• Title/Summary/Keyword: Natural target

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Statistical implications of extrapolating the overall result to the target region in multi-regional clinical trials

  • Kang, Seung-Ho;Kim, Saemina
    • Communications for Statistical Applications and Methods
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    • v.25 no.4
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    • pp.341-354
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    • 2018
  • The one of the principles described in ICH E9 is that only results obtained from pre-specified statistical methods in a protocol are regarded as confirmatory evidence. However, in multi-regional clinical trials, even when results obtained from pre-specified statistical methods in protocol are significant, it does not guarantee that the test treatment is approved by regional regulatory agencies. In other words, there is no so-called global approval, and each regional regulatory agency makes its own decision in the face of the same set of data from a multi-regional clinical trial. Under this situation, there are two natural methods a regional regulatory agency can use to estimate the treatment effect in a particular region. The first method is to use the overall treatment estimate, which is to extrapolate the overall result to the region of interest. The second method is to use regional treatment estimate. If the treatment effect is completely identical across all regions, it is obvious that the overall treatment estimator is more efficient than the regional treatment estimator. However, it is not possible to confirm statistically that the treatment effect is completely identical in all regions. Furthermore, some magnitude of regional differences within the range of clinical relevance may naturally exist for various reasons due to, for instance, intrinsic and extrinsic factors. Nevertheless, if the magnitude of regional differences is relatively small, a conventional method to estimate the treatment effect in the region of interest is to extrapolate the overall result to that region. The purpose of this paper is to investigate the effects produced by this type of extrapolation via estimations, followed by hypothesis testing of the treatment effect in the region of interest. This paper is written from the viewpoint of regional regulatory agencies.

Agricultural biotechnology: Opportunities and challenges associated with climate change (기후변화에 대응한 농업생명공학의 기회와 도전)

  • Chang, An-Cheol;Choi, Ji-Young;Lee, Shin-Woo;Kim, Dong-Hern;Bae, Shin-Chul
    • Journal of Plant Biotechnology
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    • v.38 no.2
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    • pp.117-124
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    • 2011
  • Considering that the world population is expected to total 9 billion by 2050, it will clearly be necessary to sustain and even accelerate the rate of improvement in crop productivity. In the 21st century, we now face another, perhaps more devastating, environmental threat, namely climate change, which could cause irreversible damage to agricultural ecosystem and loss of production potential. Enhancing intrinsic yield, plant abiotic stress tolerance, and pest and pathogen resistance through agricultural biotechnology will be a critical part of feeding, clothing, and providing energy for the human population, and overcoming climate change. Development and commercialization of genetically engineered crops have significantly contributed to increase of crop yield and farmer's income, decrease of environmental impact associated with herbicide and insecticide, and to reduction of greenhouse gas emissions from this cropping area. Advances in plant genomics, proteomics and system biology have offered an unprecedented opportunities to identify genes, pathways and networks that control agricultural important traits. Because such advances will provide further details and complete understanding of interaction of plant systems and environmental variables, biotechnology is likely to be the most prominent part of the next generation of successful agricultural industry. In this article, we review the prospects for modification of agricultural target traits by genetic engineering, including enhancement of photosynthesis, abiotic stress tolerance, and pest and pathogen resistance associated with such opportunities and challenges under climate change.

The Study of the Beach Change into Structures (인공 구조물에 의한 해빈변형 연구)

  • Kim, Hyo Seob;Jung, Byung Soon;Oh, Byung Cheol
    • Proceedings of the Korea Water Resources Association Conference
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    • 2004.05b
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    • pp.1445-1449
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    • 2004
  • Even though there can be a relative long-term or short-term change of their size in natural beaches due to various changes of sea condition such as the location, weather condition (wind and rain) and sea water flow, the budget of deposits in a specific area is generally regarded to be in a condition of equilibrium in terms of technology. However, as coasts are developed by many different kinds of ways (such as construction of sea walls and estuarine, dredging for gathering the aggregate and shore protection construction for establishing a structure) and sources of silt and gravel from rivers are decreased in balanced beaches, the beaches are in a serious danger of lack of sand and sand sources which are one of the maul elements to consist of them. Many swimming beaches in East Sea are directly exposed by waves generated and transmitted from outer seas. On the other hand, the Song-Do sandy beach which is this study's target area has a great condition for beach development because it locates the deepest place that is relatively shallow in Young-Il Man and there is big energy decrease given to waves from outer seas while the waves are reaching the Song-Do beach. Nevertheless, it is considered that artificial condition changes such as dredging for site extension by POSCO, getting straight of Hyoung-San Gang river flow and extension of Po-Hang harbor caused the sand loss of the beach. Therefore, some recovery plans of Song-Do sandy beach will be presented in this study and they will be compared and examined each other by numerical modeling experiment. After that, the best plan will be recommended.

