• Journal of Life Science
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• v.11 no.2
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• pp.83-86
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• 2001

The long terminal repeat (LTR) elements of human endogenous retrovirus (HERV) have been found to be coexpressed with genes located nearby. It has been suggested that the LTR elements have contributed to the genetic variation of human genome connected to various diseases. Recently, HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using genomic DNAs derived from schizophrenia, we performed PCR amplification and identified six HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity (87.7-99.5%) with HERV-W LTR (AF072500). Sequence analysis of the HERV-W LTR elements revealed that clone W-sch1 showed identical sequence with the AC003014 (PAC clone RP1-290B4) derived from human Xq23. Clone W-sch2 was closely related to the AC0072442 derived from human Y chromosome by phylogenetic analysis. Our data suggest that new HERV-W LTR elements in schizophrenia may be very useful for further studies to understand neuropsychiatric diseases.

• Journal of the Korean housing association
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• v.18 no.1
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• pp.83-93
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• 2007

Following the previous ones, this study is intended to explore methods of qualitative assessment on the view from apartment units. It first complemented and analyzed the attributes of landscape elements and then set up questionnaire items based on these attributes to identify the tendencies in apartment inhabitants' recognition of landscape elements, and then conducted a preference assessment on the test cases sampled on the basis of picture and other data collected in the previous studies to identify the characteristics of the preference for the view from apartment units according to landscape elements. Consequently, the following results have been derived. First, the landscape elements seen from apartment units may be classified into a total of sixteen categories, and the overall ratio of natural elements to artificial ones is shown to be approximately one to three. Second, it is also shown that apartment dwellers tend to prefer natural landscape elements over artificial ones, and the preferences for the distance to and location of landscape elements exhibit certain variance depending on the type of the elements. Third, the analysis of the preference for landscape elements has revealed that the types of landscape elements, the make-up and diversity of landscape elements, and the perceived distance to landscape elements as well as the resultant feeling of openness all affect the preference tendencies.

• Korean Institute of Interior Design Journal
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• v.20 no.5
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• pp.245-253
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• 2011

As interests towards health rapidly increase recently, interests and demand for hospital interior space are increasing as well. Therefore, most of today's hospitals that have been functionally designed are transforming into healing environments that consider psychological aspects, in order to assist patients forget about fear, desperation and have peace of mind. With such creation method of healing environment, natural elements can be applied to spaces in order to allow patients feel vitality, hope and adapt positive thinking, and these can eventually lead to affluent fusion of humans, nature and space. Through case analyses of how natural elements are applied to hospital's interior space, this study understands its characteristics. According to the findings, nature is largely classified into light, water, plant, stone/soil, and its application methods can be classified into center, transition, continuity, division, opening and closure. As evident from case analyses, application of natural elements to hospital's interior space promotes exchanges among patients through community formation, and achieves the effect of spatial concentration and public place. Also, ambiguity of exterior and interior boundary creates a sense of expansion and continuous effect, and can also provide a healing environment that can fully absorb natural environment open to patients. This study aims to be of service when designing hospital's interior space, with its natural element application method for healing environment research, and wishes for continuous studies on healing environments with more diverse methods.

• 한국방재학회:학술대회논문집
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• 2007.02a
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• pp.315-318
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• 2007

In order to reduce the amount of damage from natural disasters, we needs prevention meteorological database classified into the cause of disaster, damage elements etc. For this, we have analyzed four data, such as Statistical yearbook of calamities issued by the National Emergency Management Agency and Annual Climatological Report issued by the Korea Meteorological Administration and Recently 10 years for natural disaster damage and Statistics Yearbook from the Ministry of Government Administration and Human affairs. Through the analysis of disaster data, we have selected input variables, such as causes and elements, occurrence frequencies, vulnerable areas of natural disaster, etc. In order to reduce damage from natural disaster, the prevention activities and forecasting based on meteorological parameters and damage datas are required. In addition, it is necessary to process meteorological information for disaster prevention activities. Through these procedure, we have established the foundation of database about natural disasters. This database will be used to assess the natural disasters and build risk model and natural disasters mitigation plan.

• Structural Engineering and Mechanics
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• v.29 no.5
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• pp.531-550
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• 2008

This paper adopts the numerical assembly method (NAM) to determine the exact solutions of natural frequencies and mode shapes of a multi-span and multi-step beam carrying a number of various concentrated elements including point masses, rotary inertias, linear springs, rotational springs and springmass systems. First, the coefficient matrix for an intermediate station with various concentrated elements, cross-section change and/or pinned support and the ones for the left-end and right-end supports of a beam are derived. Next, the overall coefficient matrix for the entire beam is obtained using the numerical assembly technique of the conventional finite element method (FEM). Finally, the exact solutions for the natural frequencies of the vibrating system are determined by equating the determinant of the last overall coefficient matrix to zero and the associated mode shapes are obtained by substituting the corresponding values of integration constants into the associated eigenfunctions.

