• Pediatric Infection and Vaccine
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• 제4권1호
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• pp.150-154
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• 1997

Since 1972, a unique lymphadenitis called as subacute necrotizing lymphadenitis has been described in many Japanese literature. Originally described in Japan, it now appears worldwide. It mainly affects young women and usually manifests as fever and lymphdenopathy. The pathology is characterized by necrosis with loss of nodal architecture, infiltration with many histiocytes, and an absence of granulocytes. We report a case of subacute necrotizing lymphadenitis in axillary area. 4 10-year-old male child was admitted with a one-month history of fever, swelling in the axillary area. He treated with intravenous antibiotics. Despite treatment he remained febrile for the next ten days. 4 dissection of the axillary swelling was then performed, as was a diagnostic lymph node biopsy. The patient's condition resolved over several days and he was discharged.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1993년도 제27차 학술대회 초록집
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• pp.110-110
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• 1993

괴사성 임프절염(기구찌 병)은 원인이 알려지지 않은 새로운 질병으로서 주로 젊은 여자의 경부 임프절을 침범하여 임프절 비대를 일으키며, 대부분 수개월 내에 자연 소실되는 양호한 임상 경과를 보인다. 임상적으로 국소 임프절 비대가 특징적이며 때로는 압통, 발열, 체중 감소, 백혈구 수의 감소 또는 적혈구 침강 속도의 증가를 보이며 악성 임프종 및 결핵과의 감별을 요한다. 특징적인 조직 병리학적소견은 임프절의 괴사, 세포핵 붕괴 등을 보이고 형질세포의 침윤은 없다. 저자들은 1990년 3월부터 1993년 1월까지 괴사성 임프절염으로 확진된 19례를 검토한 후 본 질환의 보다 정확한 진단과 적절한 치료를 위하여 보고하는 바이다.

• 대한기관식도과학회지
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• 제2권2호
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• pp.264-267
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• 1996

Necrotizing lymphadenitis is a peculiar reactive condition with a predilection for cervical lymph nodes commonly in young women. It is characterized by persistent, painless cervical adenopathy with or without fever. Although the histologic features may be confused with those of malignant lymphoma, to our knowledge the natural history has been benign in all cases to date. The excised lymph nodes were moderately enlarged and typically showed focal, well-circumscribed, paracortical, necrotizing lesions, and abundant karyorrhectic debris, scattered fibrin deposits, aggregates of large mononuclear cells, and a paucity of plasma cells and neutrophils. Recently we experienced two female cases of necrotizing lymphadenitis and report with a review of literature.

• Pediatric Infection and Vaccine
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• 제10권1호
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• pp.123-126
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• 2003

저자들은 내원 10일 전부터 발현된 경부 종괴를 주소로 내원한 12세 여아에서 혈청학적 검사상 증명된 Yersinia 감염을 동반한 아급성 괴사성 림프절염 1례를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제3권2호
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• pp.212-216
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• 2000

아급성 괴사성 림프절염은 주로 젊은 여성에서 흔한 양성 질환으로 알려져 있다. 그러나 소아에서도 드물지 않게 보고가 있어 소아 불명열의 원인으로서 생각되어져야 한다. 아울러 전형적인 증상들 외에 간염이 동반될 수도 있는데 이 경우 예후는 양호하며 특이한 간조직 소견을 보이지는 않는다. 저자들은 아급성 괴사성 림프절염의 진단이 내려진 환아에서 합병된 간염을 경험하고 간조직검사를 시행하였기에 문헌 고찰과 함께 보고하는 바이다.

• Pediatric Infection and Vaccine
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• 제8권1호
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• pp.118-122
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• 2001

저자들은 이전의 보고와 달리 알레르기의 과거력이 없으면서 ANA 양성을 보인 6세된 여아에서 아급성 괴사성 림프절염 1례를 경험하였기에 주로 자가 면역 질환과의 관련성에 대한 최근의 문헌 고찰과 함께 보고하는 바이다.

