• 생물정신의학
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• 제22권4호
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• pp.216-222
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• 2015

Objectives The principal aim of the present study was to investigate the characteristic depressive symptoms in patients with social anxiety disorder (SAD) and panic disorder in comparison to patients with depressive disorder. Methods This study included 132 patients with SAD, 128 panic disorder and 64 depressive disorder (major depressive disorder, dysthymia etc.) patients without comorbid psychiatric disorders. The Beck Depressive Inventory (BDI) is used to measure depressive symptoms. We divided BDI into three categories originally described by Shafer AB, including negative attitude toward self, performance impairment, and somatic symptoms. We compared the depressive symptoms of SAD, panic disorder and depressive disorder by using ANOVA. Results Negative attitude toward self was noticeable in SAD (SAD $0.54{\pm}0.23$, panic disorder $0.41{\pm}0.17$, depressive disorder $0.46{\pm}0.11$, p < 0.001). Performance impairment and somatic symptoms were remarkable in panic disorder than in SAD and depressive disorder (performance impairment : SAD $0.39{\pm}0.21$, panic disorder $0.44{\pm}0.14$, depressive disorder $0.40{\pm}0.09$, p = 0.009 ; somatic symptoms : SAD $0.07{\pm}0.10$, panic disorder $0.15{\pm}0.12$, depressive disorder $0.14{\pm}0.08$, p < 0.001). Conclusions The results facilitate an approach to optimal treatment for patients with comorbidity of anxiety disorder and depression.

• 대한한의학회지
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• 제27권3호
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• pp.151-168
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• 2006

Objectives: To help the Oriental medicine clinical studies for the common cold treatment, this study analyzed the tendency of research into complementary medicine on the common cold recently published in PubMed. Methods: This study analyzed 26 research papers on complementary medicine on the common cold published in PubMed Over the past 10 years. It measured annually and for each country the number of papers published, the number of subjects, the period of research, the area of trial, the method of study, the objective of study, and intervention, respectively and intervention, the objective of study, and the result of trials overall. Results: There were research papers concerning treatment, prevention, safety of herbal medicine, inducement, and improvement of symptoms of the common cold in the study objective the most among them concerned treatment of the common cold. There were more positive results compared to negative results for treatment and prevention. The results for safety and symptom improvement were positive, while the results for the inducement were indeterminate. There were research papers about using food and medicine, acupuncture, hydrotherapy, and cold exposure in intervention the most among them were about using food and medicine. The food and medicine interventions were Echinacea preparations, vitamins, zinc preparations, Baptisia, Thuja, the root of North American ginseng, probiotic bacteria, troxerutin, garlic, Andrographis paniculata, and caffeine. The use of Echinacea preparations was the most frequent among them. Conclusions: Recent research results of complementary medicine on the common cold were more positive than negative.

• 생물정신의학
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• 제5권1호
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• pp.122-128
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• 1998

본 연구는 만성 정신분열병 여성환자에서 항정신병약물에 대한 estrogen병합투여 효과를 정신병리 측면에서 조사한 것이다. Estrogen 투약군과 대조군으로 나누어 8주에 걸쳐 시행하였고, 그 결과를 PANSS, CGI를 통하여 비교하였다. 8주간의 연구기간 동안 PANSS, CGI모두에서 투약군이 대조군보다 유의한 호전을 보였다. 투약군에서 연구 8주동안의 PANSS 각 소항목군의 변화율은 양성증상 30.52%, 음성증상 15.06%, 일반정신병리증상 13.60%로 양성증상이 다른 군에 비하여 큰 호전을 보였다. 이상의 연구결과는 만성정신분열병의 치료에 있어 기존의 항정신병 약물과 estrogen의 병합투여가 치료적 효과적가 있다는 것을 제시하였다. 또한 estrogen의 항정신병적 효과의 기전은 명확치 않지만, estrogen이 뇌에서 도파민과 세로토닌체계에 영향을 주어 정신분열병의 호전에 기여했을 것으로 추측된다.

• 대한불안의학회지
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• 제16권2호
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• pp.106-112
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• 2020

