• 대한화장품학회지
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• 제47권2호
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• pp.155-161
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• 2021

본 연구는 항균 활성을 갖는 천연 소재를 검색하고 화장품의 보존제로써 적용을 위해 진행되었다. 디스크 확산법(disc diffusion method)을 통해 피부 병원성균 3 종(Staphylococcus aureus, Escherichia coli (E. coli), Pseudomonas aeruginosa)과 효모균(Candida albicans (C. albicans))에서의 천연 항균 소재 9 종을 검색하였다. Inhibition zone 크기를 측정한 결과, 오배자 추출물(Rhus Semialata gall (Gallnut) extract), 참나무 목초액 (Oak vinegar) 그리고 폴리리신(ε-polylysine)은 10 mm 이상으로 다른 추출물에 비해 우수한 항균활성을 나타내었다. 병원성균 3종과 효모균, 곰팡이균(Aspergillus brasiliensis (A. brasiliensis))에서 최소살균농도(minimum bactericidal concentration, MBC)를 측정한 결과, 오배자 추출물과 참나무 목초액은 5 종의 병원성균에서 10 ~ 20 mg/mL와 20 ~ 40 mg/mL, 폴리리신의 경우 진균류에서 0.5 ~ 2 mg/mL으로 살균 작용에 의한 항균효과를 각각 확인하였다. Checkerboard 방법에 따라 오배자 추출물과 참나무 목초액, 오배자 추출물과 폴리리신의 혼합 비율에 따른 시너지 효과(synergistic effect), 부가 효과(additive effect), 무관함(indifferent) 그리고 상쇄효과(antagonistic effect)를 평가하였다. 그 결과, 단독으로 사용할 때보다 오배자 추출물과 참나무 목초액 복합물은 E. coli, C. albicans, A. brasiliensis를, 오배자 추출물과 폴리리신 복합물은 C. albicans, A. brasiliensis를 4 배 낮은 농도에서 99.9% 억제하며 항균 시너지 효과를 확인하였다. 오배자 추출물과 참나무 목초액 복합물은 S. aureus와 P. aeruginosa를 2 배 낮은 농도에서 억제하며 부가 효과가 확인되었다. 이로써, 오배자 천연 복합물은 항균 시너지 효과를 발휘할 수 있음을 입증했을 뿐만 아니라 넓은 항균 스펙트럼을 갖춘 천연 방부 시스템으로써 화장품에서 응용할 수 있을 것으로 기대된다.

• 대한화장품학회지
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• 제43권4호
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• pp.321-327
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• 2017

본 연구는 기존의 인공적으로 합성된 유기 자외선 차단제를 대체하는 안정적인 식물유래 천연 자외선 차단제(BHC-S)를 개발하기 위하여 수행하였다. 땅콩싹추출물, 병출추출물 및 곰피추출물로 구성된 천연 자외선 차단제(BHC-S)는 합성 자외선 차단제인 Parsol MCX-XR (OMC)와 동등 수준의 자외선 차단 효과를 가질뿐만 아니라, 피부에 대한 안전성을 가지며, 주름개선 등 다기능성 효과를 가지는 것으로 확인되었다. 이로써, 자외선 차단 및 항노화을 위한 천연 화장품 원료로서의 이용이 가능할 것으로 판단된다.

• 농업과학연구
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• 제41권3호
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• pp.193-203
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• 2014

Natural Monument is a designated cultural property as part of the country. According to Article 2 of the Cultural Properties Protection Act, a national, ethnic and global heritage artificially or naturally formed, with a great historical, artistic, scientific and landscape significance is defined as a cultural heritage. Animals, plants, topography, geology, minerals, caves, biological products and special natural phenomena, having a great of historic, scenic and scientific value, are defined as the monument. According to Article 3 of Cultural Properties Protection Act, the conservation, management and utilization of National Heritage should be kept intact in its original form. So, Natural monuments are managing as retained its original form under the Basic Principles of current law. The highest population of coniferous tree in natural monument plant is ginkgo tree including 22 objects, followed by pines, junipers that order. And in case of broadleaf tree, there are zelkova trees, retusa fringe trees, pagoda trees, cork oaks, silver magnolias and etc. There are many of reported efficacy in available natural monument plants. The efficacy of plant species on pharmaceutical like anti-cancer, anti-diabetic, anti-obesity, antioxidant activity, neuroprotective, improves cholesterol, anti-inflammatory, liver protection and anti-bacterial efficacy, on cosmetics and beauty like the inhibiting formation of skin wrinkles, whitening effect, variety of materials and the efficacy of the proposed utilization of its various papers and etc have been widely reported. Before the Nagoya Protocol enters into force, the future role of the National Research Institute for Cultural Properties Administration of Cultural Heritage should be obtain a legal right to manage the social, cultural and national natural monument with emotional value to the plant genetic resource as a natural monument efficient ways to study and preserve traditional knowledge biological resources by securing a claim to the sovereignty of the material will be ready.

