• Title/Summary/Keyword: Naphthoquinone derivative

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Griseusin C, a Novel Quinone Derivative from a Marine-Derived Fungus Penicillium sp.

  • Li, Xiang;Zheng, Yinan;Sattler, Isabel;Lin, Wenhan
    • Archives of Pharmacal Research
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    • v.29 no.11
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    • pp.942-945
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    • 2006
  • A novel quinone derivative, Griseusin C (1), along with a known quinone, Naphthoquinone C (2), was isolated from the lyophilized culture broth of the marine-derived fungus Penicillium sp. The structures were elucidated on the basis of extensive 1D-and 2D-NMR, as well as HRESIMS, spectroscopic analysis. The relative stereochemistries of the compounds were assessed by NOESY analysis.

Analysis of Characteristics and Dyeing Properties of Gromwell Colorants(Part I) -Components and Characteristics of Gromwell Colorants- (자초색소의 특성분석 및 염색성(제1보) -자초색소의 성분과 특성-)

  • Choi, Hee;Shin, Youn-Sook
    • Journal of the Korean Society of Clothing and Textiles
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    • v.24 no.7
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    • pp.1081-1087
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    • 2000
  • Gromwell colorants were extracted with methanol and dried. Four fractions were obtained by silica gel adsorption column chromatography using step-wise elution method. Relative ratio of four fraction is 1.00:0.07:0.22:0.30(Fl:F2:F3:F4) and gromwell colorants mainly consist of Fl, F3 and F4. IR analysis shows that each fraction has similar structure. Main component of gromwell extracts is acetyl derivative of naphthoquinone, and the rest are isobutyl derivative and isovaleryl derivative etc., in order. Gromwell colorants exhibit relatively good affinity to protein and polyamide fibers, but low affinity to cellulose and regenerated cellulose fibers.

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Inhibition of Growth Factor-induced MAP kinase and Akt Activation by NQ304, a 1,4-Naphthoquinone Derivative in Rat Aortic Vascular Smooth Muscle Cells

  • Kim, T-J;Hong, J-T;Ryu, C-K;Park, Y-S;Song, Y-S;Yu, M-U;Jeon, J-S;Jin, Y-R;Yun, Y-P
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.160-160
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    • 2001
  • We recently reported that, 2-chloro-3-(4-hexylphenyI)-amino-l, 4-naphthoquinone(NQ304), a naphthoquinone derivative, had potent inhibitory effects on the platelet aggregation in vitro and thrombosis in vivo. Furthermore, we reported the antiplatelet mechanism of NQ304 by the reduction of the thromboxane A2 formation, inhibition of adenosine triphosphate release and intracellular calcium mobilization.(omitted)

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Isolation and Antimicrobial Activity of a Naphthoquinone from Impatiens balsamina (봉선화의 항균활성성분(抗菌活性成分)과 항균력(抗菌力)에 관(關)한 연구(硏究))

  • Kang, Soo-Chul;Moon, Young-Hee
    • Korean Journal of Pharmacognosy
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    • v.23 no.4
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    • pp.240-247
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    • 1992
  • Impatiens balsamina Linne(Balsaminaceae) known as 'BONG SUN HWA' in Korea and has been used for the treatment of scrofulosis, carbunculus and dysenteria etc. Bioassay-guided fractionation of MeOH extract from the whole plants of Impatiens balsamina has afforded a simple naphthoquinone derivative, 2-methoxy-1,4-naphthoquinone. The structure of this compound was established by spectroscopic methods. This compound possessed strong antifungal activity against Candida albicans, AspergiIlus niger, Crytococcus neoformans and Epidermophyton floccusum. The activity of 2-methoxy-1,4-naphthoquinone on E. floccusum $(MIC{\;}:{\;}5.0{\;}{\mu}g/ml)$ was the same potency as that of nystatin. It showed also strong antibacterial activity against gram-positive bacteria Bacillus subtilis as well as gram-negative bacteria Salmonella typhimurium. Although the activity of this compound on gram-negative bacteria was lower than that of gram-positive bacteria.

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ANTIPLATELET AND ANTITHROMBOTIC ACTIVITIES OF VK-708, A NEWLY SYNTHESIZED VITAMIN K DERIVATIVE

  • Jin, Yong-Ri;Ryu, Chung-Kyu;Shin, Hwa-Sup;Yun, Yeo-Pyo
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.118-118
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    • 2002
  • It has been reported that vitamin K analogues have various pharmacological effects such as antiviral, antifungal, anticancer, and antiplatelet activities. It has also been reported that some synthetic naphthoquinone compounds showed antiplatelet activities.(omitted)

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Naphthalene Derivative Supported Activated Carbon Composite Electrode with Enhanced Capacitance and Potential Window

  • Hu, Mengyang;Park, Jeong Ho;Lee, Kwang Se;Ko, Jang Myoun
    • Journal of Electrochemical Science and Technology
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    • v.10 no.2
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    • pp.99-103
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    • 2019
  • A derivative of 1,4-Naphthoquinone coded HBU671 was synthesized and used in addition to activated carbon as composite electrode for supercapacitor application. From the electrochemical properties analysis, a specific capacitance of about $300F\;g^{-1}$ exhibited almost two times of that of activated carbon at a scan rate of $100mV\;s^{-1}$ and a potential window of - 0.2 - 1V. This improvement is due to the inherent redox reaction in HBU671. Cycle test also proved that this composite is still stable even after 1000 cycle within the applied potential window and it is highly recommended for practical application.

