• Title/Summary/Keyword: Negative Weights

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Epidemiologic Characteristics of Death in Breast Cancer Patients and Health Promotion Plans : Using Korean Cancer Registry data (유방암 환자 사망의 역학적 특성과 건강증진 방안 : 국가 암등록 자료를 이용하여)

  • Young-Hee Nam
    • The Journal of Korean Society for School & Community Health Education
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    • v.24 no.1
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    • pp.1-15
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    • 2023
  • Objectives: The purpose of this study was to identify the major influencing factors of breast cancer death and to suggest policy measures to promote the health of breast cancer patients. Methods: The method of this study performed statistical analysis by applying weights to 2,300 cases of breast cancer registration statistics in Korea collected in 2018 due to the relatively small number of mortality data compared to survival. Statistical processing of the collected data was analyzed using SPSS 26.0. Results: The epidemiologic characteristics of death in breast cancer patients were 31.8% in those aged 70 years or older, and the mortality rate was 5.25 times higher in patients aged 70 years or older than those aged 39 years or younger. The anatomical site code was 36.4% in C50.4~C50.6, and the mortality rate was 1.82 times higher in C50.4~C50.6 than in C50.0~C50.1. The tumor size was 40.4% and larger than 4cm, and the mortality rate was 4.53 times higher in tumors larger than 4cm than those smaller than 1cm. The degree of differentiation was 13.9% in the poorly differentiated group, and the mortality rate was 4.38 times higher in the poorly differentiated group than in the highly differentiated group. In the hormone receptor test, non-triple negative cases were 59.6%, and the mortality rate was 0.57 times lower in non-triple negative cases than in triple negative cases. As for lymph node involvement, the presence or absence of lymph node involvement was 78.8%, and the mortality rate with lymph node involvement was 1.36 times higher than that without lymph node involvement. The survival period of 13 to 24 months was the highest at 26.5%, and the average survival period was 25.68 months (±14.830). Conclusion: A policy to advance the timing of national health examinations for early detection of breast cancer is necessary. In addition, a bill for the mandatory placement of health educators in medical institutions for patients with special diseases such as breast cancer should be prepared.

Effects of Dietary Supplementation of Mixed Probiotics on Production Performance and Intestinal Environment in Broiler Chicken (혼합 생균제의 사료 내 첨가 급여가 육계의 생산성과 장내 환경에 미치는 영향)

  • Oh, Seong Taek;Kang, Chang Won;Kim, Eun Jib
    • Korean Journal of Poultry Science
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    • v.41 no.2
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    • pp.143-149
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    • 2014
  • This study was conducted to investigate the effects of dietary supplementation of the mixture of probiotics (MP) on growth performance, size of small intestine, cecal microflora and ammonia concentrations in broiler chicks. A total of 700, one-day-old male broiler chicks were randomly allotted to four treatments with seven replications having 25 birds per pen. The birds were fed one of the four experimental diets; containing no antibiotics nor MP (negative control, NC), containing antibiotics without MP(positive control, PC), negative control with MP 0.1% and negative control with MP 0.2% for 5 weeks. During overall experiment, birds in PC and MP treatments had higher final BW and daily BW gains than birds in NC treatments; however, the significance was not identified. The feed conversion ratio of the chicks fed the diet containing MP was significantly improved as compared to those fed the NC diets. The weights of jejunum were increased by the MP (p<0.05), but weights of duodenum, ileum and length of small intestine were similar among the groups. Birds in PC treatment showed lower populations of total microbes and lactic acid bacteria than other groups (p<0.05), cecal ammonia concentrations of the chicks fed the diet containing MP were significantly decreased as compared to those of NC and PC (p<0.01). In conclusion, MP added to the broiler diets improved the feed conversion rate and reduced cecal ammonia concentration.

