• 제목/요약/키워드: Narcotics

검색결과 82건 처리시간 0.026초

경막외 Morphine 투여에 의한 극심한 호흡억제 및 두개강내 공기음영 (Severe Respiratory Depression and Intracranial Air after Epidural Morphine -Subdural or Epidural Injection?-)

  • 강미경;문동언;서재현
    • The Korean Journal of Pain
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    • 제6권2호
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    • pp.270-274
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    • 1993
  • Massive extradural spread, distinguished from subarachnoid injection that sometimes follows the introduction of small amounts of local anesthetics or narcotics during attempted epidural anesthesia or analgesia, has been attributed to subdural injection. A 64-year-old woman was admitted for partial radical hysterectomy under general anesthesia after insertion of lumbar epidural cathter by loss of resistance technique with 5 ml of air. In this case, we experienced severe respiratory depression and loss of consciousness after administration of 4 mg of morphine for postoperative pain control. We confirmed air shadows at right silvian and suprasella cisterna region by CT scanning. Patients was recovered without sequele after 2 days, As this case resembles a "massive epidural", it is suggested that subdural injection rather than epidural injection may explain the phenomenon.

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소아환자 마약성 진통제 금단증상관리에 대한 간호사의 지식과 태도 (Pediatric Nurses' Knowledge and Attitude on Iatrogenic Narcotic Analgesic Withdrawal Symptoms Management)

  • 이가영;박정윤
    • 중환자간호학회지
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    • 제11권3호
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    • pp.35-44
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    • 2018
  • Purpose : This study investigates pediatric nurses' knowledge and attitudes regarding iatrogenic narcotic analgesic withdrawal symptoms management (INAWSM). Methods : In this cross-sectional study, 253 pediatric nurses working at a tertiary hospital in Seoul participated. Instruments were the inventory consisting questionnaires on 35 items knowledge and 12 items attitude for INAWSM. Further, descriptive statistics, t-test, and analysis of variance were used to evaluate the nurses' knowledge and attitudes. Results : The correct answers rate of knowledge toward INAWSM was 44.9%. With respect to the pediatric nurses' attitudes, the participants scored an average value of $2.83{\pm}0.25$ out of 4 points. The factor related to the knowledge and attitude level was age, pediatric nursing experience, educational experience, and educational needs. Conclusions : Results revealed that pediatric nurses had inadequate knowledge and attitude on INAWSM despite a compulsory education. Therefore, it is necessary to develop an efficient INAWSM educational program.

Antihypertensives affects on the drug metabolism of buprenorphine

  • Ahn, Mee-Ryung;Yoo, Tae-Moo;Sohn, Soo-Jung;Park, In-Sook;Suh, Soo-Kyung;Yang, Ji-Sun;Choi, Hong-Serck
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.81.1-81.1
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    • 2003
  • Buprenorphine(BPN) is used to treat withdrawal syndromes in narcotic addictions. When narcotics are stopped, withdrawal syndromes such as pupil dilation and blood pressure increment are appeared. And BPN is often prescribed concomitantly with antihypertensives. We researched whether combined medicines of BPN and antihypertensives affected on the metabolism of BPN. After BPN was incubated with antihypertensives such as nifedipine, verapamil, captopril and propranolol in rat or human microsomes, amounts of BPN and its metabolite, norbuprenorphine (NBPN), were measured. (omitted)

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청소년 마약류 중독 치료를 위한 디지털치료제 예술치료 적용을 위한 문헌연구 (Literature Review on Applying Digital Therapeutic Art Therapy for Adolescent Substance Addiction Treatment)

