• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.407.3-408
• /
• 2002

A portable near infrared (NIR) system which was newly integrated by our lab has been used to develop a non-invasive blood glucose monitoring. The portable NIR system includes a tungsten halogen lamp, a photo diode array type-InGaAs detector, and specialized reflectance fiber optic probes. The shape of probes is composed of two parts. one for illumination into sample and the other for receiving the radiation from sample. Three kinds of probes with different distance between illumination and receiving part. such as 0.03. 0.1. and 0.5mm, were investigated for optimization. (omitted)

• Journal of Gastric Cancer
• /
• v.21 no.2
• /
• pp.191-202
• /
• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.

• Publications of The Korean Astronomical Society
• /
• v.27 no.4
• /
• pp.209-212
• /
• 2012

We present the results of the near-infrared (NIR) to mid-infrared (MIR) slit spectroscopic observations of the diffuse emission toward nine positions in the nearby irregular galaxy Large Magellanic Cloud (LMC) with the Infrared Camera (IRC) on board AKARI. The unique characteristic of AKARI/IRC provides a great opportunity to analyze variations in the unidentified infrared (UIR) bands based on continuous spectra from 2.5 to $13.4{\mu}m$ of the same slit area. The observed variation of $I_{3.3}/I_{11.3}$ suggests destruction of small-sized UIR band carriers, polycyclic aromatic hydrocarbons (PAHs) in harsh environments. This result demonstrates that the UIR $3.3{\mu}m$ band provides us powerful information on the excitation conditions and/or the size distribution of PAHs, which is of importance for understanding the evolutionary process of hydrocarbon grains in the Universe. It also suggests a new diagnostic diagram of two band ratios, such as $I_{3.3}/I_{11.3}$ versus $I_{7.7}/I_{11.3}$, for the interstellar radiation conditions. We discuss on the applicability of the diagnostic diagram to other astronomical objects, comparing the LMC results with those observed in other galaxies such as NGC 6946, NGC 1313, and M51.

• Korean Journal of Soil Science and Fertilizer
• /
• v.45 no.4
• /
• pp.497-502
• /
• 2012

This study investigates the prediction of soil OM on Korean soils using the Visible-Near Infrared (Vis-NIR) spectroscopy. The ASD Field Spec Pro was used to acquire the reflectance of soil samples to visible to near-infrared radiation (350 to 2500 nm). A total of 503 soil samples from 61 Korean soil series were scanned using the instrument and OM was measured using the Walkley and Black method. For data analysis, the spectra were resampled from 500-2450 nm with 4 nm spacing and converted to the $1^{st}$ derivative of absorbance (log (1/R)). Partial least squares regression (PLSR) and regression rules model (Cubist) were applied to predict soil OM. Regression rules model estimates the target value by building conditional rules, and each rule contains a linear expression predicting OM from selected absorbance values. The regression rules model was shown to give a better prediction compared to PLSR. Although the prediction for Andisols had a larger error, soil order was not found to be useful in stratifying the prediction model. The stratification used by Cubist was mainly based on absorbance at wavelengths of 850 and 2320 nm, which corresponds to the organic absorption bands. These results showed that there could be more information on soil properties useful to classify or group OM data from Korean soils. In conclusion, this study shows it is possible to develop good prediction model of OM from Korean soils and provide data to reexamine the existing prediction models for more accurate prediction.

• Journal of Sensor Science and Technology
• /
• v.28 no.5
• /
• pp.305-310
• /
• 2019

The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishing the concentrations of HbA1c control solutions at 5%, 7%, and 9%.

• The Bulletin of The Korean Astronomical Society
• /
• v.41 no.2
• /
• pp.54.1-54.1
• /
• 2016

Stellar wind and radiation pressure from massive stars can trigger the formation of new generation of stars. The sequential age distribution of stars, the morphology of cometary globules, and bright-rimmed clouds have been accepted as evidence of triggered star formation. However, these characteristics do not necessarily suggest that new generation of stars are formed by the feedback of massive stars. In order to search for any physical connection between star forming events, we have initiated a study of gas and stellar kinematics in NGC 1893, where two prominent cometary nebulae are facing toward O-type stars. The spectra of gas and stars in optical and near-infrared (NIR) wavelength are obtained with Hectochelle on the 6.5m MMT and Immersion GRating INfrared Spectrograph on the 2.7m Harlan J. Smith Telescope at McDonald observatory. In this study, the radial velocity field of gas across the cluster is investigated using $H{\alpha}$ and [N II] ${\lambda}$ 6584 emission lines, and that of the cometary nebula Sim 130 is also probed using 1-0 S(1) transition line of $H_2$. We report a distinctive velocity field of the cometary nebulae and many ro-vibrational transitions of $H_2$ even at high energy levels in the NIR spectra. These properties indicate the interaction between the cometary nebulae and O-type stars, and this fact can be a clue to triggered star formation in NGC 1893.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.42 no.2
• /
• pp.173-181
• /
• 1997

