• 한국통신학회논문지
• /
• 제28권4A호
• /
• pp.224-231
• /
• 2003

본 논문에서는 한국의 전파환경을 도시 계획법에서 지정한 지역세분을 기초로 4개의 대분류와 8개로 소구분하고 건폐율, 용적율, 건물간 거리 그리고 식물계수로 세분화하여 Hata 모델과 비교하고 Kor-231 모델을 제안하였다. 정확하고 기본적인 전파 특성을 위하여 공업지역과 주거지역을 선정하여 LOS와 N-LOS의 전파환경에서 전송거리에 따른 수신전력과 RMS 지연확산의 변화를 측정하였다. 측정결과를 Kor-231 모델과 비교하면 LOS의 수신전력이 25.5dB와 14.5dB, RMS 지역확산은 101ns와 35ns이며, N-LOS의 수신전력은 4.1dB와 1.6dB, RMS 지역확산은 74ns에서 200ns의 차이로 분석되었다.

• The Plant Pathology Journal
• /
• 제27권4호
• /
• pp.310-314
• /
• 2011

Nonstructural protein 3 (NS3) encoded by RNA3 of Rice stripe virus (RSV), known to be a suppressor of gene silencing, was cloned and sequenced. The cloned NS3 gene is composed of 636 nucleotides encoding 211 deduced amino acids, and showed a high degree of similarity with the equivalent genes isolated from Korea, Japan and China. The NS3 gene promoted the enhancement of transient gene expression and suppressed transgene co-silencing. In the transient GFP expression via agroinfiltration, GFP expression was dramatically enhanced in terms of both protein yield and expression period in the presence of NS3. The highest accumulation of GFP protein reached to 6.8% of total soluble proteins, which corresponded to a two-fold increase compared to that obtained in the absence of NS3. In addition, NS3 significantly suppressed the initiation of GFP co-silencing induced by the additive GFP infiltration in GFP-transgenic Nicotiana benthamiana. The NS3 gene was also found to be a stronger suppressor than Cucumber mosaic virus 2b. These observations are believed to be derived from the strong suppressive effect of NS3 on gene silencing, and indicate that NS3 could be used as an effective enhancer for the rapid production of foreign proteins in plants.

• Journal of Microbiology and Biotechnology
• /
• 제33권5호
• /
• pp.600-606
• /
• 2023

Dengue virus (DENV) is a widespread arbovirus. To efficiently establish infection, DENV evolves multiple strategies to hijack the host innate immune response. Herein, we examined the inhibitory effects of DENV serotype 2 (DENV2) nonstructural proteins on RIG-I-directed antiviral immune response. We found that DENV2 NS2A, NS2B, NS4A, and NS4B significantly inhibited RIG-I-mediated IFN-β promoter activation. The roles of NS2B in RIG-I-directed antiviral immune response are unknown. Our study further showed that NS2B could dose-dependently suppress RIG-I/MAVS-induced activation of IFN-β promoter. Consistently, NS2B significantly decreased RIG-I- and MAVS-induced transcription of IFNB1, ISG15, and ISG56. Mechanistically, NS2B was found to interact with MAVS and IKKε to impair RIG-I-directed antiviral response. Our findings demonstrated a previously uncharacterized function of NS2B in RIG-I-mediated antiviral response, making it a promising drug target for anti-DENV treatments.

• Bulletin of the Korean Chemical Society
• /
• 제7권5호
• /
• pp.385-388
• /
• 1986

The reaction of cupric nitrate trihydrate with S-2-pyridyl thioates in acetonitrile was studied. The major products were the corresponding carboxylic acids and $[Cu(NO_3)(C_5H_4NS)(C_5H_5NS$)] (Complex A). Sometimes $[Cu(NO_3)(C_5H_4NS)(H_2O$)] was also obtained in addition to Complex A. When Complex A was recrystallized in dimethylsulfoxide, $[Cu(NO_3)(C_5H_4NS)(C_5H_5NS)$ {$(CH_3)_2SO$}$_2]{\cdot}2H_2O$ was crystallized. The structures of these copper complexes and the role of cupric nitrate in the hydrolysis of S-2-pyridyl thioates are discussed.

