• Title/Summary/Keyword: NOTCH4

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Design and simulation of small size high-Tc superconducting magnet (소형 고온 초전도 마그넷 설계 및 시뮬레이션)

  • 김민기;강형곤;정동철;한병성
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1994.11a
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    • pp.192-197
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    • 1994
  • High-Tc superconducting magnet properties were dependent upon design conditions such as its radius, length, critical current and notch size. In order to study, design and the simulation for small size magnet were implemented. We know that intensity of magnetic fields controled by critical current and factor ${\alpha}$( R$_2$/R$_1$) and uniformity controled by notch size. The optimal condition of intensity and uniformity magnetic field in this experiments are R$_1$=3[cm], R$_2$=12[cm], Z=10[cm], ${\alpha}$=4, notch=6[cm], critical current=12[A].

A Study on the Fatigue Fracture Behavior of Weld Toe Notch in Structure Steel (구조용강에서 용접 Toe Notch의 피로파괴거동에 관한 연구)

  • 차용훈;김하식;노승희
    • Proceedings of the KWS Conference
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    • 1996.05a
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    • pp.115-118
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    • 1996
  • 1. The crack is inifiated at a toe notch and reptured for the skip and continuous welding. 2. Fatigue life of continuous welding is greater than that of skip welding and fatigue life of 2pad continuous welding appears 1.7 times more than that of pad continuous welding. 3. For the skip and continuous welding, fatigue than that of welding materials appears shorter than that of welding materials because of the effect of plastic strain and compressive residual stresses at the crack tip, which are generated by the over loading. 4. Inter-relationship between da/dN-ΔK and delayed phenomenon increases linearly at the state growth area of heat effect section for the skip and continuous welding.

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Plastic collapse behaviour of statically indeterminate beams with a crack under concentrated load (집중하중하의 균열을 갖는 부정정보의 소성붕괴거동)

  • 남기우
    • Journal of Ocean Engineering and Technology
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    • v.10 no.4
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    • pp.67-74
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    • 1996
  • The paper focuse on the effect of a crack subjects to collaspe behabiors of statically indeterminate beams under concentrated load. Through the experiment and calculation, it was revealed that the collaspe load of statically indeterminate beams is much higher than that of statically determinate beams. The cumulative AE event counts of statically determinate beams was less than that of statically indeterminate beams, and the center notch beams sas revealed less than that of the side notch beams.

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Indole-3-Carbinol Promotes Goblet-Cell Differentiation Regulating Wnt and Notch Signaling Pathways AhR-Dependently

  • Park, Joo-Hung;Lee, Jeong-Min;Lee, Eun-Jin;Hwang, Won-Bhin;Kim, Da-Jeong
    • Molecules and Cells
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    • v.41 no.4
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    • pp.290-300
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    • 2018
  • Using an in vitro model of intestinal organoids derived from intestinal crypts, we examined effects of indole-3-carbinol (I3C), a phytochemical that has anticancer and aryl hydrocarbon receptor (AhR)-activating abilities and thus is sold as a dietary supplement, on the development of intestinal organoids and investigated the underlying mechanisms. I3C inhibited the in vitro development of mouse intestinal organoids. Addition of ${\alpha}$-naphthoflavone, an AhR antagonist or AhR siRNA transfection, suppressed I3C function, suggesting that I3C-mediated interference with organoid development is AhR-dependent. I3C increased the expression of Muc2 and lysozyme, lineage-specific genes for goblet cells and Paneth cells, respectively, but inhibits the expression of IAP, a marker gene for enterocytes. In the intestines of mice treated with I3C, the number of goblet cells was reduced, but the number of Paneth cells and the depth and length of crypts and villi were not changed. I3C increased the level of active nonphosphorylated ${\beta}$-catenin, but suppressed the Notch signal. As a result, expression of Hes1, a Notch target gene and a transcriptional repressor that plays a key role in enterocyte differentiation, was reduced, whereas expression of Math1, involved in the differentiation of secretory lineages, was increased. These results provide direct evidence for the role of AhR in the regulation of the development of intestinal stem cells and indicate that such regulation is likely mediated by regulation of Wnt and Notch signals.

