• Journal of Korean Medical classics
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• v.34 no.2
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• pp.85-94
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• 2021

Objectives : Pulse diagnosis is one of the main diagnostic methods of Korean Medicine that understands the patient's condition and illness by reading changes in the patient's pulse, which is described in terms of pulse condition While they are described in detail in medical texts, it is difficult to grasp their true nature, as the written descriptions fail to do justice to the experience of pulse taking it tries to convey. As a way to approach pulse condition the effect of the body's tension on the radial vein was measured using an ultrasonic device, after which the measured changes and how they could be reflected in pulse condition were studied. In other words, changes in the radial vein following induced tension were analyzed. Methods : 1) The thickness of the subject's radial vein was measured using a linear probe of an ultrasonic device[LOGIQ 5 Basic, GE, USA]. 2) Fatigue level was increased through artificial stimulation using the Gripmeter[ks-301, Lavisen, Korea]. 3) Thickness of the radial vein post tension induction was measured. 4) The results were analyzed with the Tukey test or paired t-test as post hoc tests. Results : Thickness of the radial vein of the subject pre- and post- Gripmeter stimulation decreased with significance. Conclusions : Constriction of the radial vein that happened after tension induction could be linked to the Tight Pulse[緊脈] that is related to patterns of contraction and pulling.

• Investigative Magnetic Resonance Imaging
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• v.19 no.2
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• pp.67-75
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• 2015

Purpose: To investigate the value of image post-processing software (FreeSurfer, IBASPM [individual brain atlases using statistical parametric mapping software]) and inversion time (TI) in volumetric analyses of the hippocampus and to identify differences in comparison with manual tracing. Materials and Methods: Brain images from 12 normal adults were acquired using magnetization prepared rapid acquisition gradient echo (MPRAGE) with a slice thickness of 1.3 mm and TI of 800, 900, 1000, and 1100 ms. Hippocampal volumes were measured using FreeSurfer, IBASPM and manual tracing. Statistical differences were examined using correlation analyses accounting for spatial interpretations percent volume overlap and percent volume difference. Results: FreeSurfer revealed a maximum percent volume overlap and maximum percent volume difference at TI = 800 ms ($77.1{\pm}2.9%$) and TI = 1100 ms ($13.1{\pm}2.1%$), respectively. The respective values for IBASPM were TI = 1100 ms ($55.3{\pm}9.1%$) and TI = 800 ms ($43.1{\pm}10.7%$). FreeSurfer presented a higher correlation than IBASPM but it was not statistically significant. Conclusion: FreeSurfer performed better in volumetric determination than IBASPM. Given the subjective nature of manual tracing, automated image acquisition and analysis image is accurate and preferable.

• Journal of Acupuncture Research
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• v.26 no.1
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• pp.49-57
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• 2009

Objectives : During the past three decades there has been a significant evolution of laser acupuncture application in the nature of the clinical approach and the research of traditional medicine and laser therapy field. However, there have been no standard and guideline of laser equipment can be applied as laser acupuncture. This study aims to investigate the condition of laser equipment required as a laser acupuncture method. Methods : First, we performed literature search using the Medline(from 1999 to Oct 2008) to confirm types and ranges of laser equipments that can be applied as laser acupuncture. In addition, we investigated the characters of acupoints such as sites and depths, and compared with penetrating depths of each laser. Results : A total of 37 articles for clinical studies using laser acupuncture were selected, and 41 lasers were used. GaAs laser was used three times, GaAlAs laser 14, InGaAlP 18, HeNe laser 4, and Argon laser and CO2 laser were used one time, respectively. From all 361 points of fourteen meridians, depths of 341 points(94.5%) were 1 cun(2.3-3.2cm) or less. The mean depth of all points was 0.48 cun(1.1-1.5cm). Hence, it appeared that the majority of therapeutic lasers satisfied with the condition. HeNe, InGaAlP, GaAlAs, GaAs lasers are recommended for laser acupuncture, however, it may plausible that other surgical lasers could be used as the laser acupuncture, because it have the biostimulation effect to some extent, too. Conclusions : It is suggested that to select appropriate laser type and give the adequate output power to reach the acupoints under the skin using laser acupuncture. Further evaluation and research for the condition of laser acupuncture are warranted.

