• Title/Summary/Keyword: Negative conversion

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Antibody changes in paragonimiasis patients after praziquantel treatment as observed by ELISA and immunoblot (폐흡충증에서 치료 후 혈청내 특이 항체의 변화)

  • 조승열;김석일
    • Parasites, Hosts and Diseases
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    • v.27 no.1
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    • pp.15-22
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    • 1989
  • To observe antibody changes after praziquantel treatment in paragonimiasis, a total of 46 serum samples from 13 serologically diagnosed patients was collected for 4~28 months. The specific antibody (IgG) levels were measured by enzyme- linked immunosorbent assay (ELISA). All but one patient who needed retreatment became symptom-free within a week. Antibody levels were dropped near to or below a cut-off absorbance (abs.) of 0.25 in varying intervals from 4 to 18 months. Of 9 patients who were retested within 3 months, 5 revealed temporary elevation of antibody level. After the elevation, the levels be낙an to decline slowly to negative ranges. If treated earlier after symptoms developed, the temporary elevation did not occur and intervals to negative conversion were shorter. By sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) /immunoblot, antigen-antibody reactions in individual patient faded gradually without significant changes in reacting antigen bands.

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Recovery Rate of Nontuberculous Mycobacteria and the Clinical Course of Nontuberculous Mycobacterial Pulmonary Disease at a Secondary Hospital (일개 2차 의료기관에서의 비결핵성 마이코박테리아 분리비율 및 폐질환의 임상 경과)

  • Lee, Jae Kwang;Kwon, Hwuck Young;Kwon, Jong Kyu;Lee, Hwa Jeong;Lee, Dong Wook;Lee, Yu Jin;Yoon, Kyung Hwa;Song, Do Young;Lee, Byung Ki;Kim, Yeon Jae
    • Tuberculosis and Respiratory Diseases
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    • v.67 no.3
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    • pp.199-204
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    • 2009
  • Background: To examine the recovery rate of nontuberculous mycobacteria (NTM) from respiratory specimens and the clinical course of NTM pulmonary disease at a 700-bed secondary hospital. Methods: This study analyzed the results of 843 acid-fast bacilli (AFB) culture-positive respiratory specimens from 650 subjects collected between May 2003 and April 2008. In addition, the clinical course of NTM pulmonary disease, diagnosed using criteria established by the American Thoracic Society, was examined. Results: There were 67 (7.9%) NTM isolates recovered from 52 (8.0%) subjects. Among the 535 AFB smear-positive specimens, 34 (6.3%) NTM isolates were recovered. There were 33 (10.7%) NTM isolates were recovered from 308 AFB smear-negative specimens. Of 52 subjects with isolated NTM, M. intracellulare was the most common species at 73.1% (n=33), followed by M. kansassi (n=7), M. abscessus (n=2), M. fortuitum (n=2), and M. avium (n=1). Sixteen (30.8%) patients had NTM pulmonary disease and the most common causative organism was M. intracellulare (n=14, 87.5%). Of these, 6 cases attained negative conversion in culture, 4 cases failed to attain negative conversion because of poor cooperation or expiration from complicated underlying lung disease, and 5 cases were transferred to a higher-grade hospital. Conclusion: The recovery rate of NTM from respiratory specimens was relatively low and the most common species was M. intracellulare. Patients with NTM pulmonary disease showed variable clinical outcomes.