Correlation and Combining Ability related to the Growth Characteristics in F1 Hybrids by Diallel Cross of Viola tricolor (팬지의 일대 잡종에서 생육관련 형질의 상관관계 및 조합능력)

  • Song, C.Y.;Hong, K.H.;Kang, Y.K.;Lee, K.H.;Kim, J.C.
    • Journal of Practical Agriculture & Fisheries Research
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    • v.4 no.1
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    • pp.70-79
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    • 2002
  • This study was conducted to determine correlations and combining abilities of leaf lengths, leaf widths, petiole lengths, number of branches, number of leaves, leaf areas, fresh weights, dry weights and number of flowers in F1 crosses made with the partial seven-parent diallel cross in Viola tricolor. Leaf lengths and leaf widths showed highly positive correlation with petiole length and negative correlation with number of branches, number of leaves and number of flowers. There was positive correlation between the number of leaves and flowers as well as between leaf area and fresh weight. Mean squares of general combining ability(GCA) and specific combining ability(SCA) were highly significant for all the parameters. Variance component values of SCA were greater than those of GCA for all the parameters except leaf length, implying preponderance of non-additive gene actions for these characters. The lines C and G for leaf lengths and widths, the lines A and F for number of leaves, the lines A, B and G for leaf areas, and the lines B and F for number of flowers showed relatively high GCA effects. The crosses of A×B and B×D exhibited high SCA effects on increasing leaf lengths, leaf widths, number of leaves, fresh weights and number of flowers. And also the crosses of B×E and D×G exhibited high SCA effects on decreasing leaf lengths, leaf areas and fresh weights as well as increasing number of flowers. The broad sense heritabilities of most characters were high compared with the narrow sense one. Those of leaf length, leaf width, petiole length and number of leaves were high in both the broad and narrow sense heritabilities.

Comparison of Principle Components and Internal Quality of Eggs by Age of Laying Hens and Weight Standard (산란 주령 및 중량 규격에 따른 계란의 주요 성분 및 내부 품질 비교)

  • Lee, Jae Cheong;Kim, Sun Hyo;Sun, Chang Wan;Kim, Chang Ho;Jung, Samooel;Lee, Jun Heon;Jo, Cheorun
    • Korean Journal of Poultry Science
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    • v.40 no.1
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    • pp.49-55
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    • 2013
  • The objective of this study was to compare the principle components and internal quality of eggs by age of laying hens and weight standard. The eggs (2,140 in total) used were from Hy-Line Brown reared from 18 to 63 weeks of ages and all were higher than appearance grade B by animal grading standard of Korea. Eggs were investigated their principle components, internal quality index, and their relationship. The weights of whole egg, shell, yolk, and albumen were increased while albumen height and Haugh unit were decreased by age of laying hens. When the composition of egg was investigated after sorting by ages, the ratio of egg yolk increased while that of albumen decreased. Egg shell composition was not shown significant difference by age. Age of laying hens had positive correlation with the weights of whole egg, shell, yolk, and albumen while albumen height and Haugh unit showed negative correlation. Also, the albumen height and Haugh unit were decreased by increase of weight of whole egg or principle components of egg.

Assessments of Rice Yield Loss According to Infection Time of Neck Blast (병 이삭도열병의 발병시기에 따른 수량감소 비교)

  • Shim, Hong-Sik;Kim, Yong-Ki;Han, Seong-Sook;Sung, Jae-Mo
    • Research in Plant Disease
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    • v.9 no.2
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    • pp.68-71
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    • 2003
  • Correlation between rice yield loss and infection time of neck blast after panicle emergence was analyzed in paddy fields at Icheon in 1999 and 2000. As the neck blast occurred at early heading stage, the yield loss of a early maturity variety, Jinmibyeo, ranged from 83.9% to 81.6%, while it ranged from 44.3% to 33.1% when the disease developed 30 days after heading. The regression equations of yield loss(y) caused by the neck blast infection time(x) in Jinmibyeo were y =1.2717x + 79.523(R2 = 0.9487) and y = 1.6872x + 74.545(R2 = 0.7993) in 1999 and 2000. In a mid-lately maturity variety, Chucheongbyeo, yield loss ranged from 64.9% to 47.8% when the disease developed at early heading stage. While it ranged from 29.1% to 8.9% when the disease occurred 40 days after heading. The regression equations of yield loss caused by the disease in Chucheongbyeo were y= 1.2717x + 79.523($R^2$ = 0.9487) and y = 1.6872x + 74.545(($R^2$ = 0.7993) in 1999 and 2000. Weights of 1,000 rice grains of Jinmibyeo and Chucheongbyeo were also drastically decreased to 38.3% and 57.3%, respectively, compared to healthy control when the disease occurred at early heading stage. However, weights of the two cultivars were 87.6% and 92.9% compared to control when the disease developed after 40 days of heading. Results indicated that there is a highly negative correlation between rice yield loss and infection time of the neck blast.

