• Title/Summary/Keyword: Negative therapy

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Feasibility Study of Docetaxel and Cyclophosphamide Six- Cycle Therapy as Adjuvant Chemotherapy for Japanese Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Patients

  • Abe, Hajime;Mori, Tsuyoshi;Kawai, Yuki;Tomida, Kaori;Kubota, Yoshihiro;Umeda, Tomoko;Tani, Tohru
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.8
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    • pp.4835-4838
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    • 2013
  • Background: We compared treatment completion rates and safety of docetaxel and cyclophosphamide sixcycle therapy (TC6) with docetaxel followed by 5FU, epirubicin and cyclophosphamide (T-FEC) therapy in Japanese patients with human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Materials and Methods: We administered TC6 q3w or T-FEC q3w to HER2-negative breast cancer patients. The primary endpoint of this trial was toxicity. As second endpoints, the treatment completion rate and relative dose intensity were evaluated. Results: The TC6 and T-FEC group consisted of 22 and 21 patients, respectively. Concerning hematological toxicity, grade 3 or higher adverse reactions included neutropenia and febrile neutropenia. As non-hematological adverse events, exanthema and peripheral neuropathy were frequently reported in the TC6 group, whereas more patients of the T-FEC group reported nausea and vomiting. In TC6, the treatment completion rate was 86.4% and the relative dose intensity of docetaxel was 93.2%. In T-FEC, the values were 95.2% and 98.9%, respectively. Conclusions: These results suggest that TC6 is tolerable in Japanese, and that this regimen can also be performed in outpatient clinics. However, with the TC6 regimen, the compliance was slightly lower than with the T-FEC regimen, and supportive therapy needs to be managed appropriately.

Muscle Activity Based on Real-time Visual Feedback Training Methods by Rehabilitative Ultrasound Image in Elderly and Relationship between Heckmatt Scale, Muscle Thickness and Tone : A Pilot Study

  • Shin, Janghoon;Lee, Wanhee
    • Physical Therapy Rehabilitation Science
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    • v.10 no.1
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    • pp.82-89
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    • 2021
  • Purpose: This study is to investigate the muscle activity based on real-time visual feedback training methods by rehabilitative ultrasound image in elderly and correlation between Heckmatt scale grade, muscle tone and thickness. Design: Cross-sectional study: Pilot study Methods: 6 elderly participated in the study with 2 conditions. Under the condition of rehabilitation ultrasound imaging equipment, all subjects performed voluntary maximal muscle contraction of the quadriceps 3 times using visual feedback based on Rehabilitative Ultrasound Imaging 1.0 (RUSI 1.0). Under the condition of only ultrasound images, all subjects performed voluntary maximal muscle contraction of the quadriceps 3 times using ultrasound image-based visual feedback. The muscle thickness and tone of the quadriceps were measured and the grades were classified by Heckmatt scale and all variables were comparative analyzed. Results: Heckmatt scale grade showed a negative correlation with muscle thickness at relaxation (p<0.05), and a negative correlation with the difference value obtained by subtracting muscle thickness at relaxation from muscle thickness at contraction in ultrasound image condition (p<0.05). The muscle tone during relaxation showed a negative correlation with the muscle thickness during relaxation (p<0.05). Conclusion: In the case of voluntary maximum muscle contraction of the quadriceps muscle in the elderly, it can be seen that the muscle thickness is getting larger when the RUSI 1.0-based visual feedback is provided than with only ultrasound image provided. And the lower Heckmatt scale grade is, the thicker the muscle is, and the lower the muscle tone is.

The Influence of COVID-19 on Physical Activity, Sleep Quality, and the Quality of Life in Adults by Age Group

