• Title/Summary/Keyword: Nd:YAG

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Laser Induced Microjet Drug Delivery System: Drug Permeation Depending on Laser Wavelength and Pulse Duration (레이저 유도 마이크로젯을 활용한 약물 전달 방식: 레이저 파장 및 펄스길이에 따른 약물 침투 분석)

  • Jang, Hun jae;Ham, Hwi chan;Yoh, Jai ick
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.41 no.7
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    • pp.463-468
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    • 2017
  • For transdermal drug delivery, needless injection system is composed of laser and microjet injector. Main mechanism of microjet injector is the laser-induced bubble. Nd:YAG and Er:YAG laser are used as a power source. Laser parameters such as pulse duration and wavelength are considered, which are core parameters to control the bubble motion. The Nd:YAG laser, pulse duration is short than bubble life time making cavitation like bubble while in Er:YAG laser, long pulse duration and high absorption in water drive bubble as a boiling bubble. Detailed motion of bubble and microjet is captured by the high speed camera. So it is observed that microjet characteristics are determined by the bubble behavior. The performance of drug delivery system is evaluated by fluorescent staining of guinea pig skin.

Investigation of Zircaloy-4 weldability using a pulsed Nd:YAG laser (펄스형 Nd:YAG 레이저를 이용한 지르칼로이-4 용접특성 조사)

  • 김수성;김덕현;김철중;이종민
    • Journal of Welding and Joining
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    • v.9 no.1
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    • pp.23-31
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    • 1991
  • Laser beam weldability of zircaloy-4was investigated using a pulsed Nd: YAG laser of 200W average power. Mechanical properties of laser and GTA bead-on-plate welded zircaloy-4 test specimens were compared. The influence of plasma generated during laser welding was analyzed and optimum laser welding parameters were investigated.

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Effect of Nd:YAG laser irradiation on adherence of retrograde filling materials: evaluation by micro-computed tomography

  • Kim, Minyoung;Kim, Hyeon-cheol;Kwak, Sang Won;Yoon, Tai Cheol;Kim, Euiseong
    • The Journal of the Korean dental association
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    • v.54 no.11
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    • pp.865-873
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    • 2016
  • Background/Purpose: The purpose of this study was to evaluate the effect of Nd:YAG irradiation on adherence of retrograde filling materials (mineral trioxide aggregate [MTA] and Super-EBA) by micro-computed tomography (CT) measurement and to observe the dentinal surface after irradiation by scanning electron microscopy (SEM). Materials and methods: Forty retrofilling models using extracted human teeth were divided into four groups according to the material and method used: ProRoot MTA (MTA group), Super-EBA (EBA group), MTA with Nd:YAG laser irradiation (LMTA group), and Super-EBA with Nd:YAG laser irradiation (LEBA group). All specimens were stored in 100% humidity for 24 hours until micro-CT was performed. The gap volume of the tooth/material interface was measured using the CTAn program. In six samples, the laser-irradiated dentin surface was observed using SEM. Results: The mean percent difference in gap volume was not statistically significant between the Nd:YAG laser-irradiated groups and non-irradiated in both materials(P > 0.05). The gap volume in the MTA group was significantly lower than that in the EBA group (P < 0.05). Examination of the non-irradiated specimens by SEM showed patent dentinal tubules. In contrast, alterations in the texture of the dentin surface and obliteration of the dentinal tubules were evident in the Nd:YAG laser-irradiated specimens. Conclusion: In this study, changes in the dentinal surface after Nd:YAG irradiation did not affect adherence between the apical filling material and the dentin wall.

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Q-Switched Nd YAG's SHG conversion techniques for a skin diseased treatment (피부질환 치료를 위한 Q-Switched Nd:YAG의 SHG 변환기술)

  • Kim, Whi-Young
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.6
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    • pp.1141-1149
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    • 2009
  • Pulse style Nd: YAG Laser is suitable in skin remaking treatment, in compliance with the ramp continuous oscillation until of course normal takeoff, the Q-switch and mode motive takeoff the takeoff form which is various is possible and it is coming to be widely used in microsurgery and skin remaking promotion. According to therapeutic objective very it is important to control a energy density. Control of energy density the method which controls the pulse repetition rate of Laser output is mainly used. From the research which it sees pulse style Nd: It will be able to control the pulse repetition rate of YAG, the 2nd harmonic occurrence Laser (second harmonic generation: SHG) with the energy part of the light-wave which is a footnote wave number will hold and nonlinear decision it propagates and is converted by energy of the light-wave which is a footnote wave number the actual condition which and it applies the second harmonic occurrence in compliance with a secondary nonlinearity it leads and until skin deep part therapeutic possibility is the thing it will be able to observe simply.