  • 김지원;변혁
    • 트랜스-
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    • 제16권
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    • pp.1-31
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    • 2024
  • 디지털 매체의 발전은 청소년들이 마약류 구매 환경에 쉽게 접근하며 소셜 네트워크 서비스(SNS)와 메신저 서비스를 통한 마약류 구매 및 복용 사례가 증가하고 있다. 이러한 환경에 노출된 청소년들은 마약류 중독으로 인한 신경학적 및 정신 건강 문제를 겪을 위험이 있으며, 이는 범죄에 노출될 위험을 증가시킨다. 따라서, 국가 차원에서의 관리와 지원이 절실히 필요하다. 마약에 노출된 청소년들을 위한 지속 가능한 치료 방안을 모색하는 것은 중대한 과제로 부상하고 있다. 재발 위험이 높은 마약류 중독 치료를 위해선 비용이 효율적이며 사용자 친화적인 치료 프로그램이 필요하다. 본 연구는 디지털 플랫폼을 활용하여 청소년들이 자발적으로 참여할 수 있는 치료 환경을 조성하고, 예술을 활용한 치료적 콘텐츠 개발을 목표로 하는 문헌 연구를 수행한다. 청소년 약물 중독에 대한 사회적 인식과 치료 현황을 검토하고, 마약류 중독이 청소년의 뇌 활동 및 인지 기능 저하에 미치는 영향을 분석하여, 중독된 뇌 기능의 재활을 촉진할 수 있는 디지털 치료제 개발에 관한 방안을 선행 연구 사례 분석을 통해 모색한다. 또한, 디지털 치료적 접근법과 예술치료의 통합이 치료 과정에 어떠한 이점을 제공할 수 있는지를 탐구하며, 연극 치료, 음악 치료, 미술치료 등 다양한 치료 프로그램이 청소년에게 미치는 치료적 효과의 증대 가능성을 제안한다. 예술 치료 요법의 적용은 도구의 확장, 표현의 다양화, 데이터의 확보, 동기 부여 측면에서 긍정적 효과를 기대할 수 있다. 이러한 접근을 통해 청소년 마약류 중독 치료의 효과성이 증대될 것으로 예상된다. 종합적으로 볼 때, 본 연구는 청소년 마약류 중독에 대한 사회적 상황을 고려한 경제적이며 지속 가능한 치료 방안을 제공하는 디지털 치료제 및 관련 애플리케이션 개발을 위한 기초 연구를 수행하고자 한다.

여성 건강교육을 위한 건강흥미 조사연구 - 일부 여자 대학생을 중심으로 - (A Study of the Health Interests of Women's College Students in Inchun and Ansan)

  • 양순옥;김진향
    • 한국보건간호학회지
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    • 제11권1호
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    • pp.51-65
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    • 1997
  • The purpose of this study was to make a comparative analysis of nursing students interest in health matters concerning themselves and compare it to non-nursing students. The results were to be categorized and used as health content recommendation when organizing health curriculum and planning health education programmes. The instruments used this study were 'The Health Inventory and The Health Need Inventory introduced to 80 items from 125 items by Lee in Korea(1980). There was a very high correlation between the 125 items and condensed 80 items (r=0.9508, t=11.0643. p<.001). The convenience sample was chosen from 226 nursing students and 204 non-nursing students in the departments of humanities of college in Inchun and Ansan from March 4 to April 5. 1996. Data were analyzed by the SAS computer Program. The results are as follow: When comparing health interest of nursing student group with non-nursing student group, total group mean of nursing students was significantly higher than that of non-nursing students (t=2.977 p<.01). But the rank order of the nursing student group was similar to that of the non-nursing group. and what nursing student felt interested was coincident with what non-nursing students felt as being necessary. The most interested health area between nursing student and non-nursing students were ${\ulcorner$personal hygiene & grooming${\lrcorner}$ ${\ulcorner$weight control${\lrcorner}$, ${\ulcorner$sex education${\lrcorner}$ ${\ulcorner$mental health${\lrcorner}$. On the other hand the least interested health areas were. ${\ulcorner$smoking and health${\lrcorner}$ ${\ulcorner$alcohol and health${\lrcorner}$, ${\ulcorner$drug and narcotics${\lrcorner}$ In non -nursing students but in nursing students ${\ulcorner$structure and function of body${\lrcorner}$, ${\ulcorner$dental health${\lrcorner}$ ${\ulcorner$safety${\lrcorner}$. Comparing students health interest by major In college, total group mean of nursing students is significantly higher than that of non-nursing students in 14 health areas including ${\ulcorner$community health${\lrcorner}$, ${\ulcorner$control and prevention disease${\lrcorner}$ ${\ulcorner$consumer health${\lrcorner}$ ${\ulcorner$family health${\lrcorner}$ ${\ulcorner$mental health${\lrcorner}$ ${\ulcorner$personal hygiene and grooming${\lrcorner}$ ${\ulcorner$safety${\lrcorner}$ ${\ulcorner$structure and function of body${\lrcorner}$, ${\ulcorner$sex education${\lrcorner}$ ${\ulcorner$alcohol and health ${\lrcorner}$ ${\ulcorner$ drug and narcotics${\lrcorner}$ and ${\ulcorner$smoking and health${\lrcorner}$ The following recommendations could be made considering the above mentioned factors: 1. The priority of health content should reflect the items to the highest interest area of students and highest need area of adults. 2. The health items which were significantly different in the area of health interest, by major, should be used in planning health education programmes and organizing health curricula.