  • Kim, Tae-Yeon;Choi, Sil-Ah
    • The Journal of Korean Physical Therapy
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    • v.34 no.1
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    • pp.18-25
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    • 2022
  • Purpose: The purpose of this study was to identify changes in physical activity, sleep quality, and quality of life (QOL) during COVID-19 in adults by age group. Methods: An online survey was conducted on a total of 160 participants who were divided into three groups by age; young adults, middle-aged adults, and old adults. The participants responded to the self-reported assessment of the impact of social distancing during COVID-19, International Physical Activity Questionnaire (IPAQ), Pittsburgh Sleep Quality Index (PSQI), and Short Form-36 Health Survey (SF36). Descriptive statistics, analysis of variance, and Pearson's correlation were used for data analysis. Results: There were significant differences between the three age groups in physical activity (p<0.05) and PSQI (p<0.01) and a post hoc analysis showed that the young adults' group had significantly higher physical activity than the old adults' group, while the old adults' group had significantly lower scores of PSQI (better sleep quality) than the others. The young adults' group showed a significant negative correlation between the stress from social distancing and QOL (r=-0.27, p<0.05) and between PSQI and QOL (r=-0.48, p<0.05). For the middle-aged adults' group, there was a significant negative correlation between PSQI and QOL (r=-0.53, p<0.05). The old adults' group showed a significant negative correlation between the stress from social distancing and physical activity (r=-0.35, p<0.05) and PSQI (r=-0.50, p<0.05), while there was a significant positive correlation between physical activity and PSQI (r=0.30, p<0.05) and QOL (r=0.30, p<0.05). Conclusion: The results of this study could be used as basic data for the promotion of physical and mental health in the post-COVID-19 era.

The effect of Positive psychology program using Complementary and Alternative Therapies on Negative emotions, Career decision making Self-Efficacy, Self-Compassion, and Flourish of Nursing students (보완대체요법을 활용한 긍정심리프로그램이 간호대학생의 부정적 정서, 진로결정 자기효능감, 자기자비, 플로리시에 미치는 효과)

  • Hyangjin Park;Hyun-Jung Jang
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.6
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    • pp.615-625
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    • 2023
  • This study was attempted to improve the mental and psychological health of nursing students through the intervention of positive psychological programs using complementary alternative therapy. This study applied a Non-equivalent control group pre-test and post-test design to verify the effects of negative emotions, career decision making self-efficacy, self-compassion, and flourish in nursing students. The experimental group is the students who received the positive psychology program using complementary and alternative therapy, and the control group is the students who did not receive the program. The collected data were analyzed using the SPSS Version 21.0 program. The experimental group showed higher career decision making self-efficacy, self-compassion, and flourish scores and lower negative emotion scores than the control group that did not participate in the education. After applying the positive psychology program using complementary and alternative therapy, it contributed to the expansion of the nursing intervention area using complementary and alternative therapy by reporting positive research effects on career decision making self-efficacy, self-compassion, and flourish.

Clinical Outcome after Treatment with the First-line Drugs in Patients with Persistent Positive Sputum Smear and Negative Sputum Culture Results (지속적인 객담 도말양성 및 배양음성인 폐결핵환자에서 일차항결핵제로 치료종결한 후의 임상성적)

  • Kwon, Eun-Su;Lee, Jong-Youk
    • Tuberculosis and Respiratory Diseases
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    • v.51 no.4
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    • pp.325-333
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    • 2001
  • Background : This study aimed to estimate the clinical outcome and identify the characteristics of a group of patients with pulmonary tuberculosis who completed anti-tuberculosis therapy with the First-line drugs in spite of having positive smear results with negative sputum culture results over the previous six months. Method : A retrospective chart review of 21 patients who fulfilled the above criteria between 1995 and 1999 was performed. The laboratory data as well as the clinical data of the patients with positive smear results and negative culture results over a six months period were reviewed. Results : The negative conversion of sputum culture results was achieved within $1.3{\pm}1.2$ months and the negative conversion of the sputum smear results was accomplished during $9.5{\pm}3.3$ months. Chest X-rays at 5 months following the institution of anti-tuberculosis therapy from all patients revealed improvements. Four out of 21 patients(19%) relapsed during the follow up, $15.2{\pm}13.4$ months after administering anti-tuberculosis therapy for $13.3{\pm}3.1$ months. Relapses were confirmed from between 3 months and 4 months after the treatment completion. Only one of the four relapses had no past history of anti-tuberculosis therapy and the others had prior treatment twice (p<0.01). The period of anti-tuberculosis treatment was extended to a mean of $4.6{\pm}2.6$ months in 12 patients. However, prolongation of anti-tuberculosis therapy had no affect on the relapse rate (odds ratio, 95% CI 0.18, 2.15). Conclusion : Prolongation of therapy with the First-line drugs is not necessary for patients with persistently positive smear results over 6 months and negative culture results. A patient who has had prior anti-tuberculosis therapy more than twice should be paid the closest attention.