• Journal of The Korea Institute of Healthcare Architecture
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• v.9 no.1
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• pp.53-60
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• 2003

In this study, I investigate the critical evaluation elements at the architectural competition held nationwide in Germany. These evaluation elements, which can be regarded as the important design evaluation criteria, are selected by the design competition committee. Generally, in Germany the design competition committee consist of professors and famous architects who have theoretical and practical abilities with their own office. I classify and analyze the critical evaluation elements of seventy committee members, working on the selected nine prize-winners in Germany from 1997 to 2001. I conclude that the critical evaluation elements, ordered by frequency are : (1)circulation, (2)context, (3)function, (4)landscape & outside space, (5)organization of space, (6)arrangement of building, (7)form, arrangement of building, (7)form, (7)growth & change, (9)elevation design, (10)utilization of natural light. These design evaluation growth & change, (9)elevation design, (10)utilization of natural light. These design evaluation criteria for Hospital Architecture in Germany also can be applied to the evaluation methods of the korean Healthcare facility design.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2006.11a
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• pp.248-252
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• 2006

This study is intended to understand the intrinsic attributes of the view from the apartment unit in consideration of the diverse and complex elements of the view. To this end, the Questionnaire survey was conducted to identify the tendency in the recognition by apartment dwellers. The Questionnaire survey was conducted for the apartment residents to identify their interest in and the general trend in their recognition of the view from the living rooms of their housing unit, where Questionnaire items regarding landscape elements, the distances to and location of the landscape elements, and floor locations were compiled on the basis of the results from the field survey in the previous study. Consequently, the following results have been derived. 1) Apartment residents recognize not only natural landscape elements but also artificial elements, and prefer natural elements to artificial ones. 2) It is also indicated that they recognize the distances to and locations of landscape elements and that the satisfaction for the distance and location varies depending on the type of the landscape elements. 3) Furthermore, the floor of each unit is shown to result in certain differences in the recognized landscape elements. The cross-analysis between the floor and satisfaction indicates that the higher the floor, the more satisfied the residents are with the view.

• Animal cells and systems
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• v.6 no.2
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• pp.167-170
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• 2002

The long terminal repeats (LTRs) of human endogenous retrovirus (HERV) have been found to be coexpressed with sequences of closely located genes. It has been suggested that the LTR elements have contributed to the structural change or genetic variation of human genome connected to various diseases and evolution. We examined the HERV-W LTR elements in various cancer cells (2F7, A43l , A549, HepG2, MIA-PaCa-2, PC-3, RT4, SiHa, U-937, and UO-31). Using genomic DNA from the cancer cells, we performed PCR amplification and identified twelve new HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity (88-99％) with HERV-W LTR (AF072500). A phylogenetic tree obtained by the neighbor-joining method revealed that HERV-W LTR elements could be mainly divided into two groups through evolutionary divergence. Three HERV-W LTR elements (RT4-2, A43l-1, and UO3l-2) belonged to Group 1, whereas nine LTR elements (2F7-2, A549-1, A549-3, HepG2-3, MP2-2, PC3-1, SiHa-8, SiHa-10, and U937-1) belonged to Group 11. Taken together, our new sequence data of the HERV-W LTR elements may contribute to an understanding of tissue-specific cancer by genomic instability of LTR integration.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.35 no.11
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• pp.61-68
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• 2019

The analysis of outdoor and indoor spatial composition with natural elements is required for the creation of healing environment in healthcare facility to provide basic data for the planning of hospital architecture. Literature review of healing environment and investigation on characteristics of spatial composition in architectural works and healthcare facilities have been conducted. The spatial composition of outdoor space for refuge and prospect from indoor space of Seoul National University Hospital have been analyzed. The result of this research can be summarized as followed. First of all, the main natural elements for healing environment are consisted with refuge in outdoor space and prospect from indoor space. The second one is that natural elements in Seoul National University Hospital are located in central, posterior, and lateral area of main hospital and connectivity, integration, and ERAM(3) which the characteristics of outdoor spatial composition with space syntax are focused on the museum of medicine and landscape area in the center of hospital. The third one is that the outdoor refuge and prospect from indoor space in Seoul National University Hospital can be replaced with cultural heritage like the site of Kyungmogungji and Changgyeonggung palace in and next to the hospital. In addition to the outdoor and indoor spatial composition, it is necessary to analyze the relationship between elements to develop the healing environment of hospital architecture.

• Journal of the Korean Home Economics Association
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• v.48 no.7
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• pp.77-87
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• 2010

This study investigated users' perceptions and attitudes toward Korean traditional elements in contemporary spaces. We collected and analyzed the article contents of two design magazines, from their issues of January 2000 through December 2009, for a total of 87 cases. The results were as follows. First, the important motives for applying traditional elements to current living spaces were individual tastes, preference for a secluded life, and the users' childhood memories. Second, the most frequently used traditional element was traditional structure. Others were traditional spatial compositions and the use of natural materials. The two main purposes for renovating a space or constructing a building were to preserve traditional ambience or to add convenience and practical use to it. Third, the most frequently mentioned advantages of traditional elements were their environment-friendly characteristics, such as connecting to nature and using natural materials. Fourth, the users preferred, in order, Ma-dang, natural environments, doors/windows of various types and multiple functions, Toet-maru, Dae-cheong, and Nu-maru.