• 한국응용과학기술학회지
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• 제35권4호
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• pp.1487-1495
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• 2018

본 연구에서 최근 한국 제주 지역에서 큰 관심을 보이고 있는 맞춤형화장품 소재 개발 일환으로서 제주도에서 자생하는 육상식물 50종과 해상식물 10종에 대해 주름개선 검증을 위한 콜라겐 생성 효과와 히알루론산 생성 효과를 조사하였다. 콜라겐과 히알루론산은 피부 노화에 영향을 주는 주요 요인으로 인식되고 있다. 실험 결과, 육상식물 50종 추출물 중에서 점나도나물추출물($100{\mu}g/mL$)은 190% 이상 콜라겐을 생성하였으며, 살갈퀴추출물($100{\mu}g/mL$)은 160% 이상, 팔손이추출물($10{\mu}g/mL$), 금사철추출물($100{\mu}g/mL$), 기수초추출물($100{\mu}g/mL$), 보리수나무추출물($100{\mu}g/mL$), 땅채송화추출물($100{\mu}g/mL$), 나비나물추출물($100{\mu}g/mL$), 갓추출물 ($100{\mu}g/mL$)은 140% 이상 콜라겐 생성 효과를 보였다. 해상식물 10종 추출물 중에서는 큰열매모자반추출물($50{\mu}g/mL$)이 190% 이상 콜라겐을 생성하였으며, 붉은뼈까막살추출물($100{\mu}g/mL$), 누운청각추출물($100{\mu}g/mL$), 우단청각추출물($100{\mu}g/mL$)의 경우는 140% 이상 콜라겐 생성 효과를 보였다. 제주 육상식물 50종 추출물 중에서 기수초추출물($100{\mu}g/mL$)이 140% 이상 히알루론산 생성 효과를 보였으며, 팔손이추출물($20{\mu}g/mL$), 등나무추출물($100{\mu}g/mL$)은 130% 이상의 히알루론산 생성 효과를 나타냈다. 해상식물 10종 추출물 중에서는 자루바다표고추출물($100{\mu}g/mL$)이 가장 효과가 좋았으며, 이 외에도 붉은뼈까막살추출물($100{\mu}g/mL$), 누운청각추출물($100{\mu}g/mL$), 우단청각추출물($100{\mu}g/mL$)에서 120% 이상 히알루론산 생성 효과를 보였다. 이들 콜라겐과 히알루론산 생성 효과가 양호한 제주 자원들은 향후 맞춤형화장품의 피부 고민을 해결하는 데 적용될 수 있는 가능성을 보여 주었다.

• 공업화학
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• 제20권3호
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• pp.346-350
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• 2009

자연상태의 물질들은 많은 유용한 성분들을 포함하고 있다. 이 성분들 중에서, 천연 영양 성분들은 기능성 식품 또는 화장품, 의약품의 첨가제로써 활용 되고 있다. 이러한 영양성분들을 유용하게 활용하기 위해 각 성분들에 대한 최적의 용매 선택방법을 제시하였다. 각 성분에 대한 용해도 파라미터를 계산하였으며 총 용해도 파라미터는 분산성, 극성, 수소결합 효과로 구성되고 이들 기여도가 각각 계산되었다. 용질과 용매의 용해도 파라미터에 의해 chi(${\chi}_{12}$)파라미터가 결정되었으며 chi파라미터에 의해 아미노산 성분들에 대한 최적의 용매-용질쌍이 선정되었다.