THE EFFECT OF CAVITY CONFIGURATION ON MARGINAL LEAKAGE OF CLASS 5 RESTORATION (와동형태가 5급 와동 수복물의 변연누출에 미치는 영향)

  • Park, Jeong-Kil;Hur, Bock;Lee, Hee-Ju
    • Restorative Dentistry and Endodontics
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    • v.26 no.2
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    • pp.162-170
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    • 2001
  • The purpose of this study was to investigate the effect of cavity configurations on the marginal leakage of class 5 glass ionomer cement and composite resin restorations. Four types of cavities such as saucer shape. notch shape. combined shape(notch shape occlusally and saucer shape gingivally). and U shape were prepared on the buccal and lingual surfaces of 80 extracted premolars(40 cavities for each shape). Occlusal cavity margins were placed at enamel and cervical margins were placed at dentin. 10 cavities of each shape were restored with Ketac Fil as a conventional glass ionomer cement. Fuji II LC improved as a resin modified glass ionomer cement, Z 100 as a hybrid composite resin. and Tetric Flow as a flowable composite resin (40 cavities for each material). After thermocycling, teeth were immersed in 5% basic fuchsin solution for 6 hours and sectioned longitudinally in a buccolingual direction through the center of the restoration. The dye penetrations at the tooth restoration interface were examined by stereomicroscope. The Result were as follows 1. In saucer shape, notch shape and combined shape, composite resin restorations showed lesser leakage than glass ionomer restorations(p<0.05) and in U shape. Tetric Flow showed the least marginal leakage and others were decreased as Z 100. Fuji II LC improved, Ketac Fil in that order. There were statistically significant difference between Tetric Flow and Fuji II LC improved. Ketac Fil and between Z 100 and Ketac Fil(p<0.05). 2. In Ketac Fil restoration group, saucer shape showed the highest marginal leakage and U shape showed the least marginal leakage and others were decreased as notch shape, combined shape in that order. There were statistically significant difference between saucer shape and combined shape, U shape and between notch shape and U shape(p<0.05). 3. In Fuji II LC improved restoration group, U shape showed the least marginal leakage. There were statistically significant difference between U shape and other three shapes(p<0.05). 4. The cavity configuration had no significant effect on marginal leakage of composite resin restorations(p>0.05).

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Anatomic Characteristics of Supraorbital Foramina in Korean Using Three-Dimensional Model

  • Woo, Sang Woo;Lee, Hye Joo;Nahm, Francis Sahngun;Lee, Pyung Bok;Choi, Eun Joo
    • The Korean Journal of Pain
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    • v.26 no.2
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    • pp.130-134
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    • 2013
  • Background: The aims of this study were to analyze the anatomic variations of supraorbital foramina/notches in Koreans and to compare the results with those of previous studies examining other races. We evaluated the three-dimensional computed tomography (3D-CT) images of human faces using multidetector computed tomography (MDCT). Methods: A total of 395 adults (232 men and 163 women) were enrolled and the 3D-CT images of their faces were reviewed in this study. In this study, the data from the images included the presence, shape, width and distance from the nasion to the supraorbital foramina/notches. ANOVA was used to assess the main effects of gender and side (right or left foramen/notch), and comparisons of the means were done by paired t-test. Results: The most common shapes in Koreans were a single notch (39.5%) on the right hand side and a single foramen (42.3%) on the left hand side. The incidence of a single foramen in Koreans was high compared to other races. The mean foramen diameter was $2.34{\pm}0.78$ mm, and the mean distance from the nasion was $27.19{\pm}4.03$ mm. The mean notch diameter was $3.37{\pm}1.71$ mm, and the mean distance from the nasion was $23.42{\pm}2.45$ mm. Conclusions: This is the first study on the variations of supraorbital foramina/notches in Koreans using 3D-CT images of faces. The anatomic characteristics of the supraorbital foramina/notch will help in performing nerve blocks and maxillofacial surgery.

PERIODONTAL RESPONSE FOLLOWING APPLICATION OF INTRUSIVE FORCES TO THE INCISORS WITH BONE LOSS AND PERIODONTAL DISEASE IN ADULT DOGS (골결손과 치주질환 유도 후 성견 절치의 실험적 함입이동시 치주조직의 반응)