Surgical Management of Multidrug Resistant Pulmonary Tuberculosis (다제내성 폐결핵 환자에서의 수술적 치료)

  • 성숙환;강창현;김영태;김주현
    • Journal of Chest Surgery
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    • v.32 no.3
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    • pp.287-293
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    • 1999
  • Background: Medical treatment of multiple drug resistant(MDR) pulmonary tuberculosis has been quite unsuccessful. We analyzed our experience to identify the benefits and complications of the pulmonary resection in MDR pulmonary tuberculosis. Material and Method: A retrospective review was performed in 27 patients who unerwent pulmonary resection for MDR pulmonary tuberculosis between January 1994 and March 1998. Mean age was 40 years and the average history of diagnosis prior to surgery was 3.1 years. All had resistance to an average of 4.4 drugs, and received second line drugs selected according to the drug sensitivity test. Most patients (93%) had cavitary lesions as the main focus. Bilateral lesions were identified in 19 patients (70%), however, the main focus was recognized in one side of the lung. Eleven patients (41%) were converted to negative sputum smear and/or culture before surgery. Result: Pneumonectomy was performed in 9 patients, lobectomy in 16 and segmentectomy in 2. There was no operative mortality. Morbidity had occurred in 7 patients (26%), prolonged air leak in 3 patients, reoperation due to bleeding in 2, bronchopleural fistula in 1, and reversible neurologic defect in 1. Median follow up period was 15 months (3-45 months). Sputum negative conversion was initially achieved in 22 patients (82%), and with continuous postopertive chemotherapy negative conversion was achieved in other 4 patients (14%). Only one pneumonectized patient (4%) failed due to considerable contralateral cavity. Conclusion: For patients with localized MDR pulmonary tuberculosis and with adequate pulmonary reserve function, surgical pulmonary resection combined with appropriate pre and postoperative anti-tuberculosis chemotherapy can achieve high success rate with acceptable morbidity.

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EFFECT OF DIETARY PROTEIN AND ENERGY LEVELS ON THE PERFORMANCES OF STARCROSS LAYERS

  • Salah Uddin, M.;Tareque, A.M.M.;Howlider, M.A.R.;Jasimuddin Khan, M.;Ahmed, S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.5 no.4
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    • pp.723-731
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    • 1992
  • Two similar experiments were designed to evaluate the interaction of dietary CP and ME levels on the production performance parameters at the age between 155 and 300 days in Starcross layers. In both experiments, the feed intake and mortality decreased but the egg weight, body weight gain and feed conversion efficiency increased as the dietary CP and ME levels increased. The CP intake was highest CP and lowest ME levels. With the increasing CP and decreasing ME levels, the ME intake decreased significantly (Experiments 1 & 2). The $CP{\times}ME$ interactions were significant only on mean egg weight and egg production in Experiment 2. In both the experiments, the CP levels were positively correlated with CP intake, egg weight, body weight gain and egg production and negative correlation with feed intake, mortality percentage and ME intake. The ME levels showed negative correlation with feed intake, protein intake, mortality percentages and positive correlation with all other parameters in both experiments. The highest values were noted for all the parameters (except mortality percentages) in Experiment 1 than that recorded in Experiment 2.

A Study on the VFC type A/D Converter (VFC type A/D Converter에 관한 연구)

  • 김춘성;이종각
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.15 no.6
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    • pp.87-90
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    • 1978
  • In previous VFC type A/D converter high linearity charateristics knave been achieved to several hundred kHz, and in the converter with maximum output frequency of several MHz, the conversion linearity is poor in upper frequency range. In this paper the problem of the extension of the output frequency to MHz range is studied in the following two view points: First, a tunnel diode VCO is used to increase the output frequency range to several MHz. Second, the linearity between the input voltage and the frequency of the output pulse is accomplished by using negative pulse feedback circuit. From the experimental results, it was followed that the linearity of the proposed converter was about 0.209 percent at the frequency of 3.7MHz.