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가토의 좌골신경에 Morphine, Meperidine, Pentazocine을 주사한 후 미세형태학적 및 신경생리학적 변화 (Ultrastructural and Neurophysiological Changes Observed Following Injection of Morphine, Meperidine and Pentazocine in the Sciatic Nerves of Rabbits)

  • 전재규;김세연;배정인
    • The Korean Journal of Pain
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    • 제5권2호
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    • pp.213-220
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    • 1992
  • Morphine, meperidine 및 pentazocine을 가토의 좌골신경에 주입한 후 마약제의 신경차단 유무와 약제 주입 후 4시간, 24시간 및 1주에 좌골 신경을 절취하여 신경조직학적 변화를 관찰하였다. 좌골신경에 약제를 주입한 후 신경자극에 의한 반응과 뒷다리 운동을 관찰한 결과, morphine군은 신경차단 효과가 없었고 meperidine군과 pentazocine군은 약제주입 5분 후부터 근육이완이 시작되어 10분 후부터 근육수축이 나타나지 않았으며 뒷다리에 마비증상은 약제주입 60분 후부터 부분적으로 회복되기 시작하여 90분 후에는 정상으로 회복되는 양상의 신경차단 효과가 있었다. 광학 현미경적 소견으로는 모두 4시간부터 1주까지의 표본에 특기할만한 변화가 없었으며, 전자 현미경적 소견에서 morphine군은 1주 후 소견에서 유수신경섬유와 무수신경섬유에 경미한 수포양을 보였다. Meperidine군은 4시간 후 소견으로 유수신경섬유의 축삭돌기에 경미한 수포양이 있었고 무수신경의 마이엘린화되는 소견이 있었으며, 24시간 후 유수신경섬유에 경미한 수포양이 있었고 무수신경섬유가 정상으로 되었으며 1주 후 특기할 만한 변화가 없었다. Pentazocine군은 약제주입 4시간 후 유수신경섬유에 경미한 수포양을 보였으며 24시간 후 유수신경 섬유와 무수신경섬유에 중등도의 수포양이 나타났으며 1주 후 경미한 수포양을 나타내었다. 주입된 약제중 morphine이 가장 수포양이 적었으며 pentazocine이 심한 변화를 나타내었고, 전단계 쥐 실험에서 나타났던 meperidine주입 1주 후의 심한 신경조직 손상은 본 실험에서 나타나지 않았다.

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산업장 여성 근로자의 건강과 약물사용 (A Study on Health condition and Drug use of Female Workers in Incheon area)

  • 조원순
    • 한국보건간호학회지
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    • 제9권2호
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    • pp.17-32
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    • 1995
  • The purpose of this study is to promote health for young female workers. It is based on questionnaires collected from 215 female workers in Incheon area. This study includes health condition (fatigue scores), occupational disease, knowledge of abused drugs and the actual condition of drug use. The results are summerized as follows: - $47.4\%$ visited their health center and were treated with diseases like cold and headache $(34.9\%)$, gastroenteric disease $(6.5\%)$, trauma $(7.9\%)$ and chronic disease such as diabetes and hypertension $(3.3\%)$ - $44.7\%$ received regular health education and $4.7\%$ among them received education on abused drugs. - $20.5\%$ were suffering from work related diseases such as gastroenteric disease, headache, trauma, repiratory disease, skin problem, arthritis, low back pain, shortsightness and tuberculosis. - Total mean fatigue score as an indication of health status was $9.0\pm5.4$ points out of 30 points. Physical mean score (group I) was $3.92\pm2.2$ points and psychological mean score was $2.5\pm2.3$ points and neurosensory mean score was $2.6\pm2.1$ points out of each 10 points. - They recognized analgesics $(55.0\%)$ and the next are laxatives $(49.8\%)$, inhalants $(40.0\%)$, narcotics $(24.2\%)$, stimulants $(24.0\%)$, antihistamines$(5.9\%)$, diuretics $(3.0\%)$, tranquilizer $(2.4\%)$ and sedatives $(1.4\%)$ - They used analgesics $(37.2\%)$ the most and then laxatives $(6.0\%)$, stimulants$(5.6\%)$, diuretics $(1.9\%)$, antihistamines$(0.5\%)$, And nobody used tranquilizer, sedatives, narcotics and inhalant. - The relationship between career, drug abuse education, health center utilization and and the actual condition of drug using was examined. The longer the career and the more educated with drug abuse, the less drug used. And those who utilized health center rarely used more drugs. - The relationship between career, health center utilization, the score of fatigue and use of analgesics was also examined. Those group who have a longer career above 3 years and the group who have never used health center used more analgesics. And the group of fatigue score above 11.0 points used a little more analgesics than the other group. These results indicate that analgesics are the most frequent used drugs among female workers. Those analgesics such as geborin, penzal, saridon, aspirin, tyrenol should be used properly. These basic data is submitted for the education and consultation which are carried out by industrial nurses for promoting health of industrial workers.