Micro-patterning of Multi-layered Magnetic Metal Films Using Nd:YAG Laser (Nd:YAG Laser를 이용한 자성금속 막의 패턴 식각)

  • Chae, Sang-Hun;Seo, Yeong-Jun;Song, Jae-Seong;Min, Bok-Gi;An, Seung-Jun;Lee, Ju-Hyeon
    • Korean Journal of Materials Research
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    • v.10 no.2
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    • pp.171-174
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    • 2000
  • In this study, the laser patterning of sputter-deposited amorphous CoNbZr films has been tried usig Nd: YAG laser. However, the metal film was not removed because of its high reflectance of the alser on the metal surface. To solve this problem, authors tried to screen-print a block polymer on the metal film and then irradiate the laser on the polymer. This is a new method which was suggested by this study. Using this new method, the metal films were effectively removed with the laser power of 114W even though the metal films was not removed with the laser power of 332W using the conventional method. This result leads to the conclusion that the block polymer acts as a laser energy absorbing and transferring layer.

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A COMPARATIVE STUDY OF WOUND HEALING AFTER SKIN INCISION WITH SCALPEL, $CO_2$, AND Nd:YAG LASER IN RATS (수술칼, $CO_2$ 및 Nd:YAG 레이저에 의한 절개 창상의 치유에 관한 비교 연구)

  • Choi, Jae-Sun;Ryu, Sun-Youl
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.22 no.1
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    • pp.33-42
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    • 2000
  • The purpose of this study was to compare the wound healing process after skin incision using scalpel, $CO_2$ laser and pulsed Nd:YAG laser in rats. After skin on the back was incised 3 cm long, rats were sacrificed at 1, 3, 7, 14, 21 and 28 days. Macroscopic, histologic and immunohistochemical examinations using the collagen type IV and the CD34 antibodies which are necessary to the forming process of new capillary were performed. Results obtained were as follows ; Macroscopically the initial wound healing of the laser group was about $1{\sim}2$ weeks slower than that of the scalpel group. There weren't however any remarkable differences in all groups in 4 weeks after incision. By histologic finding, acute inflammatory cells were more prominent during the initial wound healing in the scalpel group than in the other groups. Epithelialization started in the order of scalpel, $CO_2$ and Nd:YAG laser group after skin incision. By the Masson's trichrome stain, collagen synthesis in the Nd:YAG laser group was more slowly initiated than in the other groups. But it was completed at the $3{\sim}4$ weeks in all groups. Immunohistochemically, collagen type IV and CD34 expression were markedly increased at 2 weeks in the scalpel and $CO_2$ laser group. Meanwhile, in the Nd:YAG laser group, these reactions were observed later tan the other groups. Collagen type IV and CD34 expression were decreased in all groups after 4 weeks. These results suggest that $CO_2$ and Nd:YAG laser showed similar healing process compared with scalpel and a potential substitute for scalpel in skin incision.

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Efficient Diode Pumped High Power Nd:YAG Laser with a Gold Coated Flow Tube (금코팅 유리관 반사체를 이용한 다이오드 여기 고출력 고효율 Nd:YAG 레이저)

  • 이종민;문희종;이종훈;한재민;이용주
    • Korean Journal of Optics and Photonics
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    • v.9 no.3
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    • pp.186-190
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    • 1998
  • We fabricated a diode-side pumped high power Nd:YAG laser with a gold coated flow tube(diameter of 10mm) and three sets of 140W diode bar. The diameter of Nd:YAG rod was 6mm and its length was 130mm. We obtained 130W cw power from a linear resonator with an 11% output coupler, which corresponds to the slope efficiency of 43% and the optical efficiency of 31%. The measured beam quality factor(M$^2$) reached about 85 which is fairly large due to the large size of the rod. Thermal lensing of the rod was measured to be 5.3-7.4D/$kW_{pump}$ when the laser was operating.

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Influence of process parameters on the kerfwidth for the case of laser cutting of CPS 1N sheet using high power CW Nd:YAG laser (고출력 연속파형 Nd:YAG 레이저를 이용한 CSP 1N 냉연강판 절단시 공정변수의 절단폭에 미치는 영향)

  • Kim Min-Su;Lee Sang-Hoon;Park Hyung-Jun;Yoo Young-Tae;Ahn Dong-Gyu
    • Journal of the Korean Society for Precision Engineering
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    • v.22 no.7 s.172
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    • pp.19-26
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    • 2005
  • The objective of this study is to investigate the influence of process parameters, such as power of laser, cutting speed of laser and material thickness, on the practical cutting region and the kerfwidth fer the case of cutting of CSP IN sheet using high power Nd:YAC laser in continuous wave(CW) mode. In order to obtain the practical cutting region and the relationship between process parameters on the kerfwidth, several laser cutting experiments are carried out. The effective heat input is introduced to consider the influence of power and cutting speed of laser on the kerfwidth together. From the results of experiments, the allowable cutting region and the relationship between the effective heat input and kerfwidth fur the case of cutting of CSP 1N sheet using high power CW Nd:YAG laser have been obtained to improve the dimensionalaccuracyofthecutarea.