Objective : Social anxiety disorder (SAD) is characterized by fear of social threat and exhibits limbic hyper-reactivity toward social stimuli such as emotional faces. A previous study identified the uncinate fasciculus (UF) sub-tract as particularly related to facial memory. To explore the white matter tract relating to face-specific brain regions, we investigated the UF sub-tract in SAD. Methods : The diffusion tensor images of 22 patients with SAD and 20 healthy controls were analyzed with tractography. The UF sub-tract was delineated using the regions of interest of face patches in the anterior temporal lobe and the orbitofrontal cortex, and fractional anisotrophy (FA) and total number of streamlines (ST) were analyzed. We examined the group comparison of FA and ST of the UF sub-tract and correlations of FA and ST with the social anxiety symptoms such as the Liebowitz Social Anxiety Scale (LSAS), the Social Interaction Anxiety Scale (SIAS), the Social Phobia Scale (SPS) and the Fear of Negative Evaluation scale (FNE) in SAD. Results : There were no group differences in FA and ST of the UF sub-tract. However, negative correlations were observed between ST of the right UF sub-tract and severity of social anxiety symptoms (LSAS, r_s=-0.480, p=0.024; SIAS, r_s=-0.580, p=0.005; SPS, r_s=-0.590, p=0.004; FNE, r_s=-0.675, p=0.001) in patients with SAD. Conclusion : Although patients with SAD did not show quantitative abnormalities in the UF sub-tact connecting face-specific brain regions, this structure seems to play a role in the symptom severity of SAD.

• 종양간호연구
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• 제11권3호
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• pp.237-246
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• 2011

Purpose: The aim of this study was to investigate the relationships between stigma, distress, and quality of life (QOL) in patients with lung cancer. Methods: The subjects of the study were 123 lung cancer patients who visited the outpatient department of S hospital in Seoul from July 21st to August 29th, 2011. To measure stigma, distress, and QOL, Cataldo Lung Cancer Stigma Scale, Hospital Anxiety and Depression Scale (HADS), and EORTC QLQ-C30 (Quality of Life Questionnaire, Core 30) were used in this study. The collected data were analyzed using frequency, average, t-test, ANOVA, and Pearson correlation with SPSS WIN 19.0. Results: Stigma showed positive correlations with anxiety, depression, and symptom (r=.37, p<.001; r=.44, p<.001; r=.23 p=.012), while it showed negative correlations with global QOL and function (r=-.26, p=.003; r=-.40, p<.001). Anxiety and depression also positively correlated with symptoms (r=.43, p<.001; r=.58, p<.001) while anxiety and depression negatively correlated with global QOL (r=-.40, p<.001; r=-.56, p<.001) and function (r=-.64, p<.001; r=-.66, p<.001). Conclusion: The findings of the study demonstrated that lung cancer patients experienced stigma and distress that had a negative influence on the subjects' QOL. Thus the study's findings can be useful in developing psychosocial nursing strategies to improve QOL of lung cancer patients in the future.

• 생물정신의학
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• 제18권4호
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• pp.225-231
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• 2011

Objectives Atypical antipsychotics show better treatment efficacy, safety and tolerability than typical antipsychotics. Among the adverse events observed during treatment with antipsychotics, extrapyramidal syndrome (EPS) and negative symptoms has been greatly reduced. But still, weight gain is receiving growing attention. The aim of this study was to investigate the association between therapeutic response to atypical antipsychotics and weight gain in admission status. Methods The study was conducted for Korean inpatients with schizophrenia in a university hospital in Seoul, between Jan 2006 and Dec 2010. Data was collected by reviewing the medical record of 39 consecutively hospitalized patients with Schizophrenia (DSM-IV) at a university hospital. Positive and Negative Symptom Scale (PANSS), Body Mass Index (BMI) and body weights were measured. Results No significant difference was observed for sex, age, illness onset age, family history of schizophrenia, numbers of hospitalization before treatment, educational years, marriage status, occupational status and subtype of schizophrenia between weight gainers and non-weight gainers. Regarding treatment response to atypical antipsychotics, weight gainers show significantly more PANSS decrease than non-weight gainers during admission period. Conclusions Our findings suggest that it appears to be more likely to respond to atypical antipsychotics in weight gainers than non-weight gainers (that weght gainers appear to be more likely to respond to atypical antipsychotics than non-weight gainers). These results show that the antipsychotic-induced body weight gain is associated with therapeutic response of antipsychotics in Korean inpatients with schizophrenia.

• 동아시아식생활학회지
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• 제19권4호
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• pp.493-502
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• 2009

This study aimed to examine the relationship between nutrient intake and attention deficit hyperactivity (ADH) of children suffering atopic dermatitis. We examined clinical symptoms as well as the status of ADH and the dietary intake of 47 children with atopic dermatitis aged between 4 and 6 against 84 children in the control group. Family history of the atopic dermatitis group was significantly higher than the control group. There was no significant difference between the diet habit of the two groups. The daily energy intake of the atopic dermatitis group and the control group were 1,189.7 kcal and 1245.0 kcal, respectively. There was no significant difference between the nutrient intake of the two groups. In regards to the clinical symptom items, the point for 'anxieties' was 0.5 in the atopic dermatitis group, which was significantly higher than 0.3 of the control group (p<0.05). In terms of the detailed items in ADH assessed by kindergarten teachers, the point for 'changeable feeling' was 0.8 in the atopic dermatitis group, which was significantly higher than 0.5 of the control group (p<0.05). As for the correlation among nutrient intake, the ADH score and clinical symptoms, total fat intake (p<0.05) and animal fat intake (p<0.05) showed a significantly negative correlation with the point of ADH assessed by the teachers, while the intake of fiber (p<0.05) displayed a significantly negative correlation with the point of ADH assessed by the parents. Since atopic dermatitis and ADH may be caused by the same dietary factors, it will be necessary to conduct more studies in this field in the future. In addition, appropriate nutrition management will be necessary for children in the growing period who suffer from atopic dermatitis.

