• 대한한의학회지
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• 제35권3호
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• pp.40-48
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• 2014

Objectives: This study aimed to review the characteristics of personalized medicine and Korean medicine, and the correlation between personalized medicine and Korean medicine. Methods: We investigated various studies in PubMed, Scopus and domestic Korean medicine journals. In addition, we discussed the topic based on literature. Results: Western medicine developed as evidence-based medicine. However, its limitations are being reached, so a new paradigm of medicine is needed. As a result, personalized medicine has appeared. Recently, through the development of human genomics, personalized medicine has been researched on the basis of individual genetic characteristics. Korean medicine has developed with a unique holistic approach and treats not the disease itself but the patient's body. Its characteristic is well expressed through syndrome differentiation and treatment. Syndrome differentiation represents the nature of person-centered medicine and becomes the root of personalized medicine. Conclusions: Compared with genome-based personalized medicine of Western medicine, Korean medicine could be classified as syndrome-based personalized medicine. It would be great to apply this characteristic to clinical practices.

• 동의생리병리학회지
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• 제16권1호
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• pp.23-31
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• 2002

This research aims is to study physiolgy and pathology of lung on Suenbal-Sukkang action occuring with the exchang of Metal and Fire of nature. The exchange of Metal and Fire(金火交易) represents differience of temperature inside and outside of the atmosphere in according to Sun-heat on earth descended in passing Hazi(夏至). On the above fact, the Suenbal-Sukkang( action representing the Exchang of Metal and Fire happens in lung of body with properties of metal. too. These phenomena are physiological phenomenas of Pulmonary series(肺系). Accordingly, the action of Suenbal-Sukkang radiates heat and converge water with the properties of Autumn-Metals in change actions of nature. In order To interpret physiology action of Pulmonary energy(肺氣), I have studied Metal-glass theory(金鏡說) of Muk Za(墨子), and made a comparative study of a climatic change passing from summer to autumn in four season caused by the revolution of earth Thus, to interpret the action of Suenbal-Sukkang can be inferred by the phenomena of physiology and pathology of Pulmonary series. From the result of this study, I know that functions representing of the Suenbal-Sukkang take place in processing the exchange of Metal become phenomena in physiology of Pulmonary series(大腸, 皮膚, 鼻, …), and abnormal functions functions representing the Suenbal-Sukkang become pathological phenomenas of Pulmonary series.

• 동의생리병리학회지
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• 제16권1호
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• pp.1-7
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• 2002

The development of life science has given many insights into life phenomenons to mankind. Nevertheless, many questions for various phenomenon in life has not been satisfied. Recently, scientific development in human's knowledge showed the limitation of science comparing With the variety of life phenomenon. The fundmental reason of the limitation is thought that the subject of study in life science has been material, and so life has been thought a matter of material in life science. The thought of Hu Jun about this problem, the nature of living things is an important interest in Korean Traditional Medicine, Haneuihak(韓醫學). In this study, the view of human body and disease of Hu Jun(許浚) about the nature of living things which was appeared in 『Donguibogam』 was illuminated. The content of 『Donguibogam』 was edited in the order of Naekyung(內景篇; internal part of the body)ㆍOuihyung(外形編; external part of the body)ㆍJabbyung(雜病篇; diseases)ㆍTangaek(湯液偏; medicinal decoction)ㆍChimgu(針灸篇; acupuncture and moxibustion). The part of Naekyung(內景篇; internal part of the body) is thesis about basic theories and his thought about human body and life, which was seen in ‘Shinhyungjangbu-do(身形臟腑圖; figure of body and shape, and the organs and viscera)’ㆍthe part of ‘Jeong(精)’ㆍ‘Gi(氣)’ㆍ‘Sin(神)’ theory. In this study, the parts which were related with his view of life were selected and compared with the China philosohy of those days to elucidate what is his thought of life appeared in 『Donguibogam』.

• 셀메드
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• 제6권3호
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• pp.15.1-15.4
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• 2016

Evidence based practice (EBP) is a system of applying the most current and valid high quality evidence to support clinical decision making in a healthcare setting. In the twenty five years since its inception, EBP has become the accepted benchmark for excellence in healthcare. Although the system emerged within the biomedical sciences, in the years since EBP has become normative across all healthcare modalities from dentistry, allied health to complementary and alternative medicine (CAM). Practicing evidence based medicine within any modality potentially offers the patient the best available care based on high quality evidence. Yet it is the nature of the evidence that provokes some questions about the suitability of EBP across all modalities of healthcare. The meta analysis of randomized controlled trial (RCT) stands at the pinnacle of the hierarchy of evidence in EBP. This forms a challenge to CAM due to the difficulty in reducing the elementals of a holistic naturopathic assessment of a patient into an answerable question to be tested within a RCT. On one level this makes EBP paradigmatically incompatible with CAM, yet on another level it presents the opportunity to redefine the parameters of what is considered high level evidence. EBP has become a tool, and at times a weapon wielded by governments and health insurance companies to direct healthcare funding and policy. The implications of the nature of accepted evidence are becoming far reaching. The pursuit of the best available healthcare for each individual is the focus of EBP. However, the injudicious use of this system to direct health policy is fraught with biomedical bias and dominance. This issue raises the challenge to CAM to present high level evidence according to the rules of evidence, or face the annihilation of centuries of empirical knowledge.

