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Ferment Red Ginseng Suppresses the Expression of Matrix Metalloproteinases in UVA-irradiated Human Dermal Fibroblast Cells (발효홍삼의 인간진피섬유모세포에서 UVA로 유도한 염증 및 기질단백분해효소 발현 억제 효능)

  • Lee, Keun-Hyeun;Jeong, Seung-Il;Lee, Chang-Hyun;Shin, Sang Woo;Jeong, Han-Sol
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.31 no.2
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    • pp.105-110
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    • 2017
  • Prolonged exposure to solar ultraviolet A (UVA) radiation has been known to cause premature skin aging (photo-aging). UVA radiation generates ROS thereby induce degenerative changes of skin such as degradation of dermal collagen, elastic fibers. Matrix metalloproteinases (MMPs), the proteolytic enzymes have been implicated as a major player in the development of UVA-induced photo-aging. Many studies have been conducted to block the harmful effects of UV radiation on the skin. Recently, we are interested in the availability of fermented red ginseng (FRG) as natural matrix metalloproteinases inhibitors (MMPIs). The efficacy difference between red ginseng and FRG has been compared. Both RG and FRG have no cytotoxic effects below the concentration of $300{\mu}g/ml$. Human dermal fibroblasts (HDFs) were pretreated with FRG or RG for 24h, followed by irradiation of UVA. Then, we measured the intracellular ROS production and the expression of MMP, $IL-1{\beta}$ at the mRNA level. We also examined the intracellular localization of $NF-{\kappa}B$ and MMP-9 on the FRG or RG treated and UVA-irradiated HDFs. FRG decreased the intracellular ROS production elicited by UVA. In addition, FRG decreased the mRNA expression of MMP-3, MMP-9, and $IL-1{\beta}$ more efficiently than RG. Furthermore, FRG suppressed the nuclear localization of $NF-{\kappa}B$, and the expression of MMP-9. Taken together, our results suggest that FRG is promising agents to prevent UVA-induced photo-aging by suppressing MMP expression and inflammation.

Development of a Joint University Campus as a Key Element in the Regional Innovation System in Sejong Tech Valley, South Korea

  • Lee, Seo-Jeong;Lee, Eung-Hyun;Oh, Deog-Seong
    • World Technopolis Review
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    • v.6 no.2
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    • pp.148-158
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    • 2017
  • Sejong City, which has been chosen as a new administrative capital of South Korea, has completed the first phase of its development plan with the construction of the facilities needed to accommodate central administrative organizations and the required accompanying population. Now, it is undergoing the second phase of development with a focus on strengthening the region's innovation capacity to catalyze endogenous development. The strategy for phase II is to establish a regional innovation system including building necessary infrastructure and attracting innovation agents such as universities, businesses, and research institutes. The first step for this is developing a research complex, tentatively named Tech Valley, that includes universities, research institutes, and businesses, and building infrastructure comprising a science complex, a knowledge industry center, and support facilities. Phase II of the city's development initiative includes the establishment of a joint university campus, which is to serve as a center to promote cooperation among industry actors, universities, and research institutes. The concept of a joint campus has been drawn from a need to enhance capacity for innovation and specialization in the region's industries and to maximize synergy among participating universities through the sharing of research equipment, facilities, and programs. The joint campus is expected to play a key role in creating an innovation system in the region by enhancing research capacity for strategic industries, cultivating highly skilled human resources, and leading industry-academia-research cooperation. In order to ensure the sustainable development of the new city, there is a growing need to have a main player in place that could lead the region's economic development. The joint campus will propel industrial specialization and serve as a catalyst to attract competent universities to the region. This paper will examine the concept, major functions, and the establishment and operation of the joint campus.

Implementation of NTSC TV Transmitter Module (NTSC TV Transmitter Module의 구현)

  • Kim Kwang-Tae;Sim Myoung-Su
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.43 no.2 s.308
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    • pp.28-32
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    • 2006
  • In this paper, NTSC TV Transmitter Modulo will be designed and produced which make possible playing the motion picture not only on TV but also on portable TV. NTSC TV Transmitter Module modulates signals that received Video and Audio signals from a mobile on NTSC TV CH4 mechanism. so it has an advantage of convenience that watching the motion picture of mobile on TV without any other cable through transmitting signals by wireless. But it has some demerits of long size antenna and noise sensitiveness. In the future, if some problems like a size of antenna distortion of signal and noise can be solved through continuous researching about Radio Frequency part, it is possible to play mobile motion pictures on the more media like a camcorder, DVD player and so on.