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Identifying the Determinants and the Dynamic Characteristics of ICT Non-Use: A Qualitative Study by Grounded Theory Methodolgy (정보기술 비사용의 결정요인과 동태적 성격의 규명: 근거이론방법론에 의한 질적 연구)

  • Lee, Woong-Kyu
    • The Journal of Information Systems
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    • v.27 no.1
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    • pp.1-20
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    • 2018
  • Purpose The purpose of this study is to identify the determinants of non-use and the dynamic nature of non-use by the qualitative research methodology, grounded theory methodology, as part of identifying the nature of non-use. Design/methodology/approach We applied the grounded theory methodology to a total of 23 college students, including non-users who are not currently using them, users with low intention to use them, and users with high intention to use. We extracted the codes related to the use and proposed the non-use dynamics conversion process based on the coding results. Findings First, the use of information technology can also promote the frequency of use, but can also lead to the use of negative attitudes which would fall in the state of non-use. Second, the user may have both positive and negative attitudes toward the current information technology. Third, if usage is dominated by habits, it is not so easy to change persistent use into an unused state. Fourth, factors that determine the use of specific information technology can be a factor in determining nonuse. This study has contributed to understand the essence of non - use as well as the nature of use, overcoming limitations of quantitative research approach and confirming possibility of grounded theory method in information system research.

Clinical Outcome after Treatment with the First-line Drugs in Patients with Persistent Positive Sputum Smear and Negative Sputum Culture Results (지속적인 객담 도말양성 및 배양음성인 폐결핵환자에서 일차항결핵제로 치료종결한 후의 임상성적)

  • Kwon, Eun-Su;Lee, Jong-Youk
    • Tuberculosis and Respiratory Diseases
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    • v.51 no.4
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    • pp.325-333
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    • 2001
  • Background : This study aimed to estimate the clinical outcome and identify the characteristics of a group of patients with pulmonary tuberculosis who completed anti-tuberculosis therapy with the First-line drugs in spite of having positive smear results with negative sputum culture results over the previous six months. Method : A retrospective chart review of 21 patients who fulfilled the above criteria between 1995 and 1999 was performed. The laboratory data as well as the clinical data of the patients with positive smear results and negative culture results over a six months period were reviewed. Results : The negative conversion of sputum culture results was achieved within $1.3{\pm}1.2$ months and the negative conversion of the sputum smear results was accomplished during $9.5{\pm}3.3$ months. Chest X-rays at 5 months following the institution of anti-tuberculosis therapy from all patients revealed improvements. Four out of 21 patients(19%) relapsed during the follow up, $15.2{\pm}13.4$ months after administering anti-tuberculosis therapy for $13.3{\pm}3.1$ months. Relapses were confirmed from between 3 months and 4 months after the treatment completion. Only one of the four relapses had no past history of anti-tuberculosis therapy and the others had prior treatment twice (p<0.01). The period of anti-tuberculosis treatment was extended to a mean of $4.6{\pm}2.6$ months in 12 patients. However, prolongation of anti-tuberculosis therapy had no affect on the relapse rate (odds ratio, 95% CI 0.18, 2.15). Conclusion : Prolongation of therapy with the First-line drugs is not necessary for patients with persistently positive smear results over 6 months and negative culture results. A patient who has had prior anti-tuberculosis therapy more than twice should be paid the closest attention.

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Disappearance of Hysteria(Conversion Disorder) and the Evolutionary Brain Discord Reaction Theory (히스테리아(전환장애)의 소실과 진화적 뇌신경 부조화 반응 가설)