• 폴리머
• /
• 제39권1호
• /
• pp.169-173
• /
• 2015

3-Aminopropyltrimethoxysilane(1NS) 또는 N-[3-(trimethoxysilyl)propyl]ethylenediamine(2NS)으로 표면 기능화된 실리카에 1-butyl-4-methylpyridinium chloride(Cl)와 tributylmethylammonium chloride(Amm), benzyldimethyltetradecylammonium chloride(Ben), 1-butyl-1-methylpyrrolidinium chloride(Pyr)와 같은 이온성 액체를 이용하여 표면처리한 후 메탈로센 촉매를 담지하여 에틸렌 중합을 실시하였다. $SiO_2/1NS/IL/(n-BuCp)_2ZrCl_2$ 촉매와 $SiO_2/2NS/IL/(n-BuCp)_2ZrCl_2$ 촉매의 Zr 함량은 아미노실란 화합물로만 표면 처리된 촉매보다 감소하였다. $SiO_2/1NS/IL/(n-BuCp)_2ZrCl_2$ 촉매의 중합 활성은 $SiO_2/1NS/(n-BuCp)_2ZrCl_2$ 촉매보다 증가하였다. 반면, $SiO_2/2NS/IL/(n-BuCp)_2ZrCl_2$은 Zr 함량의 감소로 중합 활성은 $SiO_2/2NS/(n-BuCp)_2ZrCl_2$ 촉매에 비해 감소하였다.

• 사상체질의학회지
• /
• 제17권1호
• /
• pp.130-141
• /
• 2005

1. Objectives The present study was carried out to investigate the effects of Chungpyesagan-tang on the $CCI_4-induced$ Liver Damage in Rats. 2. Methods Sprague-Dawley rats were devided into 5 experimental groups : Normal, $NS+CCI_4(Solid$ extract of $CCI_4$ injection group after Normal Saline feed), $CP+CCI_4(Solid$ extract of $CCI_4$ injection group after Chungpyesagantang feed), $CCI_4+NS(Nomal$ Saline feed group after $CCI_4$ injection), $CCI_4+CP(Solid$ extract of Chungpyesagantang feed group after $CCI_4$ injection). Biochemical assays for serum enzyme activities such as AST, ALT, ALP, BUN, Creatinine, Uric Acid, Total Protein, Albumin, Total Cholesterol, Triglyceride, Glucose, and mRNA Revelation of Cytochrome p450 and activities such as LPO(Lipid Peroxidation), GSH(Glutathione), GST(Glutathione-S- Transferase), Glutathione Reductase, Glutathione Peroxidase, SOD(Superoxide Dismutase), Catalase, Hydroxyproline, and ${\beta}-Glucuronidase$ were performed. 3. Results 1) $CP+CCI_4$ showed significantly lower relation of Cytochrome p450 than $NS+CCI_4$. 2) As to LPO Hydroxyproline, $CCI_4+CP$ showed significantly lower activity than $CCI_4+NS$. 3) As to GSH GST Glutathione Peroxidase Catalase, $CP+CCI_4$ showed higher activity than $NS+CCI_4$, $CCI_4+CP$ showed significantly higher activity than $CCI_4+NS$. 4) As to Glutathione Reductase SOD, $CCI_4+CP$ showed significantly higher activity than $CCI_4+NS$. 5) As to ${\beta}-Glucuronidase$, $CP+CCI_4$ showed signficantly lower activity than $NS+CCI_4$. 4. Conclusions Chungpyesagantang has the recovering effects on the $CCI_4-induced$ Liver Damage.

• 천문학회보
• /
• 제38권1호
• /
• pp.57.2-57.2
• /
• 2013

Based on N-body simulations, we find out that significant fraction of dynamically formed BH-BH (10 $M_{\odot}$ and NS-NS (1.4 $M_{\odot$ ecah) binaries are ejected from globular clusters. About 30 percent of compact stars are ejected in the form of binary. The merging time of ejected binary depends on the velocity dispersion of globular cluster. Some of ejected binaries have merging time-scales shorter than Hubble time and are expected to produce gravitational waves that can be detectable by the advanced ground-based interferometers. The merger rates of ejected BH-BH and NS-NS binaries per globular cluster are estimated to be 3.5 and 17 per Gyr, respectively. Assuming the spatial density of globular clusters as 8.4 $h^3$ clusters $Mpc^{-3}$ and extrapolating to the horizon distance of the advanced LIGO-Virgo network, we expect the detection rates solely attributed to BH-BH and NS-NS with cluster origin are to be 42 and 1.7 $yr^{-1}$, respectively. Besides, we find out that BH-NS binary ejection hardly occurs in globular clusters and dynamically formed compact binaries may possibly be the source of short GRBs whose locations are far from host galaxies.