  • Hwang, Hyeon-Shik;Park, Yang-Soo;Choi, Hong-Ran
    • The korean journal of orthodontics
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    • v.28 no.3 s.68
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    • pp.431-440
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    • 1998
  • While periodontal disease results in the extrusion of upper incisors with interdental spacing in adult patient, the intrusive movement should be executed for the rehabilitation in terms of esthetics and function. The present study was peformed to investigate the periodontal response following orthodontic intrusion of teeth with infrabony pocket. Bone defect and periodontal disease were produced adjacent to the both maxillary second lateral incisors in four adult dogs. Four weeks later, a flap operation was performed to eliminate inflammation and a reference notch was made on the root surface at the level of bottom of each defect. Two weeks after periodontal surgery, 4 weeks of intrusion and subsequent another 4 weeks of retention was executed on the right side of incisors while left incisors served as the control. Through the histologic analysis, following results were obtained. 1. Histologic section of control side showed the reduction of pocket depth after flap operation. However, the status of long junctional epithelium was observed while new connective tissue attachment occurred in a small area adjacent newly formed cementum 2. Epithelial attachment was less around the intruded incisor while new connective tissue attachment was much more compared to the control side. 3. Plenty of cells were observed in the connective tissue around the reference notch of the intruded incisor and the degree of the new cementum formation was higher in the intruded incisor than the control. The results of the present study suggested that an orthodontic intrusion of periodontally involved and extruded incisors could be carried out with a desirable periodontal response, provided that inflammation is under control.

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SRR and CSRR Loaded UWB Antenna with Tri-Band Notch Capability (SRR과 CSRR을 이용한 삼중 대역 차단 초광대역 안테나)

  • Yoo, Min-Yeong;Lim, Sung-Joon
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.23 no.3
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    • pp.320-327
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    • 2012
  • In this paper, a novel ultra wide band(UWB) antenna with tri-band notch capability is proposed. The proposed antenna can reject WiMAX(3.3~3.7 GHz), WLAN IEEE 802.11a/n(5.15~5.825 GHz), and ITU(8.025~8.4 GHz) bands. Band rejection capability is achieved only split ring resonators(SRRs) and complementary SRRs(CSRRs). The SRR under the radiating patch, the CSRR loaded on the radiating patch, and the CSRRs on the ground of the CPW feeding reject the WiMAX, WLAN, and ITU bands, respectively. The simulation and measurement results demonstrate the performances of the proposed antenna.

Inherent Damage Zone Model for fatigue Strength Evaluation of Cracks and Notches (영역피해모델에 의한 균열 및 노치의 피로강도평가)

  • Kim Won-Beom;Paik Jeom-Kee;Fujimoto Yukio
    • Journal of the Society of Naval Architects of Korea
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    • v.43 no.4 s.148
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    • pp.494-503
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    • 2006
  • Inherent damage zone model is presented to explain the fatigue properties near the fatigue limit and the crack growth threshold consistently Inherent damage zone model assumes that the stress at a point which is located at a small distance, $r_0$, an inherent length of the material that represents the size of effective damage zone, from the crack initiation position governs the fatigue characteristics regardless of the geometric configuration of the specimen; smooth specimen, notched specimen or cracked specimens with short and long crack length. A special feature of the paper is using the exact stress distributions of notched and cracked specimens at the strength evaluations. Analytical elastic solutions by Neuber and Westergaard are employed for this purpose Relationship between fatigue limit of smooth specimen and threshold stress of cracked specimen, occurrence condition of non-propagating crack at the root of elliptic notch and circular hole and relationship between stress concentration factor and fatigue notch factor are discussed quantitatively based on the proposed model.

Estimation of optimal nasotracheal tube depth in adult patients

  • Ji, Sung-Mi
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.17 no.4
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    • pp.307-312
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    • 2017
  • Background: The aim of this study was to estimate the optimal depth of nasotracheal tube placement. Methods: We enrolled 110 patients scheduled to undergo oral and maxillofacial surgery, requiring nasotracheal intubation. After intubation, the depth of tube insertion was measured. The neck circumference and distances from nares to tragus, tragus to angle of the mandible, and angle of the mandible to sternal notch were measured. To estimate optimal tube depth, correlation and regression analyses were performed using clinical and anthropometric parameters. Results: The mean tube depth was $28.9{\pm}1.3cm$ in men (n = 62), and $26.6{\pm}1.5cm$ in women (n = 48). Tube depth significantly correlated with height (r = 0.735, P < 0.001). Distances from nares to tragus, tragus to angle of the mandible, and angle of the mandible to sternal notch correlated with depth of the endotracheal tube (r = 0.363, r = 0.362, and r = 0.546, P < 0.05). The tube depth also correlated with the sum of these distances (r = 0.646, P < 0.001). We devised the following formula for estimating tube depth: $19.856+0.267{\times}sum$ of the three distances ($R^2=0.432$, P < 0.001). Conclusions: The optimal tube depth for nasotracheally intubated adult patients correlated with height and sum of the distances from nares to tragus, tragus to angle of the mandible, and angle of the mandible to sternal notch. The proposed equation would be a useful guide to determine optimal nasotracheal tube placement.