• The Korean Journal of Physiology and Pharmacology
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• 제14권3호
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• pp.185-189
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• 2010

The present study demonstrates the effect of fibrates, agonists of $PPAR{\alpha}$ on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-$1{\beta}$ (10 ng/ml), $IFNP{\gamma}$ (10 ng/ml), and TNF-$\alpha$ (10 ng/ml) cause a significant increase of cell proliferation in a time-dependent manner. Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and $10\;{\mu}M$) reduced the $IFNP{\gamma}$ and IL-$1{\beta}$-induced cell proliferation in a dose-dependent manner. To address the involvement of IL-6 on the $IFNP{\gamma}$ and IL-$1{\beta}$-induced cell proliferation, released IL-6 level was measured. $IFNP{\gamma}$ and IL-$1{\beta}$ cause an increase of released IL-6 protein level in a time-dependent manner. Furthermore, pretreatment with IL-6 antibody (0, 0.1, 1, 2.5, and 5 ng/ml) dose-dependently inhibited the $IFNP{\gamma}$ and IL-$1{\beta}$-induced cell proliferation. However, bezafibrate and fenofibrate did not affect increased mRNA and protein levels of IL-6 in $IFNP{\gamma}$ and IL-$1{\beta}$-stimulated astrocytes. Taken together, these results clearly suggest that activation of $PPAR{\alpha}$ attenuates the $IFNP{\gamma}$ and IL-$1{\beta}$-induced cell proliferation through IL-6 independent pathway.

• Journal of Microbiology and Biotechnology
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• 제29권8호
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• pp.1212-1220
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• 2019

The study of metabolomics in natural products using the diverse analytical instruments including GC-MS, LC-MS, and NMR is useful for the exploration of physiological and biological effects and the investigation of drug discovery and health functional foods. Cordyceps militaris has been very attractive to natural medicine as a traditional Chinese medicine, due to its various bioactive properties including anti-cancer and anti-oxidant effects. In this study, we analyzed the metabolite profile in 50% ethanol extracts of C. militaris fruit bodies from three development periods (growth period, matured period, and aging period) using $^1H-NMR$, and identified 44 metabolites, which are classified as 16 amino acids, 10 organic acids, 5 carbohydrates, 3 nucleotide derivatives, and 10 other compounds. Among the three development periods of the C. militaris fruit body, the aging period showed significantly higher levels of metabolites including cordycepin, mannitol (cordycepic acid), and ${\beta}-glucan$. Interestingly, these bioactive metabolites are positively correlated with antitumor growth effect; the extract of the aging period showed significant inhibition of HepG2 hepatic cancer cell proliferation. These results showed that the aging period during the development of C. militaris fruit bodies was more highly enriched with bioactive metabolites that are associated with cancer cell growth inhibition.

• 생명과학회지
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• 제31권8호
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• pp.745-754
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• 2021

면역 기능의 저하는 각종 감염에 대한 저항력의 부족을 초래하여 다양한 질병 유발에 기여하며, 면역 억제제의 부작용을 감소시키거나 면역력을 높이기 위해 면역 조절 생체 물질이 사용되고 있다. 침향은 침향나무의 방향족수지 부분이며 전통적으로 다양한 질병을 치료하기 위한 목적으로 사용되어왔다. 비록 선행 연구들에 의하여 침향이 신체의 면역력을 향상시킬 수 있다는 사실이 밝혀졌지만 이에 대한 근거는 여전히 부족한 실정이다. 본 연구에서는 인도네시아에서 구입한 A. malaccensisd 침향 메탄올 추출물의 면역 자극 효과를 RAW 264.7 대식세포 모델에서 평가하였다. 본 연구의 결과에 의하면 침향 추출물은 세포 독성이 없는 조건에서 식작용을 현저하게 향상시켰으며다. 또한 침향 추출물 처리된 RAW 264.7 세포는 활성화된 대식세포의 전형적인 형태를 보였으며, iNOS 발현 증가에 따른 NO 생성의 생성을 크게 증가시켰다. 아울러 TNF-α, IL-1β 및 IL-6과 같은 cytokine의 발현과 분비를 증가시켰으며, MAPKs 신호 전달 경로를 활성화시켰다. 따라서 본 연구의 결과는 고대 서적을 기반으로 침향의 효과를 확인하는 데 중요한 의미가 있으며, 침향이 잠재적인 면역 강화 효과가 있다는 근거를 제시하는 것이다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 C
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• pp.1558-1560
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• 2004

Liquid-immersed pole transformers have utilized an insulation system consisting of natural cellulose-based materials and mineral oil for many years. If the transformers are installed with the abruptly changing load over limitation, its insulation materials are apt to unexpected aging with high temperature. Therefore we have been conscious of developing a transformer that is more thermally stable then conventional types. To measure temperature distribution in the winding of conventional and newly designed transformers, temperature sensors were installed fordirect reading of oil and conductor temperatures at transformers. And we conducted accelerating aging test for these transformers. The measuring data had made use of the design to hybrid insulation system. Also we could find the possibility of this insulation system to apply in pole mounted transformers.

