.579-595
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    • 2022
  • This study is a qualitative case study of secondary science teachers who are doing educational activities in YouTube. In particular, this study attempts to interpret this case based on Foucault's concept of 'Heterotopia', which means a space that allows for private freedom or deviance by reflecting various utopias without the norms and constraints from every day or real space. Five secondary science teachers who voluntarily opened a personal channel on the YouTube platform and actively uploaded their own videos related to science education participated in the study. In order to understand the experiences of five secondary science teachers, data were individually collected through semi-structured in-depth interviews, and the collected data were analyzed using qualitative case study method. For valid interpretation of the study, we also referred to the video contents, teacher training materials, and teaching and learning materials produced by the participants. As a result of the study, seven themes were revealed: 'Desire for one's own unique educational activities,' 'Youtube as an extended classroom space,' 'Expanded network of relationships beyond the classroom barrier,' 'Satisfaction of desire for recognition and experience of identity as a YouTuber,' 'Tension between the educational space and the YouTube,' 'Space to be reborn as a craftsman,' and 'Finding one's own direction as a Teacher-YouTuber.' Given those findings, we found that the identity and desire of secondary science teachers, which were limited in the existing secondary schools and classrooms, was expanded in a new space called YouTube. In addition, we suggested that YouTube could be a space where science teachers can realize their own ideals and feel the joy. And simple regulating teacher's behavior in Youtube space only based on norms and standards shared in traditional educational space would rather hinder their healthy construction of identity and growth.

A Study about Building a Community of Practice of Experts for Sharing and Using Research Data (연구데이터 공유 및 활용을 위한 전문가 실천공동체 구축에 관한 연구)

  • Na-eun, Han
    • Journal of the Korean Society for Library and Information Science
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    • v.56 no.4
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    • pp.181-203
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    • 2022
  • This study analyzed domestic and foreign literature and examined cases of foreign Community of Practice(CoP) of experts to find out what benefits researchers can gain from participating in their CoP, how the CoP was established, and how data is shared within the CoP. In addition, this study discussed on how to establish a CoP of experts in Korea for sharing and using research data. By participating in the CoP of experts, members can be provided with the opportunity to build an experts' network and have a chance to meet with various experts, to acquire and share their expertise and information, to receive help from other experts, to learn about their expertise, and to have opportunities for professional experiences. In addition, this study discussed 4 factors such as operation method and management system, memberships and number of members, activities, and management of data and repository for establishing a CoP of experts for sharing and using research data. This study provides a knowledge base for building a CoP of experts in Korea.

A Study on Deep Learning based Aerial Vehicle Classification for Armament Selection (무장 선택을 위한 딥러닝 기반의 비행체 식별 기법 연구)

  • Eunyoung, Cha;Jeongchang, Kim
    • Journal of Broadcast Engineering
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    • v.27 no.6
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    • pp.936-939
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    • 2022
  • As air combat system technologies developed in recent years, the development of air defense systems is required. In the operating concept of the anti-aircraft defense system, selecting an appropriate armament for the target is one of the system's capabilities in efficiently responding to threats using limited anti-aircraft power. Much of the flying threat identification relies on the operator's visual identification. However, there are many limitations in visually discriminating a flying object maneuvering high speed from a distance. In addition, as the demand for unmanned and intelligent weapon systems on the modern battlefield increases, it is essential to develop a technology that automatically identifies and classifies the aircraft instead of the operator's visual identification. Although some examples of weapon system identification with deep learning-based models by collecting video data for tanks and warships have been presented, aerial vehicle identification is still lacking. Therefore, in this paper, we present a model for classifying fighters, helicopters, and drones using a convolutional neural network model and analyze the performance of the presented model.

Heating Characteristics of Planar Heater Fabricated with Different Mixing Ratios of MXene-CNT-WPU Composites (MXene-CNT-WPU 복합소재 기반 면상발열체의 배합 비율에 따른 발열 특성)

  • Hyo-Jun, Oh;Quy-Dat, Nguyen;Yoonsik, Yi;Choon-Gi, Choi
    • Clean Technology
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    • v.28 no.4
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    • pp.278-284
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    • 2022
  • This study presents an excellent planar heater based on low-dimensional composites. By optimizing the ratio of 1D carbon nanotubes (CNT) and 2D MXene (Ti3C2TX), it is possible to create a planar heater that has superior electrical conductivity and high heat generation characteristics. Low-dimensional composites were prepared by mixing CNT paste and MXene solution with eco-friendly waterborne polyurethane (WPU). In order to find the optimal mixing ratio for the MXene-CNT-WPU composites, samples with MXene to CNT weight ratios of 3:1, 1:1, 1:3, 1:7, and 1:14 were investigated. In addition to these different weight ratios, 5 wt% WPU was equally applied to each sample. It was confirmed that the higher the weight ratio of CNT, the lower the sheet resistance and the higher the heating temperature. In particular, when the MXene-CNT-WPU planar heater was fabricated by mixing MXene and CNT at a weight ratio of 1:7 and 1:14, the heating temperature was higher than the heating temperature of a CNT-WPU planar heater. These characteristics are due to the optimized mixture of the 1D materials (CNT) and the 2D materials (MXene) causing the formation of a flat surface and a dense network structure. The low-dimensional composites manufactured with the optimized mixing ratios found in this study are expected to be applied in flexible electronic devices.

A Study on the Research Trends of Archival Preservation Papers in Korea from 2000 to 2021 (국내 기록보존 연구동향 분석: 2000~2021년 학술논문을 중심으로)

  • Yonwhee, Na;Heejin, Park
    • Journal of Korean Society of Archives and Records Management
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    • v.22 no.4
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    • pp.175-196
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    • 2022
  • This study aims to determine the research trends in archival preservation through keyword analysis, understand the current research status, and identify the research topics' changes over time. The degree and betweenness centrality analyses were conducted and visualized on 463 "archival preservation studies" articles published from 2000 to 2021 in various academic journals, using NetMiner 4.0. The collected research papers were divided into three time periods according to when they were published: the first period (2000-2007), the second period (2008-2014), and the third period (2015-2021). The subject keywords for the research papers on archival preservation in Korea that have influence and expandability are as follows. Across all periods, these were "electronic records" and "long-term preservation." In addition, if taken separately per period, the "OAIS reference model" and "electronic records" dominated the first and second periods, respectively, while the "records management standard table" and "long-term preservation" both dominated the third period. A conceptual framework and theory-oriented study for archival preservation, such as "digital preservation," "digitalization," and the "OAIS reference model," dominated the first period. During the second period, more research focused on procedures and practical applications related to conservation activities, such as "electronic record," "appraisal," and "DRAMBORA." In contrast, the majority of the research in the third period was on technical implementation according to the changes in the records management environment, such as "data set," "administrative information system," and "social media."