Evaluation of General Toxicity and Genotoxicity of the Silkworm Extract Powder

  • Heo, Hyun-Suk;Choi, Jae-Hun;Oh, Jung-Ja;Lee, Woo-Joo;Kim, Seong-Sook;Lee, Do-Hoon;Lee, Hyun-Kul;Song, Si-Whan;Kim, Kap-Ho;Choi, Yang-Kyu;Ryu, Kang-Sun;Kang, Boo-Hyon
    • Toxicological Research
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    • v.29 no.4
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    • pp.263-278
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    • 2013
  • The silkworm extract powder contain 1-deoxynojirimycin (DNJ), a potent ${\alpha}$-glycosidase inhibitor, has therapeutic potency against diabetes mellitus. Therefore, natural products containing DNJ from mulberry leaves and silkworm are consumed as health functional food. The present study was performed to evaluate the safety of the silkworm extract powder, a health food which containing the DNJ. The repeated toxicity studies and gentic toxicity studies of the silkworm extract powder were performed to obtain the data for new functional food approval in MFDS. The safety was evaluated by a single-dose oral toxicity study and a 90 day repeated-dose oral toxicity study in Sprague-Dawley rats. The silkworm extract powder was also evaluated for its mutagenic potential in a battery of genetic toxicity test: in vitro bacterial reverse mutation assay, in vitro chromosomal aberration test, and in vivo mouse bone marrow micronucleus assay. The results of the genetic toxicology assays were negative in all of the assays. The approximate lethal dose in single oral dose toxicity study was considered to be higher than 5000 mg/kg in rats. In the 90 day study, the dose levels were wet at 0, 500, 1000, 2000 mg/kg/day, and 10 animals/sex/dose were treated with oral gavage. The parameters that were monitored were clinical signs, body weights, food and water consumptions, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy findings, organ weights, and histopathological examination. No adverse effects were observed after the 90 day administration of the silkworm extract powder. The No-Observed-Adverse-Effect-Level (NOAEL) of silkworm extract powder in the 90 day study was 2000 mg/kg/day in both sexes, and no target organ was identified.

Estimation of Genetic Parameters of Body Weights in Hanwoo Steers(Korean Cattle), Bos Taurus Coreanae Using Random Regression Model (임의회귀모형을 이용한 한우 거세우 체중의 유전모수 추정)

  • Seo, Kang- Seok;Salces, Agapita J.;Yoon, Du- Hak;Lee, Hong- Gu;Kim, Sang- Hoon;Choi, Te- Jeong
    • Journal of Animal Science and Technology
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    • v.50 no.2
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    • pp.151-156
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    • 2008
  • The study aimed to estimate genetic parameters of body weights in Hanwoo steers using random regression model and compare it with single trait animal model. A total of 1,372 Hanwoo steers that belonged to progeny testing program of the Hanwoo Genetic Improvement conducted at the Livestock Improvement Main Center of the National Agricultural Cooperative Federation (LIMC-NACF) in Rep. of Korea were used. Results of the random regression model fitting quadratic function revealed heritability values from 0.17 to 0.30 for the whole testing days up to 800 days. The results of the animal model showed estimated heritability values ranged from 0.24 to 0.36. Estimates of permanent environmental correlations tended to increase with increasing test in days. Unlike in the direct genetic correlation that at early stage the estimate was slightly negative it was 0.30 then increased to approach unity at later stage of test. Comparing the results between random regression model and the animal model showed not much differences and both followed similar pattern and therefore the use of random regression model for the national genetic evaluation of Hanwoo could be implemented.