• 한국염색가공학회지
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• 제24권3호
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• pp.213-220
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• 2012

In this study, we investigated the effect of natural vegetable treatment agent on the bleaching and damage of human hair during permanent wave formation. The vegetable treatment agent was prepared by fermenting the mixture of tea leaves (10g), black rice (100g), black bean (100g), corn (100g), malt (50g), and water(500g) at room temperature for 1 week. The degree of bleaching and damage was checked by Munsell value 'L' and morphological changes of hair in FE-SEM. When the hair was bleached, the Munsell value 'L' was almost same regardless of adding the vegetable treatment to the bleaching solution. But when the hair was permanently waved, the curl formation ability was high and the damage was low in the case of adding the vegetable treatment. This means that the vegetable treatment covers the scale of hair and protects the hair from the chemicals.

• 한국수정란이식학회지
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• 제33권3호
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• pp.159-168
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• 2018

Bovine colostrum is necessary for newborn calves to survive, grow and receive immunity from their mother. Cows in Korea produce about 35kg of colostrum, 4Kg of which is fed to the calf, and the rest is discarded. The bovine colostrum causes the harmful side effects to human, such as allergies and digestive problems; so, it is prohibited by law to consume colostrum itself as a food. However, many scientific research data have suggested that components in the colostrum can improve human health and has the ability to help treat diseases. In line with the trend of food and pharmacy industries using natural product materials, which attract positive attention, recently, some ingredients in colostrum have been used in the production of food supplements, and it has been used in its raw form in some cosmetics. This review introduces the active ingredients and physiologically active substances contained in bovine colostrum, summarizes the efficacy of physiological enhancement of the colostrum, which has been proven by scientific methods to date, and also suggests the possibility of industrial applications of colostrum as an animal-derived natural material.

• 한국염색가공학회지
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• 제30권3호
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• pp.208-215
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• 2018

The objective was to investigate the efficacy of Metasequoia(Metasequoia glyptostroboides) cone colorants as a new functional dye for wool fiber. Effects of dyeing conditions and mordanting on dye uptake, color change, and colorfastness were investigated for wool fiber. Compared with cotton and silk fibers, wool fiber showed better affinity for the Metasequoia cone colorants. Fe and Cu mordants improved dye uptake, and mordanting did not change the color of dyed fabric with YR Munsell color. Colorfastness to rubbing and washing was as good as grade 4, whereas lightfastness of the dyed fabrics was above grade 3. Antimicrobial activity of the colorants was very high 99.3% of reduction rate toward S. aureus. It was confirmed that Metasequoia cone colorants can be utilized as a new functional natural dye for wool fiber. In addition, considering its high antimicrobial functionality it could be applied to cosmetics and food.

• KSBB Journal
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• 제27권5호
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• pp.319-323
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• 2012

Vitamin C or L-ascorbic acid, an essential nutrient for humans with antioxidative property, was coated with natural wax to be used as functional additives for cosmetics. Coating of vitamin C was performed using carnauba wax and olive wax in self-designed reaction chamber for 60 min. The yield of coated vitamin C with carnawuba wax and olive wax were up to $94.6{\pm}1.2%$ and $82.5{\pm}1.4%$, respectively. The stability of the carnauba wax-coated vitamin C in the lotion was improved 17.8% than that of uncoated vitamin C during 30 day storage at $25^{\circ}C$. Color and the layer separation of the lotion added with the coated vitamin C showed better property than with the uncoated vitamin C. The coated vitamin C can be applied to cosmetic ingredients as a stable additive.

• Journal of Microbiology and Biotechnology
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• 제28권8호
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• pp.1299-1309
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• 2018

We previously reported on lactophoricin (LPcin), a cationic ${\alpha}-helical$ antimicrobial peptide derived from bovine milk, which has antimicrobial effects on Candida albicans as well as Gram-positive and Gram-negative bacteria. In this study, we designed the LPcin-YK3 peptide, a shorter analog of LPcin, and investigated its antimicrobial activity. This peptide, consisting of 15 amino acids with + 3 net charges, was an effective antimicrobial agent against the on the Gram-positive strain, Staphylococcus aureus (MIC: $0.62{\mu}g/ml$). In addition, the hemolytic activity assay revealed that the peptide was not toxic to mouse and human erythrocytes up to $40{\mu}g/ml$. We also used circular dichroism spectroscopy to confirm that peptide in the presence of lipid has ${\alpha}-helical$ structures and later provide an overview of the relationship between each structure and antimicrobial activity. This peptide is a member of a new class of antimicrobial agents that could potentially overcome the problem of bacterial resistance caused by overuse of conventional antibiotics. Therefore, it could be used as a therapeutic or natural additive, particularly in the cosmetics industry.