• 대한후두음성언어의학회지
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• 제25권1호
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• pp.13-15
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• 2014

Presbyphonia is defined as voice change caused by aging. Since presbyphonia is one of the natural aging processes, the treatment should be considered for the patients complaining communication difficulties. The treatment should not only target on presbylaryngis, but also on underlying systemic conditions such as lung function, neurological diseases and medications. Therefore, the treatment for the patients with presbyphonia should be multidisciplinary including underlying disease control, voice therapy and surgical treatment. Although various experiments on treatment of presbylaryngis are currently being tried, repeated injection laryngoplasty is still playing an important role because presbyphonia is destined to get worse over time.

• 펄프종이기술
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• 제35권1호
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• pp.48-53
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• 2003

The objective of this study was to find in what color Korean handmade paper(Hanji) is dyed when it is dyed with a pigment extracted from waste onion peelings using different kinds of mordant, and how the paper is discolored and variety of strength under the condition of accelerated aging test. The results of this experiment are as follows. 1. Korean handmade paper was dyed in different colors according to the kinds of mordant. Mainly it was dyed in orange-brown, and sometimes in gold or khaki. 2. Korean handmade paper dyed was not discolored much, which suggests that the pigment is strong under the condition of aging. 3. As for durability, Korean handmade paper dyed in gold was strongest. Korean handmade paper, to which aluminum sulfate, iron sulfate or sodium dichromate was applied as mordant, had poor durability. Thus, these were not suitable as mordant.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2002년도 학술발표회 발표논문집
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• pp.353-356
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• 2002

In this study, the clay samples collected in the area Mokpo carry out laboratory soil test. Under three different curing $temperature-20^{\circ}C,\;50^{\circ}C,\;80^{\circ}C$ and 4 terms of curing day -1day, 7days, 14days, 40days for each, the remolded and reconsolidated samples had been made. To find out an aging effects and geotechnical characteristics between undisturbed samples and reconsolidated samples, laboratory tests were preformed. In the results, it was found that mechanical properties of undisturbed natural samples were similar to high temperature reconsolidation clay. The curing temperature influence on simulating aging effect more than the curing day does and the best curing condition are $80^{\circ}C$, 27days.

• 한국주거학회논문집
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• 제25권1호
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• pp.73-80
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• 2014

Korea is quickly transforming into an aging society. As a reaction to the accelerated aging society in recent years, there is a growing need to introduce sustainable housing policies and strategies for aging society. The main purpose of this study is to explore where people want to live after retirement. Especially, this study focuses on the residential environment such as housing types, residential location, and living environment. The main findings are as follows. First, people preferred living in a sububan-style housing in the suburban or rural areas to living in a city-style housing in the urban areas. Second, people have a strong preference for the importance of convenience in using natural environment, medical service, and cultural facilities. Third, the family life style has been changed from children-oriented life style to couple-oriented life style by showing that people like to stay with a spouse rather than with their children after retirement.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 D
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• pp.1404-1406
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• 1998

The outdoor polymeric insulating materials such as silicone rubber, ethylene propylene diene monomer(EPDM), ethylene vinyl acetate(EVA) and epoxy are aged by various natural environment with the long-term performance in outdoor. In this paper, the effects of UV-ray on surface of silicone rubber were investigated by using the weather-Ometer. The accelerated aging stresses were simulated by UV radiation. high temperature and humidity as well as water spray. These the aging characteristics were examined through contact angle measurements, tracking resistance test, FT-IR and SEM/EDS analysis. the experimental results showed that tracking resistance decreases with increase in the UV-ray irradiation period. But the surface of silicone rubber kept hydrophobicity. It is found that the inorganic filler such as $Al(OH)_3$ improves tracking resistance and the $TiO_2$ is very effective in preventing degradation of silicone rubber surface from UV-ray.

• Elastomers and Composites
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• 제42권1호
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• pp.32-46
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• 2007

고무부품의 신뢰성을 확보하기 위해서 고무재료의 기계적 물성을 정확히 파악하는 것이 매우 중요하다. 본 연구에서는 천연 및 합성고무에 대해 다양한 환경조건에서 물성시험을 수행하여 경도, 신율 및 응력-변형률 관계와 동 특성을 파악하였다. 또한, 고무부품의 유한요소 해석에 필요한 비선형 재료상수를 단축인장과 이축인장시험을 통해 결정하였다.