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Assessment of Inundation Rainfall Using Past Inundation Records and CCTV Images (CCTV영상과 과거침수기록을 활용한 침수 강우량 평가 - 강남역을 중심으로 -)

  • Kim, Min Seok;Lee, Mi Ran;Choi, Woo Jung;Lee, Jong Kook
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.30 no.6_1
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    • pp.567-574
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    • 2012
  • For the past few years, the video surveillance market has shown a rapid growth due to the increasing demand for Closed Circuit Television(CCTV) by the public sector and the private security industry. While the overall utilization of CCTV in the public and private sectors is expanding, its usage in the field of disaster management is less than sufficient. Therefore, the authors of this study, in an effort to revisit the role of CCTV in disaster situations, have carried out a case analysis in the vicinity of the Gangnam Station which has been designated as a natural disaster-prone area. First, the CCTV images around the target location are collected and the time and depth of inundation are measured through field surveys and image analyses. Next, a rainfall analysis was conducted using the Automatic Weather Station(AWS) data and the past inundation records. Lastly, the authors provide an estimate of rainfall for the areas around the station and suggest viable warning systems and countermeasures. The results from this study are expected to make positive contributions towards a significant reduction of the damages caused by the floods around the Gangnam Station.

A Study of Damage District Forecast by Combine Topograph Modeling of Insular Areas Using GIS

  • Choi, Byoung Gil;Na, Young Woo;Ahn, Soon Myoung
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.35 no.2
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    • pp.113-122
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    • 2017
  • Natural disasters caused by climate change are increasing globally. There are few studies on the quantitative analysis methods for predicting damages in the island area due to sea level rise. Therefore, it is necessary to study the damage prediction analysis method using the GIS which can quantitatively analyze. In this paper, we analyze the cause and status of sea level rise, quantify the vulnerability index, establish an integrated terrestrial modeling method of the ocean and land, and establish a method of analyzing the damage area and damage scale due to sea level rise using GIS and the method of making the damage prediction figure was studied. In order to extract the other affected areas to sea level rise are apart of the terrain model is generated by one requires a terrain modeling of target areas are offshore and vertical reference system differences in land, found the need for correction by a tidal observations and geoid model there was. Grading of terrain, coastline erosion rate, coastal slope, sea level rise rate, and even average by vulnerable factors due to sea level rise indicates that quantitative damage prediction is possible due to sea level rise in the island area. In the case of vulnerable areas extracted by GIS, residential areas and living areas are concentrated on the coastal area due to the nature of the book area, and field survey shows that coastal changes and erosion are caused by sea level rise or tsunami.

Tourism market segmentation in Cheju Island based on fashion image of clothing souvenir and characterisitcs of sub-segments (관광기념 의류상품 패션이미지 추구에 따른 시장세분화 및 세분시장 특성 연구 -제주 관광객 소비자들을 대상으로-)