The Effects of Music Therapy on Cognitive Function and Depression in Demented Old Adults (음악요법이 치매노인의 인지기능과 우울에 미치는 효과)

  • Gwon, Ja-Youn;Kim, Jung-Soo
    • Research in Community and Public Health Nursing
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    • v.9 no.2
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    • pp.336-349
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    • 1998
  • The purpose of this study was to test the effects of music therapy on cognitive function and depression in demented old adults. This study was made with one -group in a pre- and post-test design. The subjects were seven demented old adults over, sixty-five years and with mild to moderate cognitive impairment, residing at a nursing home. Music therapy was given by one researcher and one research assistant for thirty to forty minutes twice a week for 4 months. Music therapy was conducted with the subjects both listening and singing with a cassette player and a double-handed drum. In order to evaluate the effects of music, we measured the level of cognitive function and depression at the beginning and at the end of the music therapy session by means of an MMSE- K developed by Kwon and Park and the Depression Inventory developed by Chon. The Data were analyzed using descriptive statistics and a paired t - test analysis using a SPSS PC package. The results are as follows: 1) The subjects of the music therapy showed improvement in cognitive function. The MMSE-K score was significantly increased after music therapy. Especially, memory recall was very significantly. 2) The subjects of the music therapy showed a slight decrease in depression. However, there was no significant difference in the degree of depression between mean scores measured before and after music therapy. The results suggest that music therapy is effective in improving and maintaining cognitive function in demented old adults. And we suggest that long-term music therapy will be required to improve depression in demented old adults. These findings are encouraging the idea that music therapy may improve cognitive impairment.

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Method of Fuzzing Document Application Based on Android Devices (안드로이드 기반 문서 어플리케이션의 퍼징 방법론 연구)

  • Jo, Je-Gyeong;Ryou, Jae-Cheol
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.25 no.1
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    • pp.31-37
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    • 2015
  • As the forms of cyberattacks become diverse, there has been reported another case of exploiting vulnerabilities revealed while processing either a document or multimedia file that was distributed for attacking purpose, which would replace the traditional method of distributing malwares directly. The attack is based upon the observation that the softwares such as document editer or multimedia player may reveal inherent vulnerabilities on some specific inputs. The fuzzing methods that provide invalid random inputs for test purpose could discover such exploits. This paper suggests a new fuzzing method on document applications that could work in mobile environments, in order to resolve the drawback that the existing methods run only in PC environments. Our methods could effectively discover the exploits of mobile applications, and thus could be utilized as a means of dealing with APT attacks in mobile environments.

Real-time Task Scheduling Algorithm using Multi-dimensional Methodology (다차원 기법을 이용한 실시간 태스크 스케줄링 알고리즘)

  • Cho, Moon-Haeng;Lee, Cheol-Hoon
    • Proceedings of the Korea Contents Association Conference
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    • 2009.05a
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    • pp.810-815
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    • 2009
  • In recent years, embedded systems such as cellular phones, Portable Multimedia Player, intelligent appliance, automobile engine control are reshaping the way people live, work, and play. Thereby, applications for embedded systems become increasingly sophisticated and complicated, such embedded computing platforms must use real-time operating systems (RTOSs) with time determinism. These RTOSs must not only provide predictable services but must also be efficient and small in size and it's kernel services should also be deterministic by specifying how long each service call will take to execute. Having this information allows the application developers to better plan their real-time application software so as not to miss the deadline of each task. In this paper, we present the complete generalized algorithm using multi-dimensional methodology to determine the highest priority in the ready list with 2r levels of priorities for an arbitrary integer number of r.

