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http://dx.doi.org/10.3795/KSME-B.2017.41.7.463

Laser Induced Microjet Drug Delivery System: Drug Permeation Depending on Laser Wavelength and Pulse Duration  

Jang, Hun jae (School of Aerospace Engineering, Seoul Nat'l Univ.)
Ham, Hwi chan (School of Aerospace Engineering, Seoul Nat'l Univ.)
Yoh, Jai ick (School of Aerospace Engineering, Seoul Nat'l Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.41, no.7, 2017 , pp. 463-468 More about this Journal
Abstract
For transdermal drug delivery, needless injection system is composed of laser and microjet injector. Main mechanism of microjet injector is the laser-induced bubble. Nd:YAG and Er:YAG laser are used as a power source. Laser parameters such as pulse duration and wavelength are considered, which are core parameters to control the bubble motion. The Nd:YAG laser, pulse duration is short than bubble life time making cavitation like bubble while in Er:YAG laser, long pulse duration and high absorption in water drive bubble as a boiling bubble. Detailed motion of bubble and microjet is captured by the high speed camera. So it is observed that microjet characteristics are determined by the bubble behavior. The performance of drug delivery system is evaluated by fluorescent staining of guinea pig skin.
Keywords
Er:YAG Laser; Nd:YAG Laser; Cavitation; Boiling Bubble; Microjet; Drug Delivery;
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