  • 홍희숙;장애란;현지은;김현미
    • Journal of the Korean Society of Clothing and Textiles
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    • v.25 no.2
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    • pp.303-314
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    • 2001
  • The purposes of this study were 1) to identify different sub-segments of tourism market in Cheju island based on fashion image of clothing souvenir and 2) to provide manufactures with useful information for developing cultural fashion goods related to Cheju island. The data were collected via a self-administered questionnaire from 192 female tourist(20-59 years old) in Cheju and analyzed by factor analysis, cluster analysis, one-way ANOVA and $\chi$$^2$-test. Six factors of fashion image were found image were found and labeled as: Sexy/feminine, wild/mannish, easy/simple, Cheju, ecology, natural image. Four factors of benefit sought were also identified: Practicality/economic-value, fashionability/preference of design, reputation and souvenir-value. Three groups were identified based on fashion image sought: Image of primitive nature(G1: 37.7%), image of nature in the city(G2: 20.1%), sexy/feminine image(G3: 42.2%). There were significant differences among sub-groups in age, fashion innovation, benefit sought and intention of buying Gal-ot. Younger females(20-30 ages) were included more in group 1 than group 2 while older females(40-50 ages) were included more in group 2. Group 1 had a higher score of fashion innovation comparing group 3. Group 1 had the highest scores on practicality/economic-value and souvenir-value. However, group 2 placed the highest importance on reputation as well as practicality/economic-value and group 3 had the lowest scores on all types of benefit. Group 1 and group 2 had intention of buying Gal-ot more than group 1. Based on the results of this study, manufactures may implement target marketing strategies on group 1 which sought the image of primitive nature and group 2 which sought the image of nature in the city.

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The Comparisons of Anthropometric Data According to Measurement Methods (측정방법에 따른 인체측정치의 비교 분석)

  • Yi, Kyong-Hwa;Kim, Ji-Eun
    • Journal of the Korean Society of Clothing and Textiles
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    • v.37 no.1
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    • pp.39-50
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    • 2013
  • This study estimates the measurements required to make garments but omitted from Size Korea 2010. Before the estimation of the measurements, the differences of the measurement methods were reviewed through previous research related to clothing construction and various measurement protocols that include previous Size Korea 2010 projects and ISO. The research target was 308 females aged 20 to 30 who lived in Seoul and the surrounding Gyeonggi province. A total of 43 measurements were obtained by the direct measurement method and analyzed in this study. In addition, 17 measurements which differ from the measurement method were also measured directly. These 17 measurements items were waist height, waist back height, waist height natural indentation, body rise, rise length, waist back length 1 & 2, posterior shoulder length 1 & 2, arm length 1 & 2, upper arm circumference 1 & 2, elbow circumference 1 & 2, and waist circumference 1 & 2. To analyze the differences in measurements, the subjects were divided into 2 age groups (20's and 30's). The results were as follows: First, there were big differences in stature, waist height, shoulder length, total length, and neck shoulder point to breast points by age groups; however, there were no differences in 17 measurement (such as shoulder angles) by age groups. Second, it was determined that 'waist circumference 1 & 2', 'waist back length 1 & 2', 'arm length 1 & 2', 'elbow circumference 1 & 2', 'upper arm circumference 1 & 2' and 'body rise & rise length' had significant differences by measurement methods in the entire group as well as each age group. Third, the values of 8 measurements omitted from Size Korea 2010 were estimated using similar measurements. The results of the correlation analysis were utilized to select reasonable independent measurements. Finally, 10 regression equations were obtained by regression analysis; subsequently, these will be useful for estimation of omitted measurements in Size Korea 2010.

Vascular Plants of Seoak District in Gyeongju National Park (경주국립공원 서악 지구의 관속식물상)

  • You, Ju-Han
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.17 no.3
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    • pp.13-33
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    • 2014
  • The purpose of this study is to offer the raw data for establishing the management and restoration plan by objective surveying and analysing the flora distributed in Seoak District, Gyeongju National Park, Korea. The flora summarized as 411 taxa including 92 families, 285 genera, 363 species, 2 subspecies, 41 varieties and 5 forms. The rare plants designated by Korea Forest Service were 2 taxa including Exochorda serratifolia and Potentilla discolor. The Korean endemic plants were 3 taxa including Philadelphus schrenkii, Lespedeza maritima and Weigela subsessilis. The specific plants by floristic region were 16 taxa including Asplenium sarelii, Pyrrosia petiolosa, Vitex negundo var. incisa and so forth. The target plants adaptable to climate change were 2 taxa including Lespedeza maritima and Carpesium macrocephalum, and the plants with approval for delivering oversea were 4 taxa including Exochorda serratifolia, Glycine soja, Lespedeza maritima and Weigela subsessilis. The naturalized plants were 51 taxa including Phytolacca americana, Viola papilionacea, Lamium purpureum and so forth. The invasive alien plants were 3 taxa including Ambrosia artemisiifolia, Aster pilosus and Lactuca scariola. NI(Naturalized Index) was 12.4% of all 411 taxa of surveyed flora in this study and UI(Urbanized Index) was 15.9% of all 321 taxa of naturalized plants in Korea. Potentilla discolor in rare plant, Philadelphus schrenkii in endemic plant and Dictamnus dasycarpus in specific plant were established the conservation plan. Whereas, invasive alien plants such as Ambrosia artemisiifolia, Aster pilosus and Lactuca scariola should be removed as soon as possible. The damaged sites in Seoak District were divided between wildfire area and farmland. To restore a forest fire site, we will have to apply a natural renewal and community planting. In case of farmland, we will have to do ecological planting using native species and constrcut a forest wetland.