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Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization

  • Pyo, Jae-Sung;Lee, Hee-Sang;Park, Yu-Jin;Jo, Ji-Yeong;Park, Yong-Hoon;Choe, Sang-Gil;Lee, Mi-Young;Lee, Jae-Sin
    • Mass Spectrometry Letters
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    • 제3권1호
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    • pp.15-17
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    • 2012
  • Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could be identified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil and mirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl (TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes could be identified by GC-MS after the derivatization.

비디오 흉강경을 이용한 자연성 기흉의 치료 (Video-assisted Thoracoscopic Stapled Resection for Spontaneous Pneumothorax)

  • 박진상
    • Journal of Chest Surgery
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    • 제28권3호
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    • pp.297-302
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    • 1995
  • Video-assisted thoracic surgery [VATS is emerging as a viable alternatives to thoracotomy when surgical treatment of spontaneous pneumothorax is required.Apical blebs and bullaes of the lung can be resected,and pleural abrasion can be accomplished with minimal postoperative pain and a shorter postoperative stay in hospital. We compared our results with thoracoscopic management of spontaneous pneumothorax in 20 patients [group I with a group of 32 patients previously subjected to lateral limited thoracotomy [group II . Indications for operation, sex distribution, and average age [groupI, 24.7 years ; group II, 34.4 years were comparable. Operation time [112.42 54.7 min versus 124.8 35.3 min ; P 0.03 and chest tube duration [64.4 52.3 hours versus 97.7 45.4 hours ; P 0.01 were less in group I. Postoperative hospital stay was less in group I[3.84 0.99 days;P 0.01 , as was the use of parenteral narcotics after 48 hours. [5/20=25% versus25/32=78% . Pain was quantitated by verbal rating scale in postoperative 1 to 3 days. Patients undergoing VATS experienced significantly less postoperative pain. Postoperative complication was less in group I[1/20=5% versus 3/32=8.3% . In conclusion, Video-assisted thoracoscopic management of spontaneous pneumothrax allows performance of the standard surgical procedure while avoiding the thoracotomy incision.Video-assisted thoracic surgery [VATS is safe and offers the potential benefits of shorter postoperative hospital stays and less pain with cosmetic benefits.

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한일 세관행정 변화와 전략적 대응방안 (Suggesting Strategic Countermeasures to the Change of Customs Administration in Korea and Japan)

  • 라공우;강진욱;김형철
    • 통상정보연구
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    • 제14권1호
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    • pp.273-299
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    • 2012
  • 일본의 관세 및 세관행정은 매우 보수적이었으며 사회안전 및 국민 안전확보와 무역원활화 가운데 사회안전 및 국민안전확보 측면을 강조해 왔으며, 최근에는 지적재산권 침해물품에 대한 문제를 중요한 과제로 인식하고 있다. 이에 반해서 우리나라의 경우는 통관간소화를 추진하는 과정에서 수출입 신고내용과 물품의 일치여부를 검사비율이 현저하게 낮아져 수입업자가 악용할 수 있는 여지를 두고 있다. 이러한 가운데 일본의 관세 및 세관행정의 변화는 우리나라에게 어느 정도 시사점을 제시하고 있다고 보여진다. 따라서 본 논문에서는 일본의 관세 및 세관행정에 대한 변화에 대한 시사점을 도출하고 이러한 일본의 변화에 대한 우리나라의 대응방안을 제시하였다.

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