• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.407.3-408
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• 2002

A portable near infrared (NIR) system which was newly integrated by our lab has been used to develop a non-invasive blood glucose monitoring. The portable NIR system includes a tungsten halogen lamp, a photo diode array type-InGaAs detector, and specialized reflectance fiber optic probes. The shape of probes is composed of two parts. one for illumination into sample and the other for receiving the radiation from sample. Three kinds of probes with different distance between illumination and receiving part. such as 0.03. 0.1. and 0.5mm, were investigated for optimization. (omitted)

• Journal of Gastric Cancer
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• 제21권2호
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• pp.191-202
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• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.

• 천문학논총
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• 제27권4호
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• pp.209-212
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• 2012

We present the results of the near-infrared (NIR) to mid-infrared (MIR) slit spectroscopic observations of the diffuse emission toward nine positions in the nearby irregular galaxy Large Magellanic Cloud (LMC) with the Infrared Camera (IRC) on board AKARI. The unique characteristic of AKARI/IRC provides a great opportunity to analyze variations in the unidentified infrared (UIR) bands based on continuous spectra from 2.5 to $13.4{\mu}m$ of the same slit area. The observed variation of $I_{3.3}/I_{11.3}$ suggests destruction of small-sized UIR band carriers, polycyclic aromatic hydrocarbons (PAHs) in harsh environments. This result demonstrates that the UIR $3.3{\mu}m$ band provides us powerful information on the excitation conditions and/or the size distribution of PAHs, which is of importance for understanding the evolutionary process of hydrocarbon grains in the Universe. It also suggests a new diagnostic diagram of two band ratios, such as $I_{3.3}/I_{11.3}$ versus $I_{7.7}/I_{11.3}$, for the interstellar radiation conditions. We discuss on the applicability of the diagnostic diagram to other astronomical objects, comparing the LMC results with those observed in other galaxies such as NGC 6946, NGC 1313, and M51.

• 한국토양비료학회지
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• 제45권4호
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• pp.497-502
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• 2012

This study investigates the prediction of soil OM on Korean soils using the Visible-Near Infrared (Vis-NIR) spectroscopy. The ASD Field Spec Pro was used to acquire the reflectance of soil samples to visible to near-infrared radiation (350 to 2500 nm). A total of 503 soil samples from 61 Korean soil series were scanned using the instrument and OM was measured using the Walkley and Black method. For data analysis, the spectra were resampled from 500-2450 nm with 4 nm spacing and converted to the $1^{st}$ derivative of absorbance (log (1/R)). Partial least squares regression (PLSR) and regression rules model (Cubist) were applied to predict soil OM. Regression rules model estimates the target value by building conditional rules, and each rule contains a linear expression predicting OM from selected absorbance values. The regression rules model was shown to give a better prediction compared to PLSR. Although the prediction for Andisols had a larger error, soil order was not found to be useful in stratifying the prediction model. The stratification used by Cubist was mainly based on absorbance at wavelengths of 850 and 2320 nm, which corresponds to the organic absorption bands. These results showed that there could be more information on soil properties useful to classify or group OM data from Korean soils. In conclusion, this study shows it is possible to develop good prediction model of OM from Korean soils and provide data to reexamine the existing prediction models for more accurate prediction.

• 센서학회지
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• 제28권5호
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• pp.305-310
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• 2019

The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishing the concentrations of HbA1c control solutions at 5%, 7%, and 9%.

• 천문학회보
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• 제41권2호
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• pp.54.1-54.1
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• 2016

Stellar wind and radiation pressure from massive stars can trigger the formation of new generation of stars. The sequential age distribution of stars, the morphology of cometary globules, and bright-rimmed clouds have been accepted as evidence of triggered star formation. However, these characteristics do not necessarily suggest that new generation of stars are formed by the feedback of massive stars. In order to search for any physical connection between star forming events, we have initiated a study of gas and stellar kinematics in NGC 1893, where two prominent cometary nebulae are facing toward O-type stars. The spectra of gas and stars in optical and near-infrared (NIR) wavelength are obtained with Hectochelle on the 6.5m MMT and Immersion GRating INfrared Spectrograph on the 2.7m Harlan J. Smith Telescope at McDonald observatory. In this study, the radial velocity field of gas across the cluster is investigated using $H{\alpha}$ and [N II] ${\lambda}$ 6584 emission lines, and that of the cometary nebula Sim 130 is also probed using 1-0 S(1) transition line of $H_2$. We report a distinctive velocity field of the cometary nebulae and many ro-vibrational transitions of $H_2$ even at high energy levels in the NIR spectra. These properties indicate the interaction between the cometary nebulae and O-type stars, and this fact can be a clue to triggered star formation in NGC 1893.