• Journal of Korean Medical classics
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• v.19 no.3
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• pp.365-380
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• 2006

All of the disease which was referred in ${\ulcorner}$Diagnosis and Treatment of the Woonded, Carbuncle, intestinal infection and acute eczema in Synopsis of Golden Chamber${\lrcorner}$ are belong to surgery. Woonded in this chapter, specially, come under in case occur by metal, and spoke that this thing is metal wounded(金瘡). I am considered by something to use Wangbulryuhaengsan(王不留行散) in wound that is not festered, Baenongtang(排膿湯) and Baenongsan(排膿散) in wound that is festered. Carbuncle is one of Venus festering nature file that happen in skin and muscle because blood does not circulate with flag and part's flare, calorification, pain, puffiness are characteristic. Carbuncle is agreed with concept of inflammation of modern medicine. When treat carbuncle, without using surgery medical treatment, used together internal medicine surgery medical treatment. Intestines carbuncle(腸癰) is come in inflammation in abdominal cavity as kind of inflammation, partiality peritoneum festering disease round present cecum as one of inside carbuncle. I think, when treat intestines carbuncle, in case cold and moisture become stasis and heat is less, Uiibujapaedoksan(薏苡附子敗毒散) can be used. Independently of festering, Daehwangmokdantang(大黃收丹湯) can be used in case heat and extravasated blood become stasis. Saliva ulcer on the vulva is comes in impetigo In Case of young child, and is come in Venus eczema in case is general. Prognosis of saliva ulcer on the vulva widespread thing can treat by arm, leg at Lips region, but it does not treat to grow at Lips region from limb, and treatment uses Hwangryunbun(黃連粉)

• Journal of Yeungnam Medical Science
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• v.35 no.1
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• pp.70-75
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• 2018

Background: Otitis media with effusion (OME) is defined as middle ear effusion without acute signs of infection. OME usually resolves spontaneously; however, persistent OME may require the insertion of a ventilation tube. This study investigated risk factors for persistent OME in children who undergo ventilation tube insertion. Methods: Children who were admitted to undergo ventilation tube insertion at Jeju National University Hospital between August 2015 and July 2016 were enrolled as the case group. Healthy children without persistent OME from August 2016 to July 2017 were enrolled as the control group. Baseline characteristics and predisposing factor data were collected using an interview questionnaire. Middle ear fluids were collected from the case group. Results: A total of 31 patients underwent ventilation tube insertion. The mean age of the case group was 4.53 years, with a male-to-female ratio of 21:10. Twenty-nine (93.5%) children attended a daycare center, and 21 (67.7%) had experience with bottle feeding. Fifteen (48.4%) children in the case group and 3 (9.7%) in the control group first attended a daycare center at <1 year of age (odds ratio=9.96; 95% confidence interval=2.44-39.70; p=0.001). No bacteria were found in middle ear fluid collected from the 31 operated children. Nasopharyngeal bacterial colonization was found in 13 (41.9%) and 17 (54.8%) children in the case and control groups, respectively. Conclusion: Earlier attendance at a daycare center was the only predisposing factor for ventilation tube insertion in our study. The aseptic nature of middle ear fluids found in children with OME highlights the efficacy of antimicrobial use.

• Tuberculosis and Respiratory Diseases
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• v.40 no.6
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• pp.709-713
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• 1993

Inflammatory pseudotumor, also known as plasma cell granuloma, is a rare, benign tumor that affects at all ages and frequently involves the lung, gastrointestinal tract, and salivary gland. They are the most common, isolated, primary lesion of the lung in children less than 16 years of age, and usually present as circumscribed, peripheral, parenchymal tumors, which may be static or increase slowly in size without causing symptoms. Surgical excision is the treatment of choice bacause of the location and benign nature of this lesion. The prognosis after resection is excellent. Adjuvant therapeutic modalities include radiation and steroid therapy. Recently, we experienced a case of inflammatory pseudotumor of the lung, the diagnosis of which was made by percutaneous fine needle aspiration cytology examination. We tried steroid and the lesions of the lung was completely resolved. We report this case with a review of literatures.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.1
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• pp.33-40
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• 2021

Recently, antibody-drug conjugates (ADCs) are used to deliver efficient cytotoxic payloads selectively in cancer cells. In the designing of an ADC, the antibody is connected to a toxic payload via a covalent linker, which helps to solubilizes the typical hydrophobic payload as well as stabilizes the linkage over circulation. The development of the linkers for the antibody drug conjugate is still in demand. Initially, the acid, disulfide, and cathepsin-sensitive ADCs attracted considerable attention for the delivery of a potent cytotoxic payload but suffer from instability in human and mouse plasma with a short half-life. In addition, It also suffer from a solubility issue that induces aggregation, which is the major problem in their development. ADCs associated with sulfatase and phosphatase cleavable linker are highly soluble due to the anionic nature of sulfate and phosphate groups. The ADCs also showed high stability in human and mouse plasma. Therefore, to overcome these limitations, sulfatase and phosphatase cleavable linkers were developed. This review focuses on the recently reported advantages of sulfatase and phosphatase cleavable linkers for ADCs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.5
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• pp.245-254
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• 2020

