• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.81.2-81.2
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• 2004

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.145-146
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• 1998

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.105-106
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• 1998

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.317.1-317.1
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• 2001

• Journal of Preventive Medicine and Public Health
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• v.42 no.6
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• pp.343-348
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• 2009

The final decision of study design in molecular and genetic epidemiology is usually a compromise between the research study aims and a number of logistical and ethical barriers that may limit the feasibility of the study or the interpretation of results. Although biomarker measurements may improve exposure or disease assessments, it is necessary to address the possibility that biomarker measurement inserts additional sources of misclassification and confounding that may lead to inconsistencies across the research literature. Studies targeting multi-causal diseases and investigating gene-environment interactions must not only meet the needs of a traditional epidemiologic study but also the needs of the biomarker investigation. This paper is intended to highlight the major issues that need to be considered when developing an epidemiologic study utilizing biomarkers. These issues covers from molecular and genetic epidemiology (MGE) study designs including cross-sectional, cohort, case-control, clinical trials, nested case-control, and case-only studies to matching the study design to the MGE research goals. This review summarizes logistical barriers and the most common epidemiological study designs most relevant to MGE and describes the strengths and limitations of each approach in the context of common MGE research aims to meet specific MEG objectives.

• Journal of agricultural medicine and community health
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• v.31 no.2
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• pp.119-144
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• 2006

The Korea rural health study, a large prospective cohort study, the objectives of this study are exploration for potential causes of agricultural injuries and diseases among farmers. Current medical research suggests that they may have higher rates of some traumatic injuries, pesticide poisoning, infectious diseases, musculoskeletal diseases, asthma and other respiratory diseases. This study is designed to identify occupational, lifestyle, and environmental factors of workplace that may affect the rate of diseases in farming population. Round 1, initial cohort recruitment, will begin in 2006 and conclude in 2009. Round 2, follow-up will begin in 2010 and conclude in 2014. Approximately 54,000 persons will be selected to study population. Nested case-control studies and case-crossover studies will be conducted for getting to the bottom of agriculture-related diseases. Recruitment and follow-up are conducted in collaboration with multi-centers. As data on the exposures and health outcomes of this study population are collected and analyzed in 2014. This study will be evaluated by public health experts for effort, achievement, adequacy of performance, efficacy, process of study and so on. The author expects that this cohort study may reduce agricultural injuries and diseases and will provide information that agricultural workers can use in making decisions about their health. Also, this study will be significant basis for strengthening the competitiveness of agriculture in Korea.

• Journal of Preventive Medicine and Public Health
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• v.39 no.6
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• pp.493-498
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• 2006

Objectives : Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea. Methods : Among the members of the Korean Multi-Center Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using long-term stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables. Results : The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337). Conclusions : This study provides no evidence for an association of the serum glucose level with gastric cancer.

• Journal of Preventive Medicine and Public Health
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• v.41 no.3
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• pp.159-164
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• 2008

Objectives : The purpose of this systematic review was to investigate the association between dietary intake of citrus fruits and prostate cancer risk. Methods : Authors searched electronic databases and the reference lists of publications of diet and prostate cancer studies until August 2007. All of the epidemiological studies that obtained individual data on dietary intake of citrus fruits and presented risk estimates of the association between intake of citrus fruits and risk of prostate cancer were identified and included. Using general variance-based methods, study-specific odds ratios (OR)/ relative risk (RR) and associated confidence interval (CI)/ standard error (SE) for highest versus lowest intake of citrus fruits level were extracted from each paper. Results : Eleven articles including six case-control studies, one nested case-control study and four cohort studies, proved eligible. Overall summary OR using random effect model did not show an association in risk of prostate caner with intake of citrus fruits (summary OR=1.03, 95% CI=0.89-1.19) with large heterogeneity across studies that we were unable to explain ($I^2$=67.88%). The summary ORs in case-control studies and cohort studies were 1.10 (95% CI=0.97-1.22) and 1.05 (95% CI=0.96-1.14), respectively. Conclusions : Pooled results from observational studies did not show an association between intake of citrus fruits and the risk of prostate cancer, although results vary substantially across studies.

• 대한임상약리학회:학술대회논문집
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• 2001.12a
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• pp.32-33
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• 2001

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.101-102
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• 1998