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A Study of Factors influencing the Attitudes and Dispositions of Doping in Elite Golf Players (엘리트 골프선수들의 도핑에 대한 사고방식 및 성향에 미치는 요인)

  • Kim, Tae-Gyu;Cha, Jung-Hoon;Cha, Kwang-Suk;Kim, Kee-Hyun
    • Journal of Digital Convergence
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    • v.14 no.8
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    • pp.527-536
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    • 2016
  • The purpose of this study is to identify the factors influencing the attitudes and dispositions of doping in elite golf players. 136 elite golfers (75 male, 61 female) were participated in this study and responded to Performance Enhancement Attitude Scale, Perfectionism in Sport Scale and Perceived Motivational Climate in Sport Questionnaire-2. Data that were collected analyzed by hierarchical multi regression. In male golfers, unequal recognition (UR) of coach had a positive effect on the attitudes and dispositions of doping, and rivalry (R) had a negative effect on that. In female golfers, Coach's criticism (CC) had a positive effect on the attitudes and dispositions of doping. The effective anti-doping program which reflects the results of this study should be developed and implemented for elite golf players who need the anti-doping education.

A study on Korean Climate Change Governance in Mass Media : Focused on Daily Newspapers (우리나라 언론에 나타난 기후변화 거버넌스 연구 : 일간지를 중심으로)

  • Hong, Young Sik;Lee, Deokro
    • The Journal of the Korea Contents Association
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    • v.19 no.12
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    • pp.38-56
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    • 2019
  • Climate change is tough global issue with human being to tackle in cooperative manners, because climate change affects globally and has long-term detrimental impacts. To get a clue to this intricate problem, vertical governance (global, regional, national, and local) with horizontal governance should be well orchestrated. In this research, we analyzed about 24,000 articles in Korean daily newspapers from 1990 to 2018 to find out vertical and horizontal governance characters of Korean climate change. The result showed that Korean government followed the global issues but lacks relations with neighbor countries. and found a little actions in local government. In horizontal governance aspect, Korean government approached the climate change as a tool for economic development and lead the issues without communication with other two player which are market and civil society. We proposed to use market mechanism to facilitate the participation and Climate Change Framework Act to setup the mechanism for cooperation.

An Exploratory Study on the Possibility of Creative Quality Management (창조적 품질경영의 가능성에 대한 탐색적 연구)

  • Oh, Hyung-Sool;Seong, Baek-Seo;Kim, Seon-Min
    • Journal of the Korea Safety Management & Science
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    • v.11 no.1
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    • pp.103-113
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    • 2009
  • Motorola which had developed and commercialized wireless telephone and mobile phone for the first time in the world made a decision on the separation of the mobile unit from the Motorola due to the continuous bad performance turn. In addition, the Korean company named Raincom which had developed and commercialized MP3 player have been disappeared since Raincom failed to compete with iPod of Apples. What is the main cause the companies that have been top of the world level weed out of IT product market? For less product life cycle and globalization of market, the company's competitiveness tends to be determined based on company's creative capability, rather than process implementation capability. Thus, companies spent a great amount of time and effort in the introduction of creativity management and R&D activities. However, as company's continuous investment on R&D and innovation activities did not lead to business performance, they starts to pay much attention on the effective R&D and innovation activities. Therefore, this paper tries to solve the limitation of the effectiveness of R&D activities by introducing the concept of 'creative quality'. The creative quality is executed by the creative process, which is designed for getting over the limitation of the traditional brainstorming method. This paper presents the concept so called 'creative quality management' and expects it to be an alternative to conquest the limitation of six sigma management.

Recognition of the Type and Cause of Trolling (<리그 오브 레전드> 트롤링의 유형과 발생 원인에 대한 인식 -사용자 심층인터뷰를 중심으로-)

  • Seo, Seong-Eun;Kim, Chi-Yo
    • Journal of Korea Game Society
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    • v.15 no.4
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    • pp.93-110
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    • 2015
  • This study aimed at identifying user recognition of the types and causes of online game trolling through in-depth interview with users of . Online game trolling refers to anti-social behaviors to do acts provoking other users to anger intentionally so induce their actual reaction in online games. Types of online game trolling contained flaming, griefing, unskilled player and lack of understanding on user's rule. And users are recognizing as problems that anonymity is excessively high in the game, a single game has undue significance, team play is given too much emphasis in a situation lacking in social cohesivenessk as the structural causes of trolling in . Accordingly, in order to decrease online game trolling, it is urgent to improve the game-structured layer causing trolling rather than regulate trollers only.