The purpose of this study was to investigate the effects of natural herb mixture containing Laminaria japonica Areschoung (LAM) on fine dust-induced bronchitis in mice. Laminaria japonica Areschoung is main content of LAM, which is including fucoidan. Fucoidan extracted from phaophyta is known to prevent bronchitis and to defend against bacteria and virus infection. In this study, we experienced the effect of LAM on bronchitis and investigated gene expressions (e.g ; IL-8, COX-2, MCP-1) and bio-markers (e.g ; IL-8, PGE2, MUC5AC) associated with bronchitis by using A549 cells. Also, we investigated whether LAM can suppress the bronchitis in fine dust-induced animal models. We injected fine dust (50 ㎕) twice as INT (Intra-Nasal-Trachea) method. Then LAM (200 mg/kg and 400 mg/kg) were oral administered for 14 days. We analyzed the number of immune cells, immunoglobulin E, bio-markers level associated with bronchitis. LAM significantly decreased bio-marker (IL-1β, IL-6, IL-8, TNF-α, Histamine, PGE2), immune cells (white blood cell, neutrophil, lymphocyte, monocyte), and immunoglobulin E, that are increased by fine dust. Taken together, this study suggest that LAM can be used as effective herbal extract for bronchitis.

• CELLMED
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• v.5 no.2
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• pp.9.1-9.14
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• 2015

The so-called "Needham's Grand Question" (NGQ) can be formulated as why modern science was developed in Europe despite the earlier successes of science and technology in ancient China. Numerous answers have been proposed. In this review, it will be pointed out that traditional Chinese natural philosophy (TCNP) and traditional Chinese medicine (TCM) are in fact dealing with problems of highly complex dynamical systems of Nature and human beings. Due to the lack of mathematical machinery in dealing with such complex phenomena, a holistic approach was taken by ancient Chinese instead. It was very successful for the first eighteen centuries. In the recent three centuries, however, the reductionist and mechanistic viewpoints of Western natural philosophy, sciences, and medicine have been prevalent all over the world up to now. The main obstacle in preventing the advancement of TCM, TCNP and its sciences is actually the lacking of proper mathematical tools in dealing with complex dynamical systems. Fortunately, the tools are now available and a "chaotic wave theory of fractal continuum" has been proposed recently. To give the theory an operational meaning, three basic laws of TCNP are outlined. These three laws of wave/field interactions contrast readily with those of Newton's particle collisions. Via the proposed three laws, TCM, TCNP and its sciences can be unified under the same principles. Finally, an answer to NGQ can be accurately given. It is hoped that this review will help promoting a genuine understanding of natural philosophy, sciences, and medicine in an ecumenical way.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1285-1290
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• 2004

From a view point of Hyungsang medicine a study is made on depressive syndromes through 'Donguibogam(東醫寶鑑)' ,'Clinical lectures by Mr. Jeesan(芝山先生 臨床學特講)' and other literature. Depressed energy(?) originally meant the disorder of vital energy in the circulation of nature with the lapse of time. In later, it has been changed to mean the disease of man, especially related to the mind. Depressive syndromes come from the stagnation of the Ki or the abnormal circulation(rising, falling, coming and going), which happens when man cannot adjust oneself to the circumstances due to the disharmony between internal and external conditions. Depressive syndrome easily attacks the following types of persons; Dam type person with excessive Ki and deficient Hyung(形), manly woman, womanly man, Bird type person who shows a great variety of emotion, Turtle type person declined to melancholy, Ki type person apt to be depressive, and Shin type person with upward gush of the fire. It also attacks the persons who have smudgy face with the scar between eyebrows, those whose pulses are mixture of two different kinds and those whose pulses extend on two ranges in Jeesan's diagram. Depressive syndromes recorded in 'Donguibogam' are globus hystericus, chest congestion, gastric discomfort, cough and asthma caused by depressed Ki, abdominal mass, edema, and tympanites. The most effective prescriptions for depressive syndromes are Eajintang(二陳湯), Guibitang(歸脾湯), Hyangsosan(香蘇散), and Gamisachiltang(加味四七湯).