• 한방안이비인후피부과학회지
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• 제36권2호
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• pp.45-59
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• 2023

Objectives : The purpose of this study is to analyze the various methods of sound therapy(ST) applied to tinnitus patients and their effectiveness, and to suggest an effective method that can be applied in clinical settings. Methods : Studies published from January 2018 to March 2023 were searched on 5 databases(Pubmed, RISS, OASIS, KISS, KCI). All RCTs that applied sound therapy as a main treatment method were included. Results : 14 studies were included. In 13 studies, sound therapy was statistically significant in improving tinnitus. Basic sound therapy was used in 6 studies(42%), followed by tinnitus rehabilitation therapy(TRT)(n=5, 35%). White noise(n=11, 75%) and nature sound(n=4, 28%) were the most frequently used sound sources. In the case of intensity, mixing point were the most common with 6 studies(42%). The mobile application(n=4) was the most frequently used implement. The application time of sound therapy per day was more than 3 hours(n=7), and the total treatment period was more than 3 months(n=9). Conclusions : Our findings indicate that sound therapy could be considered as an intervention for tinnitus patients. For better use, we suggest a basic type of sound therapy or TRT using white noise or nature sound at the mixing point level provided as a mobile phone application. In addition, the treatment period is recommended to be more than 3 hours/day for 3 months.

• Journal of Dental Anesthesia and Pain Medicine
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• 제20권5호
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• pp.263-269
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• 2020

Fibromyalgia is a syndrome characterized by chronic pain in the skeletal system accompanied by stiffness, sleep disturbance, fatigue, and psychiatric problems, such as anxiety and depression. Fibromyalgia commonly affects orofacial health, presenting with a variety of oral manifestations, including temporomandibular disorder, xerostomia, glossodynia, and dysgeusia. Therefore, oral healthcare providers need to be aware of this clinical entity to effectively manage oral symptoms and provide proper oral self-care modification and education on the nature of fibromyalgia. This review focuses on the epidemiology, pathophysiology, clinical manifestation, diagnosis, orofacial concerns, and treatment of fibromyalgia.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.8.1-8.2
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• 2016

A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in the pathogenesis of chronic diseases such as diabetes mellitus. So, with availability of modern technologies to understand the intricate nature of relations among complex systems, we need to move forward to the future by taking complex systems model.

• 동의생리병리학회지
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• 제17권1호
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• pp.31-36
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• 2003

The causes of disease as well as the mechanisms that result in the presenting signs and symptoms of patients are basic elements in oriental medicine. The location of the disease is the region on which the cause and the nature of the disease acts. Syndrome reflects the cause of the disease and the pathological change and the location of the disease. It is customary to classify the location of the disease into two major categories. First is based on the exterior and interior and the second is based on the five internal organs. Exterior syndrome is caused by the invasion of exopathogen in skin and hair, channels and collaterals. Interior syndrome refers to the syndrome located deeply in the interior of the body such as five internal organs. The location of the disease is very important to distinguish different syndromes in the diagnosis and the treatment of a disease.

• The Korean Journal of Pain
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• 제22권2호
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• pp.176-180
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• 2009

Cases of pyogenic spondylodiscitis are relatively rare diseases that concern 2-7% of total cases of osteomyelitis. Owing to the low frequency and initial nonspecific nature of signs and symptoms, diagnosis is often delayed up to 2-6 months. If the proper treatment is not established due to a diagnostic delay, there is a possibility of a serious neurologic deficit and spinal instability. We report two cases of infectious spondylodiscitis which were misdiagnosed as compression fracture and spinal stenosis respectively. They could be correctly diagnosed after MRI and laboratory test and under the recovery state after an antifungal and antibiotic medication. Special careful attention during the diagnostic procedure is a really important step considering the diagnostic delay and its resultant unsatisfactory outcome.

• Parasites, Hosts and Diseases
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• 제47권1호
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• pp.65-68
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• 2009

Excretory-secretory products of Toxocara canis larvae have been considered as a major functional antigen in immune responses against toxocariasis. We studied ultrastructural localization of T. canis second-stage larval antigen using a seropositive human serum under immunogold electron microscopy. High-density gold particles were observed in the secretory cells, excretory duct, intestinal epithelium, and cuticle of the larval worm sections. The distribution of the positive reactions in the larval worms suggests that the nature of the antigen is excretory-secretory antigen including waste metabolites and secretory enzymes.