Breeding Strategies to Increase Production Potential of Major Food Crops in Korea (식량생산능력 향상을 위한 농작물 육종전략)

  • Kim Gwang Ho;Kim Seok Dong;Park Mun Ung;Mun Heon Pal
    • Proceedings of the Korean Society of Crop Science Conference
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    • 1999.11a
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    • pp.80-101
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    • 1999
  • Self-sufficiency ratio of food crops in Korea is estimated under $20{\%}$ in 2010 because total food consumption including feed will be increased. but food grain production will be decreased. It is necessary to maintain the optimum level of food self-sufficiency rate to secure national food demand/supply balance and non-trade and multiple function of agriculture in Korea. It will be possible to produce more food grains having the acceptable quality if the appropriate policy and cropping techniques are developed and practised in future. Breeding for high yielding varieties should be the first target to raise the production potential of food crops . Number of varieties developed during last 30 years is counted as 353 in food crops. New varieties developed in 1990s showed the higher yield potential and the improved agronomic characteristics compared with 1970s and 1980s varieties. But number of varieties planted on the farmer's field over $5{\%}$ of national planting area is less than one third of total varieties developed Breeding efforts to maintain planting area of main food crops should be focussed on consumer's demand and farmer's need. They are the best quality variety in each field of crop utilization, the newly designed variety adapting to changes of natural, rural and cropping environment, and the higher yielding variety. It is also needed to develop new quality crop varieties for inducing more consumption of crop grain produced in Korea for direct food or processing. Development of barley varieties for animal feed. high income soybean varieties, high quality wheat variety. and super yielding rice and barley varieties are also needed to keep or maximize national food production potential. In order to establish the appropriate cropping technique for domestic food security, the strong and continuous interest and financial support on crop breeding are required, and the inter-disciplinary and inter-institutionary researches should be strengthened for successful crop breeding.

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Real-Time Recognition Method of Counting Fingers for Natural User Interface

  • Lee, Doyeob;Shin, Dongkyoo;Shin, Dongil
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.10 no.5
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    • pp.2363-2374
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    • 2016
  • Communication occurs through verbal elements, which usually involve language, as well as non-verbal elements such as facial expressions, eye contact, and gestures. In particular, among these non-verbal elements, gestures are symbolic representations of physical, vocal, and emotional behaviors. This means that gestures can be signals toward a target or expressions of internal psychological processes, rather than simply movements of the body or hands. Moreover, gestures with such properties have been the focus of much research for a new interface in the NUI/NUX field. In this paper, we propose a method for recognizing the number of fingers and detecting the hand region based on the depth information and geometric features of the hand for application to an NUI/NUX. The hand region is detected by using depth information provided by the Kinect system, and the number of fingers is identified by comparing the distance between the contour and the center of the hand region. The contour is detected using the Suzuki85 algorithm, and the number of fingers is calculated by detecting the finger tips in a location at the maximum distance to compare the distances between three consecutive dots in the contour and the center point of the hand. The average recognition rate for the number of fingers is 98.6%, and the execution time is 0.065 ms for the algorithm used in the proposed method. Although this method is fast and its complexity is low, it shows a higher recognition rate and faster recognition speed than other methods. As an application example of the proposed method, this paper explains a Secret Door that recognizes a password by recognizing the number of fingers held up by a user.