• 동서간호학연구지
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• 제14권1호
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• pp.68-77
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• 2008

Purpose: This Study aims to explore the Wormwood smoke(Ssukjahun) experiences of women and to provide the data to develop Korean traditional nursing intervention for women. Methods: A sample of 15 women aged between 20 to 60 years with Ssukjahun experiences was interviewed and content analysis was used to analyze the data. Results: Six categories and Thirty attributes were derived for Ssukjahun experiences in women. The reason of Ssukjahun is related to illness included vaginitis, insomnia, mental depression, circulation down of hand and feet, repeat abortion, dysmenorrhea, hemorrhoids, disc, rheumatism, and asthma. The place of Ssukjahun was home, oriental hospital and Ssukjahun room. Also method of Ssukjahun included steam methods and burn the wormwood. The time-consuming of Ssukjahun was about 30 minutes. The response and effect in Ssukjahunincluded relax, decreasing rhinitis, weight reduction, feel better, increasing circulation, sleep well, reducing constipation, insomnia, hemorrhoid, back pain, asthma, and dysmenorrhea. The negative effect of Ssukjahun included vesicle, headache, itching sense, generalache, acne, and edema. However, women who did Ssukjahun believed that is the belligerent reaction because it is gone after several times. The preference of Ssukjahun than hospital treatment is related to side effect of medication, temporary method for reducing symptom. Recommends: It is recommended for nurses to understand experience of Ssukjahun in women. If Ssukjahun is to be own nursing intervention, it has to find solutions to encourage positive experiences and overcome negative experiences. Also it recommended research for experience of men.

• 대한간호학회지
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• 제48권2호
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• pp.208-220
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• 2018

Purpose: The aim of this study was to analyze the effects of neurofeedback training for reducing stress and enhancing self-regulation in late adolescence to identify the possibility of use for nursing intervention. Methods: A nonequivalent control group pre-post quasi-experimental design was used. Participants were 78 late adolescents assigned to the experimental group (n=39) that received the neurofeedback training and the control group (n=39). Data were collected on heart rate variability (HRV) and skin conductance level (SCL) to assess stress-biomarker response. The questionnaire contained 164 items from: Positive and Negative Affect Schedule (PANAS), Symptom Checklist-90-Revised (SCL-90-R) and Self-regulatory Ability scale. The neurofeedback training was based on the general adaptation syndrome and body-mind medicine. The intervention was conducted in a total of 10 sessions for 30 minutes per session with high-beta, theta and sensory motor rhythm training on scalp at central zero. Results: There were significant difference in standard deviation of normal to normal interval (p=.036) in HRV and SCL (p=.029) of stress-biomarker response between the two groups. Negative affect (p=.036) in PANAS and obsessive compulsive (p=.023) and depression (p<.001) in SCL-90-R were statistically significant. Self-regulation mode (p=.004) in self-regulation ability scale showed a significant difference between the two groups. Conclusion: The results indicated that the neurofeedback training is effective in stress-biomarkers, psychoemotional stress response and self-regulation. Therefore, neurofeedback training using neuroscientific approach based on brain-mind-body model can be used as an effective nursing intervention for late adolescents in clinics and communities for effective stress responses.

• 대한한방부인과학회지
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• 제18권3호
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• pp.192-202
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• 2005

Purpose : To investigate relation between Heart rate variability(HRV) and Kupperman's index. Methods : From 2004, 3, 15 to 2004, 4, 10, a total 18 female patients(age 40-61) was recruited. but 2 patients was excluded. one was under hormone raplacement therapy, the other was under drug treatment. We measured patient's HRV by SA-2000E(Medicore Co., Ltd., Korea), and they fulfilled kupperman's index and　qustionnaire.　Results : The mean age of patient was 50.13${\pm}$5.78 years. 6 of 16 patients was menopause, 12 of 16 patients had menstruation. half of 16 patients had a understanding about climacteric syndrome. Investigating relation between HRV and kupperman's index, kupperman's index had positive correlation with heart rate significantly. Kupperman's index had negative correlation with SDNN significantly. Kupperman's index had negative correlation with RMS-SD significantly. Conclusion : In this study, we presented relation between HRV and kupperman's index. Furthermore, large scale study is required.