• 대한기관식도과학회지
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• 제6권1호
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• pp.21-28
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• 2000

Background:Subacute necrotizing lymphadenitis or Kikuchi's disease is unknown ethiology and self-limiting process. This disease predominantly affects young women age but rarely affects pediatrics, and usually manifests as lymphadenopathy and fever. Even though this disease is self-limited, benign process, many cases are misidentified as malignant lymphoma. The purpose of this study is to report the clinicopathologic finding, radiological finding and many labolatory test and to compare with characteristics of adult patients in this disease. Meterial and Methods:We reviewed 27 pediarics patients with subacute necrotizing lymphadenitis by excision biopsy or fineneedle aspiration cytology.Result:The most common symptomes were palpation of cervical lymh node(88.9%) and fever(66.7%). The common site of the involvement was cervical lymph node. The multiple involvement was 93% and bilateral involvement was 59%. Leukopenia(52%) and elevated erythrocyte sedimentation rates(93%) appeared in abnormal laboratory data. Microscopically, the characteristic finding was the wide area of florid nuclear dusts engulfed by histiocytes and well-circumscrbed area with eosinophilic fibrinoid material. There was a striking degree ofkaryorrhexis and an absence of granulocyte with paucity of plasma cell. All patients recovered with the conservative treatment and there was no specific complication and recurrence. Conclusion : We reviewed pediatric patients with this disease. Characteristics of this disease inpediatric patients were similar to adult patients.

• 대한기관식도과학회지
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• 제6권2호
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• pp.164-171
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• 2000

Background and Objectives： Necrotizing lymphadenitis or Kikuchi's disease is characterized by cervical lymphadenopathy of unknown etiology with unique histologic findings in young female patients. The importance of this disease lies in the fact that it can be easily misdiagnosed as malignant lymphoma, hence, clinicians need to aware of this disease entity. The purpose of this study is to report the clinicopathologic findings, radiographic findings, and many laboratory tests in order to contribute to the diagnosis and treatment of necrotizing lymphadenitis. Materials and Methods： We evaluated 31 patients, who were diagnosed as necrotizing lymphadenitis by excisional biopsy or fine needle aspiration cytology or ultrasound guided 18G cutting needle biopsy, retrospectively. Result : The median age was 24.8 years (range 12 to 43 years) and the male to female ratio was 1 : 2.4(9：22), with 14 females (45.1%) under 30 years. The common chief complaints were neck mass, easy fatigue and fever. Lymph node enlargement was limited to the cervical area in most cases (28cases : 90.3%). The involved lymph nodes were usually multiple (20cases : 64.5%), unilateral (26cases 83.9%) and small sized. Leukopenia (19cases : 61.3%) and elevation of ESR (18cases : 58.1%) appeared most frequently in the abnormal laboratory data. These symptoms will be gone spontaneoulsy without any specific treatment in several weeks or months. Conclusion : We should consider open biopsy or fine needle aspiration cytology or ultrasound guided cutting needle biopsy with lymph node in patients who have cervical lymphadenopathy with easy fatigue and fever, especially young women to exclude other conditions such as malignant lymphoma and tuberculosis, etc.

• Annals of Clinical Neurophysiology
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• 제9권2호
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• pp.93-96
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• 2007

A 34-year-old man presented with a severe headache, fever, and cervical lymphadenopathy followed by generalized tonic-clonic seizure. Evaluations showed splenomegaly, elevated liver enzymes, and 380 white blood $cells/mm^3$ in the cerebrospinal fluid. Two weeks after admission, he developed sudden vertigo. Examination revealed spontaneous horizontal-torsional nystagmus to the right and bithermal caloric tests documented left canal paresis. A cervical lymph node biopsy disclosed subacute necrotizing lymphadenitis. We report a case of aseptic meningitis and unilateral vestibulopathy associated with histiocytic necrotizing lymphadenitis (Kikuchi's disease).

• 대한기관식도과학회지
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• 제4권1호
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• pp.127-131
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• 1998

Histiocytic necrotizing lymphadenitis(NHL), or Kikuchi-Fujimoto disease, is of unknown origin that causes persistently enlarged cervical lymph nodes unresponsive to antibiotic therapy, usually in young women. Symptoms of NHL include tender cervical adenopathy, fever, weight loss, and night sweats. Laboratory studies usually reveal leukopenia and increased erythrocyte sedimentation rate. Lymph node biopsy reveals areas with frank cell necrosis, karyorrhexis, and absence of plasma cells. NHL follows a benign course, but shoud be differentiated from other diseases such as inflammatory, granulmomatous and malignant lymphadenopathies. We describe . three cases of NHL with a review of the literature.