  • Song, Ji Young
    • Korean Journal of Psychosomatic Medicine
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    • v.24 no.1
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    • pp.28-42
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    • 2016
  • Objectives : The author tried to find out reasons why and how hysteria(and conversion disorder) patient numbers, which were so prevalent even a few decades ago, have decreased and the phenotype of symptoms have changed. Methods : The number of visiting patients diagnosed with conversion disorder and their phenotype of symptoms were investigated through chart reviews in a psychiatric department of a University hospital for the last 12 years. Additionally, the characteristics of conversion disorder patients visiting the emergency room for last 2 years were also reviewed. Those results were compared with previous research results even if it seemed to be an indirect comparisons. The research relied on Briquet P. and Charcot JM's established factors of the vicissitudes of hysteria(and conversion disorder) which has been the framework for more than one hundred and fifty years since hysteria has been investigated. Results : The author found decreased numbers and changes of the phenotype of the hysteria patients(and conversion disorder) over the last several decades. The decreased numbers and changes of the symptoms of those seemed to be partly due to several issues. These issues include the development of the diagnostic techniques to identify organic causes of hysteria, repeated changes to the symptom descriptions and diagnostic classification, changes of the brain nervous functions in response to negative emotions, and the influence of human evolution. Conclusions : The author proposed that the evolutionary brain discord reaction theory explains the causes of disappearance of and changes to symptoms of hysteria(conversion disorder). Most patients with hysteria(conversion disorder) have been diagnosed in the neurological department. For providing more appropriate treatment and minimizing physical disabilities to those patients, psychiatrists should have a major role in cooperating not only with primary care physicians but with neurologists. The term 'hysteria' which had been used long ago should be revived and used as a term to describe diseases such as somatic symptom disorder, functional neurological symptoms, somatization, and somatoform disorders, all of which represent almost the same vague concept as hysteria.

Theoretical considerations on the giant magnetoimpedance effect in amorphous ribbons

  • Phan, Manh-Huong;Nguyen Cuong;Yu, Seong-Cho
    • Proceedings of the Korean Magnestics Society Conference
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    • 2003.06a
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    • pp.60-61
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    • 2003
  • Theoretical considerations on a giant magneto-impedance (GMI) effect in amorphous ribbons (i.e., thin films) have been made in terms of the expressions of effective permeability and impedance derived in the frame of classical electrodynamics and ferromagnetism. The dependence of GMI effect on the external do magnetic field (H$\_$ext/) and the frequency of alternating current are simulated and discussed in the knowledge of energy conversion consisting of the current energy loss, the ferromagnetic energy consumption, and the magnetic energy storage in the film. The obtained results are summarized as follow: (a) As frequency f< 20 ㎒, the real part of effective permeability (${\mu}$′) changes slightly. The peak of the ${\mu}$′curve always locates at H$\_$ext/=H$\_$ani/ - the anisotropy field. However, the peak value of ${\mu}$′ tends to increase with increasing frequency in the frequency range of 11-20 ㎒. (b) In the frequency range, f= 21-23 ㎒, a negative peak additionally appears. Meanwhile, both the positive and negative peak values rapidly increase with increasing frequency and their peak positions shift towards a high H$\_$ext/. (c) The positive peak value of ${\mu}$′ starts to decrease at f= 29 ㎒ and its negative peak does so at about 35 ㎒. Then, both peaks keep such a tendency and their peak positions move to high H$\_$ext/, as increasing frequency. (d) The dependence of the imaginary part of effective permeability (${\mu}$") on the external dc magnetic field and the frequency of the alternating field indicates that there is only one peak involved in ${\mu}$" for the whole frequency range. (e) The impedance vs. magnetic field curves at various frequencies show that there is a critical value of frequency around f= 18-19 ㎒ where the transition between two frequency regimes occurs; the one (low frequency) in which ${\mu}$′ predominantly contributes to the GMI effect and the other (high frequency) in which ${\mu}$" determines the GMI effect.

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Development of Digital map Ver.2.0 representation conversion system for 1/5,000 Topographic mapping (1/5,000 지형도제작을 위한 수치지도 Ver.2.0 자료변환 시스템 개발)

  • 황창섭;이재기
    • Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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    • 2004.04a
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    • pp.321-328
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    • 2004
  • Since National Geographic Information System was started, topographic maps have been made with computer aided editing of digital map, instead of etching map-size negative film. topographic mapping system's necessity is growing more and more, because digital map has changed into Ver.2.0 which include attributes of feature. On the basis of the previous study for analyzing correlation between the digital map feature code and the 1/5,000 topographic map specifications and trying to develop fundamental modules which will play a core role in topographic mapping system, in this study, we apply some 1/5,000 digital maps Ver.2.0 to topographic mapping system have implemented and try to analyze the result.

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