• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2008년도 추계학술발표회
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• pp.243-244
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• 2008

• Bulletin of the Korean Chemical Society
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• 제28권10호
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• pp.1824-1826
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• 2007

• 대한예방한의학회지
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• 제17권2호
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• pp.179-187
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• 2013

Objectives : In many cases, patient's symptoms have been recorded on EMR in natural language instead of medical terminologies. It is possible to build a database by analyzing the symptoms of Korean Medicine(KM) that indicates patient's symptoms in natural language. Using the database, when doctors record patient's symptoms on EMR in natural language, conversely it'll be also possible to extract the symptoms of KM from those natural language. The database will enhance the value of EMR as a medical data. Methods : In this study, we aimed to make data structure of the terminologies that represent the symptoms of KM. The data structure is combinations of smallest unit in natural language. We made the database by analyzing morpheme of the natural language to express the symptoms of KM. Results & Conclusions : By classifying the natural language in 15 features, we made the structure of concept and the data available for morphological analysis.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.501-502
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• 2010

• Biomolecules & Therapeutics
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• 제27권4호
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• pp.395-403
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• 2019

Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 ($PM_{2.5}$) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and $PM_{2.5}$ severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or $PM_{2.5}$. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and $PM_{2.5}$.

• 대한한의학원전학회지
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• 제33권2호
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• pp.13-32
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• 2020

Objectives : To define an everyday ethics for students and doctors of Korean Medicine, people who desire treatment, cultivation and healing through Korean Medical means by determining its conditions and characteristics. Ways of constructing its contents fit for contemporary society were discussed. Methods The threefold Heaven-Earth-Human theory, Yinyang theory, circulation of the Five Phases along with contents of classics such as 『Huangdineijing(黃帝內經)』, 『Guanzi(管子)』, 『Zhongyong(中庸)』, 『Daxue(大學)』, 『Beijiqianjinyaofang(備急千金要方)』, 『Donguibogam(東醫寶鑑)』 were newly interpreted or quoted for explanation. Results : The elements that construct natural ethics and Natural Ethics were established as following: the natural perspective of Nature and People, natural sustainability as fundamental principle, co-existence and initiative circulation as fundamental rules, education and cultivation of lay people, and professional character and competence. Conclusions : The authors suggest a reconstruction of the inherent philosophy, ethics, principle, rule, life guidelines of Korean Medicine within the framework of "natural ethics" and "Natural Ethics" as a prior task for better integration of traditional KM into contemporary society.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.139.2-140
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• 2003

Tannin-rich fruit of Cornus officinalis Sieb. et Zucc has been used as an ingredient in several prescriptions of Oriental medicine. Cornis fructus was extracted by successive extraction. Cornis fructus extracts were investigated for antimicrobial and antioxidative activities. Antimicrobial effects used disk diffusion method. All extracts were examined against Streptococcus mutans. (omitted)

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.85-91
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• 2019

Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent complications of diabetes, affect sensory, motor, and autonomic nerves. This study aimed to investigate whether 7,8-dihydroxyflavone (7,8-DHF) protects SH-SY5Y neuronal cells against high glucose-induced toxicity. In the current study, we found that diabetic patients exhibited higher lipid peroxidation caused by oxidative stress than healthy subjects. 7,8-DHF exhibits superoxide anion and hydroxyl radical scavenging activities. High glucose-induced toxicity severely damaged SH-SY5Y neuronal cells, causing mitochondrial depolarization; however, 7,8-DHF recovered mitochondrial polarization. Furthermore, 7,8-DHF effectively modulated the expression of pro-apoptotic protein (Bax) and anti-apoptotic protein (Bcl-2) under high glucose, thus inhibiting the activation of caspase signaling pathways. These results indicate that 7,8-DHF has antioxidant effects and protects cells from apoptotic cell death induced by high glucose. Thus, 7,8-DHF may be developed into a promising candidate for the treatment of diabetic neuropathy.

• Bulletin of the Korean Chemical Society
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• 제29권8호
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• pp.1594-1596
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• 2008

• The Korean Journal of Physiology and Pharmacology
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• 제16권3호
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• pp.187-192
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• 2012

In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Antinociceptive action of hop extract was maintained at least for 60 min. Moreover, cumulative response time of nociceptive behaviors induced with intraplantar formalin injection was reduced by hop extract treatment during the 2nd phases. Furthermore, the cumulative nociceptive response time for intrathecal injection of substance P ($0.7{\mu}g$) or glutamate ($20{\mu}g$) was diminished by hop extract. Intraperitoneal pretreatment with naloxone (an opioid receptor antagonist) attenuated antinociceptive effect induced by hop extract in the writhing test. However, methysergide (a 5-HT serotonergic receptor antagonist) or yohimbine (an ${\alpha}_2$-adrenergic receptor antagonist) did not affect antinociception induced by hop extract in the writhing test. Our results suggest that hop extract shows an antinociceptive property in various pain models. Furthermore, the antinociceptive effect of hop extract may be mediated by opioidergic receptors, but not serotonergic and ${\alpha}_2$-adrenergic receptors.