• 한국의사학회지
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• 제29권2호
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• pp.61-69
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• 2016

This study was performed to examine the clinical discussion records where Lee Gong-yoon, participated in Royal treatment at Joseon Dynasty, was involved. Lee Gong-yoon who scouted from the outside had participated in the medical center of the Royal Family for several years as a royal doctor. But he preferred aggressive prescriptions and behaved indiscreet. Eventually, he was exiled when Kyung-Jong who was the 20th king of the Joseon Dynasty died. He was harshly criticized until the year crown prince ascended the throne following Kyung-Jong. But some officials started to defend him since March of the next year. They recognized Lee Gong-yoon's aggressive prescriptions and indiscreet behavior. But mentioned that some very aggressive prescriptions didn't come from his own idea. After they proved their insistence true, his place of exile was changed from island to outland. Different from other doctors who focused on patients' 元气 ($yu{\acute{a}}nq{\grave{i}}$), Lee Gong-yoon focused on removing patients' symptoms when he decided to cure a disease. And also he had considerable insight of "醫學入門 ($y{\bar{i}}xu{\acute{e}}r{\grave{u}}m{\acute{e}}n$)". Despite of his high degree of medical knowledge, unconventional character and behavior made the end of his life unfortunate.

• 동아시아식생활학회지
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• 제25권1호
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• pp.73-86
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• 2015

The present study was performed to evaluate food behavior and nutritional status of children in a community child center using nutrition quotient according to age and growth index of children. The number of subjects enrolled in this study was 152 including 73 boys and 79 girls. Participants consisted of children from 5 to 12 years old, who visited a community child center in the area. Growth index was assessed through body mass index by height and weight and examined according to age. Subjects were divided into underweight, normal weight, overweight and obese according to questionnaire, which consisted of five categories including balance, diversity, moderation, regularity and practice, were analyzed by SPSS statistical program. Current results show significant differences in the diversity and regularity (p<0.05, p<0.001, respectively). Additionally, four items in the form of 10 questions showed significant differences related to habits of sodium-related food intake. This study design will be a useful tool in the evaluation of food behavior and nutritional status of preschoolers or elementary school children in community child centers, together with food frequency questionnaires related with sodium food intake.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2005년도 춘계학술발표대회
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• pp.675-678
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• 2005

고성능의 컴퓨터들이 많이 보급되었으며, 또한, 클러스터 시스템 기술의 발전으로 클러스터 시스템의 활용이 크게 늘고 있다. 이러한 고성능의 시스템을 사용하는 사용자들은 다수의 시스템에서 수행하는 작업들을 관리(실행, 모니터링, 삭제, 결과물 관리 등)할 때에 반복적인 작업들이 많이 존재한다. 그러므로, 이러한 반복적인 작업을 손쉽게 수행해 줄 수 있는 기능이 제공된다면 업무를 효율적으로 처리할 수 있을 것이다. 이 논문에서는 분산된 다수의 시스템에서 작업을 수행할 때 스케쥴러(예: PBS, NQS)와 작업을 수행하는 일을 대신해줄 수 있는 통합 작업 스케쥴러(CJS, Consolidation Job Scheduler)를 설계하고, 그 prototype을 구현해 보았다. 스케쥴러의 종류가 많기 때문에 여기서는 PBS와 NQS에 한정하여 구현하였다.

• 한국식생활문화학회지
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• 제30권4호
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• pp.439-446
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• 2015

This study considered network quotient (NQ) of deluxe hotel employees and schematized characteristic attributes of being selected by employees with image through correspondence analysis in terms of cognition degree. Self-administrated questionnaires were completed by employees (292 samples) and data were analysed by frequency, t-test, one-way ANOVA, reliability and correspondence analysis. First, the hotel employees indicated the high average value in "participating in special education or seminar for improving ability ($3.85{\pm}0.76$). Second, as a result of analyzing difference according to gender, the average value in men was higher than in women. It was indicated that the higher age and career lead to a rise even in the average value of relationship index. Third, in consequence of carrying out correspondence analysis in order to prepare image map according to cognition level on relationship index in hotel employees, the measurement item that is placed in the closest distance to the response as saying of not so very was the response as saying of "having a lunch (dinner) engagement twice or three times a week." On the other hand, the response as saying of "tending to have many acquaintances compared to coworkers" was schematized in the close distance to the response as saying of very so.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.407-426
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• 2008