• 한국작물학회지
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• 제42권2호
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• pp.173-181
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• 1997

태양복사 스펙트럼을 이용하여 벼 군락의 엽면적지수를 비파괴적인 방법으로 추정하고자 1993년 경기도 수원기상대 포장에서 조생종 진부벼와 중만생종 대청벼, 일품벼를 공시하여 벼 군락의 태양광 반사특성과 엽면적지수의 시기별 변화를 조사한 결과는 다음과 같다. 1. 출수이전의 생육기간동안에 태양광의 파장별 반사율은 가시광 파장대에서는 0.1이하로 낮았고, 근적외광 파장대에서는 0.1∼0.5 이상이었다. 가시광 파장대에서는 LAI가 증가할수록 반사율이 감소하였고, 근적외광 파장대는 LAI가 증가할수록 반사율도 증가하였다. 2. 출수전에 근적외광 파장대(720∼1,100nm)의 반사율을 가시광 파장대 (400∼700nm)의 반사율로 나눈 비율이 LAI와 높은 상관을 보였으며, 가시광 파장대중에서는 녹색, 적색파장보다 청색파장(400∼500nm)의 반사율로 나눈 비율이 높은 상관을 보였다. 3. 근적외광 파장의 반사율을 청색파장의 반사율로 나눈 비율중에서 특히 R910/R460 비율이 LAI와 가장 높은 정의 상관을 보였다. 4. 출수이전의 R910/R460과 LAI의 회귀식을 이용한 추정식 Y=0.160799-X0.79776는 실측치와의 상관관계가 매우 높았다. 5. 출수이후엔 근적외광 파장(720∼1,100nm)의 반사율을 적색파장(600∼700nm)의 반사율로 나눈 비율이 청색이나 녹색파장의 반사율로 나눈 것보다 LAI와의 상관이 높았다.

• 대한원격탐사학회지
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• 제14권3호
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• pp.307-314
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• 1998

To examine the detectability of the yellow sand and/or aerosol from China crossing over the Yellow Sea within the range of OSMI wavelengths(400-900 nm), we have investigated the optical characteristics of aerosols in yellow sand events observed on April, 1998 in Seoul. The spectral reflectance(%) and aerosol optical thickness in the range of Visible(VIS) and near Infrared (NIR) wavelengths were derived from the measurements of solar radiation using the GER-2600 spectroradiometer and sunphotometer during the April, 1798. The average spectral reflectance for the yellow sand events is over 40% and higher around 14:30 than 12:00 LST, but that for clear days is about 20% both at 12:00 and 14:30 LST in the range of 500-900 nm. The aerosol optical thickness at 501 nm varied from 0.25 on very clear day to 1.01 during a so-called "yellow-sand" episode and that for 673 nm varied from 0.14 to 0.92, respectively.

• 한국작물학회지
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• 제42권3호
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• pp.255-262
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• 1997

벼 군락에서 건물생산량을 태양광의 반사스펙트럼 특성을 이용하여 추정하고자 1993년 4월부터 10월까지 경기도 소재 수원기상대 구내 포장에서 조생종 진부벼와 중만생종 대청벼, 일품벼를 공시 품종으로 하고 생육시기별 태양광 반사스펙트럼과 건물중을 조사한 결과 다음과 같다. 1. 출수전에 근적외광 파장대(720∼l,100nm)의 반사율을 가시광 파장대 (400∼700nm)의 반사율로 나눈 비율이 건물생산량과 상관이 높았으며, 가시광 파장대 중에서도 녹색, 적색파장보다 청색파장(400∼500nm)의 반사율로 나눈 비율이 건물생산량과의 상관이 높았다. 2. 적외광 파장의 반사율을 청색파장의 반사율로 나눈 비율 중에서 특히 R910 /R460 비율이 건물생산량과 가장 높은 정의 상관을 보였다. 3. 출수이전에 R910/R460 비율과 건물생산과의 회귀식을 이용한 추정식 Y=21.24284 X-212.734는 실측치와의 상관관계는 매우 높았다. 4. 출수이후엔 근적외광 파장(720∼l,100nm)의 반사율을 적색파장(600∼700nm)의 반사율로 나눈 비율이 청색이나 녹색파장의 반사율로 나눈 비율보다 건물생산량과의 상관이 더 높았다.

• 대한원격탐사학회지
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• 제28권5호
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• pp.501-508
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• 2012

알베도는 지구 복사균형을 이루는 요소 중에서 지표의 에너지 균형에 직접적으로 영향을 주는 인자로 알려져 있다. 이러한 알베도 변화는 토양 수분량, 식생, 태양광의 입사 각도, 적설 등의 변화를 포함하여 지구 복사균형과 그것이 기후와 식생 변화에 미치는 영향력을 이해할 수 있는 결정적인 변수로 작용한다. 따라서 알베도 변화 모니터링은 기후 변화 예측에서 필요한 과정 중 하나이다. 본 연구에서는 동북아시아의 알베도 변화를 관측하기 위하여 2001년부터 2011년의 MODIS Albedo 16-Day 자료를 이용하였다. 연간 알베도 변화에서 식생이 활발한 토지피복의 알베도 값이 NIR 밴드에서 높은 알베도 값을 VIS 밴드에서 낮은 알베도 값을 가짐을 확인하였고, 2002년을 기준으로 고비사막 부근과 만주지역의 알베도 값이 변화를 보여 식생 변화 지역으로 사료되어 세부 연구영역으로 선정하였다. 또한 최솟값의 변화로 두 지역 모두 2010년 이후 식생이 악화됨을 감지할 수 있었다.