Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.81.1-81.1
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- 2003
Antihypertensives affects on the drug metabolism of buprenorphine
- Ahn, Mee-Ryung (National Institute of Toxicological Research, Korea Food & Drug Administration) ;
- Yoo, Tae-Moo (National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
- Sohn, Soo-Jung (National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
- Park, In-Sook (National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
- Suh, Soo-Kyung (National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
- Yang, Ji-Sun (National Institute of Toxicological Research, Korea Food & Drug Administratio) ;
- Choi, Hong-Serck (National Institute of Toxicological Research, Korea Food & Drug Administration)
- Published : 2003.10.01
Abstract
Buprenorphine(BPN) is used to treat withdrawal syndromes in narcotic addictions. When narcotics are stopped, withdrawal syndromes such as pupil dilation and blood pressure increment are appeared. And BPN is often prescribed concomitantly with antihypertensives. We researched whether combined medicines of BPN and antihypertensives affected on the metabolism of BPN. After BPN was incubated with antihypertensives such as nifedipine, verapamil, captopril and propranolol in rat or human microsomes, amounts of BPN and its metabolite, norbuprenorphine (NBPN), were measured. (omitted)
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