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Relationship between time management and anxiety of Occupation Therapy students

  • Lee, Hye-Sun
    • International Journal of Advanced Culture Technology
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    • v.9 no.4
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    • pp.254-259
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    • 2021
  • Time management skills are essential for Occupation Therapy students' success, and development of clinical competence. The purpose of this study was to determine the relationship between time management skills and anxiety and academic motivation of nursing students. This study was carried out on 95 Occupation Therapy students. Data were collected using demographic Questionnaire, Time Management Questionnaire (TMQ), Spielberger State-Trait Anxiety Inventory (STAI) and Academic Motivation Scale (AMS), which was completed t by self-report. Data were analyzed using SPSS 20 software with descriptive and analytical statistics such as ANOVA, independent t-test, Regression and Pearson Correlation Coefficient. The results also showed a statistically significant negative correlation between the students' TMQ scores and the state anxiety (r= -0.282, p< 0.005) and trait anxiety scores (r= -0.325, p<0.005). Moreover, there was a statistically significant positive correlation between the students' TMQ scores and AMS scores (r= 0.279, p< 0.005). Regarding the findings, it seems that it is necessary to plan for improving time management skills in order to enhance academic motivation and reduce anxiety rates among Occupation Therapy students.

Effect of Scapular Stabilization Exercise on Patients With Neck Pain Classified According to Passive Scapular Elevation Test (수동 견갑골 거상 검사에 따라 분류된 경부통 환자의 견갑골 안정화운동 효과 비교)

  • Kim, Ha-Yeon;Kim, Suhn-Yeop;Jang, Hyun-Jeong;Joo, Myung-Kyu
    • Physical Therapy Korea
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    • v.19 no.3
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    • pp.51-60
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    • 2012
  • This study aimed to determine the usefulness of classifying patients with neck pain on the basis of the results of passive scapular elevation test. We classified 21 patients with neck pain into positive (n=12) and negative (n=9) groups on the basis of passive scapular elevation test; the 2 groups then equally performed scapular stabilization exercise program for 30 min, 3 times a week, for 4 weeks. Visual analogue scale (VAS), neck disability index (NDI), and range of motion (ROM) were recorded both before and after the intervention for both groups. Paired t-test was used to determine that there were significant changes between before and after the intervention, and independent t-test was used for analyzing changes between two groups of dependent variables. After 4 weeks of training, we observed significant decrease in pain and disability (p<.05) and a significant increase in rotation, flexion, extension, and side-bending ROM (p<.05) in both groups. Further, between pre- and post-intervention evaluations, we observed a significant decrease in pain and disability and a significant increase in rotation and flexion ROM in the positive group than in the negative group (p<.05). These results indicate that passive scapular elevation test may be used to identify mechanical disorders of the cervicoscapular muscle in patients with neck pain. Therefore, we recommend the use of passive scapular elevation test to determine appropriate treatment intervention when treating patients with neck pain.

Effects of Personality and Sensory Processing on College Life Adaptation in Students Majoring in Occupational Therapy (작업치료 전공 대학생의 성격과 감각처리가 대학생활 적응에 미치는 영향)

  • Chun-Yeop Lee;Nam-Hae Jung
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.4
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    • pp.237-246
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    • 2023
  • Purpose : This study investigated the effects of personality and sensory processing on college life adaptation in students majoring in occupational therapy. Methods : We conducted a survey study on 251 college students from March to May 2023. Personality, sensory processing, and college life adaptation were measured through the international personality item pool, adolescent/adult sensory profile, and student adaptation to college questionnaire, respectively. The general characteristics of students were analyzed using frequency analysis, and differences in college life adaptation and sensory processing characteristics were analyzed using independent t-tests and one-way ANOVA. The relationship between personality, sensory processing, and college life adaptation scores was analyzed using Pearson correlation analysis. The impact of personality and sensory processing on college life adaptation was analyzed using multivariate regression analysis using SPSS 25.0. Results : Correlations of all five personality factors, except openness to experience, were observed with students' college life adaptation. According to sensory processing characteristics, differences in college life adaption showed significant differences in sensory avoidance, poor registration, and sensory sensitivity. The variance of college life adaptation explained by each factor (based on R2) were 46% by personality and 26% by sensory processing. Among personality traits, neuroticism had a negative effect on college life adaptation, agreeableness and extroversion had positive effects, and low registration during sensory processing had a negative effect. Conclusion : This study suggests the provision of various activities and creation of an environment for college students with low sensory registration and neurotic traits to encourage positive changes. The results can be used to design a program that helps college students adapt to occupational therapy majors.