The bentonite slurry has been used as the stabilize suspension for wet process bored pile construction in Thailand. The bentonite suspension has benefit on filtration in the sand layer, but it creates thick cake film along pile shaft and loose sedimentation at pile toe. The base grouting technique was widely used to rectify the soft base or loose sedimentation problem of bored pile. The base grouting technique was not increased only end bearing capacity, but was also more increase in skin friction capacity of the bored piles. The comprehensive researches on base grouting was carried out by installing PVC casing inside the shaft to allow the drilling through the pile base in order to collect the soil sample below the pile tip. The polymer based slurry recently was used to replace the bentonite slurry to overcome the thick cake film along pile shaft as well as loose sedimentation at pile toe. The extent research on polymer slurry by physical model was performed to verify the real behavior of polymer. The appropriate mixing ratio of polymer was proposed. The design skin friction coefficient, $\beta$ and end bearing coefficient, Nq, for sand layer base on fully instrumented tested pile were proposed. The application on remedial of the lose capacity bored pile with large displacement in Bangladesh was proposed and discussed.

• 한국재료학회지
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• 제32권5호
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• pp.280-286
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• 2022

Corrosion is a natural, inevitable process, and is one of the world's most serious problems. Losses incurred due to corrosion are extremely expensive for society. Several technological strategies have been explored and implemented to address these losses. The use of inhibitors to prevent corrosion is a common and efficient method to reduce corrosion losses. This review covers Al and Al-composite corrosion inhibitors in chloride-containing solutions, because of their popularity in a broad array of industrial applications. A vast number of studies in the literature detail the common tendency of Al and Al-composites with reinforcements to deteriorate. Accordingly, it is worthwhile to employ inhibitors to protect them, as discussed in the present work. The emphasis is on selecting the smartest corrosion inhibitor and evaluating its performance. According to the study, the most commonly used corrosion inhibitors are 1,4-naphthoquinone (NQ), 1,5-naphthalene diol, 3-amino-1,2,4-triazole-5-thiol (ATAT), ammonium tetrathiotungstate, clotrimazole, amoxicillin, antimicrobial and antifungal drugs. Electrochemical impedance spectroscopy (EIS), potentiodynamic (PDP), and weight loss were among the most commonly used modern electrochemical technologies to test inhibitors' efficacy under environmental conditions.

• 대한한방내과학회지
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• 제32권3호
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• pp.387-396
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• 2011

Objectives : Recently a lot of research is being done for find antidiabetic medicine which has no side effects. This study aimed to investigate the antidiabetic and antiobesity effects of Supungsunki-hwan partitioned prescriptions on obese type 2 diabetes mouse. Methods : Type 2 diabetes mellitus and obesity were induced by Surwit's high fat, high sucrose diet for 8 weeks. Mice were divided into 3 groups of ND (normal diet, n=10) HFD (high fat and high sucrose diet, n=10) and SPP (high fat and high sucrose diet with Supungsunki-hwan partitioned prescriptions, n=10) groups. Body weights were measured every week. After 7 weeks, fasting blood sugar and oral glucose tolerance tests were conducted. After 8 weeks, blood samples of all mice were taken from their heart and analyzed biochemically. At the same time, epididymal fat pad and liver weights were measured. Histological size of white adipocyte were measured as well. Results : Compared with a HFD group, body weight, fructosamine, epididymal fat pad weight and white adipocyte size decreased. High-density lipoprotein cholesterol levels increased in the SPP group. Conclusions : These results suggest that SPP has antidiabetic and antiobesity effects in high fat, high sucrose diet induced obese mice.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.109-109
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• 1997