Studies on 1,2-Naphthoquinone-(2)diazide-5-sulfonic Acid Ester Derivatives for Pre-sensitized Offset Plates (PS 판용 1,2-Naphthoquinone-(2)diazide-5-sulfonic Acid Ester Derivatives의 합성 및 응용)

  • Ku, Yang Seo;Myung, Young Chan;Ahn, Chong Il;Kim, Sun Ho
    • Applied Chemistry for Engineering
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    • v.10 no.8
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    • pp.1169-1174
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    • 1999
  • 2-Diazo-1-naphthoquinone-5-sulfonyl chloride(NQD-Cl) was synthesized from sodium 2-diazo-naphthoquinone-5-sulfonate by chlorination. NQD-Cl was esterified with hydroxybenzophenones to give several 1,2-naphthoquinone-(2)-diazide-5-sulfonic acid ester derivatives(NQD-esters). We have compared benzophenone derivatives with methoxy group to benzophenone derivatives with hydroxy group. Solubility of each NQD-ester was studied. Each of NQD-esters was formulated with novolac base resin and PS plates were manufactured. Photosensitivity, bleachability, compatible exposed time and relative sensitivity were determined by UV spectrophotometry, imaged by UV lithographic techniques, and the gray scale method. According to the number of substituted NQD group, it showed that relative sensitivity was different from gray scale method. NQD-esters with methoxy group showed a good solubility and higher sensitivity than commercial PS ones.

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Glutathione Conjugates of 2- or 6-Substituted 5,8-Dimethoxy-1,4-Naphthoquinone Derivatives : Formation and Structure

  • Zheng, Xiang-Guo;Kang, Jong-Seong;Kim, Yong;You, Young-Jae;Jin, Guang-Zhu;Ahn, Byung-Zun
    • Archives of Pharmacal Research
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    • v.22 no.4
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    • pp.384-390
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    • 1999
  • Thirty-four glutathione conjugates of 5,8-dimethoxy-1,4-naphthoquinones (DMNQ) were synthesized and their structure was determined. The yield of GSH conjugate was dependent on size of alkyl group; the longer the size of alkyl group was, the lower was the yield. It was also found that the length of alkyl side chain influenced the chemical shift of quinonoid protons; the quinonoid protons of 2-glutathionyl DMNQ derivatives with R=H to propyl, 6.51-6.59 ppm vs. other ones with R=butyl to heptyl, 6.64-6.68 ppm. this was explained to be due to a folding effect of longer alkyl group. Glutathione (GSH) reacted with DMNQ derivative first to form a 1,4-adduct (2- or 3-glutathionyl-1,4-dihydroxy-5,8-dimethoxynaphthalenes) and then the adduct was autooxidized to 2- or 3-glutathionyl-DMNQ derivatives. Moreover, GSH reduced DMNQ derivatives to their hydrogenated products. It was suggested that such an organic reaction might play an important role for a study of metabolism or toxicity of DMNQ derivative sin the living cells.

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A Case Study of Biologically Derived Algicidal Substances (Naphthoquinone Derivative) for Mitigate of Stephanodiscus and It's Ecological Changing Monitoring (생물유래 살조물질 Naphthoquinone 유도체의 규조 Stephanodiscus 제어 효과 및 생태계 변화 모니터링: A case study)

  • Joo, Jae-Hyoung;Park, Bum Soo;Kim, Sae Hee;Han, Myung-Soo
    • Ecology and Resilient Infrastructure
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    • v.7 no.1
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    • pp.72-81
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    • 2020
  • Blooms of the small centric diatom Stephanodiscus is quite occasional in winter season in temperate freshwater ecosystems. Often, it leads to degradation of water quality and affects quality of supplied drinking water. In previous studies, naphthoquinone (NQ) compounds have been shown to be effective and selective for controlling winter bloom species Stephanodiscus hantzschii. We conducted a 5 ton scale mesocosm experiment to investigate the effects of NQ on native Stephanodiscus sp. collected from Nakdonggang River in water. After treatment with NQ 4-6 compound (0.2 μM), the cell density of Stephanodiscus sp. was rapidly reduced from 5 × 103 cells mL-1 to 0.2 × 103 cells mL-1 for 10 days. Additionally, NQ 4-6 compound did not affect physicochemical factors (water temperature, dissolved oxygen, pH, conductivity, nutrients) and biological factors (bacteria, heterotrophic nanoflagellates, zooplankton). Therefore, these findings suggest that the NQ 4-6 compound has potential as an alternative algicidal substances to effectively mitigate natural Stephanodiscus sp. blooms, and the application of NQ 4-6 compound will restore the healthy aquatic ecosystems.