• Annals of Pediatric Endocrinology and Metabolism
• /
• 제23권4호
• /
• pp.176-181
• /
• 2018

Noonan syndrome (NS) is an autosomal dominant disorder that involves multiple organ systems, with short stature as the most common presentation (>70%). Possible mechanisms of short stature in NS include growth hormone (GH) deficiency, neurosecretory dysfunction, and GH resistance. Accordingly, GH therapy has been carried out for NS patients over the last three decades, and multiple studies have reported acceleration of growth velocity (GV) and increase of height standard deviation score (SDS) in both prepubertal and pubertal NS patients upon GH therapy. One year of GH therapy resulted in almost doubling of GV compared with baseline; afterwards, the increase in GV gradually decreased in the following years, showing that the effect of GH therapy wanes over time. After four years of GH therapy, ~70% of NS patients reached normal height considering their age and sex. Early initiation, long duration of GH therapy, and higher height SDS at the onset of puberty were associated with improved final height, whereas gender, dosage of GH, and the clinical severity did not show significant association with final height. Studies have reported no significant adverse events of GH therapy regarding progression of hypertrophic cardiomyopathy, alteration of metabolism, and tumor development. Therefore, GH therapy is effective for improving height and GV of NS patients; nevertheless, concerns on possible malignancy remains, which necessitates continuous monitoring of NS patients receiving GH therapy.

• 한국패류학회지
• /
• 제30권4호
• /
• pp.391-397
• /
• 2014

동양달팽이의 EST 서열 4개의 클론을 어셈블리하여 추출되어진 NsCO-I (partial)서열의 코딩 영역은 852 bp, 284개의 아미노산으로 구성되어 있었다. BLAST 결과를 토대로 하여 유사도가 높은 68개의 서열을 추출 하였으며 MEGA6 프로그램을 통해 clustalW 엔진을 통해 다중서열정열을 수행하고 molecular phylogenetic analysis를 수행한 결과 Heterobranchia, Nudibranchia, Cephalaspidea, Sacoglossa, Pulmonata 등의 카테고리별로 잘 분류 되었으며 Mastigeulota kiangsinensis, Helix aspersa, Cepaea nemoralis, Elona quimperiana, Camaena cicatricosa, Cylindrus obtusus 등 육산패류들과 잘 묶인다는 사실을 확인 할 수 있었다.

• 한국정보통신학회논문지
• /
• 제10권12호
• /
• pp.2202-2211
• /
• 2006

EXT3NS 파일 시스템은 Network-Storage Card(NS 카드)라는 전용 하드웨어를 기반으로 하는 멀티미디어 스트리밍 서버를 위한 파일 시스템이다. EXT3NS는 NS 카드 상의 PCI memory(PMEM)를 이용, 스트리밍 시 디스크에 있는 데이터를 메인 메모리를 거치지 않고 바로 네트워크 카드로 내보냄으로써 스트리밍 서버의 성능을 향상시킨다. 본 논문에서는 NS 카드에 있는 PMEM을 기반으로 한 버퍼 캐시를 추가 설계, 구현하고, 이 버퍼 캐시가 EXT3NS 파일 시스템을 채용한 서버의 멀티미디어 스트리밍의 성능을 개선시킬 수 있음을 보인다. 또한, 제안된 버퍼 캐시 상에서 다수의 동시 사용자를 지원하는 멀티 미디어 스트리 밍 서버를 위한 버퍼 캐시 교체 정책인 Old New Section(ONS) 교체 기법을 제안한다. 제안된 OSN 교체 기법은 멀티미디어 스트리밍 환경에서 기존의 교체 정책들 보다 좋은 성능을 보인다. 성능 평가 결과, 다시 읽기동작과 무작위 읽기 동작에서 기존의 EXT3NS 파일 시스템 보다 PMEM에 캐시를 사용한 EXT3NS가 각각 평균 33MB/sec, 2.4MB/sec의 성능이 향상 되었다. 또한, 다시 읽기 동작의 경우 기존의 Least Frequently Used(LFU) 교체 정 책을 사용한 경우보다 ONS 교체 정책을 사용한 경우가 약 600KB/sec의 성능 증가를 보인다. 이러한 결과는 동시에 여러명의 사용자 요구를 처리해야 하는 대용량 멀티 미디어 스트리밍 서버에서 보다 효과적인 읽기 동작을 처리할 수 있음을 나타낸다.