Inhibitory effect on DNA topoisomerase-I, rate of glutathione conjugation and cytotoxicity of naphthoquinone derivatives were correlated. During 5 min exposure of the derivatives to glutathione (GSH), it was found that 14% of 5,8-dimethoxy-1,4-naphthoquinone(DMNQ) was converted into a GSH-conjugate, whereas 5,8-dihydroxy-1,4-naphthoquinone(DHNQ) did not interact with GSH, implying that DMNQ exerted higher electrophilicity than DHNQ. However, DHNQ (IC$\_$50/, 0.15 ${\mu}$M) showed stronger cytotoxicity in L1210 cells than DMNQ(IC$\_$50/, 0.45 ${\mu}$M). The stronger cytotoxicity of DHNQ, compared to DMNQ, could be ascribed to more rapid redox cycling. Both naphthoquinones (IC$\_$50/, 60-65 ${\mu}$M) exhibiting about the same inhibitory effect on DNA topoisomerase-I were more potent than 1,4-naphthoquinone(1,4-NQ, IC$\_$50/, 134 ${\mu}$M). Thus, 5,8-oxy groups in the structure seem to be important for the inhibition of the enzyme. DMNQ showed a broader dose range while maintaining a good antitumor activity against S-180 fluid tumor. For these reasons, DMNQ was taken as useful pharmacophore for structural modification. Introduction of 1-hydroxyalkyl groups at C-2 of DMNQ lowered all of the activities mentioned above, while acetylation of 1-hydroxyalkyl moiety enhanced the activities by 4-5 times. Introduction of the same side chains at C-6 exhibited stronger activities than 2-substituted ones. Based on these results it was suggested that the quinonoid moiety in 6-substituted DMNQ was more exposed to cellular nucleophiles such as DNA, thiols of enzymes and so on. The synthesis of DHNQ or DMNQ derivatives are going on, and the corelationship between structure-activity will be discussed.

• Journal of Microbiology and Biotechnology
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• 제19권5호
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• pp.431-438
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• 2009

The alkaline serine protease asp, which was shown to be a virulence factor of Vibrio alginolyticus as a purified protein, was cloned from V. alginolyticus EPGS, a strain recently isolated from moribund Epinephelus coioides in an outbreak of vibriosis in a mariculture farm of Shenzhen. The asp null mutant was constructed by homologous recombination with suicide plasmid pNQ705-1. Compared with the wild-type strain, the asp null mutant exhibited a significant decrease of total extracellular protease activity, and caused a IS-fold decrease in virulence of V. alginolyticus. In our previous study, the luxO and $luxR_{val}$ genes from V. alginolyticus MVP01 were cloned and identified, and the luxO-$luxR_{val}$ regulatory couple was shown to regulate various genes expression, suggesting that it played a central role in the quorum sensing system of V. alginolyticus. In this study, the regulation of the asp gene was analyzed by using RT-PCR and quantitative real-time PCR methods; we proved that its transcription was greatly induced at the late stage of growth and was regulated by a luxO-$luxR_{val}$ regulatory system.

• 정보관리학회지
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• 제5권1호
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• pp.31-52
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• 1988

정보의 자원화를 국가 발전의 기본적인 원동력으로 간주하고 있는 일본의 정책 현 황을 일본학술회의, 과학기술청, 통상산업성, 문부성을 중심으로 분석하였다. 정책이 효과적 으로 실행되기 위하여서는 최고 통치권자를 자문하는 협의 기관이 반드시 필요하며 이를 능 독적으로 활동시키기 위한 제도 또한 중요하다. 법률에 의한 명백한 임무의 부여와 관 에리 트와 지식 인간의 협력 또는 마찰의 정도가 정보 정책을 시행하는데 결정적인 요인이 됨을 현재 진행되고 있는 여러 시책 사항을 통하여 지적하였다. 문부성에서 의욕적인 정책으로 추진하여 소기의 성과를 거두고 있는 일본학술정보센터의 정책적 효과를 온라인 네트워크를 편성하는 기본 조직으로 주의 깊게 관찰할 대상임을 강조하였으며 과학기술청이 주관하는 일본 과학기술정보센터의 기능 또한 중요한 기관으로 간주됨을 분석하였다. 이들 기관 이외 에 광범위한 활동을 전개하고 있는 각급 사회 단체 연구소등 반관반민의 조직 또는 민간 레 벨의 조직은 본론에서는 제외되었다.