Isoflavone Content and its Relationship with Other Seed Quality Traits of Soybean Cultivars Collected in South Korea

  • Kim, Sun-Lim;Chi, Hee-Youn;Kim, Jung-Tae;Lee, Yeong-Ho;Park, Nam-Kyu;Son, Jong-Rok;Kim, Si-Ju
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.1
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    • pp.81-88
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    • 2006
  • The 117 soybean cultivars were collected from nine provinces in Korea, and various seed quality traits along with isoflavone contents were evaluated to elucidate their relationship. The 100-seed weight of the black soybean (31.2 g) was significantly higher (p<0.05) than yellow soybeans (28.6 g). The composition of genistein, daidzein, and glycitein accounted for 75.8, 22.8, and 1.4 % of total isoflavone in yellow soybean cultivars, while their compositions in black soybeans were 58.5, 39.7, and 1.8%, respectively. The mean contents of total isoflavone in yellow and black soybean were $l,561.6{\mu}g\;g^{-1}\;and\;l,018.3{\mu}g\;g^{-1}$. The isofalvone content showed significant variation among cultivars when classified by the seed size. In the yellow soybeans, total isoflavone content was higher in small size soybean cultivars $(1,776.0{\mu}g\;g^{-1})$ and medium size soybean cultivars $(1,714.3{\mu}g\;g^{-1})$ compared to large size ones $(1,518.5{\mu}g\;g^{-1})$. Genistein content was proved as the major factor determining the relationship between isoflavone content and 100-seed weights (r =-0.206*). Daidzein and glycitein, however, showed no significant relationship with the 100-seed weights. Isoflavone content was not significantly correlated with color parameters L (lightness) and a (redness) values, but color parameter b (yellowness) was positively correlated with glycitein (r=0.264*) in the yellow soybeans, while its negative correlation between daidzein (r=-0.245*) and total isoflavone (r=-0.256*) were observed in black soybeans. However, these findings suggested that the seed color value may not serve as an effective parameter for estimating the isoflavone intensity of the soybeans. Variation of protein and lipid contents between yellow soybeans (n=58) and black soybeans (n=59) was relatively stable, however, protein and lipid contents have no significant relationship with isoflavone content.

An Efficient Diagnosis Algorithm for Multiple Stuck-at Faults (다중 고착 고장을 위한 효율적인 고장 진단 알고리듬)

  • Lim Yo-Seop;Lee Joo-Hwan;Kang Sung-Ho
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.9 s.351
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    • pp.59-63
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    • 2006
  • With the increasing complexity of VLSI devices, more complex faults have appeared. Many methods for diagnosing the single stuck-at fault have been studied. Often multiple defects on a foiling chip better reflect the reality. So, we propose an efficient diagnosis algorithm for multiple stuck-at faults. By using vectorwise intersections as an important metric of diagnosis, the proposed algorithm can diagnose multiple defects using single stuck-at fault simulator. In spite of multiple fault diagnosis, the number of candidate faults is also drastically reduced. For fault identification, positive calculations and negative calculations based on variable weights are used for the matching algorithm. Experimental results for ISCAS85 and full-scan version of ISCAS89 benchmark circuits prove the efficiency of the proposed algorithm.

An improved Bellman-Ford algorithm based on SPFA (SPFA를 기반으로 개선된 벨만-포드 알고리듬)

  • Chen, Hao;Suh, Hee-Jong
    • The Journal of the Korea institute of electronic communication sciences
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    • v.7 no.4
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    • pp.721-726
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    • 2012
  • In this paper, we proposed an efficient algorithm based on SPFA(shortest path faster algorithm), which is an improved the Bellman-Ford algorithm. The Bellman-Ford algorithm can be used on graphs with negative edge weights unlike Dijkstra's algorithm. And SPFA algorithm used a queue to store the nodes, to avoid redundancy, though the Bellman-Ford algorithm takes a long time to update the nodes table. In this improved algorithm, an adjacency list is also used to store each vertex of the graph, applying dynamic optimal approach. And a queue is used to store the data. The improved algorithm can find the optimal path by continuous relaxation operation to the new node. Simulations to compare the efficiencies for Dijkstra's algorithm, SPFA algorithm and improved Bellman-Ford were taken. The result shows that Dijkstra's algorithm, SPFA algorithm have almost same efficiency on the random graphs, the improved algorithm, although the improved algorithm is not desirable, on grid maps the proposed algorithm is very efficient. The proposed algorithm has reduced two-third times processing time than SPFA algorithm.