Comparison and Correlation between Physical and Psychological Functions by Gender in Judo Athletes (유도선수의 성별에 따른 신체적, 심리적 기능 비교 및 상관관계 연구)

  • Hyeyoung Kim;Eunjung Chung;Ye-Jin Shin;Byoung-Hee Lee
    • Journal of Korean Physical Therapy Science
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    • v.30 no.4
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    • pp.71-81
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    • 2023
  • Background: The purpose of this study was to comparison and correlation between physical and psychological functions by gender in Judo athletes. Both the physical and psychological factors of athletes are important as factors influencing athletic performance, but there are few papers that have compared and studied the correlation between physical and psychological functions of judo players. Design: Cross sectional study Methods: The 134 participants; high school students, college students, and team players. They used physical functions to measure such as self-describing KOOS, FAOS, ODI, POMS, SCAT, ASMQ, and ACSI-28. Results: There was a significant difference in the physical function according to gender in the KOOS, but no significant difference in the FAOS and ODI. For psychological function, there was a significant difference in the vitality item in the POMS, and a significant difference in the body management, training management, life management, and unique behavior management items in the ASMQ. In the ACSI-28, there were significant differences in coping with adversity, stress repayment, concentration, freedom to worry about matches, and self-coaching behavior items. Physical function and psychological function showed a significant negative correlation. The POMS showed a negative correlation between the ASMQ and ACSI-28, whereas the SCAT showed a positive correlation. Conclusion: The results of this study are expected to be used as a basic data for sports training by gender of Judo athletes.

Comparison of Radiography Findings and Magnetic Resonance Image Findings of Lumbar Spine Instability Patients (요추 불안정 환자에서 단순방사선 소견과 자기공명영상 소견의 비교)

  • Lee, In-Hee;Park, Hee-Joon;Jin, Jong-Sik;Lee, Jyung-Hyun;Kim, Yoon-Nyun
    • The Journal of Korean Physical Therapy
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    • v.19 no.3
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    • pp.41-46
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    • 2007
  • Purpose: This study was to investigate how dose the radiography findings are to magnetic resonance (MR) image findings in the L5-S1 instability patients. The subjects of this study were comprised of eleven males and fifteen females, who had Lumbago and agreed with this research. Methods: Radiography and MR images of Lumbar spine were acquired respectively from subjects in conditions of maximum flexion and extension. The horizontal and angular displacements in lumabosacral spine radiography were used to assess the instability of lumbar spine. MR images were also used to evaluate the intervertebral disc abnormalities and change of bone marrow. Results: The results are as follows. 1. In the case of flexion transitional displacement proposed by Dupuis et al, the specificity and negative predictive value were good accuracy ($0.7{\sim}0.8$), and the negative predictive value was in average. In the case of extension displacement, the negative predictive value was about average ($0.6{\sim}0.7$), but the sensitivity, specificity and positive predictive value were below the poor (<0.6). On the other side, the specificity was about average but other things were below in the case of angular displacement. 2. In the case of flexion transitional displacement proposed by Dupuis et al., compared with the intervertebral disc abnormalities, the negative prediction value was excellent, the sensitivity good, and the specificity about average. In the case of extension, the negative prediction value was about average, but the other things were poor. On the other side the specificity and negative predictive value had good accuracy and the sensitivity and positive prediction value were below average in the case of angular displacement. Conclusion: The above results show that the radiography finding is sufficiently helpful to find the lumbar spine instability as an economic point of view.

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