To estimate the leaf area index(LAI) of rice plant by non-destructive method, spectral reflectance from rice plant canopy was measured by using the spectroradiometer (LI-1800, LICOR Inc.) with one week interval during the rice growing season at Suwon paddy field in 1993. LAI of two medium late maturing varieties, Daechungbyeo and Ilpumbyeo, and one early maturing variety, Jinbubyeo, were observed and compared with those estimated by vegetation index. The reflectance(R) of visible wavelength remained less than 0.1 over entire growing season, but that of near infrared wavelength remained from 0.1 to 0.5 with the significant positive correlation with LAI. Vegetation index determined by the reflectance of visible against near infrared wavelength showed high correlation with LAI of rice canopy. Vegetation index derived from wide band ratio, NIR(720~1, 100nm) /Blue(400~500nm), showed the highest correlation coefficient with LAI. Vegetation index derived from narrow band(10nm interval) ratio, R910/R460, from transplanting to heading stage corresponded well to measured values (Y=0.16799X-0.79776 ; $R^2$=0.94). But another vegetation index, NIR(720~1, 100nm) /Red (600~700nm), showed higher correlation with LAI than NIR /Blue did from heading stage to maturity.

• Korean Journal of Remote Sensing
• /
• v.14 no.3
• /
• pp.307-314
• /
• 1998

To examine the detectability of the yellow sand and/or aerosol from China crossing over the Yellow Sea within the range of OSMI wavelengths(400-900 nm), we have investigated the optical characteristics of aerosols in yellow sand events observed on April, 1998 in Seoul. The spectral reflectance(%) and aerosol optical thickness in the range of Visible(VIS) and near Infrared (NIR) wavelengths were derived from the measurements of solar radiation using the GER-2600 spectroradiometer and sunphotometer during the April, 1798. The average spectral reflectance for the yellow sand events is over 40% and higher around 14:30 than 12:00 LST, but that for clear days is about 20% both at 12:00 and 14:30 LST in the range of 500-900 nm. The aerosol optical thickness at 501 nm varied from 0.25 on very clear day to 1.01 during a so-called "yellow-sand" episode and that for 673 nm varied from 0.14 to 0.92, respectively.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.42 no.3
• /
• pp.255-262
• /
• 1997

To estimate the total dry matter(TDM) of rice plant by non-destructive method, spectral reflectance from rice plant canopy was measured by using the spectroradiometer (LI-1800, LICOR Inc.) with one week interval during the rice growing season at Suwon paddy field in 1993. Two medium late maturing rices, Daechung-byeo Ilpum-byeo, and one early maturing variety, Jinbu-byeo, were cultured to observe TDM, then they were compared with those estimated by vegetation index together. Vegetation index determined by the reflectance of visible against near infrared wavelength showed high correlation with TDM. Vegetation index derived from narrow band(10nm interval) ratio, R910/R460, has the highest correlation coefficient with TDM. TDM estimated from R910/R460 from transplanting to heading stage corresponded well to measured values (Y=21.2428X-212.734 ; $R^2$=0.87). But another vegetation index, NIR(720~1,100nm) /Red(600~700nm) showed higher correlation with TDM than NIR(720~1,100nm) /Blue(400~500nm) did from heading stage to maturity.

• Korean Journal of Remote Sensing
• /
• v.28 no.5
• /
• pp.501-508
• /
• 2012

Albedo is known as a factor that directly impacts on the surface energy balance one of the elements of earth radiation balance. The change of albedo includes the change of soil moisture, vegetation, solar zenith angle, snow, and so on. In addition, it operates as a crucial path to understanding feedback mechanisms between radiation balance and its influence on climate and vegetation dynamics and therefore, observing the variation of albedo is a one of the essential procedures for anticipating climate change. In this study, we used MODIS 16-Day composited Albedo data from 2001 to 2011 years with the purpose of observing the change of albedo over Northeast Asia. According to the tendency of albedo for 11 years, albedo in the area of an active vegetation has increased in near-infrared (NIR) domain and decreased in visible (VIS) domain. On the basis of local changes in vegetation in 2002, the both area of the Gobi Desert and the Manchuria was enormously changed and chosen the research area and furthermore, the vegetation of both regions had deteriorated due to the change of the minimum value since 2010.